• Asian-Australasian Journal of Animal Sciences
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• 제24권8호
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• pp.1148-1156
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• 2011

Compensatory growth of juvenile olive flounder Paralichthys olivaceus fed different diets with different feeding regime was compared. Four hundred fifty fish (twenty five fish per tank) were randomly distributed into 18 of 180 L flow-through tanks. Six treatments were prepared: fish were hand-fed with the control (C) diet to satiation twice a day, six days a week, for 8 weeks (C-8W treatment); and other groups of fish were starved for 2 weeks and then fed with the C, high protein (HP), high carbohydrate (HC), high lipid (HL), and combined protein, carbohydrate and lipid (CPCL) diets to satiation twice a day, six days a week, for 6 weeks, referred to as C-6W, HP-6W, HC-6W, HL-6W, and CPCL-6W treatments, respectively. Final body weight of fish in HP-6W treatment was higher than that of fish in C-6W, but not different from that of fish in C-8W, HC-6W, HL-6W and CPCL-6W treatments. Specific growth rate of fish in HP-6W treatment was higher than that of fish in all other treatments except for fish in CPCL-6W treatment. Feeding rate of fish in C-8W treatment was higher than that of fish in HP-6W, HC-6W, HL-6W and CPCL-6W treatments, but not different from that of fish in C-6W treatment. In addition, feeding rate of fish in C-6W treatment was higher than that of fish in HP-6W, HL-6W and CPCL-6W treatments. Feed and protein efficiency ratios of fish in HP-6W, HC-6W, HL-6W and CPCL-6W treatments were higher than those of fish in C-6W treatment. None of moisture, crude protein and ash content of the whole body of fish excluding the liver was different among treatments. Dietary supplementation of protein, carbohydrate, lipid and their combination could improve compensatory growth of fish when fish were fed for 6 weeks after 2-week feed deprivation; especially, supplementation of dietary protein was the most effective to improve compensatory growth of fish.

• 대한전자공학회논문지TC
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• 제45권12호
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• pp.120-127
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• 2008

HMIPv6는 효율적인 핸드오버를 제공하고 시그널링 오버헤드를 줄이기 위한 기술로 주목받고 있다. HMIPv6는 이러한 시그널링 오버헤드와 지역적 이동성 관리를 위해 MAP(Mobility Anchor Point)를 도입한다. MAP는 빈번한 핸드오버가 발생하는 HMIPv6 네트워크 환경에서 효율적인 이동성 관리를 이룬다. 그러나 HMIPv6는 특정한 MAP로의 부하집중과 같은 네트워크 안에 존재하는 MN(Mobile Node)와 CN(Correspondent Node)사이의 불필요한 지연을 발생시킨다. 또한 모든 패킷은 MAP를 경유하여 전송되기 때문에 MAP는 HMIPv6 네트워크에서의 경로 최적화를 방해한다. 본 논문은 HMIPv6 네트워크에서 MAP의 부하에 따라 경로를 최적화하는 방법을 제안한다. 제안하는 방법은 MAP 도메인 안에서 최적의 서비스를 제공하기 위한 임계값을 설정하고 MAP에 연결된 이동노드의 수가 임계값을 넘어서는 경우에 MAP를 거치지 않고 AR(Access Router)로 직접 전송하도록 한다. 이에 따라 제안하는 방법은 시그널링 비용을 줄일 뿐만 아니라 특정한 MAP의 부하집중을 완화시킨다.

• Molecules and Cells
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• 제44권2호
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• pp.88-100
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• 2021

Anoctamin 6/TMEM16F (ANO6) is a dual-function protein with Ca2+-activated ion channel and Ca2+-activated phospholipid scramblase activities, requiring a high intracellular Ca2+ concentration (e.g., half-maximal effective Ca2+ concentration [EC50] of [Ca2+]i > 10 μM), and strong and sustained depolarization above 0 mV. Structural comparison with Anoctamin 1/TMEM16A (ANO1), a canonical Ca2+-activated chloride channel exhibiting higher Ca2+ sensitivity (EC50 of 1 μM) than ANO6, suggested that a homologous Ca2+-transferring site in the N-terminal domain (Nt) might be responsible for the differential Ca2+ sensitivity and kinetics of activation between ANO6 and ANO1. To elucidate the role of the putative Ca2+-transferring reservoir in the Nt (Nt-CaRes), we constructed an ANO6-1-6 chimera in which Nt-CaRes was replaced with the corresponding domain of ANO1. ANO6-1-6 showed higher sensitivity to Ca2+ than ANO6. However, neither the speed of activation nor the voltage-dependence differed between ANO6 and ANO6-1-6. Molecular dynamics simulation revealed a reduced Ca2+ interaction with Nt-CaRes in ANO6 than ANO6-1-6. Moreover, mutations on potentially Ca2+-interacting acidic amino acids in ANO6 Nt-CaRes resulted in reduced Ca2+ sensitivity, implying direct interactions of Ca2+ with these residues. Based on these results, we cautiously suggest that the net charge of Nt-CaRes is responsible for the difference in Ca2+ sensitivity between ANO1 and ANO6.

• 한국응용과학기술학회지
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• 제37권4호
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• pp.682-687
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• 2020

Streptozotocin(STZ)을 45mg/kg.b.w의 용량으로 흰쥐의 미정맥에 투여 한 후 당뇨병이 유발된 당뇨 흰쥐에게 1일 1회 7일간 1,000mg/kg,b.w의 용량으로 황백에탄올 추출물을 투여 후 glucose 함량과 당대사에 관여하는 효소인 glucose-6-phosphatase(G-6-Pase), glucose-6-phosphate dehydrogenase(G-6-PDH, glucokinase(GK)활성과 glycogen 함량을 측정한 결과 황백 에탄올 추출물 투여군이 glucose 함량과 G-6-Pase 활성의 유의적인 감소를 나타내었으며 glycogen 함량과 G-6-PDH, GK의 활성은 유의적인 증가를 나타내었다. 이와 같이 황백 에탄올 추출물이 혈당강하 효과를 가졌다.

• 전자공학회논문지CI
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• 제44권5호
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• pp.20-27
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• 2007

본 논문에서는 RFID 시스템에 사용되는 무선 접속 프로토콜 중 UHF 대역 프로토콜인 ISO 18000-6의 Type A와 B 의 에어인터페이스를 분석하고, 프로토콜에서 규정된 충돌방지 알고리즘을 구현하였다. 또한 표준 프로토콜의 성능을 개선한 ISO 18000-6의 Type A와 B 충돌방지 알고리즘을 제안하고, 그 성능을 비교하였다. 개선된 알고리즘과 표준 알고리즘의 성능을 시뮬레이션을 통하여 비교한 결과, 개선된 ISO 18000-6 Type A 알고리즘의 총 인식시간 감소율은 태그 수가 100개 일 때 35.2%, 태그 수 1000개 일 때 24.3 % 감소하였다. 그리고 개선된 ISO 18000-6 Type B 알고리즘의 총 인식시간 감소율은 태그 수 100개 일 때 6.0 %, 태그 수 1000개 일 때 6.6 % 감소하였다. 따라서 본 논문에서 제안한 개선된 충돌방지 알고리즘은 RFID 시스템의 태그 인식성능을 개선하는 방안으로 적용될 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3961-3968
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• 2015

Background: Variants of human papillomavirus (HPV) show more oncogenicity than do prototypes. The HPV16 Asian variant (HPV16As) plays a major role in cervical cancer of Asian populations. Some amino acid changes in the E6 protein of HPV16 variants affect E6 functions such as p53 interaction and host immune surveillance. This study aimed to investigate activities of HPV16As E6 protein on modulation of expression of miRNA-21 as well as interferon regulatory factors (IRFs) 1, 3, 7 and c-fos. Materials and Methods: Vectors expressing E6 protein of HPV16As (E6D25E) or HPV16 prototype (E6Pro) were constructed and transfected into C33A cells. HCK1T cells expressing E6D25E or E6Pro were established by transducing retrovirus-containing E6D25E or 16E6Pro. The E6AP-binding activity of E6 and proliferation of the transfected C33A cells were determined. MiR-21 and mRNA of interesting genes were detected in the transfected C33A cells and/or the HCK1T cells, with or without treatment by culture medium from HeLa cells (HeLa-CM). Results: E6D25E showed binding activity with E6AP similar to that of E6Pro. Interestingly, E6D25E showed a higher activity of miR-21 induction than did E6Pro in C33A cells expressing E6 protein. This result was similar to the HCK1T cells expressing E6 protein, with HeLa-CM treatment. The miR-21 up-regulation significantly corresponded to its target expression. Different levels of expression of IRFs were also observed in the HCK1T cells expressing E6 protein. Interestingly, when treated with HeLa-CM, IRFs 1, 3 and 7 as well as c-fos were significantly suppressed in the HCK1T cells expressing E6D25E, whereas those in the HCK1T cells expressing E6Pro were induced. A similar situation was seen for IFN-${\alpha}$ and IFN-${\beta}$. Conclusions: E6D25E of the HPV16As variant differed from the E6 prototype in its activities on epigenetic modulation and immune surveillance and this might be a key factor for the important role of this variant in cervical cancer progression.

• Bulletin of the Korean Chemical Society
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• 제21권7호
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• pp.685-689
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• 2000

The complexation reaction between Pb2+,TI and Cd2+ions and macrocyclic ligands, 18-crown-6 ( 18C6) and dibenzo- 18-crown-6 (DB 18C6), was studied in dimethylsulfoxide (DMSO)-nitromethane (NM) and dimethyl-formamide (DMF)-nitromethane binary system s by square wave polarography (SWP) technique. The stoichiometry and stability of the complexes were determined by monitoring the shifts in half-waves or peak potentials of the polarographic waves of metal ions against the Iigand concentration. In most cases, the stability constants of complexes increase with increasing amounts of the nitromethane in mixed binary solvents used in this study. The complexes formed between 18C6 and DB18C6 and these metal cations in all cases had a stoichiometry of 1 : 1. The results obtained show that there is an inverse relationship between the formation constant of complexes and the donor number of solvents based on a Gatmann donocity scale and the stability constants show a high sensitivity to the composition of the mixed solvent systems. A linear behavior was observed for variation of log Kf of I8C6 complexes vs the composition of the mixed solvent systems in NM/DMSO and NM/DMF,but a non-linear behavior was observed in the case of DB 18C6 complexes in these binary systems. In most of the systems investigated, the Pb2+ cation forms a more stable complex with the 18C6 than other two cations and the order of selectivity of this Iigand for cations is: Pb2+ > TI+,Cd2+.

• 한국통신학회논문지
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• 제34권6B호
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• pp.615-622
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• 2009

본 논문에서는 PMIPv6(Proxy Mobile IPv6)망에서 네트워크 이동성을 지원하기 위하여 NEMO(NEtwor Mobility)가 PMIPv6 망에 접속하면 MR(Mobile Router)이 보내오는 BU(Binding Update)를 통하여 MAG(Mobile Access Gateway)가 이를 인지하고 MR과 터널을 형성할 수 있도록 알고리즘과 기존의 BCE(Binding Cache Entry)에 추가되는 데이터 필드를 제안하였다. 이를 이용하여 MR에 속해 있는 단말이 전송하는 패킷도 폐기 되지 않게 하였으며, 제안한 방식은 기존의 NEMO를 그대로 PMIPv6에 적용이 가능한 장점이 있다. 제안한 알고리즘을 통하여 PMIPv6 망에서도 네트워크 이동성을 지원할 수 있도록 하였으며, 알고리즘의 증명을 위해 실제 구현을 통하여 기존의 방식의 경우와 알고리즘의 적용과 데이터 필드의 추가로 실제 통신이 가능하다는 것을 증명하였다.

• 약학회지
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• 제38권5호
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• pp.544-554
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• 1994

Pyrrolidine-2,3-dione derivative A was synthesized from oxalylation of chiral enamine Ba. The stereostructure of its major diastereomer $(A_{maj})$ was determined as octahydro-2,3-dioxo-6aS-hyd roxy-1-(1S-methoxycarbonyl-2-phenylethyl)-cyclopenta[b]pyrrole-3aR-carboxylic acid ethyl ester Aa by means of NMR spectrum. This result implied that the asymmetric carbon-carbon bond forming reaction occurred preferentially at the ${\beta}-face$ of Ba.

• 대한전자공학회논문지SD
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• 제46권2호
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• pp.64-70
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• 2009

0.13-um CMOS 공정을 이용하여 3GHz에서 6.2dB의 gain을 갖는 피드포워드 이퀄라이저를 구현하고 14.7dB의 감쇄를 갖는 7-m SATA 케이블을 통해 6Gbps의 데이터를 에러 없이 복원하였다. 제안한 이퀄라이저 회로는 varactor의 차동 연결을 통해서 기존 이퀄라이저에서 사용되는 varactor 면적의 1/4만을 사용하도록 설계되어 pad-frame에 집적할 수 있을 뿐만 아니라, 높은 동작 주파수 및 3.6mW의 낮은 전력 소모를 유지할 수 있다.