Browse > Article

Targeted Polymeric Gene Delivery for Anti-angiogenic Tumor Therapy  

Kim, Won-Jong (Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah)
Kim, Sung-Wan (Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah)
Publication Information
Macromolecular Research / v.15, no.2, 2007 , pp. 100-108 More about this Journal
Abstract
Gene therapy has become a promising strategy for the treatment of genetically based diseases, such as cancer, which are currently considered incurable. A major obstacle in the field of cancer gene therapy is the development of a safe and efficient delivery system for therapeutic gene transfer. Non-viral vectors have attracted great interest, as they are simple to prepare, stable, easy to modify and relatively safe compared to viral vectors. In this review, an insight into the strategies developed for polyethylenimine (PEI)-based non-viral vectors has been provide, including improvement of the polyplex properties by incorporating hydrophilic spacer, poly(ethylene glycol) (PEG). Moreover, this review will summarize the strategies for the tumor targeting. Specifically, a targeted polymeric gene delivery system, PEI-g-PEG-RGD, will be introduced as an efficient gene delivery vector for tumor therapy, including its functional analysis both in vitro and in vivo.
Keywords
Gene therapy; polyethylenimine; poly(ethylene glycol); angiogenesis; targeted carrier;
Citations & Related Records

Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
연도 인용수 순위
1 J. Folkman and Y. Shing, J. Biol. Chem., 267, 10931 (1992)
2 A. W. Griffioen and G. Molema, Pharmacol. Rev., 52, 237 (2000)
3 N. Ferrara and T. Davis-Smyth, Endocr. Rev., 18, 4 (1997)
4 C. de Vries, J. A. Escobedo, H. Ueno, K. Houck, N. Ferrara, and L. T. Williams, Science, 255, 989 (1992)
5 B. Millauer, L. K. Shawver, K. H. Plate, W. Risaui, and A. Ullrich, Nature, 367, 576 (1994)
6 P. Borgstrom, K. J. Hillan, P. Sriramarao, and N. Ferrara, Cancer Res., 56, 4032 (1996)
7 H. L. Kong, D. Hecht, W. Song, I. Kovesdi, N. R. Hackett, A. Yayon, and R. G. Crystal, Hum. Gene Ther., 9, 823 (1998)   DOI   ScienceOn
8 R. J. Jin, C. Kwak, S. G. Lee, C. H. Lee, M. S. Park, E. Lee, and S. E. Lee, Cancer Gene Ther., 12, 1537 (2000)
9 W. J. Kim, T. Akaike, and A. Maruyama, J. Am. Chem. Soc., 124, 12676 (2002)
10 C. H. Ahn, S. Y. Chae, Y. H. Bae, and S. W. Kim, J. Control. Rel., 80, 283 (2002)
11 J. W. Wiseman, C. A. Goddard, D. McLelland, and W. H. Colledge, Gene Ther., 10, 1654 (2003)
12 S. M. Zou, P. Erbacher, J. S. Remy, and J. P. Behr, J. Gene Med., 2, 128 (2000)   DOI   ScienceOn
13 D. Y. Kwoh, C. C. Coffin, C. P. Lollo, J. Jovenal, M. G. Banaszczyk, P. Mullen, A. Amini, J. Fabrycki, R. M. Bartholomew, S. W. Brostoff, and D. J. Carlo, Biochim. Biophys. Acta., 1444, 171 (1999)
14 M. Ogris, S. Brunner, S. Schuller, R. Kircheis, and E. Wagner, Gene Ther., 6, 595 (1999)
15 E. Ruoslahti, Annu. Rev. Cell Dev. Biol., 12, 697 (1996)
16 P. J. Mahasreshti, J. G. Navarro, M. Kataram, M. H. Wang, D. Carey, G. P. Siegal, M. N. Barnes, D. M. Nettelbeck, R. D. Alvarez, A. Hemminki, and D. T. Curiel, Clin. Cancer Res., 7, 2057 (2001)
17 P. R. Dash, M. L. Read, L. B. Barrett, M. A. Wolfert, and L. W. Seymour, Gene Ther., 6, 643 (1999)
18 S. Zitzmann, V. Ehemann, and M. Schwab, Cancer Res., 62, 5139 (2002)
19 A. J. Schraa, R. J. Kok, A. D. Berendsen, H. E. Moorlag, E. J. Bos, D. K. Meijer, L. F. de Leij, and G. Molema, J. Control. Rel., 83, 241 (2002)
20 F. Yuan, Y. Chen, M. Dellian, N. Safabakhsh, N. Ferrara, and R. K. Jain, Proc. Natl. Acad. Sci. USA, 93, 14765 (1996)
21 Y. H. Choi, F. Liu, J. S. Kim, Y. K. Choi, J. S. Park, and S. W. Kim, J. Control. Rel., 54, 39 (1998)
22 J. M. Benns, A. Maheshwari, D. Y. Furgeson, R. I. Mahato, and S. W. Kim, J. Drug Targeting, 9, 123, (2001)   DOI
23 F. Mathot, L. van Beijsterveldt, V. Preat, M. Brewster, and A. Arien, J. Control. Rel., 111, 47 (2006)
24 M. Bikram, M. Lee, C. W. Chang, M. M. Janat-Amsbury, S. E. Kern, and S. W. Kim, J. Control. Rel., 103, 221 (2005)
25 A. von Harpe, H. Petersen, Y. Li, and T. Kissel, J. Control. Rel., 69, 309 (2000)
26 T. Tanaka, Y. Manome, P. Wen, Y. Cao, D. Kufe, and J. Folkman, Proc. Am. Assoc. Cancer Res., 38, 264 (1997)
27 P. Marschall, N. Malik, and Z. Larin, Gene Ther., 6, 1634 (1999)
28 S. Brunner, T. Sauer, S. Carotta, M. Cotton, M. Saltik, and E. Wagner, Gene Ther., 7, 401 (2000)
29 B. Millauer, L. K. Shawver, K. H. Plate, W. Risau, and A. Ullrich, Nature, 367, 576 (1994)
30 M. S. Bretscher, Cell, 85, 465 (1996)
31 D. Goula, C. Benoist, S. Mantero, G. Herlo, G. Levi, and B. A. Demeneix, Gene Ther., 5, 1291 (1998)
32 G. Neufeld, T. Cohen, S. Gengrinovitch, and Z. Poltorak, FASEB J., 13, 9 (1999)
33 R. L. Kendall and K. A. Thomas, Proc. Natl. Acad. Sci. USA, 90, 10705 (1993)
34 S. L. Hart, A. M. Knight, R. P. Harbottle, A. Mistry, H. D. Hunger, D. F. Cutler, R. Williamson, and C. Coutelle, J. Biol. Chem., 269, 12468 (1994)
35 W. J. Kim, J. W. Yockman, M. Lee, J. H. Jeong, Y.-H. Kim, and S. W. Kim, J. Control. Rel., 106, 224 (2005)
36 K. Kunath, A. von Harpe, D. Fischer, H. Petersen, U. Bickel, K. Voigt, and T. Kissel, J. Control. Rel., 89, 113 (2003)
37 B. I. Terman, M. Dougher-Vermazen, M. E. Carrion, D. Dimitrov, D. C. Armellino, D. Gospodarowicz, and P. Bohlen, Biochem. Biophys. Res. Commun., 187, 1579 (1992)
38 R. S. Warren, H. Yuan, M. R. Matli, N. A. Gillett, and N. Ferrara, J. Clin. Investig., 95, 1789 (1995)   DOI
39 M. Lee, J. Rentz, S. Han, D. A. Bull, and S. W. Kim, Gene Ther., 10, 585 (2003)
40 M. Ogris, G. Walker, T. Blessing, R. Kircheis, M. Wolschek, and E. Wagner, J. Control. Rel., 91, 173 (2003)
41 M. J. Turk, D. J. Waters, and P. S. Low, Cancer Lett., 213, 165 (2004)
42 W. Suh, S.-o. Han, L. Yu, and S. W. Kim, Mol. Ther., 6, 664 (2002)
43 G. Thurston, J. W. McLean, M. Rizen, P. Baluk, A. Haskell, T. J. Murphy, D. Hanahan, and D. M. McDonald, J. Clin. Invest., 101, 1401 (1998)
44 D. B. Fenske, I. MacLachlan, and P. R. Cullis, Curr. Opin. Mol. Ther., 3, 153 (2001)
45 S. Brunner, E. Furtbauer, T. Sauer, M. Kursa, and E. Wagner, Mol. Ther., 5, 80 (2002)   DOI   ScienceOn
46 B. Abdallah, A. Hassan, C. Benoist, D. Goula, J. P. Behr, and B. A. Demeneix, Hum. Gene Ther., 7, 1947 (1996)   DOI   ScienceOn
47 S. Y. Cheng, H. J. Huang, M. Nagane, X. D. Ji, D. Wang, C. C. Shih, W. Arap, C. M. Huang, and W. K. Cavenee, Proc. Natl. Acad. Sci. USA, 93, 8502 (1996)
48 A. Maruyama, T. Ishihara, J. S. Kim, S. W. Kim, and T. Akaike, Bioconjugate Chem., 8, 735 (1997)
49 D. Y. Furgeson, R. N. Cohen, R. I. Mahato, and S. W. Kim, Pharm. Res., 19, 382 (2002)
50 H. Iinuma, K. Maruyama, K. Okinaga, K. Sasaki, T. Sekine, O. Ishida, N. Ogiwara, K. Johkura, and Y. Yonemura, Int. J. Cancer, 99, 130 (2002)
51 K. A. Thomas, J. Biol. Chem., 271, 603 (1996)
52 C. K. Goldman, R. L. Kendall, G. Cabrera, L. Soroceanu, Y. Heike, G. Y. Gillespie, G. P. Siegal, X. Mao, A. J. Bett, W. R. Huckle, K. A. Thomas, and D. T. Curiel, Proc. Natl. Acad. Sci. USA, 95, 8795 (1998)
53 J. W. Yockman, A. Maheshwari, S. Han, and S. W. Kim, J. Control. Rel., 87, 177 (2003)   DOI   ScienceOn
54 H. Gharwan, L. Wightman, R. Kircheis, E. Wagner, and K. Zatloukal, Gene Ther., 10, 810 (2003)
55 Y. Matsumura and H. Maeda, Cancer Res., 46, 6387 (1986)
56 D. Y. Furgeson, W. S. Chan, J. W. Yockman, and S. W. Kim, Bioconjugate Chem., 14, 840 (2003)   DOI   ScienceOn
57 J. Folkman, N. Engl. J. Med., 285, 1182 (1972)
58 O. Boussif, F. Lezoualc'h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, and J. Behr, Proc. Natl. Acad. Sci. USA, 92, 7297 (1995)
59 W. J. Kim, T. Ishihara, T. Akaike, and A. Maruyama, Chem. Eur. J., 7, 176 (2001)   DOI   ScienceOn
60 K. Kunath, A. von Harpe, H. Petersen, D. Fisher, K.-H. Voigt, T. Kissel, and U. Bickel, Pharm. Res., 19, 810 (2002)
61 W. J. Kim, J. W. Yockman, J. H. Jeong, L. V. Christensen, M. Lee, Y-H. Kim, and S. W. Kim, J. Control. Rel., 114, 381 (2006)
62 R. L. Kendall, G. Wang, and K. A. Thomas, Biochem. Biophys. Res. Commun., 226, 324 (1996)
63 K. Takayama, H. Ueno, Y. Nakanishi, T. Sakamoto, K. Inoue, K. Shimizu, H. Oohashi, and N. Hara, Cancer Res., 60, 2169 (2000)
64 M. Lee and S. W. Kim, Pharm. News, 9, 597 (2004)
65 M. Bikran, C. H. Ahn, S. Y. Chae, M. Lee, J. W. Yockman, and S. W. Kim, Macromolecules, 37, 1903 (2004)
66 M. Lee, J. Rentz, M. Bikram, S. Han, D. A. Bull, and S. W. Kim, Gene Ther., 10, 1535 (2003)
67 H. K. Nguyen, P. Lemieux, S. V. Vinogradov, C. L. Gebhart, N. Guerin, G. Paradis, T. K. Bronich, V. Y. Alakhov, and A. V. Kabanov, Gene Ther., 7, 126 (2000)
68 E. I. Korpelainen and K. Alitalo, Cell Biol., 10, 159 (1998)
69 R. Pasqualini, E. Koivunen, and E. Ruoslahti, Nat. Biotechnol., 15, 542 (1997)   DOI   ScienceOn
70 A. Mori, S. Arii, M. Furutani, M. Mizumoto, S. Uchida, H. Furuyama, Y. Kondo, M. J. Gorrin-Rivas, K. Furumoto, Y. Kaneda, and M. Imamura, Gene Ther., 7, 1027 (2000)
71 M. Lee and S. W. Kim, Pharm. Res., 22, 1 (2005)
72 Q.-R. Chen, D. Kumar, S. A. Stass, and A. J. Mixson, Cancer Res., 59, 3308 (1999)
73 S. Han, R. I. Mahato, and S. W. Kim, Bioconjugate Chem., 12, 337 (2001)   DOI   ScienceOn
74 Y. Lin, L. C. Mounkes, H. D. Liqqitt, C. S. Brown, I. Solodin, T. D. Heath, R. and J. Debs, Nat. Biotechnol., 15, 167 (1997)   DOI   ScienceOn
75 R. J. Christiano and J. A. Roth, J. Mol. Med., 73, 479 (1995)
76 W. J. Kim, Y. Sato, T. Akaike, and A. Maruyama, Nat. Mater., 2, 815 (2003)   DOI   ScienceOn
77 Y. Liu, A. Thor, E. Shtivelman, Y. Cao, G. Tu, T. D. Heath, and R. J. Debs, J. Biol. Chem., 274, 13338 (1999)
78 K. Sagara and S. W. Kim, J. Control. Rel., 79, 271 (2002)
79 T. J. Wickham, P. Mathias, D. A. Cheresh, and G. R. Nemerow, Cell, 73, 309 (1993)
80 W. Arap, R. Pasqualini, and E. Ruoslahti, Science, 279, 377 (1998)   DOI
81 D. Fischer, T. Bieber, Y. Li, H. P. Elsasser, and T. Kissel, Pharm. Res., 16, 1273 (1999)