• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.10 no.1
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• pp.185-208
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• 1997

A Literatual Study on the external treatment of eye diseases, the result were as follows. 1. The external treatment of eye diseases used eyedrops(點,滴), steam bath(熏), washing(洗), plaster(敷). 2. Eyedrops used filterated decoction. 3. Eye diseases used Bomeolum(永片), Coptidis Rhiwma(黃連), Angelicae gigantis Radix(當歸) with clearing away heat and toxic materials, clearing away swelling, pain, ithing and convulsion, clearing away nebula 4. Eye diseases used B-1(晴明), B-2(찬竹), Tae-Yang(太陽), S-1(承泣), G-1(瞳子료), S-2(四白), TE-23(絲竹空), Eo-Yo(魚腰), G-14(陽白), Gu-Hu(球後), G-20(風池), B-18(肝兪), LI-4(合谷), Liv-3(太衡, B-23(腎兪), G-37(光明), Liv-2(行間), GV-23(上星), and S-36(足三里).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.12 no.2
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• pp.104-121
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• 1999

The results were as follows ; 1. The treatment method is most used reinforcing the spleen and strengthening of Ki(氣) detoxication and draining of pus on each stage. In first stage, the method of actirating blood and aeration of Lag(絡) nourishing blood and moisturizing skin is used. In ulcer stage, the method of expelling blood stasis and detoxication, promoting pus and drainage is used. In chronic stage, strengthening of Ki(氣) and blood, invigiration and dispersion is used. 2. In the frequency of prescription, the most numerous prescription is Paljintang(八珍湯) and the next are Insamyangyoungtang(人蔘養榮湯). Taglisodongum(托裏消耗飮) ect. In the frequency of medicine the most numerous medicine is Angelicae Gigantis Radix(當歸) and the next are Glycyrrhizae Radix (甘草), Astragali Radix(황기) etc. 3. In the frequency of prescription of exteral therapy. the most numerous prescription is Saengioghongo(生肌玉紅膏), Saengisan(生肌散) and the next are hongsungdan(紅升丹), guildan(九一丹) etc. In the frequency of medicine of exteral therapy, the most numerous medicine is Glycyrrhizae Radix (甘草) and the next are Calomelas(輕粉), Draconis Resina(血竭) etc.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.4
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• pp.103-112
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• 2018

Objectives The purpose of this study is to provide clinical evidences on effectiveness of herbal medicine treatment regarding pediatric growth based on recent clinical studies. Methods Selected 17 clinical studies since January 1998 to June 2018 from the Journal of Pediatrics of Korean Medicine and OASIS Traditional Medicine Knowledge Portal were reviewed. Results Medications that strengthening spleen and stomach (健脾胃藥), digestant (消導藥), supplementing kidneys (補 腎藥), and lungs (補肺藥) were frequently used. Frequently used herbs were Hoelen (茯?), Citri Pericarpium (陳皮), Glycyrrhizae Radix (甘草), Atractylodis Rhizoma Alba (白朮), Dioscoreae Rhizoma (山藥), Angelicae Gigantis Radix (當歸), Amomi Fructus (砂仁), Rehmanniae Radix Preparata (熟地黃). Conclusions This study showed that Korean herb medicine treatment can be effective for pediatric growth.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.210.1-210.1
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• 2003

Keokhachukeu-tang is the one of Chinese traditional prescription used for the treatment of liver disease. This prescription consists of Carthami Flos (6g), Persicae Semen (9g), Pteropi Faeces (9g), Corydalis Tuber (9g), Moutan Radicis Cortex (6g), Paeoniae Radix rubra (9g), Angelicae gigantis Radix (9g), Cnidii Rhizoma (9g), Linderae Radix (12g), Cyperi Rhizoma (12g), Aurantii Fructus (9g), and Glycyrrhizae Radix (3g). Water extract of Keokhachukeu-tang showed a moderate hepatoprotective effect on tacrine-induced cytotoxicity in Hep G2 cells. (omitted)

• Journal of Life Science
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• v.12 no.5
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• pp.595-604
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• 2002

The growth promoting effect of Clostridium hutyricum KCTC 1785 was investigated with natural products bearing antioxidative capacity, and combined two, three and four kinds of them. C. butyricum was showed a good growth by Lycii fructus, Sophorae flos, Chelidonium majus L., Atractylodis rhizoma alba, Paeonia japonica, alone, and two mixed com-binations were composed of Paeonia japonica and Epimedii herba, Paeonia japonica and Aurantii nobilis pericarpium, Paeonia japonica and Puerariae radix, Pneonia japonica and Angelicae gigantis radix, and three mixed combinations were organized with Epimedii herba, Sophorae flos and Nnelumbo nuclfera gaertner, and Epimedii herba, Sophorae flos and Scutellaria haicalensis george, and Epimedii herba, Sophorae flos and theae folium, and Epimedii herba, Paeonia japonica and Angelicae gigantis radix, and four mixed combinations were formed with Epimedii herba, Puerariae radix, Nelumbo nuclfera gaertner and Paeonia japonica, and Epimedii herba, Puerariae radix, Nelumbo nuclfera gaertner and Theae folium, and Epimedii berba, puerariae radix, Nelumbo nuclfera gaertner and Angelicae gigantis radix, and puerariae radix, Nelumbo nuclfera gaertner, paeonia japonica and Theae folium. As these combinations of natural products could activate some parts fo body, they might be applied to pharmaceuitcal applications, functional foods, antiaging tea, also expected to promote useful enterobacterial growth for multifunctional fermentative beverage.

• The Korea Journal of Herbology
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• v.27 no.2
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• pp.61-67
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• 2012

Objective : Angelica Gigas Nakai is a popular oriental medicine used for the treatment of vascular diseases. The aim of this study is to investigate neuroprotective effect of the water extract of Anelicae Gigantis Radix Palva (AG) in transient middle cerebral artery occlusion (tMCAO)-induced ischemic rats via the regulation of angiogenesis-related molecules. Methods : Sprague-Dawley rats were intraperitoneally administrated with AG water extract at doses of 10, 25, 50 mg/kg body weight after tMCAO (90 min occlusion). reperfusion for 24 hr infarction volumes were measured by 2,3,5-tetrazolium chloride (TTC) staining. Brain tissues were observed neuronal cell injuries by nissl staining, and also brain-blood barrier (BBB) permeability change by evans blue. Expression of vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and Tie-2 receptor protein in brain tissues was determined by western blot. Results : AG water extract significantly reduced infarction volume in ischemic brains of rats, degradation of neuronal cell, BBB permeability and expression of VEGF protein dose-dependently. Ang-1 protein was increased dose-dependantly, not significantly. Conclusion : This study suggests that AG water extract shows neuroprotective effect by preventing BBB breakdown, with regulating angiogenesis factor VEGF and Ang-1.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1507-1515
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• 2006

Angelica gigantis (AG), Rehamaninae Radix(RR), Paenia japonica (PJ), and Polygoni multiflori Radix (PM) have been used as medicinal plants to tonify the blood. General function of the drugs have been known to nourish blood and control the heart and liver meridians. Recently, several studies have proposed mechanisms by which some oriental medicinal herbs work on the immune system. However, it is uncertain whether aqueous-extract of these drugs has immunomodulatory effect yet. In this study, I investigated the immune promotive effects of the water-extracted AG, RR, PJ and PM. The water-extracted AG, RR, PJ and PM inhibited NO production and iNOS expression in LPS stimulated RAW 264.7 macrophage cell line. Among these extracts, AG and PM induced expression of IL-2 and IFN${\gamma}$ in mouse spleen cells. In the flow cytometry analysis, PM-stimulated mouse spleen cells showed an increase in B-cell phenotype (CD45R/B220). The oral administration of Polygoni multiflori water-extracts to mice having S-180 abdominal dropsy cancer prolonged life-span more than control mice. These data suggest that among these extracts, PM has cellular and humoral immune-enhancement effect through IL-2 and IFN${\gamma}$ cytokine production, the regulation of NO production in macrophage cells and the B cell production in spleen cells.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.4
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• pp.153-164
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• 2005

Purpose : This study was designed to make a basis of in vivo or clinical study about colporrhea. Methods : This study is based on Yang's study, An investigation on the prescriptions of colporrhea(1999). We investigate the prescriptions in the Yang's study and examine the frequency of metioned single herb. Also we investigate the herb's classification. Results and Conclusion : 1) Single herb frequently used in the prescriptions was as follows. (()- Frequency) Paeoniae Radix Alba白芍藥(16), Glycyrrhizae Radix甘草(15), Poria白茯?(13),　Angelicae gigantis Radix當歸, Citri Pericapium陳皮(11), Atractylodis macrocephalae Rhizoma白朮(10), Zingiberis Rhizoma乾薑　, Atractylodis Rhizoma蒼朮, Ailanthi Cortex樗根白皮, Phellodendri Cortex黃柏, Ginseng Radix人蔘, Cyperi Rhizoma香附子(9),　Dioscoreae Rhizoma山藥, Corni Fructus山茱萸, Bupleuri Radix柴胡, Cnidii Rhizoma川芎, Gardeniae Fructus梔子(8), Rehmanniae Radix preparat熟地黃, Pinelliae Rhizoma半夏(7), Foeniculi Fructus小茴香, Scutellariae Radix黃芩, Angelicae dahuricae Radix白芷, Cinnamomi肉桂(5), CortexAlismatis Rhizoma澤瀉, Moutan Cortex牧丹皮, Aconiti iateralis preparata Radix附子, Plantaginis Semen車前子(4), Ostreae Concha牡蠣, Euphorbiae pekinensis Radix大戟, Aucklandiae Radix木香, Rhei Radix et Rhizoma大黃, Ledebouriellae Radix防風, Astragali Radix黃?, Rehmanniae Radix生地黃, Daphnis genkwa Flos莞花, Evodiae Fructus吳茱萸, Euphorbiae kansui Radix甘遂(3) 2) Herbs specifically frequently used in the prescriptions of colporrhea were as follows. Atractylodis Rhizoma蒼朮, Ailanthi Cortex樗根白皮, Phellodendri Cortex黃柏, Cyperi Rhizoma香附子, Bupleuri Radix柴胡, Gardeniae Fructus梔子　3)Herbs frequently used were classified by herbal medicine's classification. The　result was as follows. (()-The number of herbs)　補益藥（1９). 淸熱藥(18). 解表藥(10), 收澁藥(9), 溫裏藥(7), 理氣藥(6), 利水?濕藥(6), 瀉下藥（５)

• The Korea Journal of Herbology
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• v.29 no.3
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• pp.71-78
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• 2014

Objectives : This study evaluates the neuroprotective effects of Sopung-tang, a mixture of Notopterygii Rhizoma, Saposhnikoviae Radix, Angelicae Gigantis Radix, Cnidii Rhizoma, Hoelen, Aurantii Nobilis Pericarpium, Pinelliae Tuber, Linderae Radix, Angelicae Dahuricae Radix, Cyperi Rhizoma, Cinnamomi Ramulus, Asari Radix, Glycyrrhizae Radix on the cerebral infarct combined with hyperlipidemia. Method : The hyperlipidemia was induced by the beef tallow 30% diet for 14 days on Sprague-Dawley rats. The cerebral infarct was induced by the middle cerebral artery occlusion (MCAO) for 2 hours with intraluminal thread method. Then the water extract of Sopung-tang was administered a day for 5 days at 3 hours after the cerebral infarct by MCAO. Effect of Sopung-tang was evaluated with the infarct volume and edema percentage by a TTC-stained brain section, and the expressions of Bax and Bcl-2 in the brain tissue by a immunohistochemical stain method. Results : Sopung-tang reduced the infarct size partly in a TTC-stained brain section of the hyperlipidemic MCAO rats. Sopung-tang reduced the infarct volume of the hyperlipidemic MCAO rats significantly. Sopung-tang reduced the edema percentage of the hyperlipidemic MCAO rats, but not significant statistically. Sopung-tang suppressed the Bax expressions in the cerebral penumbra and caudate putamen of the hyperlipidemic MCAO rats significantly. Sopung-tang upregulated the Bcl-2 expression in the caudate putamen of the hyperlipidemic MCAO rats. Conclusion : These results suggest that Sopung-tang plays an anti-apoptotic neuroprotective effect through the suppression of Bax and up-regulation of Bacl-2 expressions in the brain tissues.

• The Korea Journal of Herbology
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• v.37 no.6
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• pp.29-36
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• 2022

Objectives : The objective of this study was to investigate the possibility for the treatment of hypertension of herbal medicines belong to Umbelliferae family. Methods : Domestic and international articles about Herbology were investigated. A review was performed via the database (DB) search engines such as Pubmed, Korean studies Information Service System (KISS), KoreaScience, and Google Scholar. Hypertension-related terms including "vasorelaxation", "vasorelaxant", "vasodilation", "vasodilatory", "vasodilative", "hypotension", and "hypotensive" were performed as search terms. Results : A list was made about herbal medicines and origin plants belonging to the Umbelliferae family in Korean Pharmacopoeia 12 and Korean Herbal Pharmacopoeia. 14 herbal medicine and 22 origin plants were searched. Ostericum koreanum root and rhizome, Notopterygium incisum root and rhizome, N. forbesii root and rhizome, Ligusticum tenuissimum root and rhizome, L. jeholense root and rhizome, Angelica gigas root, A. dahurica root, A. dahurica var. formosana root, Bupleurum falcatum root, Peucedanum japonicum root, P. praeruptorum root, A. decursiva root, Cnidium officinale rhizome, L. chuanxiong rhizome, Foeniculum vulgare fruit, and Ferula assa-foetida resin and stem showed significant vasorelaxant or hypotensive effects. Conclusion : These review results showed that Osterici seu Notopterygii Radix et Rhizoma, Ligustici Tenuissimi Rhizoma et Radix, Angelicae Gigantis Radix, Angelicae Dahuricae Radix, Bupleuri Radix, Peucedani Japonici Radix, Peucedani Radix, Cnidii Rhizoma, Foeniculi Fructus, and Ferulae Resina had vasorelaxant or hypotensive effects. The results are expected as basic data in clinical trials and experimental researches for the treatment of hypertension of herbal medicines.