• 한국통신학회논문지
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• 제32권3A호
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• pp.271-280
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• 2007

본 논문에서는 동일 채널 간섭이 존재하는 셀룰러 환경에서 OFDM 통신 시스템들이 각기 목표로 하는 전송속도를 달성하기 위한 송신 전력 조절 방안을 제시하였다. 일반적으로 다중 반송파 시스템에 대한 최적 또는 준 최적 송신 전력 할당 방안은 주파수 대역별로 채널 상태에 따라 송신 전력을 조절하는 형태인 것으로 알려져 있으며, 이는 WF(waterfilling)이나 IWF(iterative waterfilling) 형태로 발표된 바 있다. 하지만 반송파별로 송신 전력을 달리하는 방식을 구현하기 위해서는 각 대역별 채널 상태와 관련된 정보를 별도의 궤환 링크(feedback link)를 통해 수신기에서 송신기로 전송해야 한다. 만약 채널 상태가 빠르게 변하거나 반송파의 개수가 크다면 이로 인한 부담이 상당할 수가 있다. 이에 본 논문에서는 이런 부담을 줄이기 위한 방안으로 부반송파마다 동일한 송신 전력을 사용하는 방식에 대한 전력 조절 알고리듬을 제시한다. 그리고 제안한 알고리듬이 수렴한다는 것을 증명하고, 기존의 IWF 방식과 복잡도를 비교하며, 컴퓨터 실험을 통해 수렴 특성을 살펴보고자 한다.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2002년도 추계국제학술대회
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• pp.170-170
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• 2002

College of Pharmacy, Ewha womans University, Seoul, 120-750, Korea 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most potent halogenated aromatic hydrocarbon congener that induces expression of several genes including CYP1A1. Exposure to TCDD results in many toxic actions such as carcinogenesis, hepatotoxicity, immune suppression, and reproductive and developmental toxicity. Dramatic differences in dioxin toxicity have been observed between the sexes of some animal species, suggesting hormonal modulation of dioxin action. Many studies have been reported and propose several mechanisms of anti-estrogenic effects of TCDD. In contrast, the effect of estrogen on the regulation of CYP1A1 are not clear at present. There are several reports showing conflicting results. It seems that induction/inhibition of CYP1A1 may be dependent on cell-type and concentration. The purpose of this study was to investigate the regulation of TCDD-induced CYP1A1 gene expression by estradiol and its metabolites. We examined whether estradiol and its metabolites altered TCDD-mediated induction of CYP1A1 enzyme activity. 17 ${\beta}$ estradiol and 16 ${\alpha}$ estriol at non cytotoxic concentrations caused a significant concentration dependent decline of TCDD-induced EROD activity To determine whether reduced EROD activity reflected altered CYP1A1 mRNA expression, we measured CYP1A1 mRNA level by RT-PCR. And to examine whether estradiol and its metabolites have effects on TCDD-induced CYP1A1 gene expression at the transcription level, we also peformed transient transfection with an AhR responsive reporter plasmid containing the 5' flanking region of the human CYP1A1 gene to examine whether estradiol and its metabolites have effects on TCDD-induced CYP1A1 gene expression at the transcription level.

• 약학회지
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• 제56권1호
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• pp.9-13
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• 2012

We previously reported that the extract of Taraxacum platycarpum (AF-343) had several biological properties such as skin hydration and anti-inflammatory effects, thereby AF-343 be a promising anti-atopic dermatitis agent. However, few studies have been conducted to evaluate its effect on modulation of extracellular matrix proteins in human skin fibroblasts. The purpose of this study was to investigate the expressions of type I collagen, MMP-1, Smad2/3, and TIMP-1 proteins in AF-343-treated human skin fibroblasts. Human skin fibroblasts were treated by various concentrations of AF-343 (0~2 mg/ml). The expressions of type I collagen, matrix metalloproteinase-1 (MMP-1), Smad2/3, and TIMP-1 proteins were analyzed by Western blot analysis. In addition, level of type I collagen mRNA was analyzed by CAT assay. Expression of type I collagen protein was increased in AF-343-treated human skin fibroblasts by dose and time-dependent manners. Consistent with this result, the expressions of phospho-Smad2/3 in skin fibroblasts were increased and MMP-1 expression was decreased by AF-343 treatment. TIMP-1 expression was not significantly changed in AF-343 treated skin fibroblasts. Extract of Taraxacum platycarpum (AF-343)-induced up-regulation of type I collagen expression was through increased expression of phospho-Smad2/3. These results were occurred combined with down-regulation of MMP-1 in skin fibroblasts. Taken together, this study indicated that AF-343 has property of the modulation of ECM in tissue as well as skin hydration and anti-inflammation.

• Asian-Australasian Journal of Animal Sciences
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• 제24권7호
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• pp.1019-1025
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• 2011

Toll-like receptors (TLRs) play an important role in the recognition of invading pathogens and the modulation of innate immune responses in mammals. The TLR4 and TLR7 are well known to recognize the bacterial lipopolysaccharide (LPS) and single stranded (ssRNA) ligands, respectively and play important role in host defense against Gram-negative bacteria and ssRNA viruses. In the present study, coding exon fragments of these two TLRs were identified, cloned, sequenced and analyzed in terms of insertion-deletion polymorphism, within bovine TLRs 4 and 7, thereby facilitating future TLR signaling and association studies relevant to bovine innate immunity. Comparative sequence analysis of TLR 4 exons revealed that this gene is more variable, particularly the coding frame (E3P1), while other parts showed percent identity of 95.7% to 100% at nucleotide and amino acid level, respectivley with other Bos indicus and Bos taurus breeds from different parts of the world. In comparison to TLR4, sequence analysis of TLR7 showed more conservation among different B. indicus and B. taurus breeds, except single point mutation at 324 nucleotide position (AAA to AAM) altering a single amino acid at 108 position (K to X). Percent identity of TLR7 sequences (all 3 exons) was between 99.2% to 100% at nucleotide and amino acid level, when compared with available sequence database of B. indicus and B. taurus. Simple Modular Architecture Research Tool (SMART) analysis showed variations in the exon fragments located in the Leucine Rich Repeat (LRR) region, which is responsible for binding with the microbial associated molecular patterns and further, downstream signaling to initiate anti-microbial response. Considering importance of TLR polymorphism in terms of innate immunity, further research is warranted.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.993-1001
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• 2016

Type 2 diabetes mellitus patients are at increased risk of many forms of malignancies, especially of the pancreas, colon and hepatocellular cancer. Unfortunately, little is known of the possible interaction between antidiabetic drugs and anticancer agents. The present study investigates the influence of metformin (MET) and sitagliptin (SITA) on the in vitro anticancer activity of the microtubule depolymerization inhibitor agent epothilone A (EpoA). Hepatocellular liver carcinoma cell line (HepG2) viability and apoptosis were determined by the MTT test and by double staining with PO-PRO-1 and 7-aminoactinomycin D, respectively, after treatment with EpoA, metformin or sitagliptin. The levels of nuclear factor NF-${\kappa}B$ and p53 were evaluated in the presence and absence of inhibitors. While EpoA and MET inhibited HepG2 cell proliferation, SITA did not. EpoA and SITA induced higher p53 levels than MET. All tested drugs increased the level of NF-${\kappa}B$. Only MET enhanced the proapoptotic effect of EpoA. The EpoA+MET combination evoked the highest cytotoxic effect on HepG2 cells and led to apoptosis independent of p53, decreasing the level of NF-${\kappa}B$. These findings support the link between NF-${\kappa}B$ and p53 in the modulation of apoptotic effects in HepG2 cells treated by EpoA. Our studies indicate that the combination of EpoA and MET applied in subtoxic doses has a stronger cytotoxic effect on liver cancer cells than each of the compounds alone. The therapeutic advantages of the combination of EpoA with MET may be valuable in the treatment of patients with diabetes mellitus type 2 (T2DM) and liver cancer.

• 전력전자학회논문지
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• 제14권4호
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• pp.333-342
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• 2009

중성점 클램핑 방식(Neutral Point Clamped) 인버터로 알려져 있는 3레벨 NPC 인버터는 그 구조적 특성상 직류-링크(DC-link) 중성점(Neutral Point)에서 전압이 변동한다. 지금까지 많은 논문에서 이 문제에 대한 연구가 진행되었고 다양한 형태의 해결책들이 제시되었다. 그러나 인버터 내부에서 고장이 발생하여 그에 따른 고장허용제어가 NPC 인버터 시스템에 적용되었을 경우 중성점 전압변동은 정상 운전 시 나타나는 전압변동과 다르게 나타나기 때문에 고장허용 제어에 따른 중성점 전압변동에 대한 분석이 필요하다. 본 논문에서는 삼각파 비교 변조방법을 시스템에 적용하였을 경우 정상운전과 고장 발생 과 고장허용 제어 적용 시 직류-링크 중성점 전압 변동이 어떤 양상으로 나타나는지 분석하고 고장허용 제어에 의한 NPC 인버터의 고장검출 시간과 커패시터의 용량 사이의 관계를 고찰하였다. 시뮬레이션과 실험 결과를 이용하여 이론적 분석의 타당성을 검증하였다.

• 한국광학회지
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• 제34권4호
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• pp.151-156
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• 2023

파장당 200 Gb/s급 신호를 전송하는 고속 근거리 광통신 시스템을 비용 효율적으로 구축하기 위한 방안으로서 캐리어 억제 펄스 기반의 2채널 광학적 시분할 다중화 시스템을 제안한다. 캐리어 억제 펄스는 널 바이어스가 인가된 마하 젠더 변조기로 생성되며, 이는 시분할 다중화 신호를 색분산에 강인하게 만든다. 송신부에서는 캐리어 억제 펄스를 둘로 분기하고, 각각을 100 Gb/s의 4레벨 진폭 변조 신호로 변조한 후, 광학적 시분할 다중화를 통해 200 Gb/s의 신호를 생성한다. 다중화된 광 신호는 광섬유로 전송된 후, 반도체 광 증폭기로 증폭되며, 한 개의 광 검출기로 검출된다. 증폭기에 의해 발생한 잡음은 광학 필터로 제거된다. 시분할 다중화 과정에서 발생하는 누화는 다중 입력-다중 출력 이퀄라이저로 보상한다. 본 연구에서는 200 Gb/s의 고속 신호를 40 ps/nm의 색분산을 갖는 광섬유로 전송하여도 3.8×10^-3 이하의 비트 오율을 확보할 수 있음을 시뮬레이션으로 확인하였다.

• 한국정보통신학회논문지
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• 제19권3호
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• pp.697-707
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• 2015

본 논문은 CNS/ATM의 감시 기술 중 하나인 ADS-B 1090ES 시스템의 수신기 복조부 설계 및 구현에 대한 연구를 하였다. 연구된 복조부는 국제 기술문서 RTCA DO-260B와 EUROCAE ED-129에서 요구하는 모든 성능을 만족하며, 수신감도, 다이내믹 레인지 등의 성능 향상을 위하여 기존에 다중 진폭 샘플 복조 방식 중 베이스라인 다중 샘플 기술을 적용한 단일신호처리 기법을 제안하였다. 또한, 다중신호레벨튜닝 기법을 제안하여 단일신호처리 기법의 단점을 보완하고 송신출력 편차 및 수신기 하드웨어 제작 공정에 따른 균일하지 못한 수신 감도 레벨 차이에 대한 수신율 저하 문제를 최소화 하였다. 측정 결과 제안된 기법을 적용한 수신기는 다이내믹 레인지 0~-87dBm의 성능과 MTL -90dBm이 측정되었다. 이 결과는 ADS-B 1090ES 지상수신 장비의 국제 기술기준에서 요구하는 기준보다 -3dBm 낮은 우수한 성능을 나타냈으며, 이와 유사한 변조방법을 사용하는 시스템에 널리 응용이 가능할 것으로 사료된다.

• Asian-Australasian Journal of Animal Sciences
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• 제17권1호
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• pp.109-115
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• 2004

Three experiments were conducted to evaluate the effects of taurine (Tau) supplements on broiler growth performance, serum constituents and antibody production. In Exp. 1, 3 day old chicks received a basal diet supplemented with Tau at 0, 0.10, 0.20, 0.30 or 0.40% for 6 weeks. Although dietary Tau supplementing at 0.30 or 0.40% enhanced feed conversion and reduced feed consumption during 0 to 3 weeks (p<0.05), neither serum total cholesterol or anti-Newcastle disease virus (NDV) titer were affected. In Exp. 2, dietary Tau supplement at 0.25-0.75% enhanced feed conversion of broilers during 0 to 3 weeks, but daily gain and feed consumption were not affected. The 0.75% Tau supplement group displayed lower serum total cholesterol at 6 weeks (p<0.05) comparing with the control group but no difference in anti-NDV titers. In Exp. 3, broilers were treated with dietary Tau of 0 or 0.50% combined with low (0/0%), medium (0.18/0.08%), or high (0.36/0.16%) methionine (Met) levels for 6 weeks (0 to 3/3 to 6 weeks). The addition of Met significantly improved daily gain and feed conversion of broilers during 0 to 3 weeks (p<0.01). Dietary Tau interacted significantly with Met on daily gain and feed consumption. Broiler serum amino acids revealed that Met supplements only increased serum Met level, but only serum Tau level was enhanced as given dietary Tau supplementation. The broilers receiving Tau normalized serum triglycerides level by feeding with the low Met diet and tended to display higher anti-NDV titers (p<0.10). The experimental results suggest that the growth response obtained by Tau supplements results partly from interactions with sulfur amino acids. However, the modulation of the broiler lipid metabolism may be responsible for dietary Tau.

• Journal of Nutrition and Health
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• 제53권4호
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• pp.347-355
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• 2020

Purpose: Zinc is known to be associated with osteoblast proliferation and differentiation. Osterix as zinc-finger transcription factor is also related to osteoblast differentiation and bone formation. In the present study, we aimed to investigate whether zinc modulates osterix gene and protein expression in osteoblastic MC3T3-E1 cells. Methods: MC3T3-E1 cells were cultured in zinc-dependent concentrations (0, 0.5, 1, 5, or 15 µM Zn), along with osteogenic control (normal osteogenic medium) for 1 and 3 days. The gene and protein expression levels of osterix were analyzed by real-time reverse transcription polymerase chain reaction and Western blotting, respectively. Results: Zinc increased osteoblast proliferation in a concentration-dependent manner at day 1 and 3. Similarly, zinc increased the activity of osteoblast marker enzyme alkaline phosphatase in cells and media in a zinc concentration-dependent manner. Moreover, our results showed that the pattern of osterix gene expression by zinc was down-regulated within the low levels of zinc treatments (0.5-1 µM) at day 1, but it was up-regulated after extended culture period at day 3. Osterix protein expression by zinc showed the similar pattern of gene expression, which down-regulated by low zinc levels at day 1 and up-regulated back at day 3 as the early stage of osteoblast differentiation. Conclusion: Our results suggest that zinc modulates osterix gene and protein expression in osteoblasts, particularly in low level of zinc at early stage of osteoblast differentiation period.