• Journal of Korean Medical classics
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• v.27 no.2
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• pp.25-48
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• 2014

Objectives : This study aims to analyze the terms describing anti-aging effects in Dongeuibogam, and to propose the methodology for selecting medicinal herbs related to anti-aging effects. Methods : We considered aging or anti-aging theories by reviewing the major literature in korean medicine or traditional chinese medicine, and then we deduced the concepts describing anti-aging effects and the medicinal herbs for anti-aging effects. We investigated the medicinal herbs based on the terms describing anti-aging effects in Dongeuibogam and drew the methodology for selecting and classifying the medicinal herbs related to anti-aging. Results & Conclusions : The following conclusions could be drawn. 1. A set of causes and signs of aging in Dongeuibogam and a set of therapies for alleviating the aging signs in Chengumikbang, Yanglobongchinseo, and Nolohangeon was found. 2. Anti-aging effects should not be confused with disease treatments. Therefore, we defined the medical terms of anti-aging effects as "the terms expressing the effect of delaying or alleviating the subjective or objective signs of aging concretely". Based upon the terms of anti-aging effects, we defined the medicinal herbs for anti-aging effects as "the medicinal herbs whose effects are described in medical terms expressing the effects of delaying or alleviating the subjective or objective signs of aging concretely". 3. We considered Lycii Fructus, Asparagi Tuber in Dongeuibogam as examples of medicinal herbs whose effects are described in medical terms expressing anti-aging effects. It shows that we can select medicinal herbs for anti-aging effects by comparing the effects of 937 single therapies in Dongeuibogam to the terms describing anti-aging effects defined in this study. Futhermore, the results could be utilized as the basic materials of experimental study on anti-aging.

• BMB Reports
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• v.56 no.10
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• pp.537-544
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• 2023

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DR-induced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human.

• Journal of Korean Medical classics
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• v.28 no.2
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• pp.47-60
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• 2015

Objectives : To investigate the anti-aging effects of Joobang(酒方) on Dongeuibogam Methods : We analyzed the effect of 27 Joobang(酒方)s on Dongeuibogam and finally extracted 11 Joobang(酒方)s, which have anti-aging effects. Results & Conclusions : 1. We finally selected 12 terms of Joobang(酒方)'s anti-aging effect on Dongeuibogam. 2. We finally selected 11 Joobang(酒方)s as anti-aging candidates. 3. Twelve terms of Joobang(酒方)'s anti-aging effect and 11 candidates with anti-aging effects were classified into five categories. 4. We finally selected 17 medicinal herbs from the 11 candidates. 5. Eleven candidate anti-aging Joobang(酒方)s and 17 medicinal herbs proposed in this study have the potential to reduce the time required for experimental and clinical research for developing novel compounds with anti-aging effects.

• KIEE International Transactions on Power Engineering
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• v.5A no.4
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• pp.322-330
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• 2005

This paper proposes methods to incorporate station related aging failures in composite system reliability assessment. Aging failures of station components, such as circuit breakers and bus bars, are a major concern in composite power system planning and operation as an increasing number of station components approach the wear-out phase. This paper presents probabilistic models for circuit breakers involving aging failures and relevant evaluation techniques to examine the effects of station related aging outages. The technique developed to incorporate station related aging failures are illustrated by application to a small composite test system. The paper illustrates the effects of circuit breaker aging outages on bulk system reliability evaluation and examines the relative effects of variations in component age. System sensitivity analysis is illustrated by varying selected component parameters. The results show the implications of including component aging failure considerations in the overall analysis of a composite system.

• IEMEK Journal of Embedded Systems and Applications
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• v.13 no.3
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• pp.143-149
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• 2018

It has become ever harder to design reliable circuits with each nanometer technology node; under normal operation conditions, a transistor device can be affected by various aging effects resulting in performance degradation and eventually design failure. The reliability (aging) effect has traditionally been the area of process engineers. However, in the future, even the smallest of variations can slow down a transistor's switching speed, and an aging device may not perform adequately at a very low voltage. Therefore, circuit designers need to consider these reliability effects in the early stages of design to make sure there are enough margins for circuits to function correctly over their entire lifetime. However, such an approach excessively increases the size and power dissipation of a system. As the impact of reliability, new techniques in designing aging-resilient circuits are necessary to reduce the impact of the aging stresses on performance, power, and yield or to predict the failure of a system. Therefore, in this paper, a novel low power on-chip self-tuning circuit considering the aging effects has been proposed.

• Journal of Communications and Networks
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• v.15 no.4
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• pp.338-351
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• 2013

Multiple-input multiple-output (MIMO) communication may provide high spectral efficiency through the deployment of a very large number of antenna elements at the base stations. The gains from massive MIMO communication come from the use of multi-user MIMO on the uplink and downlink, but with a large excess of antennas at the base station compared to the number of served users. Initial work on massive MIMO did not fully address several practical issues associated with its deployment. This paper considers the impact of channel aging on the performance of massive MIMO systems. The effects of channel variation are characterized as a function of different system parameters assuming a simple model for the channel time variations at the transmitter. Channel prediction is proposed to overcome channel aging effects. The analytical results on aging show how capacity is lost due to time variation in the channel. Numerical results in a multicell network show that massive MIMO works even with some channel variation and that channel prediction could partially overcome channel aging effects.

• Animal cells and systems
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• v.4 no.3
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• pp.231-237
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• 2000

The effects of microgravity and hypergravity on aging are still poorly documented, particularly in mammals. However, there is a growing interest for the use of the fruit fly, Drosophila melanogaster, and this species may be now considered as a model organism in gravitational biology studies dealing with aging.

• BMB Reports
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• v.49 no.2
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• pp.81-92
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• 2016

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.10a
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• pp.854-859
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• 2008

This study describes the aging behavior of soils and its mechanism, which have been reported in the literatures mainly by Mitchell(1986) and Schmertmann(1991). It could be known that aging of soils has both positive and negative effects on mechanical properties of soils. In order to show aging effects on dam behavior, a parametric study was carried out based considering the presence of a weak area within clay core zone of the fill dam. From the comparison of results obtained from numerical analysis and filed investigation, age-softening phenomena occurred within core zone during about 30 years after its completion.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.5 no.2
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• pp.13-19
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• 2009

As the operating time in nuclear power plants (NPPs) increases, the integrity of nuclear components may be continually degraded due to aging effects of systems, structures and components. Recently, a number of NPPs are being operated beyond their design life to produce more electricity without shutting down. The critical issue in extending a lifetime is to maintain the level of safety during the extended operation period while satisfying the international regulatory standards. Therefore, it is beneficial to build a monitoring system to measure an aging status. In this paper, the Aging Monitor (AM) based on lots of aging database obtained from the operating plants and research results on the aging effects was developed to monitor, manage and evaluate the aging phenomena systematically and effectively in NPPs. The AM for the CANDU is divided into 6 modules: (1) Aging Alarm/Coloring Monitor, (2) Aging Database, (3) Aging Document, (4) Real-time Integrity Monitor, (5) Surveillance and Inspection Management System, and (6) Continued Operation and Periodic Safety Review (PSR) Safety Evaluation. The proposed system is expected to provide the integrity assessment for the major mechanical components of an NPP under concurrent working environments.