• Journal of Pharmaceutical Investigation
• /
• v.27 no.1
• /
• pp.15-22
• /
• 1997

The mucosal route of administration(nasal, buccal, conjunctival and vaginal) has recently been considered as an alternative to parenteral delivery for many peptide drugs because enzymatic degradation of these agents may be partly avoided. The objective of these study was to establish the optimal mucosal administration dosage form of $LHRH/[D-Ala^6]LHRH$, based on presystemic metabolism. We reported previously the peptidase inhibition effect of medium chain fatty acid salts(sodium caprylate, soadium caprate and sodium laurate), EDTA and STDHF on the proteolysis of $LHRH/[D-Ala^6]LHRH$ in rabbit mucosal homgenates. We also reported that EDTA, STDHF and sodium laurate markedly increased the potency of $LHRH/[D-Ala^6]LHRH$ solution applied vaginally. In the present study, by administration of polycarbophil hydrogel containing LHRH the ovulation inducing activity was 3.3 times greater than solution. These results indicate not only peptidase inhibitor but also polycarbophil hydrogel significantly improved the absorption of this drug. The results of this study would provide the feasibility as a rational dosage form for improving bioavailability and self administration of this hydrogel by the vaginal application.

• Polymer(Korea)
• /
• v.33 no.5
• /
• pp.490-495
• /
• 2009

The reactive compatibilization of amorphous poly-${\alpha}$-olefins (APAO)/amorphous polyamide (aPA) blends was carried out using two kinds of reactive compatibilizers such as maleated polypropylene and ethylene-glycidyl methacrylate-methyl acrylate copolymer. The grafting reaction rates between aPA and the compatibilizers were examined using FT-IR, SEM and rheometer. The effect of the reactive compatibilization on the mechanical property of the blends was investigated with a universal testing machine. The adhesion strength of the blends including a hydrocarbon tackifier resin, C9 was also measured.

• Journal of the Korean Applied Science and Technology
• /
• v.25 no.4
• /
• pp.525-532
• /
• 2008

To prepare a solution type acrylic pressure-sensitive adhesive, quarter polymers were synthesized from butyl acrylate(BA), 2-ethylhexylacrylate(2-EHA) as a base monomer, methyl methacrylate(MMA) as a comonomer, each of methacrylic acid(MAA), acrylic acid(AA) as a functional monomer. Acrylic solution type pressure-sensitive adhesives(PSA's) of isocyanate derivative crosslinking PSA's were prepared by crosslinking of BEMM, BEMA with toluene-2,4-diisocyanate. The structure of adhesive was identified by FT-IR. The viscosity was measured by using Brookfield DV-III and molecular weight was measured by using gel permeation chromatography. The physical properties of polyethylene film coated with BEMMT, BEMAT were measured as a function of the concentration. As the result, BEMMT(0.6, 0.8), BEMAT(0.6) showed peel adhesion of $160{\sim}180\;g_f$/25 mm width and shear adhesion of more than 24 hours, and tackiness of $4/32{\sim}6/32$ which was relevant to commercial usage.

• Water for future
• /
• v.28 no.4
• /
• pp.147-154
• /
• 1995

Scour characteristics of noncohesive bed materials at the downstream of free-falling jet were analyzed through hydraulic experiments. It was assumed that the downstream had no special energy dissipators. Flow characteristics of free falling jet from rectangular section were studied, and scour characteristics with and without mounds, which were generated at the downstream of the scour hole, were comparatively analyzed for various bed materials, discharges and tailwater depths. Not only the equilibrium scour depth but also the height of mound could be expressed as a function of densimetric Froude number. Densimetric Froude number had closer relationship with the equilibrium dimensionless scour depth than other dimensionless parameters. It was suggested that the mound effects should be considered at the design stage of bed protection works.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.33 no.4
• /
• pp.41-46
• /
• 2005

In this paper, a new method for suppressing microwelding on the RF MEMS (Radio Frequency Microelectromechanical System) direct contact switches is introduced. Two kinds of refractory metals, tungsten and molybdenum were coated onto the contact point of the switches and the effect of the coating was examined. The changes in insertion loss and isolation at the switch were measured by using network analyzer and power loss was evaluated by power measurement. The results revealed that while tungsten and molybdenum showed higher contact resistance than gold in low input power range, they enhanced the power handling capability and reliability of the switches in high input power region.

• Elastomers and Composites
• /
• v.44 no.1
• /
• pp.69-75
• /
• 2009

Asphalt sealants for the crack repair of asphalt concrete road were prepared using waste lubricant oil in this work. The waste lubricant oil was compounded with asphalt(AP-5), SBS triblock copolymer, a tackifying agent(petroleum resin), and antioxidants. Cone penetration, softening point, ductility, elongation by tensile adhesion, and resilience of asphalt sealant compounds were measured. Cone penetration of asphalt sealant compounds increased with the increase of waste lubricant oil content while their softening point, ductility, and resilience decreased. By the addition of talc as an extender, softening point and resilience of asphalt sealants increased, but cone penetration, ductility, and elongation by tensile adhesion of those decreased with the proportion of talc content. The most economic asphalt sealant which could pass an ASTM specification could be manufactured by the big decrement of petroleum resin content.

• Journal of Industrial Technology
• /
• v.18
• /
• pp.7-16
• /
• 1998

This paper is an experimental study of investigating the reinforcing effect and the behavior of cohesionless slope installed with reticulated root pils. Reduced scale model tests with plane strain conditions were performed to study the behavior of the strip footing located on the surface of cohesionless slopes reinforced with root piles. Model tests were carried out with Jumunjin Standard Sand of 45% relative density prepared by raining method to have an uniform slope foundation during tests. Slope of model foundation was 1 : 1.5 and a rigid model slop. Parametric model tests were performed with changing location of model footing, arrangements of root piles and angles of pile installation. On the other hands, the technique with camera shooting was used to monitor sliding surface formed with discontinuty of dyed sand prepared during formation o foudation. From test results, parameters affecting the behavior of model footing were analyzed qualitatively to evaluate their effects on the characteristic of load - settlement, ultimate bearing capacity of model footing and failure mechanism based on the formation of failure surface.

• Journal of Life Science
• /
• v.13 no.3
• /
• pp.349-354
• /
• 2003

In order to manufacture the high-quality products as well as to promote their consumption, processing conditions for anchovy snacks were investigated. Seasoning juice-1 were made for 7% sugar, 2% salt, 5% soy sauce, 2% ginger, 1% pepper, 5% garlic, 5% onion, 2% glasswort extract and 0.5% taurine with water. Seasoning juice-2 were made for 15% frying powder, 15-20% starch syrup, 10% soybean powder and 2% sesame powder with water. Sensory evaluation revealed that overall acceptability of anchovy snacks with 30% moisture before popping, 15% frying powder and 15-20% starch syrup in seasoning juice-2 with 20 seconds popping time exceeded other groups of samples.

• Journal of the Korean Geosynthetics Society
• /
• v.13 no.4
• /
• pp.69-75
• /
• 2014

The shear strength characteristics of an unsaturated earth material are highly important not only for evaluating the seepage characteristics but also the stability of levee for a lifelong. In this study, unsaturated strength characteristics of Nak-dong river sand and clay that frequently used for the levee construction in southern province of Korea were analyzed using unsaturated triaxial compressive test. The strength characteristics due to the variation of matric suction were analyzed using multi-stage compression technique and the results were directly compared with the non-linear formulation for the apparent cohesion ($C_{max}$), and the friction component ${\varphi}^b$ were determined and evaluated from the test for the application of linear Mohr-Coulomb failure criteria. Cohesion and friction characteristics of the unsaturated levee material under various suction phases were also explored during this study.

• Journal of the Korea Institute of Building Construction
• /
• v.14 no.2
• /
• pp.163-169
• /
• 2014

Engineers in the construction field have been using bonded waterproofing sheets in an attempt to resolve the imbalance in the quality, the risk of fire, safety of workers, and environmental pollution, as well as to eliminate separate use of organic adhesives on the surface of concrete. Recently, self-laminated waterproofing sheets have been developed. The purpose of this research is to find an appropriate processing speed according to the changes in physical properties, and visual observation of the waterproofing sheets laminated by the aluminum thin-film and viscosity layer that can be attached through self-adhesiveness on the surface of concrete and waterproofing sheets. Therefore, this research is conducted using a physical performance test. Based on the result of the test, when the high-frequency inductive heating apparatus was used, an improved adhesion and bonding stability effect were confirmed after the anti-hydrostatic pressure and bond strength in the temperature condition, and the surface observation in the processing speed condition.