Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Targeted Polymeric Gene Delivery for Anti-angiogenic Tumor Therapy

  • Kim, Won-Jong (Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah) ;
  • Kim, Sung-Wan (Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah)
  • Published : 2007.03.31
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Abstract

Gene therapy has become a promising strategy for the treatment of genetically based diseases, such as cancer, which are currently considered incurable. A major obstacle in the field of cancer gene therapy is the development of a safe and efficient delivery system for therapeutic gene transfer. Non-viral vectors have attracted great interest, as they are simple to prepare, stable, easy to modify and relatively safe compared to viral vectors. In this review, an insight into the strategies developed for polyethylenimine (PEI)-based non-viral vectors has been provide, including improvement of the polyplex properties by incorporating hydrophilic spacer, poly(ethylene glycol) (PEG). Moreover, this review will summarize the strategies for the tumor targeting. Specifically, a targeted polymeric gene delivery system, PEI-g-PEG-RGD, will be introduced as an efficient gene delivery vector for tumor therapy, including its functional analysis both in vitro and in vivo.

Keywords

References

  1. J. Folkman, N. Engl. J. Med., 285, 1182 (1972)
  2. J. Folkman and Y. Shing, J. Biol. Chem., 267, 10931 (1992)
  3. A. W. Griffioen and G. Molema, Pharmacol. Rev., 52, 237 (2000)
  4. E. I. Korpelainen and K. Alitalo, Cell Biol., 10, 159 (1998)
  5. N. Ferrara and T. Davis-Smyth, Endocr. Rev., 18, 4 (1997)
  6. G. Neufeld, T. Cohen, S. Gengrinovitch, and Z. Poltorak, FASEB J., 13, 9 (1999)
  7. C. de Vries, J. A. Escobedo, H. Ueno, K. Houck, N. Ferrara, and L. T. Williams, Science, 255, 989 (1992)
  8. B. I. Terman, M. Dougher-Vermazen, M. E. Carrion, D. Dimitrov, D. C. Armellino, D. Gospodarowicz, and P. Bohlen, Biochem. Biophys. Res. Commun., 187, 1579 (1992)
  9. B. Millauer, L. K. Shawver, K. H. Plate, W. Risaui, and A. Ullrich, Nature, 367, 576 (1994)
  10. R. S. Warren, H. Yuan, M. R. Matli, N. A. Gillett, and N. Ferrara, J. Clin. Investig., 95, 1789 (1995) https://doi.org/10.1172/JCI117809
  11. P. Borgstrom, K. J. Hillan, P. Sriramarao, and N. Ferrara, Cancer Res., 56, 4032 (1996)
  12. F. Yuan, Y. Chen, M. Dellian, N. Safabakhsh, N. Ferrara, and R. K. Jain, Proc. Natl. Acad. Sci. USA, 93, 14765 (1996)
  13. K. A. Thomas, J. Biol. Chem., 271, 603 (1996)
  14. B. Millauer, L. K. Shawver, K. H. Plate, W. Risau, and A. Ullrich, Nature, 367, 576 (1994)
  15. R. L. Kendall and K. A. Thomas, Proc. Natl. Acad. Sci. USA, 90, 10705 (1993)
  16. R. L. Kendall, G. Wang, and K. A. Thomas, Biochem. Biophys. Res. Commun., 226, 324 (1996)
  17. C. K. Goldman, R. L. Kendall, G. Cabrera, L. Soroceanu, Y. Heike, G. Y. Gillespie, G. P. Siegal, X. Mao, A. J. Bett, W. R. Huckle, K. A. Thomas, and D. T. Curiel, Proc. Natl. Acad. Sci. USA, 95, 8795 (1998)
  18. H. L. Kong, D. Hecht, W. Song, I. Kovesdi, N. R. Hackett, A. Yayon, and R. G. Crystal, Hum. Gene Ther., 9, 823 (1998) https://doi.org/10.1089/hum.1998.9.6-823
  19. K. Takayama, H. Ueno, Y. Nakanishi, T. Sakamoto, K. Inoue, K. Shimizu, H. Oohashi, and N. Hara, Cancer Res., 60, 2169 (2000)
  20. A. Mori, S. Arii, M. Furutani, M. Mizumoto, S. Uchida, H. Furuyama, Y. Kondo, M. J. Gorrin-Rivas, K. Furumoto, Y. Kaneda, and M. Imamura, Gene Ther., 7, 1027 (2000)
  21. W. Suh, S.-o. Han, L. Yu, and S. W. Kim, Mol. Ther., 6, 664 (2002)
  22. W. J. Kim, J. W. Yockman, M. Lee, J. H. Jeong, Y.-H. Kim, and S. W. Kim, J. Control. Rel., 106, 224 (2005)
  23. W. J. Kim, J. W. Yockman, J. H. Jeong, L. V. Christensen, M. Lee, Y-H. Kim, and S. W. Kim, J. Control. Rel., 114, 381 (2006)
  24. O. Boussif, F. Lezoualc'h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix, and J. Behr, Proc. Natl. Acad. Sci. USA, 92, 7297 (1995)
  25. B. Abdallah, A. Hassan, C. Benoist, D. Goula, J. P. Behr, and B. A. Demeneix, Hum. Gene Ther., 7, 1947 (1996) https://doi.org/10.1089/hum.1996.7.16-1947
  26. M. Lee and S. W. Kim, Pharm. Res., 22, 1 (2005)
  27. R. J. Jin, C. Kwak, S. G. Lee, C. H. Lee, M. S. Park, E. Lee, and S. E. Lee, Cancer Gene Ther., 12, 1537 (2000)
  28. Y. Liu, A. Thor, E. Shtivelman, Y. Cao, G. Tu, T. D. Heath, and R. J. Debs, J. Biol. Chem., 274, 13338 (1999)
  29. T. Tanaka, Y. Manome, P. Wen, Y. Cao, D. Kufe, and J. Folkman, Proc. Am. Assoc. Cancer Res., 38, 264 (1997)
  30. Q.-R. Chen, D. Kumar, S. A. Stass, and A. J. Mixson, Cancer Res., 59, 3308 (1999)
  31. S. Y. Cheng, H. J. Huang, M. Nagane, X. D. Ji, D. Wang, C. C. Shih, W. Arap, C. M. Huang, and W. K. Cavenee, Proc. Natl. Acad. Sci. USA, 93, 8502 (1996)
  32. M. Lee and S. W. Kim, Pharm. News, 9, 597 (2004)
  33. R. J. Christiano and J. A. Roth, J. Mol. Med., 73, 479 (1995)
  34. A. Maruyama, T. Ishihara, J. S. Kim, S. W. Kim, and T. Akaike, Bioconjugate Chem., 8, 735 (1997)
  35. M. Bikran, C. H. Ahn, S. Y. Chae, M. Lee, J. W. Yockman, and S. W. Kim, Macromolecules, 37, 1903 (2004)
  36. Y. H. Choi, F. Liu, J. S. Kim, Y. K. Choi, J. S. Park, and S. W. Kim, J. Control. Rel., 54, 39 (1998)
  37. W. J. Kim, T. Ishihara, T. Akaike, and A. Maruyama, Chem. Eur. J., 7, 176 (2001) https://doi.org/10.1002/1521-3765(20010105)7:1<176::AID-CHEM176>3.0.CO;2-M
  38. W. J. Kim, T. Akaike, and A. Maruyama, J. Am. Chem. Soc., 124, 12676 (2002)
  39. W. J. Kim, Y. Sato, T. Akaike, and A. Maruyama, Nat. Mater., 2, 815 (2003) https://doi.org/10.1038/nmat1021
  40. D. Fischer, T. Bieber, Y. Li, H. P. Elsasser, and T. Kissel, Pharm. Res., 16, 1273 (1999)
  41. P. Marschall, N. Malik, and Z. Larin, Gene Ther., 6, 1634 (1999)
  42. A. von Harpe, H. Petersen, Y. Li, and T. Kissel, J. Control. Rel., 69, 309 (2000)
  43. K. Kunath, A. von Harpe, D. Fischer, H. Petersen, U. Bickel, K. Voigt, and T. Kissel, J. Control. Rel., 89, 113 (2003)
  44. C. H. Ahn, S. Y. Chae, Y. H. Bae, and S. W. Kim, J. Control. Rel., 80, 283 (2002)
  45. S. Han, R. I. Mahato, and S. W. Kim, Bioconjugate Chem., 12, 337 (2001) https://doi.org/10.1021/bc000176q
  46. J. W. Yockman, A. Maheshwari, S. Han, and S. W. Kim, J. Control. Rel., 87, 177 (2003) https://doi.org/10.1016/S0168-3659(02)00345-0
  47. M. Lee, J. Rentz, S. Han, D. A. Bull, and S. W. Kim, Gene Ther., 10, 585 (2003)
  48. M. Lee, J. Rentz, M. Bikram, S. Han, D. A. Bull, and S. W. Kim, Gene Ther., 10, 1535 (2003)
  49. S. Brunner, T. Sauer, S. Carotta, M. Cotton, M. Saltik, and E. Wagner, Gene Ther., 7, 401 (2000)
  50. S. Brunner, E. Furtbauer, T. Sauer, M. Kursa, and E. Wagner, Mol. Ther., 5, 80 (2002) https://doi.org/10.1006/mthe.2001.0518
  51. H. Gharwan, L. Wightman, R. Kircheis, E. Wagner, and K. Zatloukal, Gene Ther., 10, 810 (2003)
  52. J. W. Wiseman, C. A. Goddard, D. McLelland, and W. H. Colledge, Gene Ther., 10, 1654 (2003)
  53. S. M. Zou, P. Erbacher, J. S. Remy, and J. P. Behr, J. Gene Med., 2, 128 (2000) https://doi.org/10.1002/(SICI)1521-2254(200001/02)2:1<2::AID-JGM83>3.0.CO;2-O
  54. K. Kunath, A. von Harpe, H. Petersen, D. Fisher, K.-H. Voigt, T. Kissel, and U. Bickel, Pharm. Res., 19, 810 (2002)
  55. D. Y. Kwoh, C. C. Coffin, C. P. Lollo, J. Jovenal, M. G. Banaszczyk, P. Mullen, A. Amini, J. Fabrycki, R. M. Bartholomew, S. W. Brostoff, and D. J. Carlo, Biochim. Biophys. Acta., 1444, 171 (1999)
  56. H. K. Nguyen, P. Lemieux, S. V. Vinogradov, C. L. Gebhart, N. Guerin, G. Paradis, T. K. Bronich, V. Y. Alakhov, and A. V. Kabanov, Gene Ther., 7, 126 (2000)
  57. M. Ogris, S. Brunner, S. Schuller, R. Kircheis, and E. Wagner, Gene Ther., 6, 595 (1999)
  58. Y. Matsumura and H. Maeda, Cancer Res., 46, 6387 (1986)
  59. G. Thurston, J. W. McLean, M. Rizen, P. Baluk, A. Haskell, T. J. Murphy, D. Hanahan, and D. M. McDonald, J. Clin. Invest., 101, 1401 (1998)
  60. Y. Lin, L. C. Mounkes, H. D. Liqqitt, C. S. Brown, I. Solodin, T. D. Heath, R. and J. Debs, Nat. Biotechnol., 15, 167 (1997) https://doi.org/10.1038/nbt1097-997
  61. D. Goula, C. Benoist, S. Mantero, G. Herlo, G. Levi, and B. A. Demeneix, Gene Ther., 5, 1291 (1998)
  62. K. Sagara and S. W. Kim, J. Control. Rel., 79, 271 (2002)
  63. M. Ogris, G. Walker, T. Blessing, R. Kircheis, M. Wolschek, and E. Wagner, J. Control. Rel., 91, 173 (2003)
  64. J. M. Benns, A. Maheshwari, D. Y. Furgeson, R. I. Mahato, and S. W. Kim, J. Drug Targeting, 9, 123, (2001) https://doi.org/10.3109/10611860108995628
  65. D. Y. Furgeson, R. N. Cohen, R. I. Mahato, and S. W. Kim, Pharm. Res., 19, 382 (2002)
  66. D. Y. Furgeson, W. S. Chan, J. W. Yockman, and S. W. Kim, Bioconjugate Chem., 14, 840 (2003) https://doi.org/10.1021/bc025542f
  67. R. Pasqualini, E. Koivunen, and E. Ruoslahti, Nat. Biotechnol., 15, 542 (1997) https://doi.org/10.1038/nbt1097-997
  68. E. Ruoslahti, Annu. Rev. Cell Dev. Biol., 12, 697 (1996)
  69. T. J. Wickham, P. Mathias, D. A. Cheresh, and G. R. Nemerow, Cell, 73, 309 (1993)
  70. M. S. Bretscher, Cell, 85, 465 (1996)
  71. P. J. Mahasreshti, J. G. Navarro, M. Kataram, M. H. Wang, D. Carey, G. P. Siegal, M. N. Barnes, D. M. Nettelbeck, R. D. Alvarez, A. Hemminki, and D. T. Curiel, Clin. Cancer Res., 7, 2057 (2001)
  72. D. B. Fenske, I. MacLachlan, and P. R. Cullis, Curr. Opin. Mol. Ther., 3, 153 (2001)
  73. P. R. Dash, M. L. Read, L. B. Barrett, M. A. Wolfert, and L. W. Seymour, Gene Ther., 6, 643 (1999)
  74. S. L. Hart, A. M. Knight, R. P. Harbottle, A. Mistry, H. D. Hunger, D. F. Cutler, R. Williamson, and C. Coutelle, J. Biol. Chem., 269, 12468 (1994)
  75. W. Arap, R. Pasqualini, and E. Ruoslahti, Science, 279, 377 (1998) https://doi.org/10.1126/science.279.5353.998
  76. S. Zitzmann, V. Ehemann, and M. Schwab, Cancer Res., 62, 5139 (2002)
  77. H. Iinuma, K. Maruyama, K. Okinaga, K. Sasaki, T. Sekine, O. Ishida, N. Ogiwara, K. Johkura, and Y. Yonemura, Int. J. Cancer, 99, 130 (2002)
  78. M. J. Turk, D. J. Waters, and P. S. Low, Cancer Lett., 213, 165 (2004)
  79. M. Bikram, M. Lee, C. W. Chang, M. M. Janat-Amsbury, S. E. Kern, and S. W. Kim, J. Control. Rel., 103, 221 (2005)
  80. F. Mathot, L. van Beijsterveldt, V. Preat, M. Brewster, and A. Arien, J. Control. Rel., 111, 47 (2006)
  81. A. J. Schraa, R. J. Kok, A. D. Berendsen, H. E. Moorlag, E. J. Bos, D. K. Meijer, L. F. de Leij, and G. Molema, J. Control. Rel., 83, 241 (2002)