• The KIPS Transactions:PartC
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• v.11C no.7 s.96
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• pp.951-958
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• 2004

Nowadays NGN is developed for supporting the e-Commerce, Internet trading, e-Government, e-mail, virtual-life and multimedia. Internet gives us the benefit of remote access to the information but causes the attacks that can break server and modify information. Since 2000 Nimda, Code Red Virus and DSoS attacks are spreaded in Internet. This attack programs make tremendous traffic packets on the Internet. In this paper, we designed and developed the Bandwidth Controller in the gateway systems against the bandwidth saturation attacks. This Bandwidth con-troller is implemented in hardware chipset(FPGA) Virtex II Pro which is produced by Xilinx and acts as a policing function. We reference the TBF(Token Bucket Filter) in Linux Kernel 2.4 and implemented this function in HDL(Hardware Description Language) Verilog. This HDL code is synthesized in hardware chipset and performs the gigabit traffic in real time. This policing function can throttle the traffic at the rate of band width controlling policy in bps speed.

• Journal of Animal Science and Technology
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• v.47 no.2
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• pp.167-176
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• 2005

PIGK(phosphatidylinositol glycan, class K) is a subunit of GPI transamidase that cleaves the signal peptide in proproteins and replaces it with GPI. In addition, the structure and synthesis of GPI are critically involved in some of the cellular actions of insulin. Therefore, PIGK would be essential for mammalian development and many specific cellular functions as well as for metabolic activity of insulin associated with GPI. Two types of" full-length cDNAs of porcine PIGK were cloned through RT-PCR and RACE experiments. One is thought to be a normal form(consist of 395 amino acids) and the other is considered as an alternative spliced form(consist of 371 amino acids) which contains additional 63 bps in intron 7. Since a stop codon was contained within the insertion, the spliced form has a shorter coding sequence than that of normal form. A missense mutation (T314I) in exon 6 was detected and used for genotyping to estimate association with the growth and fat deposition traits for 545 $F_2$ animals(Korean native boars ${\times}$ Landrace). From the PCR-RFLP analysis using HpyCH4III, CT genotype showed highly significant relationship(P< 0.01) with carcass fat contents.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.08a
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• pp.94-94
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• 2011

본 논문은 "차세대 반도체용 진공공정의 실시간 측정/진단/제어 기술개발"과제의 제 3 세부과제 "스마트형 진공 배기 진단 제어 시스템 개발"의 주요 연구 실적을 소개한다. 본 세부과제는 (1)진공펌프 및 배기 시스템의 다중 상태변수 측정 장치 개발, (2)공정별 펌프 상태 및 공정 조건 data base 구축 및 진단 알고리즘 개발(e-Diagnostics Level 2 FDC 수준), (3)공정별 펌프 상태 변수 측정을 통한 자기 진단 기술 개발(e-Diagnostics Level 2 FDC 수준), 그리고 (4)측정/통신 PMS (Pump Monitoring System) 개발(통신속도 56k bps 이상, e-Diagnostics Level 0~1)을 최종 목표로 추진되어 왔다. 첫 번째 주요실적은 진공배기시스템의 다중 상태변수 측정 및 평가 장치를 성공적으로 개발하였다. 본 장치는 현장에서 진공펌프의 배기속도를 3% 이내로 정밀하게 측정할 수 있는 소닉 노즐을 이용한 배기속도 측정 장치 및 기술을 성공적으로 개발 완료하였다. 그리고 측정 가능한 상태변수는 20종에 달하며 이들을 이용하여 진공펌프의 성능인자 15종과 특성치 9종을 종합적으로 평가할 수 있는 능력을 갖추었다. 두 번째 주요실적은 공정별 진공배기시스템의 자기진단 및 예지보수 기수 개발이다. 연구에서 개발된 적응형 인자모델을 이용한 상태진단 기술은 이미 학회 논문으로 소개되었으며 본 기법은 기존의 시계열 상태변수를 이용한 기존의 상태진단 기법보다 메모리 소요량을 100배로 줄였으며 그리고 연산양은 10% 이하로 줄인 획기적인 기법이라 할 수 있다. 세 번째 주요실적은 상태변수 측정, 통신, 제어 및 공정적응 기능 통합형(smart) PMS(pumper monitoring system) 개발이다. 본 장치는 CAN통신 기법을 새로이 채택하였으며 한 대의 PC로 64대의 단위 진공펌프들의 운전 상태변수를 실시간으로 수집할 수 있도록 하였다. 그리고 운전 중인 개별 진공펌프들의 운전 상태진단은 적응형 인자모델을 이용한 상태진단 기술을 응적용함으로써 매우 정확한 상태진단을 매 batch마다 수행할 수 있는 기능을 제공한다.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.34 no.2
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• pp.135-138
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• 1998

This paper describes the construction and experimetal results of prototype digital telesounder developed to monitor remotely the fish school entered in setnet. The telesounder consists of the sea station and land station. The former consists of an ultrasonic transceiving part of 50 KHz, a hand made 16 bits single board computer (SBC), and a RF MODEM of 9600 bps for data link. The SBC controls the trigger signal to transmit the ultrasonic pulse, maximum detection range, sampling rate in analog to digital converter and data link. The sampling rate of echo data was 80 ${\mu}$s. The later consists of a RF MODEM same as the former one and 486 notebook computer which displays the echogram and saves its raw data. The authors carried out some experiments to confirm the practical use of the telesounder. At results the echogram obtained on the land station is sufficiently good and clear to monitor the behavior of fish school in setnet.

• Journal of Biomedical Engineering Research
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• v.24 no.3
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• pp.151-158
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• 2003

Numerous studies of short-term, beat-to-beat variability in cardiovascular signals have used linear analysis techniques. However, no study has been done about the appropriateness of linear techniques or the comparison between linearities and nonlinearities in short-term, beat-to-beat variability. This paper aims to verify the appropriateness of linear techniques by investigating nonlinearities in short-term, beat-to-beat variability. We compared linear autoregressive moving average(ARMA) with nonlinear neural network(NN) models for predicting current instantaneous heart rate(HR) and mean arterial blood pressure(BP) from past HRs and BPs. To evaluate these models. we used HR and BP time series from the MIMIC database. Experimental results indicate that NN-based nonlinearities do not play a significant role and suggest that 10 technique provides adequate characterization of the system dynamics responsible for generating short-term, beat-to-beat variability.

• Molecules and Cells
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• v.43 no.6
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• pp.517-529
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• 2020

Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.

• Journal of Korean Physical Therapy Science
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• v.18 no.3
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• pp.87-92
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• 2011

Purpose : The purpose of this study is to have examined the influence on the blood circulation by comparing the differences between stimulating the sympathetic ganglion and the muscle group among the stimulation variables in interferential current stimulation and to have found out the most effective stimulating mode for the improvement the peripheral blood circulation in the interferential current stimulation. Method : The subjects of the study is the men and women in the twenties, who are in great condition and have no pathological report for the blood circulation influence. The intensity of the inferential current stimulation is the medium degree, 100 bps constant current, which is the comfort and overt degree to confirm the muscle contraction. The areas stimulated by the interferential current stimulation are the stellate ganglion area in the seventh cervical vertebrae and the forearm muscle area. The stimulating time is twenty minutes long. After stimulating the two areas, the change of the blood circulation has been measured. Results : Both stimulating the sympathetic ganglion and stimulating the muscle, before and after interferential current stimulation, we have seen that the amount of blood circulation was increased significantly and statistically in both two groups(p<.01) and that the amount of blood circulation was increased significantly and statistically in the case of stimulating the sympathetic ganglion(p<.01). Conclusion : The conclusion we received that inferential current stimulation had the clear influence on increasing the peripheral blood circulation. And stimulating the sympathetic ganglion area is more effective than stimulating muscle area directly.

• Environmental Analysis Health and Toxicology
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• v.13 no.3_4
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• pp.55-61
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• 1998

Glutathione-S-transferases (GSTs) detoxify electrophilic xenobiotics and reactive metabolites. Recently benzene-fused heterocycles have been shown to increase the total amount of hepatic GSTs in rats. Primarily this study aimed to determine the induction of GSTs by benzoazoles (BAs) including benzoxazole (BX), 2-methylbenzoxazole (M-BX), 2,5-dimethyl benzoxazole (D-BX), benzothiazole (BT), aminobenzothiazole (A-BT) and 2-mercaptobenzothiazole (M-BT) in rats. Hepatic cytosol and poly(A)$^+$ mRNA were prepared from rats after oral administration of BX, BT, M-BX, D-BX, A-BT and M-BT for 5 consecutive days at doses of 1 mmol/kg. Western immunoblot and northern blot analysis were conducted with rabbit anti-GST Ya, Yb$_1$, Yb$_2$, Yc antibodies and cDNA probes containing = 500 bps in the specific coding regions of Ya, Yb$_1$, Yb$_2$, Yc$_1$, and Yc$_2$, respectively. All BAs increased the amount of enzymes and mRNA levels of GSTs. BT was the most effective inducer of GSTs among the compounds examined in this study. Although A-BT and M-BT, the derivatives of BT, induced GSTs, these chemicals had lesser effect on induction of GSTs than BT. The derivatives of BX also induced less GSTs than the parent compound and the addition of methyl group to the benzene ring of BX reduced the induction of GSTs. BAs had better inductive effects on the class $\alpha$(Ya, Yc) than class $\mu$ GSTs (Yb$_1$, Yb$_2$). BAs enhanced mRNA levels of GSTs in parallel with the protein levels. These results indicate that 1) most of BAs induced various isozymes of GSTs, 2) the induction of GSTs appears to be correlated with the chemical structure of the derivatives, and 3) the expression of GST by BAs is presumably under the transcriptional regulation.

• The Journal of Society for e-Business Studies
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• v.12 no.2
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• pp.195-217
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• 2007

B2B registries provide spaces to register and retrieve information which is necessary to support B2B transactions among business partners or potential business partners. Business process specifications are one of important contents in B2B registries, and there is high complexity of representation due to complex and dynamic characteristics of business processes. Also, currently there exist several competing specification frameworks such as ebXML BPSS, WSBPEL, BPMN, and so on. This paper proposes a metadata schema to register business process specifications which are represented by different specification frameworks. The proposed schema has extensibility to register business process specifications which are represented by various different specification frameworks. Also, it extends reuse level from whole business specification processes to their components. To show the usefulness of the proposed schema, this paper demonstrates metadata extraction from business process specifications which are represented by two representative XML-based business process specification languages, ebXML BPSS and WSBPEL.

• BMB Reports
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• v.46 no.7
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• pp.358-363
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• 2013

In this paper, we firstly reported a C-type lectin cDNA clone of 1029 bps from the larvae of A. Pernyi (Ap-CTL) using PCR and RACE techniques. The full-length cDNA contains an open reading frame encoding 308 amino acid residues which has two different carbohydrate-recognition domains (CRDs) arranged in tandem. To investigate the biological activities in the innate immunity, recombinant Ap-CTL was expressed in E. coli with a 6-histidine at the amino-terminus (Ap-rCTL). Besides acted as a broad-spectrum recognition protein binding to a wide range of PAMPs and microorganisms, Ap-rCTL also had the ability to recognize and trigger the agglutination of bacteria and fungi. In the proPO activation assay, Ap-rCTL specifically restored the PO activity of hemolymph blocked by anti-Ap-rCTL antibody in the presence of different PAMPs or microorganisms. In summary, Ap-rCTL plays an important role in insect innate immunity as an pattern recognition protein.