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http://dx.doi.org/10.22889/KJP.2021.52.4.242

Gastroprotective Effect of Artemisia frigida Willd in HCl/Ethanol-induced Acute Gastritis  

Oh, Min Hyuck (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Lee, Se Hui (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Park, Hae-jin (DHU Bio Convergence Testing Center)
Shin, Mi-rae (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Sharav, Bold (Traditional Medical Research Institute)
Roh, Seong-soo (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Publication Information
Korean Journal of Pharmacognosy / v.52, no.4, 2021 , pp. 242-250 More about this Journal
Abstract
Artemisia frigida Willd (AW, Fringed sagewort), which is widespread in Mongolia, is a well-known medicinal plant as a member of the Compositae family. This study aims to explore the gastroprotective effect of water extract of AW on 150 mM HCl/60% ethanol-induced acute gastritis in 5 week old male ICR mice. Total polyphenols, total flavonoid contents, and anti-oxidant activity in vitro in AW were evaluated. First, the gross area of gastric mucosal damage was measured. Then western blot analysis was conducted to determine the possible mechanisms of action underlying the effects of AW. AW administration decreased gastric mucosal damage. Moreover, the group with AW treatment effectively inhibited nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression associated with oxidative stress. AW treatment enhanced an anti-oxidant effect through the increase of anti-oxidant proteins. Besides, the increased expressions of inflammatory cytokines induced by nuclear factor-kappa B (NF-κB) activation are alleviated through AW treatment. Taken together, AW exerted a gastroprotective effect against gastric mucosal damage. These results indicate that AW could have the potential used as a natural therapeutic drug for the treatment of acute gastritis.
Keywords
Artemisia frigida Willd; Gastroprotective; Oxidative stress;
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