• Journal of KIISE:Databases
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• v.31 no.6
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• pp.641-649
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• 2004

The relationship between chemical structures and biological activities is researched briskly in the area of 'Medicinal Chemistry' At the base of these structure-based drug design tries, medicinal chemists search the existing drugs of similar chemical structure to target drug for the development of a new drug. Therefore, it is such necessary that an automatic system selects drug files that have a set of chemical moieties matching a user-defined query moiety. Substructure searching is the process of identifying a set of chemical moieties that match a specific query moiety. Testing for substructure searching was developed in the late 1950s. In graph theoretical terms, this problem corresponds to determining which graphs in a set are subgraph isomorphic to a specified query moiety. Testing for subgraph isomorphism has been proved, in the general case, to be an NP- complete problem. For the purpose of overcoming this difficulty, there were computational approaches. On the 1990s, a US patent has been granted on an atom-centered indexing scheme, used by the RS3 system; this has the virtue that the indexes generated can be searched by direct text comparison. This system is commercially used(http://www.acelrys.com/rs3). We define the RS3 system's drawback and present a new indexing scheme. The RS3 system treats substructure searching with substring matching by means of expressing chemical structure aspredefined strings. However, it has insufficient 'rerall' and 'precision‘ because it is impossible to index structures uniquely for same atom and same bond. To resolve this problem, we make the minimum-cost- spanning tree for one centered atom and describe a structure with paths per levels. Expressing 2D chemical structure into 1D a string has limit. Therefore, we break 2D chemical structure into 1D structure fragments. We present in this paper a new index technique to improve recall and precision surprisingly.

• Journal of the Korea institute for structural maintenance and inspection
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• v.8 no.1
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• pp.175-181
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• 2004

This study is about a section where underground water level occurs at the underground 5m depth by the excavation of the ground, as a stream is adjacent to a excavation section of High Speed Railway ${\bigcirc}{\bigcirc}$ Station construction sections and a reservoir being always full of water is located at the left side of the construction section. Therefore this test is executed for the design and construction of buoyance anchors able to permanently prevent buoyance by the underground water level at working and for the stable construction and permanent smooth maintenance of structures. In this test, bar type anchors are divided according to their length and standard to execute test-anchor test, and In spot test, 9 test-anchors test, proof test to construction process, suitability test and acceptance test are executed 4 times to 9 test-anchors by dividing anchors according to the length of permanent anchor, the outer diameter of bar and boring diameter. Standard motion characteristic centering on load transmission and break mechanism of bar-type anchors for the prevention of buoyance will be showed in the thesis.

• Elastomers and Composites
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• v.38 no.3
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• pp.227-234
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• 2003

Silicone composites for high voltage insulator (HVI SC) were prepared by adding aluminum trihydrate(ATH) treated by surface treatment agent to base silicone compound at the ratio oi 100:20, 100:40, 100:60, 100:80, and 100:100, respectively And also, ATH was treated by various surface treatment agents, such as stearic arid, acryl silane, and vinyl silane under compounding process. Mechanical properties and electrical properties were investigated for the various contents of ATH and surface-treatment agents. Mechanical properties such as tensile strength, elongation, and tear strength decreased as the load of ATH increased. Volume resistivity, AC break down strength, and tracking resistance for HVI SC containing ATH treated by vinyl silane were better than those for HVI SC containing ATH treated by other surface treatment agents, such as stearic acid and acryl silane. Polymer-filler interaction of silicone composites according to surface treatment agents was studied by measuring bound rubber contend(BR). From the experimental results, BR of silicone composite containing ATH treated with vinyl silane was higher than that of the others. The degree of rule for silicone composite was investigated using Rheometer. Maximum torque of silicone composites contaning ATH treated with vinyl silane was higher than that of silicone composite contaning ATH treated with other surface agents.

• The Journal of Korean Philosophical History
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• no.35
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• pp.73-108
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• 2012

Researches about the Horaknonjaeng(湖洛論爭) have succeeded by focusing on the Osangnonbyeon(五常論辨)?Mibalnonbyeon(未發論辨). In a way of these researches, philosophic thought of Gwon Sangha(權尙夏) is dealt in a comparison and in that process his philosophic thought seems to be known. However, these researches are treating several thoughts so it is difficult to find accurately what point describes the position of his thought in the korean confucian thought as origin of Hohak(湖學). In this paper, therefore, I examine Gwon Sangha's theory of mind-nature by focusing on the understanding the concept of mind-nature in Hansujaejib(寒水齋集) and find its position in history of thought as an origin of forming Hohak. Before 1709, Horaknonjaeng don't break out, Gwan Sangha had been formed that Inmulseongsangi(人物性相異) of Osangpyeonjeon(五常偏全) based on the understanding of the fact that ensuring of Bonyeonjiseong(本然之性 性善) in Gijiljiseong(氣質之性) and under this influence scholars of Hohak formed thoughts and insisted Osangpyeonjeon(五常偏全 人物性相異) during Horaknonjaeng. In the point of Simseongilmul(心性一物) focusing on nature, he didn't admit the Jujaeseong(主宰性) of mind. This is the efforts of finishing the controversy of Simseongigi(心性二岐) and the efforts of finding the relation between Simseon(心善). Such thoughts are set before the Horaknonjaeng and basing on these influences, scholars of Hohak formed their thoughts and insisted the Gibulyongsa(氣不用事 未發氣質有善惡).

• Analyses & Alternatives
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• v.4 no.1
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• pp.63-87
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• 2020

This article not only theoretically explores the necessity and effect of constructive minilateralism and subregionalism in Northeast Asia, but also delves into a series of practical solutions from viewpoint of seeking common ground while reserving differences in this region. The main contents are as follows: First, the various obstacles that hinder the formation of regionalism, subregionalism and minilateralism in the Northeast Asia are discussed. That is to say, geopolitical realism, My Country First ideology, exclusive nationalism in the socio-historical context, and North Korea's latest provocations, etc. Second, this article explores the philosophy and basic principles of realizing Northeast Asia regionalism and minilateralism. Third, in the 21st century, Northeast Asia becomes the center of the world. It examines the core points, controversial focus and platform for building sub regionalism in the region. Finally, based on the institutional platform such as minilateralism and sub regionalism, the various ideas and practical plans of cross-border cooperation among major countries in Northeast Asia were discussed. Because there are a lot of obstacles, so first of all it is more appropriate to promote economic or functional minilateralism or sub regionalism than multilateral cooperation. In order to promote the formation of regionalism and minilateralism in Northeast Asia, the issues to be considered are as follows: First, for the sake of leading regional solidarity and minilateral economic cooperation, it is advisable for China, as a regional economic power, to implement a stable and responsible diplomacy. Secondly, regional solidarity based on credible politics and security should be promoted for a long time beyond the level of economic cooperation. Third, the primary prerequisite for the realization of Northeast Asian regionalism is that in the process of denuclearization of North Korea, the stability and peace mechanism of the Korean Peninsula should be established. Fourth, with the continued hegemonic competition between the United States and China in Northeast Asia, under the circumstance that countries in the region are pushed into so-called "East Asian Paradox", it is profoundly important for them to consider transition from the hostile relationship as the "Thucydides trap" to the order of "coexistence" in which competition and cooperation run side by side, and the two countries should explore a conversion plan for the foreign policy line. This mutual cooperation and peaceful coexistence of the US-China relationship will create a friendly atmosphere for the formation of regionalism in Northeast Asia. In the future, the cooperation of minilateralism in Northeast Asia will break the existing conflict between the maritime forces and the continental forces in order to promote peace. And along with the philosophy that "peace is economy", recent policies of common prosperity as the framework, such as China's "Belt and Road Initiative", North Korea's "Special Zone and Development Zone Policy", Russia's "New Eastern Policy", Japan's participation in the Belt and Road Initiative and South Korea's The "Korean Peninsula New Economy Map" are organically linked and it should promote the so-called "networked regionalism".

• The Journal of the Korea Contents Association
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• v.22 no.7
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• pp.264-275
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• 2022

The purpose of this study is to examine the effects of social withdrawal, depression, aggression, negative parenting attitude as parental factors, friendship as school factors, academic helplessness and smartphone dependence, persistence, etc. on adolescent delinquency experiences as perceived personal factors. was carried out to understand. For this study, first year middle school students in the first year of the Korean Children and Youth Panel Survey (KCPYS 2018) were analyzed. As a result of the study, it was found that depression, aggression, social withdrawal as individual factors of adolescents, negative parenting attitude as parent factors, academic helplessness, negative friendships, smartphone dependence, persistence, etc. as school factors influence delinquent behavior of adolescents. In addition, it was found that smartphone dependence and persistence play a partial mediating role in the process of personal factors, parental factors, and school factors affecting adolescents' delinquency experiences. Based on these results, first, we need to break stereotypes about adolescents and understand the accurate understanding of adolescents' delinquent behaviors and what expectations they have. Second, practical education is required for parents and grandparents for consistent parenting attitudes and effective parenting. Third, a positive self-awareness and correct human relationship formation program should be operated in order to improve the friendship among adolescents. Finally, correct smartphone usage and counseling interventions and prevention programs to alleviate impulsivity are needed.

• Applied Chemistry for Engineering
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• v.33 no.2
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• pp.195-201
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• 2022

The main objective of this work is to prepare Rehmannia glutinosa extract (RE) incorporated functional chitosan (CH) based biomaterials and evaluate their physical properties, RE release properties, inhibitory effect of melanogenesis, and antioxidant and elastase inhibitory activities. RE incorporated CH based biomaterials were synthesized by a casting method and UV curing process. The surface and cross sections of prepared biomaterials were characterized by a field emission scanning electron microscope (FE-SEM). The physical properties such as tensile strength and elongation at break were also investigated. To apply the transdermal drug delivery system, RE release properties were examined with pH 4.5, 5.5, and 6.5 buffer solutions and artificial skin test at 36.5 ℃. Results indicated that RE release of RE incorporated biomaterials with/without the addition of plasticizers [glycerol (GL) and citric acid (CA)] at pH 6.5 was about 1.10 times higher than that of at pH 4.5. In addition, results of the artificial skin test verified that RE was released constantly for 6 h. To verify the applicability of the prepared biomaterials, tyrosinase, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and elastase assays were investigated. Results indicated that RE incorporated biomaterials added CA exhibited tyrosinase activation, DPPH radical scavenging activity rate, and elastase activation of 45.12, 89.40, and 59.94%, respectively.

• Journal of Korean Port Research
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• v.3 no.1
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• pp.3-33
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• 1989

The amount of the Korean export & import in 1987 reached $88.3 billion which was 1.75% of the total world trade and the proportion of foreign dependence to G.N.P was 74.5%. From these facts, we can infer that the development of national economy is largely dependent upon trade. Therefore the role of transportation, especially Ocean transportation, as a basis of economic development through trade is one of the main factors that can not be passed over. Here, We can define that a port as a subsystem of transportation determines the efficiency of the total transportation system. Thus, the purpose of this paper is to contribute in improvement of the efficiency in port, reinforcement of the international competitiveness for exporting goods by the analysis of the cargo handling charges. In order to do this, this paper deals the case of B.C.T.O.C. Furthermore, this study gives some important informations related to the level of tariffs for establishing an autonomous port administration. The Summary of the conclusions of this paper is as follows ; 1) The object of port administration in Korea has been emphasized on the maximization of efficiency in using the port facilities. Nowadays, however, it should be moved to a direction that port is operated under the compound aims considering the public interests and economy. 2) For a criterian of tariff calculation, A tariff system based on the cost accounting is desirable. In general it is recommended that the cost for construction, management, and operation of port is compensated by the revenue from port operation. Therefore, it is necessary for the administration bodies of each port to establish a tariff system on the basis of the independent profit system. 3) For the investigation of actors of tariff adjustment by the Break-even point analysis, (1) When we conducted the B.E.P analysis using total cost as cost term, we got 3.8% discount in tariff at 12% of target profit rate and 1.5% discount at 15% of rate. when we set the target profit rate as 17% we could have the proper tariff level. (2) When using operating cost as cost term, we got 13.1% discount in tariff at 12% of target profit rate and 10.9% discount at 15% of rate. When setting the target profit rat as 28%, we could have the proper tariff level. 4) Comparing with the tariffs of foreign ports for the basic terminal rate, The tariff level of B.C.T.O.C showed 33% of stevedoring charge and 80% of marshalling charge incurred at Kobe port. The comparison with Singapore port gave 50% of transhipment charge and 17% - 20 % of stevedoring charge. 5) We found that the financial structure of B.C.T.O.C was better than those of other companies and the worth fixed assets ratio was too low. The fact of low worth fixed assets ratio implies that the cargo handling facilities should be increased. Moreover, The return of assets for B.T.T.O.C was good but non-operating expenses were still contained too much in. Therefore, we think that it is necessary for B.C.T.O.C. to rationalize business management. Although the present cargo handing charge for B.C.T.O.C is a proper level in terms of a public corporation, for the final recommendation in connection to the results, It is required to take the rationalization process for business management.

• 한국노년학
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• v.39 no.2
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• pp.325-345
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• 2019

The purpose of this study is a exploratory study for understanding the process of the social isolation of the socially isolated elderly through the approach to their life history. The research was analyzed by one of the methods of qualitative research on life history, the conceptual framework of 'Dimensions, turning, and adaptation' of Mandelbaum(1973). According to the results of this study, the socially isolated elderly people were found to be socially isolated by experiencing complex difficulties such as family disconnection, poverty, poor job and health deterioration. Specifically, in the area of life, there was experience of poor relationship with parent, absence of family, poverty of family and unfavorable relationship with surrounding people in life with original family before isolation. They had bad jobs in the labor market, such as hard labor, delivery, business, and chores. In the area of turning point, we experienced family break due to the separation of the original family and the spouse due to various reasons such as financial crisis, parental divorce and death, spouse affair, economic difficulty. In a transitional stage in the life, many reasons such as the financial crisis, the death of parents, the extramarital affair and economic difficulties led to the disconnection from their original family and their spouses. In an adaptive phase, participants accepted the changed life at each turning point in their lives, carrying out their roles, compromising and trying to adapt properly. He said that their current life, which has entered the social safety net system of the people's basic recipients, has led him to live a more stable life and is adapting to personal hobbies and vicarious satisfaction through networks. This result is somewhat different from previous studies in which isolated elderly people were severely exposed to the risk of depression and loneliness. However, we should also consider the characteristics of this study that interviewed elderly people with relatively low isolation. Based on the results of this research, he presented various practical policy implications.

• Asia Marketing Journal
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• v.13 no.1
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• pp.27-50
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• 2011

In today's market scenario, consumers are bombarded with similar promotional messages. It means that managers have to pay attention to promotion strategy to create strong effect as well as to break through the monotony. In this context, although there are strong needs concerning tie-in promotion, research investigating tie-in promotion is limited. Therefore, we extracted tie-in promotion tools and defined the concept of each tie-in promotion tool by analyzing various tie-in promotion cases which are executed in current market. In addition, consumer's recognition of tie-in promotion was investigated through the in-depth interview. The results of case analysis of tie-in promotion and in-depth interview are summarized as follows. First, 9 tie-in promotion tools were extracted: tie-in price reductions, tie-in coupons, tie-in membership, tie-in contests, tie-in premiums (tangibility, intangibility), tie-in payment terms, tie-in sample, tie-in event(culture event, charity event, experience event) and tie-in fund·rebate. Second, 3 categories of the recognition of the consumer for tie-in promotion were extracted: features of preferred tie-in promotion, expectation benefit of tie-in promotion, and risk factors of tie-in promotion. Especially, at the aspect of features of preferred tie-in promotion, fit between consumer pursuit benefit and tie-in promotion was found to be interesting. Moreover, the recognition of the consumer for tie-in promotion were divided with positive(preferred tie-in promotion features, expectation benefit of tie-in promotion) and negative(risk factors of tie-in promotion) factors. In conclusion, the company's effort will be necessary to lower the perceived risk level occurring from the process of accomplishing the tie-in promotion strategy since consumers recognize both positive and negative effects of tie-in promotion.