• Korean Journal of Medicinal Crop Science
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• v.10 no.2
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• pp.109-115
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• 2002

The immune activation activities of ethanol, ethanol : water(1 : 1,v/v) and water extracts from Dendropanax morbifera Lev. were compared. The crude extracts showed relatively low cytotoxicity as less than 26% by using human normal liver cell(WRL-68). For example, the ethanol extract inhibited. in MCF7 and Hep3B cells in adding 1.0 mg/mL ethanol extracts. The growth of human immune T and B cells was enhanced up to $1.22{\sim}1.27$ times by adding the crude extracts. These are a trend of increasing secretion of $cytokines(IL-6,\;TNF-{\alpha})$ from human B/T cell for 6 day cultivation. It was found that the immune activation activities of the crude extracts seemed to be higher than those obtained by using other solvents.

• Journal of Life Science
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• v.27 no.5
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• pp.561-566
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• 2017

Dendropanax morbifera Lev. is known in Korea for its golden sap and medicinal properties. The many biological activities of the leaf and stem extracts suggest that this tree could be a valuable source of medicinal compounds for the treatment of various ailments such as dermatitis, migraines, dysmenorrhea, muscle pain, and infectious diseases. However, there is little information on the composition and biological activity of the volatile fraction of D. morbifera. Therefore, in this study, the volatile compounds in leaves, stems, and sap of D. morbifera were isolated using solvent and supercritical fluid extraction (SFE), and analyzed by gas chromatography/mass spectrometry to reveal their chemical composition and identify potential compounds of interest. Fifteen compounds were identified in the leaf extracts, whereas 29 and 3 compounds were identified in the stem and sap extracts, respectively. The volatile profiles obtained using solvent and SFE differed. Esters and aromatic hydrocarbons predominated in the solvent extract of leaves and SFE extract of stems, whereas the solvent extract of stems and SFE extract of leaves contained terpenoids. Limonene, ${\alpha}$-pinene, and ${\beta}$-myrcene were identified in the volatile extract of sap, with limonene representing 96.30% of the total peak area. In addition, the antiproliferative effects of the solvent extracts of leaves and stems were evaluated, revealing that these solvent extracts were particularly effective in decreasing the proliferation of HepG2 cells.

• Journal of Chitin and Chitosan
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• v.23 no.4
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• pp.267-276
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• 2018

This study was performed to investigate the ameliorating effect of a hangover beverage mixture (SBJ) that contains Dendropanax morbifera Lev. and several medicinal plant extracts, on hepatoprotection and alcohol-metabolizing enzymes in alcohol-induced hangover in both in vitro and in vivo models. In human hepatoma cell line, HepG2, 300 mM of ethanol-induced hepatotoxicity was significantly improved by pretreatment of SBJ by dose-dependent manner. In the in vivo study, administration of alcohol to rats raised to the concentration of blood alcohol and lactate dehydrogenase (LDH). Blood alcohol and LDH levels in SBJ-treated rats significantly decreased at 0.5 h and 8 h after acute ethanol administration (40%, 4.6 g/kg body weight) as compared to alcohol-treated rats. Hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity were significantly higher in SBJ-treated rats than in alcohol-treated rats. SBJ supplementation reduced formation of malondialdehyde (MDA), and inhibited reductions of hepatic superoxide dismutase (SOD), hepatic glutathione (GSH), glutathione-S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx) levels, compared with rats administered alcohol. Plasma catalase (CAT), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels showed unaltered resulted in all experimental groups compared with the control group. These results suggest that SBJ exhibit hepatoprotective properties by enhancing ADH, ALDH activity and stimulating the antioxidant defense system in alcohol-induced hangover.

• Journal of agriculture & life science
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• v.46 no.3
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• pp.47-58
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• 2012

This study was carried out to develop assessment model for the optimal site prediction of Dendropanax morbifera, Evergreen broad-leaved trees in warm temperate zone according to climate change. It was created criterion for assessment model of the optimal site prediction by quantification method to possible analysis of quantitative and qualitative data, through study relationship between growth of tree and site environmental factors. A program of the optimal site prediction was developed using program version 3.2, an Avenue and Dialog Designer tool of ESRI as GIS(geographic information system) engine. Developed program applied to test accuracy of the optimal site prediction in study area of Wando, Jeollanam-do, having a various evergreen broad-leaved trees of warm temperate zone. In the results from analysis of the optimal site prediction on Dendropanax morbifera, the characteristics of optimal site were analyzed site environmental features with 401~500m of altitude, $15^{\circ}$ of slope, hillside of local topography, alluvium of deposit type, convex of slope type and south of aspect. The mapping area per grade of the optimal site prediction in the Dendropanax morbifera showed 1,487.2ha(25.4%) of class I, 1,020.3ha(17.4%) of class II, 2,231.8ha(38.2%) of class III and 1,110.5ha(19.0%) of class IV.

• Journal of Korean Society of Forest Science
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• v.108 no.4
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• pp.484-492
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• 2019

The aim of the present study was to compare the cold tolerance of seven different types of trees growing in southern Korea to select evergreen broad-leaved trees that can be used as street trees in large land areas experiencing climate change. The trees compared were the thorn tree, Cinnamomum camphora, Camellia japonica, Machilus thunbergii, Dendropanax morbifera, Daphniphyllum macropodum Miq., Quercus glauca Thunb., and Raphiolepis indica. When the trees were subjected to low temperature treatment, their electrolyte elution volume values appeared to increase with the decreases in the treatment temperature. The analysis of the cold tolerance of each type of tree was based on the estimated temperatures in the following order: C. japonica (-11.586℃) > R. indica (-9.348℃) > Q. glauca (-8.719℃) > M. thunbergii (-8.090℃) > D. macropodum (-7.409℃) > D. morbifera (-7.085℃) > C. camphora (-6.995℃). The relative cold tolerance difference found in the seven tree species was more than 5℃, as evaluated previously. In the Lauraceae family, the difference in cold tolerance was more than 2℃, even in the same species. The analysis showed that trees with excellent cold tolerance included Q. glauca Thunb., C. japonica, R. indica, and the thorn tree. This knowledge is required for the evaluation of the possibility of the survival of trees under cold temperature conditions in cities.

• Korean Journal of Environment and Ecology
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• v.36 no.6
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• pp.662-675
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• 2022

This study was intended to investigate and analyze the current status of the plant community structure in order to provide basic data for the systematic conservation and management of the Buxus sinica area appearing on the ridgeline connecting the Gyeokjabong(Mt.) and Keungiljae, on Bogildo Island. In consideration of location characteristics such as density, topography, and direction of B. sinica appearing in the shrub layers, a total of 26 sites were set as the survey area for representative vegetation communities or areas with changes in topography. According to DCA and TWINSPAN, it was classified into 6 communities, namely Carpinus turczaninovii-Deciduous broad-leaved, C. turczaninovii, C. turczaninovii-B. sinica, C. turczaninovii-Evergreen broad-leaved, Q. acuta, and D. trifidus-Q. acuta. The community dominated by C. turczaninovii maintains the status quo for the present moment, however, Q. acuta will dominate the surrounding area in the long term, so Q. acuta has high succesion potential. In the case of the Q. acuta and D. trifidus-Q. acuta communities, Q. acuta, known as the climax species of warm-temperate forests, will maintain dominant status. In a case of B. sinica, the community dominated by C. turczaninovii will remain in good status due to the topographical conditions, but the community dominated by Q. acuta growth difficulties are expected due to the high coverage. In the relationship between environmental factors and vegetation distribution, analysis showed that only soil pH affect vegetation distribution. Furthermore, the soil acidity (pH) was 3.78-5.30, the electrical conductivity was 0.186-0.543 dS/m, and the organic matter content was 2.25-2.89%.

• The Korean Journal of Ecology
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• v.16 no.4
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• pp.459-476
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• 1993

Vegetational structure and successional sere were investigated for the evergreen and nearby deciduous broad-leaved forests in inland areas (Turyunsan, Pulgapsan) and south- western island areas (Hongdo, Chindo). The evergreen broad-leaved forests of the four areas showed a sera1 stage with an age structure mostly under fifty years old. Dominant evergreen broad-leaved species in canopy layer were Castanopsis cuspidata var. sieboldii, Machilus thunbergii, Quercus acuta, Q. stenophylla, Q. glauca, and Ncolitsea serzceu. Succession of the forest vegetation in the surveyed areas was proceeding from deciduous broad-leaved trees to evergreen broad-leaved trees. The species of climax stage were assumed to be Machilus thunbergii, iVeolitseu sericea and Dendropanax morbifera in canopy layer, Aucuba japonica and Machilus japonica in subtree and shrub layer.

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.7
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• pp.938-947
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• 2016

Antioxidant activities and neuroprotective effects of ethyl acetate fraction from Dendropanax morbifera (EFDM) against high glucose-induced oxidative stress and neurotoxicity were investigated to confirm their physiological activities. An 80% ethanolic extract of D. morbifera showed the highest contents of total phenolic compounds as well as 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. The extract was fractionated using several solvents, and the ethyl acetate fraction showed the highest activities in ferric reducing/antioxidant power and malondialdehyde inhibitory assays. To evaluate the neuroprotective effect based on antioxidant activities, cell viability was assessed using PC12 and MC-IXC cells in $H_2O_2$- and high glucose-induced cytotoxic assays, respectively. EFDM evidently showed neuroprotective effects in all cells (neuron-like PC12 cells and human brain-originated neuroblastoma MC-IXC cells). Inhibitory effect of the extract on acetylcholinesterase (AChE) as an acetylcholine-hydrolyzing enzyme was performed to examine the effect on cognitive function. EFDM presented an AChE inhibitory effect. Finally, high-performance liquid chromatography analysis showed that the major phenolic compound of EFDM is probably a rutin.

• Korean Journal of Food Science and Technology
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• v.48 no.3
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• pp.275-283
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• 2016

An anti-amnesic effect of water extract from Dendropanax morbifera Lev. leaves (DMW) on memory dysfunction in streptozotocin-induced diabetic rats was investigated to assess its potential industrial value. Daily administration of DMW (11 weeks) significantly reduced serum glucose, insulin, and blood urea nitrogen (BUN) levels increased by an intraperitoneal injection of streptozotocin (STZ, 55 mg/kg). In addition, the administration of DMW decreased escape latency and increased the time spent in the platform quadrant in the Morris water maze test. Step-through latency in a passive avoidance test was also improved. Finally, DMW produced ameliorating effects on STZ-induced cholinergic deficit through an inhibitory effect on acetylcholinesterase and the increment of acetylcholine level in the hippocampus. These results suggest that DMW might be used as a natural substance for improving diabetic induced cognitive impairment.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.1
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• pp.73-83
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• 2015

Dendropanax morbifera Leveille (Araliaceae) is an endemic species growing in the south-western part of South Korea and has been used in folk medicine. However, the effects of Dendropanax morbifera Lev. on skin biology remain to be elucidated. In this study, we isolated 1-tetradecanol and ${\beta}$-sitosterol from the n-hexane fraction of Dendropanax mobifera Lev. and To investigate the whitening effect of the fraction, we tested the inhibition of tyrosinase activity of 1-tetradecanol. The results show that the inhibitory effect of the 1-tetradecanol was higher than water extract and n-hexane fraction. And 1-tetradecanol significantly reduced melanin contents of B16F10 cells compared to more than water extract and n-haxane fraction dose-dependantly without cell cytotoxicitiy (below $100{\mu}g/mL$). We also investigated the skin moisturizing effect using HR-1 hairless mice. The transepidermal water loss (TEWL) in the 1-tetradecanol treated group was significantly smaller than that in the other groups. To investigate the effect of the preventing hair loss by ${\beta}$-sitosterol, we observed HR-1 hairless mice through periodic growth feature. The results suggest that hair loss of mice by ${\beta}$-sitosterol was delayed and it's hair density showed the highest. These data provide evidence that Dendropanax morbifera Lev. may be a potent candidate for the improvement of both skin whitening, moisturizing and alopecia from the point of cosmetic industry view.