• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.3
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• pp.378-383
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• 2013

The purpose of this study is to evaluate the antioxidant activities of extracts from Acer tegmentosum Maxim. (AT) and the ability of these extracts to reduce the serum alcohol concentration in rats administered alcohol. The total amount of polyphenols in hot water and ethanol extracts from AT were $71.93{\pm}2.2{\mu}g/mg$ and $152.69{\pm}1.25{\mu}g/mg$, respectively, while the total amount of flavonoids in hot water and ethanol extracts from AT were $7.51{\pm}1.34{\mu}g/mg$ and $5.01{\pm}0.83{\mu}g/mg$, respectively. FRAP values in AT extracts were $1.67{\sim}1.75{\mu}M/{\mu}g$. AT extracts were capable of directly scavenging DPPH and ABTS free radicals, with higher inhibitory activities for TBA. The hepatoprotective effect of hot water extracts from AT against ethanol-induced oxidative damage was investigated. Ethanol-induced damage on HepG2 liver cells were protected by hot water extracts from AT. Administration of hot water extracts from AT (200 mg/kg) had reduced serum alcohol levels in acute alcohol-treated rats. These results indicate that AT extracts can be protective against alcohol-induced toxicity, potentially through its antioxidant properties.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.4
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• pp.473-479
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• 2013

Purpose: This article tried to find the changes of the eye and a correlation depending on watching a smartphone and taking in alcohol. Methods: This paper conducted the refraction inspection, the radius of corneal curvature, tonometry and the corneal thickness measurement and analysis for 31 persons (18 males and 13 females) who have healthy drinking habit, not having the medical history of taking medicine related with disorders of the eye, a mental disease, systemic disease and alcohol metabolism. Results: Of respirations depending on watching a smartphone, the alcohol concentration was significantly decreased in 15 minutes, 30 minutes, 45 minutes, 60 minutes and the convalescent stage. (p<0.01, p<0.001) As the result of comparing the refraction inspection after and before watching a smartphone when drinking alcohol, there was a significant difference in the cylindrical power and the axis. (p=0.005, p=0.001) The change of intraocular pressure depending on watching a smartphone after drinking alcohol was decreased significantly from 30 minutes (p<0.001), and watching a smartphone didn't have any significant effect on the corneal thickness depending on the elapsed time from when drinking alcohol. Conclusions: Watching a smartphone and taking in alcohol had a significant effect on the cylindrical power and the axis. Watching a smartphone and taking in alcohol which may cause the visual function-strain are the factors that need to consider before the refraction inspection.

• The Journal of the Convergence on Culture Technology
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• v.8 no.6
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• pp.631-636
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• 2022

Alcohol content, which is an important standard for Takju, a traditional multiple parallel fermentation liquor called makgeolli, is a factor that can affect the flavor. For alcohol content analysis, the distillation/hydrometry technique is mainly used. In this study, we analyzed the alcohol content of 14 commercially available Takju by the distillation/hydrometry technique and the improved GC method, respectively, after verifying the reliability of improved GC method. The precision and accuracy of the GC method were satisfactory, and LOQ and LOD were evaluated as 0.5% and 0.1% of ethanol contents, respectively. Among the three Takju exceeding the labelled alcohol content ±1, one Takju was quantitated as alcohol content 9.9% (by GC method) and 10.1% (distillation/hydrometry technique) exceeding labelled 6.0%. It was within the analytical error range of alcohol content for other two Takju, where the alcohol contents were exceeded -1.1%. The average precision (%RSD) of 14 Takju analyzed by the distillation/hydrometry technique (36.2%) and the GC method (12.8%), confirming that the GC method was better than the other. The improved GC method was evaluated to be effective in managing and improving the alcohol content standard of Takju with the wide range of alcohol content.

• Food Science and Preservation
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• v.21 no.3
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• pp.412-420
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• 2014

This study was performed to investigate the effect of fermented Hovenia dulcis Thunb fruit water extract on biomarkers for acute (a) ethanol-induced hangover and chronic (c) ethanol-induced liver injury in rats. For acute ethanol-induced hangover, the rats were administered distilled water (D.W., 10 mL/kg body wt.), Hovenia dulcis Thunb fruit water extract (HWE, 400 mg/10 mL/kg body wt.) and fermented HWE (FHWE, 400 mg/10 mL/kg body wt.), respectively, before 40% ethanol (5 g/kg body wt.) was administered. For chronic ethanol-induced liver injury, the rats were randomly divided into the normal control (cNC), ethanol (cET), cET-HWE and cET-FHWE groups. The cNC and cET groups were administered D.W. (10 mL/kg body wt.) before 40% alcohol (5 g/kg body wt.) was administrered for 21 days. The cET-HWE and cET-FHWE groups were administered HWE (400 mg/10 mL/kg body wt.) and FHWE (400 mg/10 mL/kg body wt.), respectively before 40% ethanol (5 g/kg body wt.) administration for 21 days. For acute ethanol-induced hangover, the serum alcohol and acetaldehyde concentrations were more significantly reduced in the aHWE and aFHWE groups than in the aET group. Moreover, the effect of FHWE was greater than that of HWE. For chronic ethanol-induced liver injury, the serum ethanol, acetaldehyde, ${\gamma}$-glutamyl transpeptidase (${\gamma}$-GTP) levels and the hepatic lipids concentration more significantly dropped in the cET-HWE and cET-FHWE groups than in the cET group. The FHWE administration showed faster recovery of the serum glucose concentration than in the cET and cET-HWE groups. The body weight reduction tended to normalize in the cET-HWE and cET-FHWE groups, which is ideal for chronic ethanol administration. These results suggest that FHWE has a protective effect against ethanol-induced liver damage, as evidenced by its ability to lower the serum ethanol and acetaldehyde concentrations after alcohol administration, and by its ability to decrease the level of ${\gamma}$-GTP and hepatic lipids. FHWE also elevated serum glucose concentration. Therefore, FHWE is effective in reducing ethanol-induced hangover and can play a beneficial role in the treatment of ethanol-induced liver damage as well as body weight reduction.

• Journal of the Korean Chemical Society
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• v.35 no.1
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• pp.3-15
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• 1991

The gaseous mixtures of iso-propanol of 10 torr with carbon dioxide of 0∼1990 torr were irradiated with Co-60 gamma radiation up to 50 kGy, and the products such as carbon monoxide, acetone, methane, ethane, C$_3$H$_a$, C$_4$H$_b$ and tert-butanol were analyzed by gas chromatography. G(CO) value of 4 was obtained from the gas mixtures containing more than 490 torr of carbon dioxide. The production rates of the organic products and the decomposition rate of iso-propanol increased linearly with the pressure of carbon dioxide, and G(-iso-Propanol) and G(Acetone) values increased by 4 and 2, respectively, with each 10 torr increment of carbon dioxide pressure. The mechanisms of the radiolytic decomposition of iso-propanol and the production of carbon monoxide and organic materials are discussed on the basis of the experimental results of the present study.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.11
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• pp.1499-1505
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• 2009

This study investigated the effect of improved liver function in rats administered with ethanol by kimchi lactic acid bacteria with high GABA producing capacity. Sprague-Dawley male rats were divided into four groups; normal diet control (NC), ethanol control (EC), ethanol＋Lactobacillus sp. OPK2-59 normal powder (EL1), ethanol＋Lactobacillus sp. OPK2-59 GABA powder (EL2) and fed for 6 weeks. Analysis showed that there were no significant differences in body weight and feed consumption among the groups during the experimental period. Also, there were no significant differences in organ weight among the groups. The test results showed total cholesterol and triglyceride in the blood concentration that were increased by ethanol administration were significantly lowered in EL2 group. Liver triglyceride was also significantly lowered in the EL2 group compared with the EC group. Serum GOT and GPT, and liver GOT levels were significantly lower in the EL2 group compared with the EC group. Serum ethanol concentration was lower in the EL1 and EL2 groups compared with the EC group. SOD activities in liver were significantly increased in the EL1 and EL2 groups compared with the EC group. These results suggest that Lactobacillus sp. OPK2-59 GABA powder improves lipid and enzyme profiles of rats administered with ethanol.

• Journal of the East Asian Society of Dietary Life
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• v.22 no.4
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• pp.473-479
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• 2012

In this study, increased alcohol decomposition efficacy (ADH) of Hoveina dulcis extract by Carbohydrate-Hydrolyzing Enzymes was investigated. Carbohydrate decomposition enzymes such as Maxinvert (Invertase), Optidex L-400 (Glucoamylase) and Rohament CL (Cellulase & Pectinase) were added to Hoveina dulcis extract at different concentrations (0.01, 0.05, 0.1, 0.5 and 1%) for 48 hrs, after which samples were taken every 6 hrs for determination of ADH activity. As the enzyme concentration became higher, ADH activity also increased. Especially, the addition of 1% Rohament CL increased enzyme activity to 76% at 30 hrs incubation, after which the increase in activity stopped. In the rat and human body experiment, enzymatic decomposition of Hovenia dulcis extract by addition of 1% Rohament CL was also effective in decreasing serum alcohol concentration and respiration. Especially, in the early stage after alcohol consumption, the efficacy of enzyme treatment of Hovenia dulcis extract was more effective. These results show that if the glycoside forms of active compounds such as flavonols in Hovenia dulcis extract are converted into aglycone forms, alcohol decomposition capability can be enhanced.

• Proceedings of the KAIS Fall Conference
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• 2010.05b
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• pp.890-893
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• 2010

알코올 섭취 후 발생하는 해부생리학적 변화가 눈의 일시적인 근시화에 미치는 영향을 알아보고자 하였다. 평균 24.5${\pm}$1.5세의 남자 8명(16 안)을 대상으로 0.42 g/kg의 알코올을 30분 간에 걸쳐 섭취토록 한 다음, 알코올 섭취 1시간, 4시간, 24시간 후의 교정굴절력, 각막곡률반경과 두께, 동공직경, 안압, 그리고 안구축의 길이변화를 측정하여 알코올 섭취 전과 비교하였다. 알코올 섭취 1시간 후에 알코올 섭취 전과 비교하여 호흡 중 알코올 농도가 가장 높았고(p<0.001), 교정굴절력의 구면 (-)굴절력 증가(p<0.05), 동공 크기의 감소(p<0.05), 안압의 하강(p<0.001), 그리고 안구축의 길이 증가가 나타났다. 알코올 섭취 4시간 후에도 모든 측정값들이 섭취 1시간 후와 동일한 경향이었다. 그러나 알코올 섭취 24시간 후에는 알코올 섭취 전과 비교하여 의의있는 변화를 보이지 않았다. 알코올 섭취로 인한 일시적인 근시화는 안압하강과 안구축의 길이변화와 관련성이 있을 것으로 판단된다.

• Journal of The Korean Society of Grassland and Forage Science
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• v.28 no.1
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• pp.49-60
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• 2008

A study was conducted to determine the effect of alcohol-fermented feedstuff formulated with byproducts on the fermentation characteristics and dry matter disappearance in the rumen. Dietary treatments were either a soybean curd-based alcohol-fermented feedstuff(AFS) and brewery grain-based alcohol-fermented feedstuff(AFB). The AFS and AFB are composed of 50% commercial beef cattle feed, 50% soybean curd dreg, 5% molasses and 0.5% yeast, and 25% commercial beef cattle feed, 25% brewery grain, 25% soybean curd dreg, 25% corn grit, 5% molasses and 0.5% yeast, respectively. The ruminally cannualted Korean cattle were utilized to investigate the change of ammonia, pH alcohol, volatile fatty acids, and DM digestibility at 0, 2, 4, 8 and 12 hr after feeding. The rumen ammonia concentrations were significantly lower in AFS and AFB with incubation time, especially at 6 hr incubation(AFS, 0.7 mg/dl; AFB, 1.5 mg/dl; control 2.5 mg/dl). Lower rumen pH was observed in AFS and AFB during the early stage of incubation, but no significant difference was found at late stage of incubation. The total VFA concentrations were not affected by diet treatments at 2 hr incubation time, but the concentration significantly decreased after that. The dry matter disappearance was significantly lower in AFS and AFB during the early stage of incubation. However, the dry matter disappearance of AFS and AFB was similar to that of control during the late stage of incubation. It is concluded that the industrial byproducts such as soybean curd dreg and brewery grain were effective materials to make an alcohol fermented feedstuffs and resulted in better fermentation characteristics in the rumen when both were applied to Hanwoo.

• The Journal of the Convergence on Culture Technology
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• v.6 no.3
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• pp.381-392
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• 2020

This study is purposed to check up the natural 12 kinds of herbal extracts suitable for hangover and based on the results of contents of phenolic compounds, ABTS radical scavenging activity, alcohol dehydrogenase (ADH), and acetaldehyde dehydrogenase (ALDH). Selected 8 kinds of herbal extracts are blended according to the efficacy and the pearson's correlation between each content and activity. C. sinensis var. sinensis, P. densiflora Gnarl and P. lobata Ohwi showed excellent ADH activity, P. lobata Ohwi had a strong correlation between the content and efficacy, and C. sinensis var. sinensis, P. densiflora Gnarl had a negative correlation. Through the ADH and ALDH activity test of F.1 to F.7, the F.7 showed the highest synergic effect and selected as an optimal formulation. F.7 intake-group, the breath alcohol concentration was significantly reduced to 58% after 30 minutes and 27% after 120 minutes, compared to right after alcohol consumption. After alcohol consumption, there was a significant improvement effect (p<0.05) in tired and thirst in the intake group compared to the non-intake group.