• Biomolecules & Therapeutics
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• v.24 no.4
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• pp.410-417
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• 2016

Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside (Rutin), and quercetin-3-(2(G)-rhamnosylrutinoside (Rham2) are mono-, di-, and tri-glycosylated forms of quercetin, respectively. In a previous study, we showed that quercetin can enhance ${\alpha}7$ nicotinic acetylcholine receptor (${\alpha}7$ nAChR)-mediated ion currents. However, the role of the carbohydrates attached to quercetin in the regulation of ${\alpha}7$ nAChR channel activity has not been determined. In the present study, we investigated the effects of quercetin glycosides on the acetylcholine induced peak inward current ($I_{ACh}$) in Xenopus oocytes expressing the ${\alpha}7$ nAChR. $I_{ACh}$ was measured with a two-electrode voltage clamp technique. In oocytes injected with ${\alpha}7$ nAChR copy RNA, quercetin enhanced $I_{ACh}$, whereas quercetin glycosides inhibited $I_{ACh}$. Quercetin glycosides mediated an inhibition of $I_{ACh}$, which increased when they were pre-applied and the inhibitory effects were concentration dependent. The order of $I_{ACh}$ inhibition by quercetin glycosides was Rutin${\geq}$Rham1>Rham2. Quercetin glycosides-mediated $I_{ACh}$ enhancement was not affected by ACh concentration and appeared voltage-independent. Furthermore, quercetin-mediated $I_{ACh}$ inhibition can be attenuated when quercetin is co-applied with Rham1 and Rutin, indicating that quercetin glycosides could interfere with quercetin-mediated ${\alpha}7$ nAChR regulation and that the number of carbohydrates in the quercetin glycoside plays a key role in the interruption of quercetin action. These results show that quercetin and quercetin glycosides regulate the ${\alpha}7$ nAChR in a differential manner.

• Journal of Korea Technology Innovation Society
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• v.13 no.3
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• pp.538-557
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• 2010

Korean Government has supplied small-medium enterprises with various technology financing programs such as R&D grant." loans, equities, guarantees since 1980's. The purpose of this study is to render policy suggestions for policy makers by analysing problems with regard to regulations. The suggestions of this study are such as the following. First, the current three months of the fund formation period should be extended within six months for general partners to have enough time to raise funds in the current tough capital market situation. Second, the government's non priority loss devotion system should keep going to prevent general partner's moral hazard. Third, in order to fulfill the policy purpose that is to create globally well-known companies, the government investment ratio should scale up from the current 20% to 30% of the total fund size in that the stable capital supply for core technology commercialization, industrialization and globalization of companies is achieved. Finally, general partners of the New Growth Engine Fund should showoff their investment abilities to the potential investors such as institutional investors by accumulating all track records and know-hows that prove their specialities and implementing action plans to achieve the best result of their investment. This study provides general considerations of the selection procedure, the government investment ratio, the government priority loss devotion system and so on when formating the public funds.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.5 no.2
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• pp.61-72
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• 2007

INTRODUCTION: Local heat and cold application has been frequently used as means of muscle relaxation and blood circulation or reinforcing muscle strength, relaxing muscle tension in clinical situation. In particular, it has been known that long-term heat and cold application for relaxing muscle tension inhibits muscle spasticity or tension. But, it has been rarely reported that what influences of heat and cold application on activation of muscle action potential. Therefore, this study aims to analyze surface temperature and electromyography activities according to the heat and cold application. METHODE: Subjects of this research were 10 normal men and women (5 men, 5 women). Hot pack and cold pack was applied to vastus medialis muscle of thigh and rectus femoris muscle for 20 min. Surface temperature of vastus medialis muscle and rectus femoris muscle was measured, knee joint of subjects was in $45^{\circ}$ flexion, sitting on a chair, maximal isometric contraction was induced, surface electromyography (sEMG) signals were collected and root mean square (RMS) and median frequency (MOF) were analyzed. All measurements were conducted before and immediately after experiment, 10 min., 20 min. and 30 min. after experiment. Data were analyzed with SPSS 12.0 program, comparison of changes in superficial temperature and sEMG signals through repeated measurement was conducted with repeated measures ANOVA and significance level $\alpha$ was 0.05. RESULTS: Changes of surface temperature of vastus medialis muscle according to cold application were radically decreased immediately after application, but it was recovered after 30 min. of application and it showed significant difference (F4. 36=72.216, P<0.001). Surface temperature of rectus femoris also showed radical decrease immediately after application, but it was recovered after 30 min. of application and showed significant difference (F4. 36=88.930, P<0.001). Changes of surface temperature of vastus medialis muscle according to heat application were radically increased immediately after application, but it was recovered after 30 min. of application and it showed significant difference (F4. 36=27.267, P<0.001). Surface temperature of rectus femoris also showed radical decrease immediately after application, but it was recovered after 30 min. of application and showed significant difference (F4. 36=19.774, P<0.001). Changes of sEMG by heat and cold application were no statistical difference. Surface temperature of skeletal muscle after heat and cold application showed significant change for 30 min., but it was found that increase or decrease of surface temperature had not great influence on sEMG activities.

• Journal of the Korean Society for Railway
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• v.13 no.2
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• pp.236-243
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• 2010

We examine the change in healthcare utilization pattern of cancer patients since the launch of KTX in 2004. It is found that during the year of 2004 and 2005 the rapid increase in the ratio of cancer patients' healthcare utilizations for the tertiary hospitals in Seoul to the total healthcare utilizations has accompanied the rapid decrease in the corresponding ratio for the tertiary hospitals in the local metropolitan areas under the influence of KTX while the corresponding ratio for the tertiary hospitals in the local cities with little influence of KTX on them has exhibited mild change. Since healthcare consumers' choice of hospitals can be characterized by "foot voting" action in the healthcare service market in Korea, such a phenomenon may have strong implication that the introduction of KTX may have affected substantially the inter-area healthcare utilization pattern by cancer patients by reducing various sorts of long-distance travel costs. Therefore, considering the potential contribution of KTX to the increase of cancer patients' accessibility to hospitals with higher qualities, support policies such as fare discount for low-income cancer patients in local areas may need to be taken into consideration where the well-designed fare discount program for low-income cancer patients may increase utilizations of KTX by lowincome cancer patients without incurring additional costs to running of KTX.

• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.89-101
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• 2014

The 'Biomechanics', which was devised to systematically train actor's material and medium, is evaluated as the first approach to an acting method in earnest with Stanislavsky's 'System'. Especially, due to the psycho-physical features of 'Biomechanics' that helps an actor to master a mechanism of human being such as stimulus, impulse and reaction, it was valued as an alternative for a naturalistic acting method that was excessively focused on the actor's emotional expression. However, the 'Biomechanics' is not utilized with activity in a field of actor training in Korea compared with Stanislavsky's 'The Method of Physical Action' which has a similar starting point as the psycho-physical feature. It is because of a political reason that a study for Meyerhold was officially forbidden in Russia until the mid-twentieth century. It is also because of a limit that incorporeal features of the 'Biomechanics' could not but be explained only by publications, especially translation. In this sense, as part of seeking for a new alternative of acting methods in Korea, this study will explore a possibility of applying the 'Biomechanics' to the actual actor training field through correct understanding of it.

• Journal of Hospice and Palliative Care
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• v.4 no.2
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• pp.154-160
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• 2001

Purpose : This study, as the first year project of setting up a community based management system, was attempted for the cancer patients and their family to improve their quality of life; investigating and managing the cancer patients, educating volunteers and connecting the patients with the volunteers were performed. Method and result : The education of managing cancer patients for the volunteers was done once in lune for 2 days to the 80 volunteers. Questions about education effect, volunteer motivation and so on were made up. The survey showed, generally, education satisfaction level was high and a longer education and an intensive course were needed and was suggested that organizing a volunteer community be needed for the continuous further education and systematic management. As the result, after the public health center and volunteers deliberated, a volunteer community consisting of 4 teams, 28 members was organized, launched in Oct. and operated for the cancer patients and their family. For investigating and enrolling the patients, advertising on a local information paper, recommending of local doctors, publicizing by educating the heads of a subdivision of the city, the heads of a neighborhood association and the people in charge of the related local communities such as women's society, and surveying the community by volunteers were performed and the total, 41 patients were registered. Management of cancer patients was carried out by volunteers in a community and in a nursing school. A regional volunteers' community is composed of 23 members and they have worked 87 times, that is 3.8 times per capita on an average. The content of duties is attending the education (41.1%) the most. A volunteers' community of nursing students composed of 12 members have worked 135 times, that is 11.3 times per capita on an average. The content of duties - consulting with patients and home visiting (37.8 %) were the most and survey for investigating the cancer patients was the second. Conclusion : This study has the meaning that this is the guiding attempt in building a community based management system, and especially the achievement of this study is that a regional society organized a volunteer community for the cancer patients by itself and went into action for the cancer patients and their family. Furthermore, to activate this volunteering, it is necessary to keep managing volunteers and running continuing education or the intensive course of the volunteers. Indeed we should let the patients have good impression on this program through publicity and education for the residents to keep track of more cancer patients. For that, systematic and powerful cooperation of a self-administrative organization is required.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.556-563
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• 2017

The purpose of this study is to verify the difference of importance-performance about human right of social worker who works in housing facilities of the disabled. Based on our result, we suggest strategies to implement human rights for the disabled. We collected data from 344 social workers in Busan. We analyzed descriptive statistics, and employed T-Test and Importance-Performance Analysis. Results found the importance level was higher than the performance level of human rights for the disabled. Second, agreement of residential space open and vote right guarantees, the importance level was higher than performance level. Items, excluding ensuring religious activities, prohibiting corporal punishment, strengthening the facility monitoring system and improve facility environment and strengthen program, featured a higher performance level than the importance level. Third, based on the IPA analysis, we derived action strategies for each IPA analysis matrix. We examined 10 items, including free communication included in the first quadrant, improvement of facilities management policy in the second quadrant, prohibition of corporal punishment and strengthening of facility monitoring system in the fourth quadrants.

• Journal of Korea Multimedia Society
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• v.16 no.6
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• pp.678-688
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• 2013

Different Different from a single attack, in DDoS Attacks, the botnets that are distributed on network initiate attacks against the target server simultaneously. In such cases, it is difficult to take an action while denying the access of packets that are regarded as DDoS since normal user's convenience should also be considered at the target server. Taking these considerations into account, the DDoS botnet detection system that can reduce the strain on the target server by detecting DDoS attacks on each user network basis, and then lets the network administrator to take actions that reduce overall scale of botnets, has been implemented in this study. The DDoS botnet detection system proposed by this study implemented the program which detects attacks based on the database composed of faults and abnormalities collected through analyzation of hourly attack traffics. The presence of attack was then determined using the threshold of current traffic calculated with the standard deviation and the mean number of packets. By converting botnet-based detection method centering around the servers that become the targets of attacks to the network based detection, it was possible to contemplate aggressive defense concept against DDoS attacks. With such measure, the network administrator can cut large scale traffics of which could be referred as the differences between DDoS and DoS attacks, in advance mitigating the scale of botnets. Furthermore, we expect to have an effect that can considerably reduce the strain imposed on the target servers and the network loads of routers in WAN communications if the traffic attacks can be blocked beforehand in the network communications under the router equipment level.

• Korean Journal of Adult Nursing
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• v.12 no.1
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• pp.40-51
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• 2000

Purpose : This study was carried out to identify the factor of decisional balance for exercise. This was composed of a set of variables at the level of decision making when the elderly decide to do exercise. It was used to classify and identify the characteristics of the stages of change for exercise to which the elderly belong, and was used to identify the variables of decisional balance which influence the stage of change for exercise in the elderly. Methods : Convenient samples of 198 subjects over age 60 in Seoul( mean age=70) were selected from community living, mentally competant older adults and the data was collected from April 1, 1999 to May 31, 1999. The research instrument was the Decisional Balance Measure for Exercise(Marcus & Owen., 1992), Stage of Change Measure(Marcus et al,1992). The data was analyzed by SAS Program. Results: 1. According to stage of change measure, without missing data,191 subjects were distributed in each stage of change for exercise : 50 subjects(26.1%), 7 subjects (3.6%), 52 subjects(27.2%), 4 subjects(2%), and 78(40.8%) belonged to the precontemplation stage, contemplation stage, preparation stage, action stage and maintenace stage. 2. Factor analysis identified 3 factors of decisional balance as appropriate factors for exercise of the elderly and named by researchers; 1)'Perceived Physical-psychological benefit', 2)'Perceived Physical-psychological burden', and 3)'Perceived time burden'. 3. The analysis of variance showed that the two components Perceived Physical - psychological benefit(F=45.95, P=.0001), and Perceived Physical-psychological burden (F=26.52, P=.0001) were significantly associated with stage of change. 4. Through the discriminant analysis, it was found that both 'Self Perceived Physical - Psychological benefit' and 'Perceived Physical-Psychological burden' were the influential variables in discriminating the three stages of change(pre-contemplation, preparation, and maintenance). Conclusion : Results are consistent with the application of the Transtheoretical model, which has been used to understand how people change health behaviors. Even though this study is a cross-sectional, not a longitudinal study, the findings of this study give useful information for exercise intervention about especially the factors relating to decision making for exercise of the elderly in the different stages of change of exercise.

• The Journal of the Korea Contents Association
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• v.16 no.9
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• pp.297-307
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• 2016

This study aims to carry out empirical analysis on the effect of care workers' awareness of professionalism on the service quality, and to provide policy level and action oriented recommendations for the improvement of care workers' awareness of professionalism and service quality based on the key findings. The study targeted care workers who work at the senior citizen care take centers at the S and Y cities in the Jeollanam-do Province, carrying out survey research. A total of 190 questionnaires among the collected questionnaires were used for the analysis. Key research methods included factor analysis, reliability analysis, descriptive statistic analysis, correlation analysis, t/F-verification and regression analysis. The following are the results. First, conviction of the care workers' awareness of professionalism towards public service and the empathy of service quality were manifested at the highest level. Second, there was a difference in the service quality according to the care workers' experience. Third, care workers' awareness of professionalism affected service quality while service quality increased as the awareness of professionalism increased. The research results were utilized to recommend the need to develop and to disseminate structured education program for the care workers, to set the guideline for the care workers' employment form and salary, and to develop structure for the care workers' ethics.