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http://dx.doi.org/10.15230/SCSK.2015.41.1.73

Effects of 1-tetradecanol and β-sitosterol Isolated from Dendropanax morbifera Lev. on Skin Whitening, Moisturizing and Preventing Hair Loss  

Lee, Sun Young (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Choi, Eun-Jin (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Bae, Dong-Hyuck (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Lee, Dong-Wook (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Kim, Sunoh (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR))
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.41, no.1, 2015 , pp. 73-83 More about this Journal
Abstract
Dendropanax morbifera Leveille (Araliaceae) is an endemic species growing in the south-western part of South Korea and has been used in folk medicine. However, the effects of Dendropanax morbifera Lev. on skin biology remain to be elucidated. In this study, we isolated 1-tetradecanol and ${\beta}$-sitosterol from the n-hexane fraction of Dendropanax mobifera Lev. and To investigate the whitening effect of the fraction, we tested the inhibition of tyrosinase activity of 1-tetradecanol. The results show that the inhibitory effect of the 1-tetradecanol was higher than water extract and n-hexane fraction. And 1-tetradecanol significantly reduced melanin contents of B16F10 cells compared to more than water extract and n-haxane fraction dose-dependantly without cell cytotoxicitiy (below $100{\mu}g/mL$). We also investigated the skin moisturizing effect using HR-1 hairless mice. The transepidermal water loss (TEWL) in the 1-tetradecanol treated group was significantly smaller than that in the other groups. To investigate the effect of the preventing hair loss by ${\beta}$-sitosterol, we observed HR-1 hairless mice through periodic growth feature. The results suggest that hair loss of mice by ${\beta}$-sitosterol was delayed and it's hair density showed the highest. These data provide evidence that Dendropanax morbifera Lev. may be a potent candidate for the improvement of both skin whitening, moisturizing and alopecia from the point of cosmetic industry view.
Keywords
Dendropanax morbifera Leveille; 1-tetradecanol; ${\beta}$-sitosterol; whitening effect; moisturizing effect; hair loss;
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Times Cited By KSCI : 3  (Citation Analysis)
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