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Adoptive Transfer of Colon Cancer Derived Peptide-specific CD8+ T Cells in HHD Mice  

Jung, Hun-Soon (School of Life and Food Sciences, Handong Global University)
Ahn, In-Sook (School of Life and Food Sciences, Handong Global University)
Do, Hyung-Ki (School of Life and Food Sciences, Handong Global University)
Lemonnier, Francois A. (AIDS-retrovirus Department, Antiviral Cellular Unit, Pasteur Institute)
Tirosh, Boaz (Department of Immunology, The Weizmann Institute of Science)
Tzehoval, Esther (Department of Immunology, The Weizmann Institute of Science)
Vadai, Ezra (Department of Immunology, The Weizmann Institute of Science)
Eisenbach, Lea (Department of Immunology, The Weizmann Institute of Science)
Do, Myoung-Sool (School of Life and Food Sciences, Handong Global University)
Publication Information
IMMUNE NETWORK / v.4, no.1, 2004 , pp. 31-37 More about this Journal
Abstract
Background: 1-8D gene is a member of human 1-8 interferon inducible gene family and is shown to be overexpressed in fresh colon cancer tissues. Three peptides 1-6, 3-5 and 3-7 derived from 1-8D gene were shown to have immunogenicity against colon cancer. Methods: To study tumor immunotherapy of these peptides we established an adoptive transfer model. $D^{b-/-}{\times}{\beta}2$ microglobulin (${\beta}2m$) null mice transgenic for a chimeric HLA-A2.1/$D^b-{\beta}2m$ single chain (HHD mice) were immunized with irradiated peptide-loaded RMA-S/HHD/B7.1 transfectants. Spleens were removed after last immunization, and splenocytes were re-stimulated in vitro. Lymphocytes from vaccinated HHD mice were transferred together with IL-2 to the tumor bearing nude mice that were challenged S.C. with the HCT/HHD/B7 colon carcinoma cell line that was found to grow in these mice. Results: Peptide 3-5 was found to be highly effective in CTL activity. Adoptively transferred anti-peptide 3-5 cytolytic T lymphocytes caused significant retardation in tumor growth. Conclusion: This study shows that peptide 3-5 can be the most effective candidate for the vaccine of adoptive immunotherapy against colon cancer.
Keywords
1-8Dgene; HHD mice; colon caner; cytotoxic T lymphocyte; adoptive transfer;
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