• 제목/요약/키워드: ADAM 10

Search Result 249, Processing Time 0.033 seconds

Intracranial stenting compared to medical treatment alone for intracranial atherosclerosis patients: An updated meta-analysis

  • Adam A. Dmytriw;Jerry Ku;Ahmed Y. Azzam;Osman Elamin;Nicole Cancelliere;Anish Kapadia;James D. Rabinov;Christopher J. Stapleton;Robert W. Regenhardt;Vitor Mendes Pereira;Aman B. Patel;Victor X.D. Yang
    • Journal of Cerebrovascular and Endovascular Neurosurgery
    • /
    • v.26 no.2
    • /
    • pp.152-162
    • /
    • 2024
  • Objective: Stroke is the second-leading cause of death globally. Intracranial atherosclerotic stenosis (ICAS) represents 10-15% of ischemic strokes in Western countries and up to 47% in Asian countries. Patients with ICAS have an especially high risk of stroke recurrence. The aim of this meta-analysis is to reassess recurrent stroke, transient ischemic attack (TIA), and other outcomes with stenting versus best medical management for symptomatic ICAS. Methods: The search protocol was developed a priori according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The OVID Medline, Embase, Web of Science, and Cochrane Library databases were searched from inception to August 14th, 2022. Results: This meta-analysis included four randomized controlled trials (RCTs), with a total number of 991 patients. The mean age of participants was 57 years. The total number of intracranial stenting patients was 495, and the number of medical treatment patients was 496. The included studies were published between 2011 and 2022. Two studies were conducted in the USA, and the other two in China. All included studies compared intracranial stenting to medical treatment for ICAS. Conclusions: In patients with ischemic stroke due to symptomatic severe intracranial atherosclerosis, the rate of 30-day ischemic stroke, 30-day intracerebral hemorrhage, one-year stroke in territory or mortality favored the medical treatment alone without intracranial stenting. The risk of same-territory stroke at last follow-up, disabling stroke at last follow-up, and mortality did not significantly favor either group. Intracranial stenting for atherosclerosis did not result in significant benefit over medical treatment.

Study on the Job Satisfaction of Customs Officials at Port Customs - Focus on Ocean Fisheries Officials at Port Customs - (항만세관 공무원의 직무만족도 향상방안 연구 -해양수산직렬 항만세관 공무원을 대상으로-)

  • Choi, Dong-Hoon;Park, Jin-Hee;Lee, Min-Gyu
    • Journal of Navigation and Port Research
    • /
    • v.39 no.3
    • /
    • pp.223-231
    • /
    • 2015
  • Korea port customs surveillance of administration is operated around the 24 hours without a break in accordance with the characteristic of trade, in this specific environment, Ocean fisheries officials are performing this important duty. This research investigated various factors which might influence Korea Customs Service civil servants who are engaged in port, based on advanced researches on job satisfaction and Herzberg's two factors(motive hygene factor), and analyzed the difference in job satisfaction in respect of job satisfaction composition according to Ocean fisheries officials at port customs sociodemographic characteristics through a survey. Also, the researcher comprehended the factors of job satisfaction which have the biggest influence on the whole job satisfaction. Based on the analysis result, The researcher expects that the results of this research can contribute to customs administration's inherent goal achievement by finding out customs civil servants' job satisfaction degradation factors, who are engaged in port surveillance of administration, and properly controlling them and improving organizational members' job satisfaction.

Dynamic Response Analysis for Upper Structure of 5MW Offshore Wind Turbine System based on Multi-Body Dynamics Simulation (다물체 동역학 시뮬레이션 기반 5MW급 해상풍력발전시스템의 상부구조물에 대한 동적 응답 해석)

  • Lee, Kangsu;Im, Jongsoon;Lee, Jangyong;Song, Chang Yong
    • Journal of the Korean Society for Marine Environment & Energy
    • /
    • v.16 no.4
    • /
    • pp.239-247
    • /
    • 2013
  • Recently renewable energy such as offshore wind energy takes a higher interest due to the depletion of fossil fuel and the environmental pollution. This paper deals with multi-body dynamics (MBD) analysis technique for offshore wind turbine system considering aerodynamic loads and Thevenin equation used for determination of electric generator torque. Dynamic responses of 5MW offshore wind turbine system are evaluated via the MBD analysis, and the system is the horizontal axis wind turbine (HAWT) which generates electricity from the three blades horizontally installed at upwind direction. The aerodynamic loads acting on the blades are computed by AeroDyn code, which is capable of accommodating a generalized dynamic wake using blade element momentum (BEM) theory. In order that the characteristics of dynamic loads and torques on the main joint parts of offshore wind turbine system are simulated similarly such an actual system, flexible body modeling including the actual structural properties are applied for both blade and tower in the multi-body dynamics model.

Supplementing Maize or Soybean Hulls to Cattle Fed Rice Straw:Intake, Apparent Digestion, In situ Disappearance and Ruminal Dynamics

  • Von, Nguyen Tien;St. Louis, David G.;Orr, Adam I.;Rude, Brian J.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.21 no.6
    • /
    • pp.807-817
    • /
    • 2008
  • Steers with ad libitum access to rice straw were assigned to four diets to evaluate the effects of maize or soybean hull supplementation on intake, in vivo digestibility, ruminal pH, VFA, ammonia-nitrogen ($NH_3-N$) and in situ ruminal disappearance of feed nutrients by cattle consuming rice straw. Supplement treatments were: no supplement (RS); soybean meal at 0.127% BW (SBM); cracked maize at 0.415% BW plus 0.044% BW soybean meal (MAIZE); or soybean hulls at 0.415% BW plus 0.044% BW soybean meal (HULLS). The MAIZE and HULLS diets were formulated to provide approximately 4 MJ of $NE_m$ per kg of diet. Rice straw DMI was not affected (p = 0.34) by supplement. Apparent dry matter (DM) digestibility was greater (p<0.001) for MAIZE and HULLS (56.6 and 60.0%, respectively) than for steers consuming SBM or RS (51.8 and 44.4%, respectively). Apparent NDF digestibility was greater (p<0.0004) for HULLS than MAIZE (61.7 vs. 58.0%, respectively) and apparent ADF digestibility was greater (p<0.0008) for HULLS than MAIZE (61.1 vs. 49.2%, respectively). There was no difference in apparent hemicellulose digestibility (p = 0.43). Analysis of ruminal fluid collected 0, 2, 4, 6, and 8 h post-feeding revealed ammonia-nitrogen was greatest (p<0.05) for steers on SBM and HULLS diets at 2 h (24.08 and 22.57 mg/dl, respectively) and total volatile fatty acids was greatest (p<0.05) for HULLS at 4 h (230 mM/L). In situ disappearance, measured at 0, 2, 4, 6, 8, 16 and 24 h, indicated that SBM, MAIZE and HULLS tended to enhance the digestibility of DM and fiber components of rice straw. In situ disappearance of rice straw DM was greatest for SBM and/or HULLS from 4 to 24 h (p = 0.03). Rice straw NDF and ADF disappearance was enhanced by supplementation from 16 to 24 h (p<0.02). Rice straw DM, NDF and ADF disappearances at 24 h were similar for MAIZE and HULLS treatments. When feeding cattle rice straw diets, energy and protein-based supplements are essential. This study showed that fiber-based supplements are just as, if not more, effective as starch-based supplements in rice straw utilization. This study shows that soybean hulls, in spite of their high fiber content, are as efficient as maize for supplementing rice straw primarily because fiber in soybean hulls is highly digestible as shown by in vivo digestibility and in situ disappearance.

Comparative analysis on genome-wide DNA methylation in longissimus dorsi muscle between Small Tailed Han and Dorper×Small Tailed Han crossbred sheep

  • Cao, Yang;Jin, Hai-Guo;Ma, Hui-Hai;Zhao, Zhi-Hui
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.30 no.11
    • /
    • pp.1529-1539
    • /
    • 2017
  • Objective: The objective of this study was to compare the DNA methylation profile in the longissimus dorsi muscle between Small Tailed Han and Dorper${\times}$Small Tailed Han crossbred sheep which were known to exhibit significant difference in meat-production. Methods: Six samples (three in each group) were subjected to the methylated DNA immunoprecipitation sequencing (MeDIP-seq) and subsequent bioinformatics analyses to detect differentially methylated regions (DMRs) between the two groups. Results: 23.08 Gb clean data from six samples were generated and 808 DMRs were identified in gene body or their neighboring up/downstream regions. Compared with Small Tailed Han sheep, we observed a tendency toward a global loss of DNA methylation in these DMRs in the crossbred group. Gene ontology enrichment analysis found several gene sets which were hypomethylated in gene-body region, including nucleoside binding, motor activity, phospholipid binding and cell junction. Numerous genes were found to be differentially methylated between the two groups with several genes significantly differentially methylated, including transforming growth factor beta 3 (TGFB3), acyl-CoA synthetase long chain family member 1 (ACSL1), ryanodine receptor 1 (RYR1), acyl-CoA oxidase 2 (ACOX2), peroxisome proliferator activated receptor-gamma2 (PPARG2), netrin 1 (NTN1), ras and rab interactor 2 (RIN2), microtubule associated protein RP/EB family member 1 (MAPRE1), ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), myomesin 1 (MYOM1), zinc finger, DHHC type containing 13 (ZDHHC13), and SH3 and PX domains 2B (SH3PXD2B). The real-time quantitative polymerase chain reaction validation showed that the 12 genes are differentially expressed between the two groups. Conclusion: In the current study, a tendency to a global loss of DNA methylation in these DMRs in the crossbred group was found. Twelve genes, TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B, were found to be differentially methylated between the two groups by gene ontology enrichment analysis. There are differences in the expression of 12 genes, of which ACSL1, RIN2, and ADAMTS2 have a negative correlation with methylation levels and the data suggest that DNA methylation levels in DMRs of the 3 genes may have an influence on the expression. These results will serve as a valuable resource for DNA methylation investigations on screening candidate genes which might be related to meat production in sheep.

Marine Algae and Early Explorations in the Upper North Pacific and Bering Sea

  • wynne, Michael J.
    • ALGAE
    • /
    • v.24 no.1
    • /
    • pp.1-29
    • /
    • 2009
  • A synthesis of early exploration and the discovery of marine algae in the upper North Pacific and Bering Sea is presented covering the period from the late 1730s to around 1900. Information is provided about these early efforts to gather natural objects, including seaweeds, and names of these algae are enumerated. The first collections of marine algae in this broad region were those made by steller and Kracheninnkov from the Kamchatka Peninsula,Russia,during the Second Kamchatkan Expedition (1735-1742) and were described by Gmelin (1768). The first known algal collections in Alaska were those made byMerck in his 1790-1791 visits to Unalaska Island during the Billings expedition (1785-1794). British-sponsored expeditions for commercial purposes and for exploration and dis-covery allowed surgeon-naturallist Archibald Menzies to garher seaweeds that Dawson Turner and others worked up back in Europe. Several of the Russian Expeditions during the first half of the 18'!' century had naturalists aboard. the first Russian circumnavigation of the globe (1803-1806), with the ships 'Nadeshda' and 'Neva,' under the com-mand of Capt. Adam von Krusenstern had naturalists Langsdorff, Tilesius, and Horner, all of whom collected sea-weeds. The naturalist Adelbert Chanmisso accompanied the Romanzof Expedition (1815-1818) on the Russian vessel 'Rurik' under the command of Otto von Kotzebue and made collections of algae in the Aleutians as well as in the Kurils and Kamchatka. The Lutke expedition of 1826-1829 consisted of thw ships. Feodor Lutke was in command of the 'Seniavin' with K.H. Mertens aboard as physician-naturalist, and the 'Moller' was under the command of staniukovich accompanied by the naturalist G. Kastalsky. The first American-sponsored scientific expedition (1838-1842) was that commanded by Charles Wilkes, and the algae that were collected were worked up by J.W. Bailey and W.H. Harvey. The Russian naturalist Ilya Voznesenskii spent the period 1839-1849 in Russian Americ (Alaska and northern California) energetically traveling and making numerous collections of natural objects as well as ethno-graphic artefact. His algae were described by F.j. Ruprecht back in St. petersbung. The Swedish scientific vessel, the'Vega' (1878-1880), was under the command of Nordenskiold. The naturalist F.R. Kjellman made algal collections from Port Clarence, Alaska, as well as from bering Island and St. Lawrence Island in the Bering sea. The Harriman Alaskan Expedition in the summer of 1899, with the ship 'George W. Elder,' was sponsored by railroad magnate E.H. Harriman of New York City and had several scientific personnel aborad, including the phycologist De Alton Saunders. Algae were collected in Alaska and Washington. During the same summer of 1899 a scientific expedition organized by the University of California and including W.L. Jepson, L.E. Hunt, A.A Lawson, and W.A. Setchell as participants also visited Alaska and made collections of alage from various locations.

Path Tracking Control of 6X6 Skid Steering Unmanned Ground Vehicle for Real Time Traversability (실시간 주행 안정성 분석을 위한 6X6 스키드 조향 무인 자율 주행 차량의 경로 추종 제어)

  • Hong, Hyosung;Han, Jong-Boo;Song, Hajun;Jung, Samuel;Kim, Sung-Soo;Yoo, Wan Suk;Won, Mooncheol;Joo, Sanghyun
    • Transactions of the Korean Society of Mechanical Engineers A
    • /
    • v.41 no.7
    • /
    • pp.599-605
    • /
    • 2017
  • For an unmanned vehicle to be driven on the off-road terrain, it is necessary to consider the vehicle's stability. This paper suggests a path tracking controller for simulation of real-time vehicle stability analysis. The path tracking controller uses the preview distance to track the given trajectory. The disturbance moment is estimated using the yaw moment observer, and this information is used for compensation in the yaw moment control. On a curved path, the vehicle's desired velocity is determined from the curvature of the path. Because the vehicle is equipped with six independent motor driven wheels, the driving torques are distributed on all the wheels. The effectiveness of the path tracking controller is verified using ADAMS/MATLAB co-simulation.

LIFE AND ASTRONOMICAL ACTIVITY OF LEE DEOK-SEONG AS AN ASTRONOMER IN THE LATE OF JOSEON DYNASTY (조선후기 천문학자 이덕성의 생애와 천문활동)

  • AHN, YOUNG SOOK;MIHN, BYEONG-HEE;SEO, YOON KYEONG;LEE, KI-WON
    • Publications of The Korean Astronomical Society
    • /
    • v.32 no.2
    • /
    • pp.367-380
    • /
    • 2017
  • The life and astronomical activity of Lee Deok-Seong (李德星, 1720-1794) was studied using various historical sources, including the astronomical almanac, Seungjeongwon-Ilgi (Daily records of Royal Secretariat of Joseon dynasty), and the Gwansang-Gam's logbooks during Joseon dynasty (A.D. 1392-1910). We present the results of the study including the following main findings. First, from the investigation of Lee's family tree, we find that a number of his relatives were also astronomers, notably Samryeok-Gwan (三曆官, the post of calendrical calculation). Second, we find that he took part in the compilation of an annual astronomical almanac over a period of at least 16 years. His major achievements in the astronomy of the Joseon dynasty were to establish a new method of calendar-making calculation and to bring astronomical materials to the Joseon court through a visit to China. The Joseon dynasty enforced the Shixianli (時憲曆, a Chinese calendar made by Adam Shall) in 1654 without fully understanding the calendar. So an astronomer and an envoy were dispatched to China in order to master the intricacies of the calendar and to learn as much of Western science as was available in that time and place. Lee Deok-Seong worked at the Gwansang-Gam (觀象監, Royal Astronomical Bureau) during the reigns of King Yeongjo (英祖) and Jeongjo (正祖). As best as we can ascertain in relation with the calculations in the Shixian calendar, Lee visited China four times. During his trips and interactions, he learned a new method for calendar-making calculations, and introduced many Western-Chinese astronomical books to Joseon academia. Lee greatly improved the accuracy of calendrical calculations, even while simplifying the calculation process. With these achievements, he finally was promoted to the title of Sungrok-Daebu (崇祿大夫), the third highest grade of royal official. In conclusion, history demonstrates that Lee Deok-Seong was one of the most outstanding astronomers in the late-Joseon dynasty.

Proposal for the Model of mobile RPG lobby layoutfrom Viewpoint of UX (UX관점에서의 모바일 RPG 로비 layout 모델 제시)

  • Kim, Seong-gon;Kim, Tae-Gyu
    • Journal of Digital Convergence
    • /
    • v.17 no.12
    • /
    • pp.467-472
    • /
    • 2019
  • Growing smartphone usage in South Korea has also accelerated the pace of development of mobile games, but competition is intensifying as the market grows. As one of the factors for the success of the game in this mobile game market, UI has been presented, suggesting that the design of such mobile game UI should be approached in terms of designing the user's experience, along with its function, aesthetic expression, function-oriented design and information delivery before. In this paper, we propose an effective lobby layout of mobile RPG using experience among UX factors. Through the layout classification of Ernest Adams and Andrew Rollings, we selected 9 mobile RPGs in the 20th place of google play cumulative sales rankings and analyzed the layout of the lobby. As a result, the lobby layout of the game, which led the first market success of the mobile RPG genre, The result was that it became the standard of the boxed game. It can be interpreted that the lobby layout, which is similar to the game used previously by the user, is effective because low entry barriers and learning are unnecessary due to the experience of using the existing RPG. Future studies may produce a common layout of a broad genre if studies are conducted to measure the optimum UX for other genres than RPG.

A Comparison of Incarnation Theology in Christianity and Daesoon Jinrihoe (基督宗教与大巡真理会的「道成肉身」思想之比较)

  • Gao, Mingwen
    • Journal of the Daesoon Academy of Sciences
    • /
    • v.34
    • /
    • pp.323-351
    • /
    • 2020
  • The purpose of this paper is to reveal how Christian ideas are indicative of Theocentricity (God-centeredness) whereas Daesoon Jinrihoe ideas are indicative of anthropocentrism (human-centeredness). This task will be accomplished through comparing incarnation theology from the Bible and The Canonical Scripture. Both Christianity and Daesoon Jinrihoe affirm that there is another world above the human world that cannot be touched by human sense organs. And they both acknowledge a supreme deity who exists in that above world. Furthermore, they share the notion that the supreme deity came into the human world after being born from a woman. Where they depart is that in Christianity, this belief refers to Jesus, the one who was born in Bethlehem more than 2,000 years ago, whereas in Daesoon Jinrihoe, it is instead believed to be Kang Jeungsan (secular name: Kang Il-Sun) who was born in Gaekmang Village in Korea more than 100 years ago. The Christian God came to the human world as an atonement for humanity and died on the cross; The God of Daesoon Jinrihoe came to the human world to help mankind settle all enmities. To this end, he traveled through the realms of Heaven, Earth, and Humanity, to recalibrate the faulty Degree Numbers. The sin mentioned in Christianity means treachery against the supreme deity. It is implied that sin is not tolerated in the world of God. Due to this, the first man, Adam, was driven out of Eden after betraying God, and afterwards, there came to be an infranchissable boundary between the world of God and the world of man. By way of comparison the faulty Degree Numbers, mentioned in Daesoon Jinrihoe, were produced naturally. In other words, the faulty Degree Number existed not only in the human world, but also in the world of divinities, and those two worlds not only interact but also affect each other. Therefore, it can be said that the two worlds of Christianity are worlds in which order and systems are completely different, and that the two worlds of Daesoon Jinrihoe are worlds that operate under the same order and systems. Both explain via this two-part division to emphasize one part as more important than the other. Christianity regards the world of God as the ultimate source and ultimate concern of the human world and emphasizes the absolute faith and worship of God is the highest value in life. But Daesoon Jinrihoe, on the other hand, argues that the human world determines the value of the divine world, and that the co-prosperity of man and his surroundings are the core values of the human era (The Era of Human Nobility). Therefore, the root cause of Christianity's theocentricity is that among the two worlds that are completely cut off from one another, they believe in God's world as the ultimate source and purpose of the human world. The root cause of Daesoon Jinrihoe's anthropocentrism is that among the two worlds that interact and influence each other, they believe the human world determines the meaning of the divine world.