• Information and Communications Magazine
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• v.29 no.11
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• pp.68-74
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• 2012

국내 차세대 이동통신 산업은 1994년 세계 최초 CDMA 상용화에 이은 CDMA2000 및 W-CDMA 구축, 세계 최초 최고의 무선 인터넷 기술인 WiBro기술의 개발 및 보급, 꿈의 통신으로 여겨지는 3.9세대 LTE시스템 구축과 보급으로 세계 최고의 뛰어나 기술력을 가진 산업으로 발전하였다. 이러한 우수한 국내 이동 통신 인프라는 기존의 조선 및 선박과 같은 전통산업과 바이오 및 의료기기와 같은 신산업과의 융합을 통하여 국가 경쟁력 한층 더 향상 시키는데 기여하였다. 또한 휴대폰분야에서도 국내 기업이 세계 최고의 경쟁력을 가진 기업으로 성장하는 등, 차세대이동통신 산업은 타 산업과 달리 기술의 빠른 추종자 (Fast Follower)에서 기술 선도자 (First Mover)로서의 지위를 가지게 되었다. 그러나, 이동통신 시스템 분야에서는 이미 중국 업체가 세계적으로 약진하고 있으며, 휴대폰 분야에서는 선도 기업과의 경쟁 및 견제, 후발 주자인 중국 및 대만 기업의 추격에 직면하고 있다. 한편 국내 휴대폰관련 중소 중견기업은 급격한 단말 환경변화에 따라 많은 어려움에 처해 있다. 따라서 본 논문에서는 차세대 이동통신 기술 선도자로서 지속적인 경쟁력 확보 및 대-중소기업 동반성장 생태계 조성을 통한 모바일 최강국 달성을 위한 이동통신 분야 국가 연구 개발 전략을 제시하고자 한다. 먼저 제I장에서는 차세대이동통신의 개념 및 분류 기준에 대하여 알아보고, 제II장에서는 차세대이동통신에 대한 국내외 현황과 국내 기술 수준 및 기술 경쟁력을 고찰한다. 제III장에서는 기술 선도자로서의 차세대이동통신 분야의 비젼을 제시하고, 이러한 비젼을 실현시키기 위한 국가연구개발 추진 전략을 제시한다. 마지막으로 제IV장에서는 우리나라 이동통신 미래상과 함께 국가연구개발 전략에 대한 결론을 맺는다.

• Microbiology and Biotechnology Letters
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• v.43 no.4
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• pp.401-404
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• 2015

Bacillus coagulans has been considered to be a prominent candidate for probiotics as well as a thermotolerant biomaterial producer. However, the species has not attracted the attention of Korean researchers, nor has it been commercialized in Korea. Therefore, isolates for functional studies are not readily available. To secure B. coagulans resources for future applications, we developed a rapid isolation method for the species from rice straw. Introduction of the enrichment culture at $50^{\circ}C$, the selection of acid producers with $CaCO_3$ supplemented medium, and the elimination of enterococci by selective medium, rendered the successful and rapid isolation of B. coagulans strains.

• Journal of the Korea Convergence Society
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• v.10 no.11
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• pp.95-100
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• 2019

In this paper, autonomous vehicles of service with existing vehicle accident for the prevention of the vehicle communication technology, self-driving techniques, brakes automatic control technology, artificial intelligence technologies such as well and developed the vehicle accident this occur to death or has been techniques, can prepare various safety cases intended to minimize the injury. In this paper, it is a study to secure safety in autonomous vehicles. This is determined according to spatial factors such as chip signals for general low-power short-range wireless communication and micro road AI. On the other hand, in this paper, the safety of boarding is improved by checking the signal from the electronic chip, up to "recognition of the emotion from residence time in the sensing area" to the biological electronic chip. As a result of demonstrating the reliability of the world countries the world, inducing safety autonomous system of all passengers in terms of safety. Unmanned autonomous vehicle riding and commercialization will lead to AI systems and biochips (Verification), linked IoT on the road in the near future, and the safety technology reliability of the world will be highlighted.

• Korean Journal of Pharmacognosy
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• v.52 no.4
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• pp.242-250
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• 2021

Artemisia frigida Willd (AW, Fringed sagewort), which is widespread in Mongolia, is a well-known medicinal plant as a member of the Compositae family. This study aims to explore the gastroprotective effect of water extract of AW on 150 mM HCl/60% ethanol-induced acute gastritis in 5 week old male ICR mice. Total polyphenols, total flavonoid contents, and anti-oxidant activity in vitro in AW were evaluated. First, the gross area of gastric mucosal damage was measured. Then western blot analysis was conducted to determine the possible mechanisms of action underlying the effects of AW. AW administration decreased gastric mucosal damage. Moreover, the group with AW treatment effectively inhibited nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression associated with oxidative stress. AW treatment enhanced an anti-oxidant effect through the increase of anti-oxidant proteins. Besides, the increased expressions of inflammatory cytokines induced by nuclear factor-kappa B (NF-κB) activation are alleviated through AW treatment. Taken together, AW exerted a gastroprotective effect against gastric mucosal damage. These results indicate that AW could have the potential used as a natural therapeutic drug for the treatment of acute gastritis.

• The Journal of the Korea Contents Association
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• v.19 no.7
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• pp.323-334
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• 2019

The purpose of this study is to propose agenda concerning the direction of agricultural science convergence research and development (R&D) under the fourth industrial revolution. For this study, we apply the Analytic Hierarchy Process (AHP) targeted at experts in the fields of agricultural academia and research operating R&D currently. Results suggest the following agendas; first, human resource training toward future is more emphasized rather than fragmentary technology innovation. Second, a flexible road map for agricultural science R&D need to be made for responding to short and long term issues relevant to the innovation. Third, mutual exchange and cooperative system need to be constructed between academia and research in order to create synergy effects. Finally, both institutional improvement and humanistic literacy should be emphasized for rapidly changing conditions and better human life under the fourth industrial revolution.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.528-532
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• 2019

The dorsal root ganglion (DRG) was isolated from mouse embryos and Schwann cells and neuronal cells were cultured in vitro. The neurons and Schwann cells were cultured separately and the two kinds of cells were cultured together for three weeks. Generation of myelination was confirmed by transmission electron microscope and confocal microscope using a myelinaion protein, myelin protein zero (MPZ) antibody. The sindbis virus was infected for three days in the myelinated culture cells and then demyelination was carried out. The process of demyelination was also confirmed by transmission electron microscopy and confocal microscopy using myelin protein zero (MPZ) antibody. The study was supported by a Basic Research Program through the National Research Foundation (NRF) funded by the Ministry of Science and Technology, ICT and Future Plans (NRF-2016R1A2B4016552 and 2017R1A2B3005753).

• Korean Journal of Pharmacognosy
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• v.52 no.3
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• pp.177-185
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• 2021

Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder in which stomach contents reflux into the esophagus, causing complications such as mucosal damage. The purpose of this study was to determine the effect of Rhei Rhizoma and Scutellariae Radix mixture (RS) in chronic acid reflux esophagitis (CARE), one of the GERD. After inducing reflux esophagitis through surgery, the group was separated and the drug was administered for 2 weeks; Normal rats (Normal, n=8), chronic acid reflux esophagitis rats (Control, n=8), tocopherol 30 mg/kg-treated chronic acid reflux esophagitis rats (Toco, n=8), Rhei Rhizoma and Scutellariae Radix mixture 100 mg/kg-treated chronic acid reflux esophagitis rats (RSL, n=8), Rhei Rhizoma and Scutellariae Radix mixture 200 mg/kg-treated chronic acid reflux esophagitis rats (RSH, n=8). Gross lesion of esophageal mucosa after RS treatment showed a superior enhancement compared with that of Control group. Additionally, RS significantly decreased the levels of MPO and MDA, effectively inhibited NADPH oxidase, and regulated the expression of the AMPK/LKB1/NF-κB pathway. Moreover, it significantly increased the expression of tight junction proteins. Taken together, RS not only alleviates inflammation of the esophageal mucosa via the AMPK/LKB1/NF-κB pathway by reducing oxidative stress, but also improves esophageal function by modulating tight junction proteins.

• Journal of Industrial Convergence
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• v.20 no.6
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• pp.7-15
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• 2022

Recently, due to the development of AI and big data technologies following the advent of the era of the 4th Industrial Revolution, the emerging metaverse industry is emerging as a new business, and in particular, from this point of view, this paper analyzes the history of metaverse and the pros and cons of "Geppetto", which is the most popular in the Korean metaverse market, and aims to give an appropriate direction for future development based on this. In order to carry out this study, we first used SWOT analysis techniques as an initial enterprise analysis method to examine the strengths and weaknesses, opportunities and threat requirements, and derive the status of each factor. Based on the factors in each of the subsequent derivatives, we wanted to explore the TOWS development strategy and present significant implications based on this.

• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.738-750
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• 2022

Objective: Alcohol is known to cause inflammation in the stomach by decreasing the protective substances of the gastric mucosa and increasing oxidative stress. The purpose of this study was to investigate the anti-inflammatory effect of Artemisiae Argyi Folium extract (AF) on alcohol-induced gastritis. Methods: The total polyphenol and flavonoid contents of AF were confirmed through an in vitro experiment. Radical scavenging activities were confirmed using DPPH and ABTS assays. In vivo experiments were conducted on mice divided into 5 groups (n=8): a normal group (Nor), an alcohol-induced gastritis group (Con), an alcohol-induced gastritis group administered 10 mg/kg sucralfate (SC), an alcohol-induced gastritis group administered 100 mg/kg AF (AFL), and an alcohol-induced gastritis group administered 200 mg/kg AF(AFH). The serum levels of reactive oxygen species (ROS) were determined, and protein expressions were confirmed in gastric tissues. Results: In alcohol-induced gastritis, AF alleviated damage to the gastric mucosa caused by alcohol. AF also decreased the serum ROS levels. Western blots showed that AF decreased the expression of NADPH oxidase and decreased the expression of the NF-κB pathway associated with inflammation. AF also decreased the expression of adhesion molecules and chemokine proteins, and increased the expression of anti-inflammatory proteins. Conclusions: AF not only reduced oxidative stress in alcohol-induced gastritis, but it also relieved gastric mucosal inflammation by regulating the expression of the NF-κB pathway.

• The Korea Journal of Herbology
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• v.37 no.5
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• pp.17-26
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• 2022

Objective : The aim of the present study is to examine hepatic lipid-lowering and anti-inflammatory effects of silymarin combined with Jakyakgamcho-tang on non-alcoholic fatty liver disease in a high fat diet-induced obese mice model. Methods : C57BL/6 mice were divided into four dietary groups: (1) Normal, (2) Control (60% high-fat diet), (3) Control + silymarin 50 mg/kg/day (Silymarin), (4) Control + Silymarin 50 mg/kg/day + Jakyakgamcho-tang 100 mg/kg/day (SPG). After 12 weeks administration, mice were sacrificed and lipids and inflammation-related biomarkers were analyzed liver and plasma. Results : Silymarin and SPG treatments significantly lowered body and liver weights compared to the Control. Serumlipids (triglyceride (TG), total cholesterol) and pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin 1𝛽, and IL-6) concentrations were significantly lowered in the Silymarin and SPG groups than the Control group. Silymarin and SPG treatments suppressed hepatic TG level and hepatic lipid droplets compared to the Control. Theses two treatments significantly increased hepatic kinase B1 and AMP-activated protein kinase protein levels, and significantly decreased hepatic key lipogenic enzymes (acetyl-CoA carboxylase, fatty acid synthase and stearyl coenzyme A desaturase 1) protein levels than the Control. SPG also significantly increased hepatic fatty acid oxidation-related protein (peroxisome proliferator-activated receptor alpha and uncoupling protein 2) levels than the Control. Conclusions: Silymarin and SPG suppressed hepatic lipid accumulation by regulating hepatic protein expression, and lowered blood pro-inflammatory cytokines concentrations though the synergic effect of silymarin and Jakyakgamchotang was not clear.