Asian Pacific Journal of Cancer Prevention

  • 제14권1호
  • /
  • Pages.449-452
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Polymorphisms in DNA Repair Genes and Risk of Glioma and Meningioma

  • Luo, Ke-Qin (Department of Emergency, the Sun Yat-sen Memorial Hospital of Sun Yat-sen University) ;
  • Mu, Shi-Qing (Beijing Tiantan Hospital, Capital Medical University) ;
  • Wu, Zhong-Xue (Beijing Tiantan Hospital, Capital Medical University) ;
  • Shi, Yi-Ni (Department of Emergency, the Sun Yat-sen Memorial Hospital of Sun Yat-sen University) ;
  • Peng, Ji-Cai (Department of Emergency, the Sun Yat-sen Memorial Hospital of Sun Yat-sen University)
  • 발행 : 2013.01.31
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초록

Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Here we conducted a case-control study to assess the role of potential SNPs of DNA repair genes on the risk of glioma and meningioma. We included 297 cases and 458 cancer-free controls. Genotyping of XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC2 Arg188His, XRCC3 Thr241Met, XRCC4 Ala247Ser, ERCC1 Asn118Asp, ERCC2 Lys751Gln and ERCC5 Asp1558His were performed in a 384-well plate format on the Sequenom MassARRAY platform. XRCC1 Arg194Trp (rs1799782) and ERCC2 Asp312Asn rs1799793 did not follow the HWE in control group, and genotype distributions of XRCC1 Gln399Arg rs25487, XRCC2 Arg188His rs3218536 and ERCC2 Asp312Asn rs1799793 were significantly different between cases and controls (P<0.05). We found XRCC1 399G/G, XRCC1 194 T/T and XRCC3 241T/T were associated with a higher risk when compared with the wild-type genotype. For ERCC5 Asp1558His, we found G/G genotype was associated with elevated susceptibility. In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas. This finding could be useful in identifying the susceptibility genes for these cancers.

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참고문헌

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피인용 문헌

  1. Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population vol.14, pp.10, 2013, https://doi.org/10.7314/APJCP.2013.14.10.5957
  2. The XRCC3 Thr241Met Polymorphism Influences Glioma Risk - A Meta-analysis vol.14, pp.5, 2013, https://doi.org/10.7314/APJCP.2013.14.5.3169
  3. Association of XRCC3 Thr241Met Polymorphisms and Gliomas Risk: Evidence from a Meta-analysis vol.14, pp.7, 2013, https://doi.org/10.7314/APJCP.2013.14.7.4243
  4. Association of Rs11615 (C>T) in the Excision Repair Cross-complementing Group 1 Gene with Ovarian but not Gynecological Cancer Susceptibility: a Meta-analysis vol.15, pp.15, 2014, https://doi.org/10.7314/APJCP.2014.15.15.6071
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  6. Genetic polymorphisms in XRCC1 gene and susceptibility to glioma in Chinese Han population vol.35, pp.1, 2014, https://doi.org/10.1007/s13277-013-1050-2
  7. Association between the Thr241Met polymorphism of X-ray repair cross-complementing group 3 gene and glioma risk: evidence from a meta-analysis based on 4,136 cases and 5,233 controls vol.35, pp.1, 2014, https://doi.org/10.1007/s13277-013-1059-6
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