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Production and biological applications for marine proteins and peptides- An overview (해양생물로부터 기능성 펩티드의 생산 및 응용)

  • Kim, Se-Kwon;Byun, Hee-Guk
    • Food Science and Industry
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    • v.51 no.4
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    • pp.278-301
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    • 2018
  • Although more than 80% of living organisms are found in marine ecosystems, only less than 10% of marine resources have been utilized for human food consumptions and other usages. It is well known that marine resources (fish, shellfish and algae) have exceptional nutritional properties; however, their functional characteristic has not been completely discovered. It is believed that metabolites (organic compounds, proteins, peptides, lipids, minerals, etc.) play an important role to show its biological properties. Marine proteins and peptides are considered to be future drugs due to their excellent biological activities with a fewer adverse side effect. Marine peptides show several biological activities, including antimicrobial, antioxidant, anti-inflammatory, anti-cancer, anti-viral, anti-tumor, anti-diabetic, anti-hypertensive, anti-coagulant, immunomodulatory, appetite suppressing and neuroprotective effects. Therefore, the pharmaceutical, nutraceutical, and cosmeceutical companies have been paid attention to the marine peptides to commercialize into products. This current review mainly focused on the above mentioned biological activities of marine peptides and protein hydrolysates as a functional food and pharmaceutical applications. To commercialize these materials in industrial level required large quantity in high-purity level, and it is complicated to produce huge quantity from the marine resources due to insufficient raw materials, unavailability of raw materials through a year, hinder the growth with geographical variations, and availability of compounds in extreme small quantities. The best solution for these issues is to introduce new modern technologies such as artificial intelligence robots, drones, submersibles and automated raw material harvesting vessels in farming industries instead of man power, which will lead to 4th industrial revolution.

Understanding policies regarding intangible cultural treasures and directions for improvement to promote the continuing tradition of Pansori (판소리 전승 활성화를 위한 무형문화재 제도의 이해와 개선 방향)

  • Choi, Hye Jin
    • (The) Research of the performance art and culture
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    • no.36
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    • pp.289-312
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    • 2018
  • Pansori has been passed down over several generations and over time have undergone continued change in accordance with the times, as well as the skills and ability of the singer. Policies regarding intangible cultural treasures were established to preserve and promote the continuing tradition of art forms including Pansori and thus must spare no effort in supporting and preserving the genre. As such, for proper implementation of the newly legislated law, it is necessary to review the agents who pass down the tradition of Pansori and whether there are any areas that need to be changed in terms of our perception of culture in general. Pansory in the $21^{st}$ century features both contemporary aspects and mass appeal and have undergone many changes in how it is enjoyed. It is our responsibility therefore, to establish how the art and universality of Pansori should be promoted. From this perspective, this study reviewed the evolution of law on intangible cultural treasures, the current status of intangible cultural treasures being passed down with a focus on national treasures and those of Jeonbuk Province to shed light on issues. Diversification is needed in the number of those who carry this intangible cultural treasure, as well as the number of categories. To that end, a survey index or practical ability index must be taken into account for the application and designation of intangible cultural treasures. The study also noted issues of the categories for designation as intangible cultural treasures and discussed directions for improvement. In the case of Pansori, suggestions for improvement were presented for the designation of skilled artists by school, regular surveys and regular application, increased role of artists for increased mass appeal, survey of regional singers, supervision and monitoring of skilled artists and establishment of a manual for the education on how to pass down the art form. In doing so, efforts should be made to make the passing down of Pansori more active and related education more systematic. Since we are in the early years of the law on intangible cultural treasures being implemented, areas of improvement will continue to be identified. It is however certain that the proper support for the art form to be handed down should be done in a way where law and culture are complementary given that Pansori is not just a Korean tradition, but a tradition of mankind.

The Tresnds of Artiodactyla Researches in Korea, China and Japan using Text-mining and Co-occurrence Analysis of Words (텍스트마이닝과 동시출현단어분석을 이용한 한국, 중국, 일본의 우제목 연구 동향 분석)

  • Lee, Byeong-Ju;Kim, Baek-Jun;Lee, Jae Min;Eo, Soo Hyung
    • Korean Journal of Environment and Ecology
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    • v.33 no.1
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    • pp.9-15
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    • 2019
  • Artiodactyla, which is an even-toed mammal, widely inhabits worldwide. In recent years, wild Artiodactyla species have attracted public attention due to the rapid increase of crop damage and road-kill caused by wild Artiodactyla such as water deer and wild boar and the decrease of some species such as long-tailed goral and musk deer. In spite of such public attention, however, there have been few studies on Artiodactyla in Korea, and no studies have focused on the trend analysis of Artiodactyla, making it difficult to understand actual problems. Many recent studies on trend used text-mining and co-occurrence analysis to increase objectivity in the classification of research subjects by extracting keywords appearing in literature and quantifying relevance between words. In this study, we analyzed texts from research articles of three countries (Korea, China, and Japan) through text-mining and co-occurrence analysis and compared the research subjects in each country. We extracted 199 words from 665 articles related to Artiodactyla of three countries through text-mining. Three word-clusters were formed as a result of co-occurrence analysis on extracted words. We determined that cluster1 was related to "habitat condition and ecology", cluster2 was related to "disease" and cluster3 was related to "conservation genetics and molecular ecology". The results of comparing the rates of occurrence of each word clusters in each country showed that they were relatively even in China and Japan whereas Korea had a prevailing rate (69%) of cluster2 related to "disease". In the regression analysis on the number of words per year in each cluster, the number of words in both China and Japan increased evenly by year in each cluster while the rate of increase of cluster2 was five times more than the other clusters in Korea. The results indicate that Korean researches on Artiodactyla tended to focus on diseases more than those in China and Japan, and few researchers considered other subjects including habitat characteristics, behavior and molecular ecology. In order to control the damage caused by Artiodactyla and to establish a reasonable policy for the protection of endangered species, it is necessary to accumulate basic ecological data by conducting researches on wild Artiodactyla more.

Ginsenosides from the fruits of Panax ginseng and their cytotoxic effects on human cancer cell lines (인삼(Panax ginseng) 열매로부터 분리한 ginsenoside의 동정 및 암세포독성 효과)

  • Gwag, Jung Eun;Lee, Yeong-Geun;Hwang-Bo, Jeon;Kim, Hyoung-Geun;Oh, Seon Min;Lee, Dae Young;Baek, Nam-In
    • Journal of Applied Biological Chemistry
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    • v.61 no.4
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    • pp.371-377
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    • 2018
  • The fruits of Panax ginseng were extracted with 80% aqueous MeOH and the concentrates were partitioned into EtOAc, n-BuOH, and $H_2O$ fractions. The repeated $SiO_2$ and octadecyl $SiO_2$ column chromatographies for the EtOAc fraction led to isolation of five ginsenosides. The chemical structures of these compounds were determined as ginsenoside F1 (1), ginsenoside F2 (2), ginsenoside F3 (3), ginsenoside Ia (4), notoginsenoside Fe (5) based on spectroscopic analyses including nuclear magnetic resonance, MS, and infrared. Compounds 2-5 were isolated for the first time from the fruits of P. ginseng in this study. All isolated compounds were evaluated for cytotoxic activities against human cancer cell lines such as HCT-116, SK-OV-3, human cervix adenocarcinoma (HeLa), HepG2, and SK-MEL-5. Among them compounds 2, 4, and 5 showed significant cytotoxicity on cancer cells. Compound 2 exhibited cytotoxicity on SK-MEL-5, HepG2, and HeLa cells with $IC_{50}$ values of 82.8, 86.8, and $78.3{\mu}M$, respectively. Compound 4 showed cytotoxicity on HCT-116, SK-MEL-5, SK-OV-3, HepG2, and HeLa cells with $IC_{50}$ values of 24.5, 25.4, 26.3, 22.0, and $24.9{\mu}M$, respectively. Compound 5 did on SK-MEL-5 cell with $IC_{50}$ value of $81.7{\mu}M$. The cytotoxicity of ginsenoside 2, 4, and 5 isolated from the fruits of Panax ginseng showed strong inhibition effect against on cancer cells, all of which have a glucopyranosyl moiety on C-3.

A Critical Review about Application of IUCN Red List Criteria at Regional Level to Korean Endangered Vascular Plants Assessed by the Ministry of Environment, Republic of Korea (환경부 멸종위기 관속식물 지정 기준으로 사용된 IUCN 지역 적색목록 평가 분석)

  • Chang, Chin-Sung;Kwon, Shin-Young;Son, Sungwon;Kim, Hui
    • Journal of Korean Society of Forest Science
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    • v.107 no.4
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    • pp.361-377
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    • 2018
  • The aim of this study was to examine whether the guideline by the Ministry of Environment (ME) successfully and appropriately applied the IUCN Red List criteria at regional level and the rare and endangered national list considered eligible. A certain number of vascular plants, which are widely distributed in the world or in east Asia, deemed to be ineligible for assessment at a regional level as Not Applicable category (NA), because it occurs at very low numbers in South Korea. Among 377 vascular plant taxa evaluated by the ME, NA included 238 species, which represented 63.1%. The number of synonymized species or illegitimate name species were 13 species, which accounted for 3.4%. 21 species (9.3%) were threatened at global level and 103 species were possibly candidates species list for Red List assessments at regional level in the near future. The proportion of NA or waiting list was 66.6% among the list assessed by the ME. The most common errors involved incorrectly application of species extinction in case of population extinction in South Korea to the assessment and provided incorrect interpretation of the Red List criteria at regional level. The most assessments proposed by ME were not backed up without quantitative data quality, justifications, and sources. It is suggested that the risk of extinction should be reassessed at least in the Korean peninsula within the light of their overall distribution including far eastern Russia and North eastern China in north and for Japan and Taiwan in south for regional assessment. The results obtained here using the IUCN criteria at regional level showed that the list proposed by the ME produced an overestimation of the number of threatened vascular plants. Also, the misapplication of the term 'species extinction' for regional assessment was open to some degree of subjectivity and misinterpretation.

A Study on the Conditions of Natural Damage of Undesignated Cultural Heritages and the Plans to Reduce Damage through Vegetation Management - With Emphasis on Samcheonsaji Temple Site on Mt. Bukhansan - (비지정 문화유적의 훼손현황과 식생관리를 통한 저감방안 연구 -북한산 삼천사지를 사례로-)

  • Hong, Hee-taek;Kim, Hyeon-beom;Lee, Mun-haeng
    • Korean Journal of Heritage: History & Science
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    • v.46 no.3
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    • pp.114-133
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    • 2013
  • This study aims to identify the natural damage of the Samcheonsaji Temple Site in Bukhansan National Park and to suggest the plans to minimize damage for the remains. The types of natural damage are classified into direct vegetation damage, indirect topographical damage, and artificial damage. The most popular causes of damage to temple sites include the roots of trees as direct vegetation damage and the soil erosion by rain or stream as topographical damage. Direct vegetation damage includes burial remains damaged by the root of trees and vines, but it is often observed that some trees have contributed to protection against collapse. Indirect topographical changes have damaged the ruins by soil erosion caused by floods or typhoons. Vegetation changes due to topographical reasons have also caused damage. Artificial reasons of damage include forestry operations and compaction by hikers. Based on the analysis of the findings, the following could be suggested as plans to resolve these problems: 1. Natural damage occurs slowly due to negligence. Therefore, it could be reduced by forestry improvement, including forest density control through thinning, planting to prevent landslides, maintaining grasslands nearby. 2. Deciduous broadleaf trees can be planted to reduce soil erosion by rainfall. It is necessary to maintain the density of forests at around $0.02{\sim}0.18trees/m^2$. 3. It would be good to grow Quercus spp and Carpinus spp or weaken the community of Robinia pseudoacacia and Pueraria lobata which disturb the ecosystem. Samcheonsaji Temple Site is located in Mt. Bukhan National Park that is a publicly owned property. Therefore, it is constantly maintained for natural preservation and vegetation management could be considered for the preservation of historical remains.

Successful Management and Operating System of a UNESCO World Heritage Site - A Case Study on the Wadi Al-Hitan of Egypt - (유네스코 세계자연유산의 성공적인 관리와 운영체계 - 『이집트 Wadi Al-Hitan』의 사례 -)

  • Lim, Jong Deock
    • Korean Journal of Heritage: History & Science
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    • v.44 no.1
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    • pp.106-121
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    • 2011
  • The number of World Natural Heritage Sites is smaller than that of World Cultural Heritage Sites. As of 2010, the total number of natural sites was 180, which is less than 1/3 of all cultural sites. The reason why the number of natural sites is smaller can be attributed to the evaluating criteria of OUV(outstanding universal value). Only 9 fossil related sites were designated as World Heritage Sites among 180 Natural Sites. This study compares their OUVs including the academic value and characteristics of the 9 World Heritage Sites to provide data and reference for KCDC(Korean Cretaceous Dinosaur Coast) to apply as a World Natural Heritage Site. This study was carried out to obtain information and data on the Wadi Al-Hitan of Egypt which was designated as a World Natural Heritage Site. The study includes field investigation for whale fossils, interviews of site paleontologists and staff, and inspections of facilities. Three factors can likely be attributed to its successful management and operating system. First, there is a system for comprehensive research and a monitoring plan. Secondly, experts have been recruited and hired and professional training for staff members has been done properly. Finally, the Wadi Al-Hitan has developed local resources with specialized techniques for conservation and construction design, which matched well with whale fossils and the environment at the site. The Wadi Al-Hitan put a master plan into practice and achieved goals for action plans. To designate a future World Natural Heritage Site in Korea, it is important to be recognized by international experts including IUCN specialists as the best in one's field with OUV. Full-time regular-status employees for a research position are necessary from the preparation stage for the UNESCO World Heritage Site. Local government and related organizations must do their best to control monitoring plans and to improve academic value after the UNESCO World Heritage Site designation. As we experienced during the designation process of Jeju Volcanic Island and Lava Tubes as the first Korean World Natural Heritage Site, participation by various scholars and specialists need to be in harmony with active endeavors from local governments and NGOs.

Insect Fauna Status of Nature Reserve Areas in Korea (국내 천연보호구역의 곤충상 현황)

  • An, Seung Lak
    • Korean Journal of Heritage: History & Science
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    • v.42 no.1
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    • pp.72-87
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    • 2009
  • This research is insect diversity analysis on the basis of survey results and bibliographies of Hongdo Island, Mts. Seoraksan, Hallasan, Daeamsan & Daeusan, Hyangnobong peak & Geonbongsan nature reserves and Dokdo Protected Natural Area among 10 designated nature reserves. The Mt. Hallasan nature reserve has 1,867 species in 22 orders and shows the highest species diversity. The species diversities of Mt. Seoraksan, Mt. Hyangnobong peak & Geonbongsan, Hongdo Island, Mt. Daeamsan & Daeusan, and Dokdo Protected Natural Area reveal 1,604 species in 19 orders, 704 species in 18 orders, 474 species in 19 orders, 468 species in 16 orders, and 114 species in 11 orders, respectively, in descending order. The order Lepidoptera shows as dominant taxa in Hongdo, Seoraksan, Hallasan, Hyangnobong peak & Geonbongsan, whereas the order Coleoptera as subdominant taxa in these areas. On the other hand, in Mt. Daeamsan & Daeusan, and Dokdo Protected Natural Area, the order Coleoptera appears as dominant taxa whereas the order Lepidoptera as subdominant taxa. The order Ephemeroptera has been shown the highest species diversity in Seoraksan which is reported to 25 species, Odonata in Hallasan to 28, Dermaptera in Seoraksan to 9, Orthoptera in Hallasan to 51, Hemiptera in Hallasan to 175, Homoptera in Seoraksan to 126, Hymenoptera in Hallasan to 183, and Diptera in Hallasan to 206. The species diversity is generally poor in Daeamsan & Daeusan, Hyangnobong peak & Geonbongsan, and Dokdo Protected Natural Area. Maybe this result is caused by the lack of various academic surveys compared to the other areas. It is needed to study systematic academic investigation on insect in the nature reserve areas in Korea, and to plan appropriate management and conservation on natural environment considering biodiversity of each nature reserve area.

The Landscape Value of Asan Oeam-ri's Folk Village as Cultural Heritage (아산 외암마을 토속경관의 문화유산적 가치)

  • Shin, Sang Sup
    • Korean Journal of Heritage: History & Science
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    • v.44 no.1
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    • pp.30-51
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    • 2011
  • During the process of modernization, many rural villages in Korea have experienced degeneration and breakdown, losing sustainability. However, Oeam village in Asan City, South Chungcheong Province (State-designated cultural heritage, Important Folk Material No. 236) has established itself as a unique folk village, which evolves with sustainability, pursuing the revival of Neo-traditionalism. Oeam village is a tribal village of the Yis from the Yean region and has maintained environmental, economic, and social sustainability and soundness for over five centuries. Thus, the village has sustained itself well enough to be a cultural asset with 'Outstanding Universal Value', in terms of its value as world cultural heritage. The village maintains its own identity, filled with a variety of traditional and scenic cultural assets that symbolize a gentry village. Those assets include Confucian sceneries (head family houses, ancestral shrines, tombs, gravestones, commemorative monuments, and pavilions), various assets of folk religion (totem poles, protective trees at the entrance of a village, shrines for mountain spirits, village forests), tangible and intangible cultural assets related to daily lives (vigorous family activities, rigorous ancestral rituals, family rituals, collective agriculture and protection of ecosystem), which have all been well preserved and inherited. In particular, this village is an example of a well-being community with a well-preserved folksy atmosphere, which is based on environmentally sound settlements (nature + economy + environment + community) in a village established according to geomancy, East Asia's unique principle of environmental design. In addition, the village has kept the sustainability and authenticity for more than 500 years, combining restraint towards the environment and the view of the environment which respects the natural order and cultural values (capacity + healthy + sustainability). Therefore, the Oeam folk village can be a representative example of a folksy and scenic Korean community which falls into the category of IV (to exemplify an outstanding type of building, architectural or technological ensemble, or landscape which illustrates significant stages in human history) and V (to exemplify an outstanding traditional human settlement, land-use, or sea-use which is representative of cultures, or human interaction with the environment especially when it has become vulnerable under the impact of irreversible change) of Unesco's World Cultural Heritage.

Historical Studies on the Nameless Buildings at the Jondeokjeong Area in Donggwoldo (동궐도상의 존덕정 영역에 나타난 무편액 건물의 조영사적 고찰)

  • Jung, Woo Jin;Sim, Woo Kyung
    • Korean Journal of Heritage: History & Science
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    • v.45 no.1
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    • pp.148-173
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    • 2012
  • The rear garden in Donggwol Palace which shared with the Changdeok Palace and the Changgyeong Palace is the salient places of technology and idea reflected the phases of the times of the Joseon Dynasty, so it is certainly one of the best Korean garden cultures. The rear garden in Donggwol which was not only the secret garden for the rest of royal family but also used as symbolic places for the various ceremonies and training its human resources has been considerably destroyed through the period of Japanese colonial rule. Thus the rear garden areas at north of Changkyung Palace were entirely transformed and a few territory from Juhabru(宙合樓) to Ongnyucheon(玉流川) keep up its surviving as the rear garden. The area of Jondeokjeong(尊德亭) which become subject on this studies from among these was constructed as flower garden after development of Ongnyucheon. The areas of Simchujeong(深秋亭), Cheoknoedang(滌惱堂), Pyemwoosa(?愚?), Mangchunjeong(望春亭), Chunhyagak(天香閣), Chungsimjeong(淸心亭) around Jondeokjeong, were situated among the beautiful scenery with the flowers and ponds. But there are only Jondeokjeong and Pyemwoosa at this moment, and the other pavilions was destroyed and transformed. For these reasons, in this studies, the formative purposes were investigated through analysing water elements, planting, ornaments and so on. According to these reasons, historical records and realities of garden construction of five pavilions : Simchujeong, Mangchunjeong, Cheoknoedang, Chunhyagak, Chungyeongak(淸燕閣) were considered to give authenticity to the restoration and reorganization as well as to accumulate basic knowledge about the conservation of environment surrounded garden architectures. These pavilions appeared at Gunggwolgi(宮闕志) and Joseonwangzosilok(朝鮮王朝實), but their names were not appeared at Donggwoldo(東闕圖). So they were ascertained through all of literatures on Donggwol Palace. Cheoknoedang and Simchujeong among these buildings could be found out as the existed buildings and the uncertain building at the northwest of Jondeokjeong was estimated as the name to Chunhyagak or Mangchunjeong. And the hypothesis that the wall surrounding Taichungmoon(太淸門) should be belong to Chungyeongak was supported. In addition, the area which did not known in connection with name and use on northeast at the Changdeok Palace, and had regarded as an impasses in the studies of Donggwoldo and the rear garden in Donggwol Palace, but the historical records of using by Yeonsangun(燕山君) and Sukjong(肅宗) were discovered at this study. And it could be uncovered that the obscure spatial space was a separate house only for king and he enjoyed play there unnoticing to others belong to palace.