• IMMUNE NETWORK
• /
• v.4 no.1
• /
• pp.31-37
• /
• 2004

Background: 1-8D gene is a member of human 1-8 interferon inducible gene family and is shown to be overexpressed in fresh colon cancer tissues. Three peptides 1-6, 3-5 and 3-7 derived from 1-8D gene were shown to have immunogenicity against colon cancer. Methods: To study tumor immunotherapy of these peptides we established an adoptive transfer model. $D^{b-/-}{\times}{\beta}2$ microglobulin (${\beta}2m$) null mice transgenic for a chimeric HLA-A2.1/$D^b-{\beta}2m$ single chain (HHD mice) were immunized with irradiated peptide-loaded RMA-S/HHD/B7.1 transfectants. Spleens were removed after last immunization, and splenocytes were re-stimulated in vitro. Lymphocytes from vaccinated HHD mice were transferred together with IL-2 to the tumor bearing nude mice that were challenged S.C. with the HCT/HHD/B7 colon carcinoma cell line that was found to grow in these mice. Results: Peptide 3-5 was found to be highly effective in CTL activity. Adoptively transferred anti-peptide 3-5 cytolytic T lymphocytes caused significant retardation in tumor growth. Conclusion: This study shows that peptide 3-5 can be the most effective candidate for the vaccine of adoptive immunotherapy against colon cancer.

• Journal of Korean Library and Information Science Society
• /
• v.41 no.1
• /
• pp.51-76
• /
• 2010

This study discussed the trends and characteristics of mental health services in the public libraries of North America. To accomplish this, this study collected its data through literature surveys, observations and interviews with librarians within the Vancouver public library system. The results show that there were many cases in which patrons asked public libraries for information on their mental health problems and the public libraries helped the patrons cope with their problems. The public libraries' assistance programs for national tragedies and natural disasters were temporary services. On the other hand, public libraries were continuously advising and guiding patrons dealing with emotional and psychological problems through the readers' advisory and information services. Specifically, public libraries were actively assisting various sensitive issues that are generated in the development of children and youths(for example, adoption, divorce and separation, remarriage, family, friendship, disabilities, death, self-esteem, emotions, bulling, violence, abuse, suicide, illness, addiction, sexual health, youth pregnancy and so on). The key role of librarians under these circumstances was to guide and recommend appropriate books and professional institutions that help solve the problems.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.15 no.2
• /
• pp.132-142
• /
• 2004

Most articles of Reactive Attachment Disorder reported Disinhibited Type children adopted from other countries. Reports from only Turkey and Korea focused on Inhibited Type of Reactive Attachment Disorder children whom raised by their own parents and whose symptoms are very similar to Autistic Disorder. Since articles of treatment of Reactive Attachment Disorder, especially for Inhibited Type are very rare, this article informed the author's experiences of treatment for Korean Reactive Attachment Disorder children since 1987. To treat Reactive Attachment Disorder patients and their parents, three important areas must be included : 1) to make a therapeutic environment for a Reactive Attachment Disorder child, 2) to make an attachment between Reactive Attachment Disorder child and his/her mother through individual play therapy, filial therapy, and group therapy with sibling or peer, 3) to catch up developmental delay by speech therapy, cognitive therapy and therapeutic education. This treatment methods can be more easily and more effectively applied to Korean patients than other methods from western countries including USA or England.

• Journal of the Korean Chemical Society
• /
• v.48 no.6
• /
• pp.616-622
• /
• 2004

Liposome powders were prepared by a freeze-drying method for the application to the field of drug carrier. The effect of maltose as a liposome stabilizer was studied on the stability and the drug-loading efficiency of the freeze-dried liposome powders. The particle size of liposomes before and after freeze-drying was determined to evaluate the liposome stability. The drug-loading efficiency was measured by Fluorescence spectrophotometer using calcein as a model drug. When maltose was added after the preparation of the liposomes, the liposomes was stable, compared to the case of maltose addition at the hydration procedure. By the addition of maltose, the liposome was stable for 30 days at $4{\sim}37^{\circ}C$, while the particle size of the liposome without maltose increased with time. The liposome showed relatively high stability when the maltose/lipids molar ratio was 3 and 6.

• The KIPS Transactions:PartA
• /
• v.14A no.4
• /
• pp.235-244
• /
• 2007

Caching and prefetching policies have been used in most of computer systems to compensate speed differences between primary memory and secondary storage devices. In this paper, we design and implement a Flash Cache Core Module(FCCM) on the YAFFS which operates on a file system layer for NAND flash memory. The FCCM is independent of the underlying kernel in order to support its stability and compatibility. Also, we implement the Dirty-Last memory replacement technique considering the characteristics of flash memory, and the waiting queue for pages to be prefetched according to page hit. The FCCM reduced the number of I/Os and the amount of prefetched pages by maximum 55%(20% on average) and maximum 55%(24% on average), respectively, comparing with caching and prefetching policies of Linux.

• Journal of the Korea Society of Computer and Information
• /
• v.27 no.7
• /
• pp.109-114
• /
• 2022

Recently, child abuse cases such as the "16-month death of adopted children" have occurred one after another in our society and have emerged as a serious social problem. Child abuse not only significantly violates children's human rights, but also leaves scars on the child's body and sometimes threatens their lives. As a result, laws related to child abuse have been revised several times and related systems have been reorganized to protect the affected children safely and grow healthy, but child abuse cases continue to occur. Therefore, it is urgent to come up with effective measures to prevent child abuse crimes and protect affected children. Therefore, this study examines the concept and related laws of child abuse, the current status of child abuse, and suggests countermeasures to effectively respond to child abuse compared to the US child abuse legislation and child protection system.

• Korean Journal of Social Welfare Studies
• /
• v.41 no.4
• /
• pp.45-79
• /
• 2010

The purpose of this study is to understand surrogate mother aged 20-30s by knowing meaning and structure of empirical phenomena. Methods is to applied to Phenomenological and heuristic Human Becoming Methodology, and the subjects of this study are four surrogate and host mothers who were on the air of SBS program, 'surrogate mother: having a baby for infertile couples(March 8, 2005)', and phenomenological and heuristic Human Becoming Methodology of Parse is applied in this study. Results is the structure that they chose surrogate mother as best option under the economic suffering, and pregnancy and bearing separated motherhood while facing unfair negotiating relationship and accepting reality of forgettable motherhood. The conceptual integration of relationship issues were: valuing, powering and transforming with the process of revealing-concealing and enabling-limiting. Finally, discussion and practical meaning was reviewed.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.18 no.5
• /
• pp.927-934
• /
• 2023

With the recent growth of the companion animal market, various social issues related to companion animals have also come to the forefront. Notable problems include incidents of dog bites, the challenge of managing abandoned companion animals, euthanasia, animal abuse, and more. As potential solutions, a variety of training programs such as companion animal-focused broadcasts and educational apps are being offered. However, these options might not be very effective for novice caretakers who are uncertain about what to prioritize in training. While training apps that are relatively easy to access have been widely distributed, apps that allow users to directly engage in training and learn through hands-on experience are still insufficient. In this paper, we propose a more efficient AR-based mobile app for companion animal training, utilizing the Unity engine. The results of usability evaluations indicated increased user engagement due to the inclusion of elements that were previously absent. Moreover, training immersion was enhanced, leading to improved learning outcomes. With further development and subsequent verification and production, we anticipate that this app could become an effective training tool for novice caretakers planning to adopt companion animals, as well as for experienced caretakers.

• Neonatal Medicine
• /
• v.17 no.1
• /
• pp.94-101
• /
• 2010

Purpose:In recent years, Korea has showed a steady increase in the frequency of teenage birth, while the overall birth rate has declined. As the teenage birth is known as a high risk pregnancy itself, we examined perinatal complications of teenage mothers and whose neonates in aspects of medical problem, and social status and support. Methods:We examined the perinatal characteristics of teenage mothers and whose babies, who were hospitalized at Korea University Ansan Hospital from January 2004 to July 2009 using medical records retrospectively. Twenty-seven teenage mothers and their 28 babies were enrolled in this study. Results:Teenage mothers were all unmarried and showed high rates of preterm labor, maternal anemia, and unexpected delivery. Among them, 11 (40.7%) were from families that were separated. Eleven mothers (40.7%) did not have any antenatal care. There were high rates of prematurity and low birth weight (60.7% and 64.3%, respectively). The complication included: respiratory distress syndrome, patent ductus arteriosus and necrotizing enterocolitis. Fourteen babies (51.9%) were not going to be brought up by their biological parents. Conclusion:Teenage pregnancy had high rates of preterm labor and associated complications, often caused by the lack of proper antenatal care. Babies from unmarried mothers were likely to be adopted and this could be a social burden. Therefore, to reduce unplanned teenage pregnancy and births, sex education and social supports should be provided to all teenagers.

• Korea journal of population studies
• /
• v.30 no.2
• /
• pp.71-95
• /
• 2007

This paper attempts to identify the principle of family succession and family patterns of yangban in the late Chosun period through an analysis of male adaptation cases found in family registration records. The primary source of analysis is the family registration documents of Uiseong Kim's from the late 17th century to the early 20th century. As a result, it is found that there is a substantial change in the patterns of family from the early and mid Chosun period to the late Chosun period. The change is the strengthening of the principle of patriarchy succession through male adoption. Looking at the data as a whole, the average number of household members is increased and the membership of kinship also expanded. In contrast to the family patterns of the early Chosun period, not only the patterns of Uiseong Kim's family are predominately immediate family or collateral family but also the majority is extended family in the 18th and 19th centuries. The male adoption cases recorded in Uiseong Kim's family registration documents take up 33.8% of the male adoption cases in the entire family registration documents. This goes to show that the strengthening of the principle of primogeniture succession at a time when child mortality rate is very high resulted in the increase of male adoption. In conclusion, the late Chosun society was a society where the seat of primogeniture was much more important than immediate hereditary members in the family succession.