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http://dx.doi.org/10.12925/jkocs.2020.37.4.682

Antidiabetic Effect of Ethanol Extract on Phelladindron amurense Rupr  

Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.4, 2020 , pp. 682-687 More about this Journal
Abstract
This study was performed to investigate the antidiabetic effect of ethanol extract of Phelladrindron Amurense Rupr (P.A) in Streptozotocin(STZ) induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45mg/kg,b.w. dissolved in citrate buffer. The ethanol extract of P. A was orally administrated once a day for 7 days at a dose of 1,000mg/kg. The content of serum glucose, was significantly decreased in P.A treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucokinase(GK) and glucose-6-phosphate dehydrogenase(G-6-PDH) were significantly increased(p<0.05), and activity of glucose-6-phoshatase(G-6-Pase) was significantly decreased(p<0.05) in P.A treated group compared to those of STZ-control group, These results indicated that ethanol extract of P.A have antidiabetic effect in STZ-induced diabetic rats.
Keywords
Phelladrindron Amurense Rupr(P.A); ethanol extract; streptozotocin; glucose-6-phoshatase(G-6-Pase); glucose-6-phosphate dehydrogenase(G-6-PDH); glucokinase(GK); antidiabetic effects;
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