• Computers and Concrete
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• v.29 no.4
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• pp.255-262
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• 2022

The present study investigates the effects of Cattaneo-Christov thermal effects of stagnation point in Walters-B nanofluid flow through lubrication of power-law fluid by taking the slip at the interfacial condition. The impacts of thermophoresis and Brownian motions are further accounted. The fluid impinging orthogonally on the surface is due to power-law slim coating liquid. The generalized newtonian fluid equation is used that obeys the power law constitutive equation to model our problem. The effect of velocity profiles, temperature for different values of n are investigated. The prandtl on the temperature distribution for partial slip and no slip cases is also observed. It is found that for larger values of prandtl number thermal diffusivity of fluid reduces and it enhance the decrease in temperature and boundary layer thickness.

• Advances in concrete construction
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• v.13 no.3
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• pp.255-264
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• 2022

Vibration is expected to occur in microtubules as tubular heterodimers. They oscillate like electric dipoles. Several research studies have estimated a frequency of vibration using the orthotropic model, a beam or rod like models and shell models, considering the surface forces. The effects of body forces on the dynamics of the microtubules were not yet taken into account. This study seeks to capture the body force effects on the vibration modes generated and on the corresponding frequency for microtubules. An orthotropic elastic shell model for the structural details of microtubules is used for the analysis. The tests are conducted out for microtubules, exposed to electro-magnetic and gravitational forces, the transverse vibration, radial mode vibration, and axial mode of vibration have accomplished. We therefore, evaluate and compare microtubules' frequencies with prior results of vibration frequency without the effects of body force.

• Advances in concrete construction
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• v.10 no.2
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• pp.141-149
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• 2020

In the present study, a mechanical model is applied to account the effects of the surrounding viscoelastic media on the buckling behavior of single microfilament within the cell. The model immeasurably associates filament's bending rigidity, neighboring system elasticity, and cytosol viscosity with buckling wavelengths, buckling growth rates and buckling amplitudes of the filament. Cytoskeleton components in living cell bear large compressive force and are responsible in maintaining the cell shape. Actually these filaments are surrounded by viscoelastic media consisting of other filaments network and viscous cytosole within the cell. This surrounding, viscoelastic media affects the buckling behavior of these filaments when external force is applied on these filaments. The obtained results, indicate that the coupling of viscoelastic media with the viscous cytosol greatly affect the buckling behavior of microfilament. The buckling forces increased with the increase in the intensity of surrounding viscoelastic media.

• Advances in nano research
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• v.12 no.4
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• pp.365-374
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• 2022

Intermediate filaments are the mechanical ropes for both cytoskeleton and nucleoskeleton of the cell which provide tensile force to these skeletons. In providing the mechanical support to the cell, they are likely to buckle. We used conventional Euler buckling model to find the critical buckling force under different boundary conditions which they assume during different functions. However, there are many experimental and theoretical studies about other cytoskeleton components which demonstrate that due to mechanical coupling with the surrounding surface, the critical buckling force increases considerably. Motivated with these results, we also investigated the influence of surface effects on the critical buckling force of intermediate filaments. The surface effects become profound because of increasing ratio of surface area of intermediate filaments to bulk at nano-scale. The model has been solved analytically to obtain relations for the critical forces for the buckling of intermediate filaments without and with surface effects. We found that critical buckling force with surface effects increases to a large extent due to mechanical coupling of intermediate filaments with the surrounding surface. Our study may be useful to develop a unified experimental protocol to characterize the physical properties of Intermediate filaments and may be helpful in understanding many biological phenomenon involving intermediate filaments.

• Advances in concrete construction
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• v.15 no.3
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• pp.171-178
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• 2023

Cytoskeleton components play key role in maintaining cell structure and in giving shape to the cell. These components include microtubules, microfilaments and intermediate filaments. Among these filaments intermediate filaments are the most rigid and bear large compressive force. Actually, these filaments are surrounded by other filaments like microtubules and microfilaments. This network of filaments makes a layer as a surface on intermediate filaments that have great impact on buckling behavior of intermediate filaments. In the present article, buckling behavior of intermediate filaments is studied by taking into account the effects of surface by using Euler Bernoulli and Timoshenko beam theories. It is found that effects of surface greatly affect the critical buckling force of intermediate filaments. Further, it is observed that the critical buckling force is inversely proportional to the length of filament. Such types of observations are helpful for further analysis of nanofibrous in their actual environments within the cell.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1999-2006
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• 2016

Background: Acute promyelocytic leukemia (APML) is characterized by the reciprocal translocation t(15;17) (p22;p12) resulting in the PML-$RAR{\alpha}$ fusion gene. A dual diagnostic and follow up approach was applied including cytogenetic demonstration of the t(15;17) translocation and detection dg PML-$RAR{\alpha}$ chimeric transcripts by molecular means. Purpose: Conventional cytogenetics involving bone marrow is beset with high probability of poor metaphase index and was substituted with phytohemagglutinin (PHA)-induced peripheral blood culture based cytogenetic analysis as a diagnostic & follow up modality in APML patients of Kashmir (North India). Both qualitative (RT-PCR) and quantitative (Q-PCR) tests were simultaneously carried out to authenticte the modified cytogenetics. Materials and Method: Patient samples were subjected to the said techniques to establish their baseline as well as follow-up status. Results: Initial cytogenetics revealed 30 patients (81%) Positive for t(15;17) whereas 7 (19%) had either cryptic translocation or were negative for t(15;17). Two cases had chromosome 16q deletion and no hallmark translocation t(15;17). Q-PCR status for PML-$RAR{\alpha}$ was found to be positive for all patients. All the APML patients were reassessed at the end of consolidation phase and during maintenance phase of chemotherapy where 6 patients had molecular relapse, wherein 4 also demonstrated cytogenetic relapse. Conclusions: It was found that PHA-induced peripheral blood cytogenetics along with molecular analysis could prove a reliable modality in the diagnosis and assessment of follow up response of APML patients.

• Advances in nano research
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• v.10 no.4
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• pp.359-371
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• 2021

A tumor immune interaction is a main topic of interest in the last couple of decades because majority of human population suffered by tumor, formed by the abnormal growth of cells and is continuously interacted with the immune system. Because of its wide range of applications, many researchers have modeled this tumor immune interaction in the form of ordinary, delay and fractional order differential equations as the majority of biological models have a long range temporal memory. So in the present work, tumor immune interaction in fractional form provides an excellent tool for the description of memory and hereditary properties of inter and intra cells. So the interaction between effector-cells, tumor cells and interleukin-2 (IL-2) are modeled by using the definition of Caputo fractional order derivative that provides the system with long-time memory and gives extra degree of freedom. Moreover, in order to achieve more efficient computational results of fractional-order system, a discretization process is performed to obtain its discrete counterpart. Furthermore, existence and local stability of fixed points are investigated for discrete model. Moreover, it is proved that two types of bifurcations such as Neimark-Sacker and flip bifurcations are studied. Finally, numerical examples are presented to support our analytical results.

• Computers and Concrete
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• v.25 no.2
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• pp.133-144
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• 2020

This paper aims to study vibration characteristics of chiral and zigzag double-walled carbon nanotubes entrenched on Donnell shell model. The Eringen's nonlocal elastic equations are being combined with Donnell shell theory to observe small scale response. Wave propagation is proposed technique to establish field equations of model subjected to four distinct end supports. A nonlocal model has been formulated to explore the frequency spectrum of both chiral and zigzag double-walled CNTs along with diversity of indices and nonlocal parameter. The significance of scale effect in relevance of length-to-diameter and thickness- to- radius ratios are discussed and displayed in detail. The numerical solution based on this nonlocal Donnell shell model can be further used to predict other frequency phenomena of double-walled and multi-walled CNTs.

• Advances in nano research
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• v.10 no.2
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• pp.165-174
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• 2021

This paper based on Sanders theory aims to investigate the vibration of SWCNTs considering the clamped-simply supported, clamped-free, clamped-clamped and simply supported-simply supported end conditions. After developing the governing equation of the objective system, the Rayleigh-Ritz technique is implemented for the purpose of obtaining the frequency equation in the eigen form. In addition, the applicability of this model for the analysis of vibration of CNTs is examined with the effect of length and ratio of height-to-radius. A detailed description of different types of SWCNTs with different indices is provided in the theoretical methodology. The effect of extended length is stimulated with increasing the radii and the model is effective because it also predicts the effect of thickness on vibration of SWCNTs. For different boundary conditions, the present results are verified with earlier literature.

• Advances in concrete construction
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• v.12 no.6
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• pp.491-497
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• 2021

Cell components play vital role within the cell when the cell under goes deformation. These components are microtubules, microfilaments and intermediate filaments. Intermediate filaments are like thread and are of different types. Like microtubules and microfilaments these components also undergo the deformation and their dynamics affected when change occurs within cell. In the present study, bending of intermediate filaments are studied keeping the nonlocal effects under consideration. It is observed that the nonlocal parameter has a great impact on the dynamics of intermediate filaments. This study is made by the application of Euler beam theory.