• Title/Summary/Keyword: C-maps

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CoMFA and CoMSIA on the Inhibition of Calcineurin-NFAT Signaling by Blocking Protein-Protein Interaction with N-(4-Oxo-1(4H)-naphthalenylidene)benzenesulfonamide Derivatives

  • Myung, Pyung-Keun;Park, Kyung-Yong;Sung, Nack-Do
    • Bulletin of the Korean Chemical Society
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    • v.26 no.12
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    • pp.1941-1945
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    • 2005
  • To raises the possibility of designing effective inhibitors, 3D-QSAR for the inhibition of calcineurin-NFAT signaling by new N-(4-oxo-1(4H)-naphthalenylidene benzenesulfonamide derivatives as inhibitors of intracellular protein-protein interactions were studied using CoMFA and CoMSIA methodology. The three templates, N-(4-oxo-1(4H)-naphthalenylidene)benzenesulfonamide (A), benzenesulfonamide (B) and 4-oxo-1(4H)-naphthalenylidene (C) were selected to improve the statistic of the present 3D-QSAR models. The best models with combination of standard field in CoMFA, and steric field and electrostatic field in CoMSIA derived from the template, B and C, because most of the compounds tend not to be aligned in template A. From the based on the CoMFA and CoMSIA contour maps, the $R_1$ and $R_2$ groups on 4-oxo-1(4H) naphthalenylidene ring are steric favor. The ortho position on the benzenesulfonyl ring is steric disfavor and the meta position is steric favor. In addition, the oxygene atom of carbonyl group will have better inhibition activities as it has a negative charge favor. From these findings, we can conclude that the analyses of the contour maps provided insight into possible modification of molecules for effective inhibitiors.

Tracing the earliest phases of star formation: A pilot survey of Planck Cold Clumps

  • Yi, Hee-Weon;Lee, Jeong-Eun;Liu, Tie;Kim, Kee-Tae;Wu, Yuefang
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.2
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    • pp.54.1-54.1
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    • 2015
  • We observed 38 Planck Cold Clumps (PCCs) in the $850{\mu}m$ dust continuum emission using the JCMT/SCUBA-2, and detected the emission in 15 clumps containing dense cores. In this poster we present the preliminary results. The PCCs are cold, dense, and thus, they are considered as objects in the early evolutionary stages of star formation. The sources in our sample were selected based on the Purple Mountain Observatory (PMO) 13CO (1-0) integrated intensity maps. In order to examine whether these cores detected in $850{\mu}m$ continuum have potential to be prestellar cores, we compare each core mass estimated from the $850{\mu}m$ continuum with the Virial mass and Bonnor-Ebert (BE) mass calculated from the 13CO (1-0) or C18O (1-0) spectra. By comparing the two column densities from the dust continuum and the 13CO (1-0) or C18O (1-0) line, we also derive the CO depletion factor, which could be an indicator of core evolution. The moment maps of the 13CO (1-0) line are used to study the physical properties (e.g. kinematics, turbulence) of PCCs. We investigate difference between the sources with and without detectable $850{\mu}m$ emission to study the formation conditions of dense cores.

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A Study of Designing Semantic Web and Policy Directions for National Knowledge and Information Management (국가지식정보자원관리를 위한 시맨틱웹 설계 및 정책방향에 관한 연구)

  • Oh, Sam-Gyun
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.15 no.1
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    • pp.43-67
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    • 2004
  • The purpose of this study is to design semantic web and policy direction for national knowledge and information management. The paper describes all the components needed to accomplish the objective: 1) creating unchangeable and unique identifiers for metadata elements, resources, and ontology classes and properties; 2) recommending active use of XML namespaces; 3) establishing metadata and application profile standards for national integrated searching; 4)developing a metadata registry to promote semantic interoperability among metadata; 5) discussing the need of creating ontologies using W3C OWL and ISO Topic Maps; 6) providing intelligent search services based on metadata; and 7) presenting future directions and tasks of national knowledge and information management.

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Depth Interpolation Method using Random Walk Probability Model (랜덤워크 확률 모델을 이용한 깊이 영상 보간 방법)

  • Lee, Gyo-Yoon;Ho, Yo-Sung
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.36 no.12C
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    • pp.738-743
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    • 2011
  • For the high quality 3-D broadcasting, depth maps are important data. Although commercially available depth cameras capture high-accuracy depth maps in real time, their resolutions are much smaller than those of the corresponding color images due to technical limitations. In this paper, we propose the depth map up-sampling method using a high-resolution color image and a low-resolution depth map. We define a random walk probability model in an operation unit which has nearest seed pixels. The proposed method is appropriate to match boundaries between the color image and the depth map. Experimental results show that our method enhances the depth map resolution successfully.

A comparative analysis of seismic and structural parameters for historical period earthquakes in Türkiye

  • Ercan Isik
    • Earthquakes and Structures
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    • v.24 no.5
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    • pp.377-391
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    • 2023
  • The high seismic risk has once again revealed in Türkiye with two major earthquakes that occurred on 06.02.2023, which took its place among the most destructive earthquakes in the last century. Totally, 65 earthquakes that occurred in the historical period in Türkiye were taken into account within the scope of this study. The seismic parameters were compared by considering the last two earthquake hazard maps for the epicenters of these earthquakes. Earthquake Intensity (I) of historical earthquakes were converted to Peak Ground Acceleration (PGA) by using suggested relations. Structural analyzes were performed for a sample reinforced-concrete building by using the obtained PGA's and predicted PGA's in the last two earthquake hazard maps. In the structural analysis, two different material groups such as low (C12-S220) and normal (C25-S420) were selected. As the material strength increased, the period value decreased, while the seismic capacity and stiffness increased. It has been determined that there are differences between the measured and proposed seismic risks for some earthquakes, and as a result, there are significant differences between the expected target displacement values from the structures. Therefore, it will not be possible to estimate the damage and to determine the building performance realistically. The main purpose of the study is to reveal whether the earthquake risk is adequately represented on seismic and structural parameters.

ESTIMATION OF THE NUMBER OF ROOTS ON THE COMPLEMENT

  • Yang Ki-Yeol
    • The Pure and Applied Mathematics
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    • v.13 no.1 s.31
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    • pp.11-18
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    • 2006
  • Let f : (X, A) ${\rightarrow}$ (Y, B) be a map of pairs of compact polyhedra. A surplus Nielsen root number $SN(f;X\;{\backslash}\;A,\;c)$ is defined which is lower bound for the number of roots on X \ A for all maps in the homotopy class of f. It is shown that for many pairs this lower bound is the best possible one, as $SN(f;X\;{\backslash}\;A,\;c)$ can be realized without by-passing condition.

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CLASSIFICATIONS OF HELICOIDAL SURFACES WITH L1-POINTWISE 1-TYPE GAUSS MAP

  • Kim, Young Ho;Turgay, Nurettin Cenk
    • Bulletin of the Korean Mathematical Society
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    • v.50 no.4
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    • pp.1345-1356
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    • 2013
  • In this paper, we study rotational and helicoidal surfaces in Euclidean 3-space in terms of their Gauss map. We obtain a complete classification of these type of surfaces whose Gauss maps G satisfy $L_1G=f(G+C)$ for some constant vector $C{\in}\mathbb{E}^3$ and smooth function $f$, where $L_1$ denotes the Cheng-Yau operator.