• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2231-2235
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• 2015

Genome-wide association studies (GWASs) of the entire genome provide a systematic approach for revealing novel genetic susceptibility loci for breast cancer. However, genetic association studies have hitherto been primarily conducted in women of European ancestry. Therefofre we here performed a pilot GWAS with a single nucleotide polymorphism (SNP) array 5.0 platform from $Affymetrix^{(R)}$ that contains 443,813 SNPs to search for new genetic risk factors in 89 breast cancer cases and 46 healthy women of Indonesian ancestry. The case-control association of the GWAS finding set was evaluated using PLINK. The strengths of allelic and genotypic associations were assessed using logistic regression analysis and reported as odds ratios (ORs) and P values; P values less than $1.00{\times}10^{-8}$ and $5.00{\times}10^{-5}$ were required for significant association and suggestive association, respectively. After analyzing 292,887 SNPs, we recognized 11 chromosome loci that possessed suggestive associations with breast cancer risk. Of these, however, there were only four chromosome loci with identified genes: chromosome 2p.12 with the CTNNA2 gene [Odds ratio (OR)=1.20, 95% confidence interval (CI)=1.13-1.33, $P=1.08{\times}10^{-7}$]; chromosome 18p11.2 with the SOGA2 gene (OR=1.32, 95%CI=1.17-1.44, $P=6.88{\times}10^{-6}$); chromosome 5q14.1 with the SSBP2 gene (OR=1.22, 95%CI=1.11-1.34, $P=4.00{\times}10^{-5}$); and chromosome 9q31.1 with the TEX10 gene (OR=1.24, 95%CI=1.12-1.35, $P=4.68{\times}10^{-5}$). This study identified 11 chromosome loci which exhibited suggestive associations with the risk of breast cancer among Indonesian women.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2593-2596
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• 2012

Aims: A case-control study of 300 gastric cancer patients and 300 controls was conducted to investigate whether the polymorphisms rs2294008 in PSCA and rs2070803 in MUC1 might be associated with risk of gastric cancer in a Chinese population. Methods: Single nucleotide polymorphisms (SNPs) were genotyped using the Sequenom MassARRAY platform. Results: The data showed that the rs2294008 TT genotype increased gastric cancer risk to an adjusted odds ratio (OR) of 2.26 (95%CI 1.25-4.07), TC to 1.72 (95%CI 1.23-2.42) and TC/TT to 1.81 (95% CI 1.31-2.50), while the rs2070803 GA genotype was associated with a decrease in risk to an adjusted OR of 0.42 (95% CI 0.28-0.62) and rs2070803 GA / AA to 0.46 (95% CI 0.32-0.67). Further stratification analysis revealed that rs2294008 in PSCA consistently increased risk of both intestinal and diffuse-type gastric cancers. The effect of rs2070803 in MUC1 was noteworthily also consistent with both subtypes. Conclusions: Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.449-452
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• 2013

Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Here we conducted a case-control study to assess the role of potential SNPs of DNA repair genes on the risk of glioma and meningioma. We included 297 cases and 458 cancer-free controls. Genotyping of XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC2 Arg188His, XRCC3 Thr241Met, XRCC4 Ala247Ser, ERCC1 Asn118Asp, ERCC2 Lys751Gln and ERCC5 Asp1558His were performed in a 384-well plate format on the Sequenom MassARRAY platform. XRCC1 Arg194Trp (rs1799782) and ERCC2 Asp312Asn rs1799793 did not follow the HWE in control group, and genotype distributions of XRCC1 Gln399Arg rs25487, XRCC2 Arg188His rs3218536 and ERCC2 Asp312Asn rs1799793 were significantly different between cases and controls (P<0.05). We found XRCC1 399G/G, XRCC1 194 T/T and XRCC3 241T/T were associated with a higher risk when compared with the wild-type genotype. For ERCC5 Asp1558His, we found G/G genotype was associated with elevated susceptibility. In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas. This finding could be useful in identifying the susceptibility genes for these cancers.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3821-3824
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• 2012

Aim: SNPs of ERCC1 and ERCC2 genes have been found to be associated with response to platinum therapy in different clinical settings. In the current study, we investigated the relationship of SNPs in ERCC1 and ERCC2 to cisplain response and survival in osteosarcoma patients. Methods: 267 consecutive patients diagnosed with osteosarcoma between January 2003 to January 2005 were followed up until the end of January 2010. ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln polymorphisms were detected based upon the Sequenom MassARRAY platform.Results: For ERCC1 Asn118Asn, the variant genotype T/T was strongly significantly associated with a higher event free survival when compared with the wild-type C/C, with an adjusted OR (95% CI) of 0.39 (0.14-0.95). ERCC2 751 A/A genotype showed increased event free survival of osteosarcoma (HR=0.44; 95%CI=0.10-0.87). However, we did not find significant association of ERCC1 Gln504Lys and ERCC2 Asp312Asn polymorphisms with prognosis of osteosarcoma. Conclusions: We first report associations of four SNPs, ERCC1 Asn118Asn, ERCC1 Gln504Lys, ERCC2 Asp312Asn and ERCC2 Lys751Gln, with risk of death from osteosarcoma in a Chinese population, indicating ERCC1 118T/T and ERCC2 A/A may be used as surrogate markers for clinical outcome of osteosarcoma treatmetn with cisplain.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4083-4087
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• 2013

We conducted an exploratory investigation of whether variation in six common SNPs of xeroderma pigmentosum complementation group F (XPF) is associated with risk of glioma in a Chinese population. Six single nucleotide polymorphisms (SNPs) were genotyped in 207 glioma cases and 236 cancer-free controls by a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). The rs1800067 G and rs2276466 G allele frequencies were significantly higher in the glioma group than controls. Individuals with the rs1800067 GG genotype were at greater risk of glioma when compared with the A/A genotype in the codominant model, with an OR (95% CI) of 2.63 (1.04-7.25). The rs2276466 polymorphism was significantly associated with moderate increased risk of glioma in codominant and dominant models, with ORs (95% CI) of 1.90 (1.05-3.44) and 1.55 (1.07-2.47), respectively. The combination genotype of rs1800067 G and rs2276466 G alleles was associated with a reduced risk of glioma (OR=0.44, 95% CI=0.19-0.98). These findings indicate that genetic variants of the XPF gene have critical functions in the development of glioma.

• 한국시뮬레이션학회논문지
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• 제23권4호
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• pp.41-49
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• 2014

능동 합성개구면소나에 의한 해저부설 소형물체 탐지처리 기술은 공간적 제약을 받는 소형 무인화 시스템에서 짧은 센서어레이 사용이 가능하므로 개구면 합성처리에 의해 탐지성능을 올릴 수가 있다. 하지만 플렛폼의 정속도 직선기동에 의한 제한조건은 여러 가지 외부 환경요인과 정확한 위상차 합성 처리에 있어서 많은 오차를 유발하게 된다. 본 연구에서는 이러한 시스템에 탑재되는 능동형 합성개구면처리에 대한 적용 가능성을 분석하고, 전용 시뮬레이터를 구성하여 진행경로 변동에 의해 발생되는 위상차 부정합에 따른 탐지해상도 성능변화를 비교 검토하고자 한다. 시뮬레이션은 코히어런트 초점처리 모델에 경로변동 모듈을 추가하여 실행하였으며, 결과에서 알 수 있듯이 합성개구면처리에 의한 해저 소형물체 탐지성능은 플렛폼의 경로변동에 의한 위상차 부정합 및 S/N비 변화에 의해 많은 변화가 있음을 알 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5839-5842
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• 2013

Aim: We assessed the association between genetic variants of XPG, XPA, XPD, CSB, XPC and CCNH in the nucleotide excision repair (NER) pathway and risk of prostate cancer. Methods: We genotyped the XPG, XPA, XPD, CSB, XPC and CCNH polymorphisms by a 384-well plate format on the MassARRAY(R) platform. Multivariate logistical regression analysis was used to assess the associations between the six gene polymorphisms and risk of prostate cancer. Results: Individuals carrying the XPG rs229614 TT (OR=2.01, 95%CI=1.35-3.27) genotype and T allele (OR=1.73, 95%CI=1.37-2.57) were moderately significantly associated with a higher risk of prostate cancer. Subjects with XPD rs13181 G allele had a marginally increased risk of prostate cancer, with adjusted OR(95%CI) of 1.53 (1.04-2.37). Moreover, individuals carrying with CSB rs2228526 GG genotype (OR=2.05, 95% CI=1.23-3.52) and G allele (OR=1.56, 95%CI=1.17-2.05) were associated with a higher increased risk of prostate cancer. The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele had accumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59). Conclusions: Our study indicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increased risk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is strongly associated with an increased risk.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.4905-4908
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• 2012

Aim: Glioma cancer is the most common type of adult brain tumor. Recent genome-wide association studies (GWAS) have identified various new susceptibility regions and here we conducted an extensive analysis of associations between 12 single nucleotide polymorphisms (SNPs) and glioma risk. Methods: A total of 197 glioma cases and 197 health controls were selected, and 9 SNPs in 8 genes were analyzed using the Sequenom MassARRAY platform and Sequenom Assay Design 3.1 software. Results: We found the MAF among selected controls were consistent with the MAF from the NCBI SNP database. Among 9 SNPs in 8 genes, we identified four significant SNP genotypes associated with the risk of glioma, C/C genotype at rs730437 and T/T genotype at rs1468727 in ERGF were protective against glioma, whereas the T/T genotype at rs1799782 in XRCC1 and C/C genotype at rs861539 in XRCC3 conferred elevated risk. Conclusion: Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk. These findings indicate that genetic variants of various genes play a complex role in the development of glioma.

• 한국산업정보학회논문지
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• 제23권4호
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• pp.23-31
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• 2018

본 논문은 1.7 GHz 주파수 대역에서 HD 비디오를 무선으로 송수신하는 2T-2R(2 Transmitter-2 Receiver) 시스템을 설계 및 구현하였다. 해당 시스템은 HDL로 설계한 LTE-TDD 송수신 모뎀을 USRP RIO에 내장된 Xilinx Kintex-7칩에 구현하여 USRP RIO를 베이스밴드로 사용하였으며, USRP RIO에서 송수신되는 신호는 자체 설계한 1.7 GHz RF송수신 모듈로 업 다운 변환을 수행한 후 자체 설계한 2x9 서브 배열 안테나를 통해 최종적으로 HD 비디오 데이터를 통신하게 된다. USRP RIO와 Host PC의 통신방식은 데이터 송수신시 발생되는 지연을 최소화하기 위해　PCI express(Peripheral Component Intercon nect express)x4를 사용하였다. 구현한 시스템은 EVM 32 dBc의 기본 성능을 보였으며, 실험환경 내 어디서든 HD 비디오를 성공적으로 송수신하였다. 본 논문에서 제안하는 내용은 6 GHz 이하의 차세대 5G 이동통신 시스템뿐만 아니라 추후 밀리미터 대역을 사용하는 광대역 5G 이동통신 시스템으로의 활용이 가능하다.

• 한국산업정보학회논문지
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• 제18권2호
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• pp.1-12
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• 2013

정보보호 시스템은 소프트웨어, 하드웨어, FPGA(Field Programmable Array) 디바이스를 이용하여 구현되었다. S/W의 구현은 다양한 정보보호 알고리즘에 대해 높은 유연성을 제공하나 속도, 전력, 안전성 측면에서 매우 취약하며, ASIC 구현은 속도, 전력 측면에서는 매우 우수하지만 구현의 특성상 다양한 보안 플랫폼을 지원할 수 없다. 이러한 문제점들의 상충관계를 개선하기 위해 최근 FPGA 디바이스 상에서의 구현이 많이 이루어 졌다. 본 논문에서는 다양한 환경에서의 정보보호 서비스를 제공하기위한 정보보호 시스템을 위한 FPGA 기반 하드웨어 가속기를 설계한다. 개발한 정보보호 시스템은 비밀키 암호알고리즘(AES : Advanced Encryption Standard), 암호학적 해쉬(SHA-256 : Secure Hash Algorithm-256), 공개키 암호알고리즘(ECC : Elliptic Curve Cryptography)을 수행할 수 있으며, Integrated Interface에 의해 제어된다. 또한 기존의 시스템에 비해 다양한 정보보호 알고리즘을 지원하여 활용도를 높였으며, 파라미터에 따라 상충관계를 개선 할 수 있기 때문에 저 비용 응용뿐만 아니라 고속의 통신장비에도 적용이 가능하다.