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http://dx.doi.org/10.7314/APJCP.2013.14.7.4083

Xeroderma Pigmentosum Complementation Group F Polymorphisms Influence Risk of Glioma  

Cheng, Hong-Bin (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University)
Xie, Chen (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University)
Zhang, Ru-You (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University)
Hu, Shao-Shan (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University)
Wang, Zhi (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University)
Yue, Wu (Department of Neurosurgery, The Fourth Affiliated Hospital, Harbin Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.7, 2013 , pp. 4083-4087 More about this Journal
Abstract
We conducted an exploratory investigation of whether variation in six common SNPs of xeroderma pigmentosum complementation group F (XPF) is associated with risk of glioma in a Chinese population. Six single nucleotide polymorphisms (SNPs) were genotyped in 207 glioma cases and 236 cancer-free controls by a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). The rs1800067 G and rs2276466 G allele frequencies were significantly higher in the glioma group than controls. Individuals with the rs1800067 GG genotype were at greater risk of glioma when compared with the A/A genotype in the codominant model, with an OR (95% CI) of 2.63 (1.04-7.25). The rs2276466 polymorphism was significantly associated with moderate increased risk of glioma in codominant and dominant models, with ORs (95% CI) of 1.90 (1.05-3.44) and 1.55 (1.07-2.47), respectively. The combination genotype of rs1800067 G and rs2276466 G alleles was associated with a reduced risk of glioma (OR=0.44, 95% CI=0.19-0.98). These findings indicate that genetic variants of the XPF gene have critical functions in the development of glioma.
Keywords
Xeroderma pigmentosum complementation group F; single nucleotide polymorphisms; glioma;
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