• Korean Journal of Psychosomatic Medicine
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• 제7권1호
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• pp.51-60
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• 1999

This study was designed to evaluate anxiety & depression symptoms and pressure pain threshold in patients with posttraumatic stress disorder(n=23) and to find out the relationship between the affective symptoms and the pressure pain threshold scores. And this was compared with healthy control subjects(n=18). The scores of pressure pain threshold were checked with algometer. The results were as follows : PTSD patients showed higher scores of anxiety & depression symptoms than that of the control group. In contrast with our hypothesis, pressure pain threshold in PTSD patients presented statistically significant higher scores than that of the control group. These results may be derived from following factors. First, chronic depression has influenced the pain perception of patients with PTSD rather than anxiety symptoms, second, abnormal state of the opiate system in PTSD patients, third, the sick role of the PTSD patients, fourth, the socio-environmental factor of the PTSD patients. In conclusion, affective symptoms, especially depression, were related to the chronic pain in patients with PTSD, however, the causality of elevated pressure pain threshold was uncertain in this study. To understand more clearly the relation between affective symptoms and chronic pain, it will be necessary to control the other specific factors.

• The Journal of the Korea Contents Association
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• 제17권2호
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• pp.105-112
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• 2017

This study recognizes it as a social problem that can be prevented by basic research on safety security design for the elderly, and aims to clearly analyze risk factors for injury. For this study, raw data from the 6th Korean National Health and Nutrition Survey were employed and analyzed. Their social characteristics were classified with standards including gender, education, EuroQoL(human locomotion, normal activity and pain uncomfortableness), the quality of life(PHQ-(1)(2)(4)), recognition on stress, activity restriction status and associated causes(bone fracture and joint injury). Their epidemiological traits were chronic diseases, 'diabetes and hip-joint pain', and health-behavioral traits were 'smoking, breakfast frequency and high-level physical activity status.' In conclusion, it can be found that damage risk of elderly rose in case of female, lower education, inconvenience or limitation, pain or discomfort in locomotion and daily activities, higher recognition of stress, lower interest in work, feeling of depression, despair, and weariness, restriction in activity caused by bone fracture and joint injury, having diabetes and hip-joint pain, smoking, low frequency in having breakfast and high-level physical activities. Based on this study, we envision that an effective solution for injury risk factors caused by the organic relation can be reached in the near future.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제18권7호
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• pp.365-374
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• 2017

This study examined the effects of the demographic and health characteristics and chronic diseases on the health-related quality of life in service employees. From January 1, 2013 to December 31, 2014, this study analyzed the data on 607 service employees based on the 2nd data of the 6th National Health and Nutrition Examination Survey with at-test, ANOVA, and hierarchical regression analysis use of SPSS. The results of the analysis showed that the quality of Life in women was lower (${\beta}=-.074$, p=.050) than that of men, and the older the subjects were, the lower their quality of life(${\beta}=307$, p=.000). Regarding the subjective health status, there was a significant increase in the "very Poor"(${\beta}=186$, p=0.027) and "good"(${\beta}=196$, p=.001) status. The quality of life improved with increasing activity (${\beta}=-0.222$, p=0.000)). Some of the subjects perceived "high stress" (${\beta}=-0.123$, p=0.003) and the others perceived "low stress"(${\beta}=-0.176$, p=0.000). The less they perceived stress, the higher their quality of life. The factors explained 24.6％ of the health-related quality of life of the subjects. Therefore, to improve health-related quality of life of service employees, more activity opportunities should be given, the subjective health status should be positively perceived and psychological measures to decrease the level of stress should be developed.

• Proceedings of the KAIS Fall Conference
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• 한국산학기술학회 2011년도 춘계학술논문집 2부
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• pp.1076-1079
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• 2011

본 연구는 일개 광역시 주민들 4000명을 대상으로 일반적 특성, 건강행태 관련 특성, 신체비활동 정도를 조사하여 신체비활동의 유발요인에 대해 알아보고자 시행되었다. 그 결과를 요약하면 다음과 같다. 걷기운동 미실천 수준의 경우 연령, 교육수준, 의료보장, 직업, 기초생활수급유무, 독감 예방접종, 체중조절시도, 고위험음주, 스트레스 인지정도, 지역사회 운동프로그램참여, 운동시설의 접근성이, 중등도 이상의 운동 미실천의 경우, 성별, 연령, 월 소득, 가구소유, 건강검진 여부, 체중 조절 시도, 현재 흡연 여부, 지역 사회 운동 프로그램참여가 통계적으로 유의했으며, 이 변수들을 이용하여 신체비활동 수준을 결과변수로 하는 로지스틱 회귀분석을 시행하여, 걷기운동의 경우 20대에 비해서 30대가 1.46배, 40대가 1.57배 미실천률이 높고, 사무직이 전문행정관리직에 비해 1.37배, 체중조절을 시도하지 않은 군이 한 군에 비해 1.70배, 스트레스를 많이 느낀 군이 안 느낀 군에 비해 1.58배, 조금 느낀 군에 비해 1.38배, 운동시설 접근성이 어려운 군이 쉬운 군에 비해 1.75배정도 높은 것으로 분석되었고, 중등도 이상 운동의 경우 여자의 경우 남자에 비해 미실천율이 1.74배, 체중조절시도를 안한 군이 한 군에 비해 1.63배, 지역사회운동프로그램참여 안한 군이 한 군에 비해 2.36배 높은 것으로 나타났다. 고령화 사회로 가고 있는 현 상황에서 여러 가지 만성질환이 대두되고 있고, 이에 따른 신체활동의 중요성이 대두되고 있다. 하지만 우리나라의 경우 신체활동 실천율이 낮은 것이 현실이다. 신체활동의 실천율을 향상시키기 위해서는 신체비활동 결정짓는 요인들에 대해 우선 파악해야 한다. 분석결과 가장 차이가 나는 것은 운동시설의 접근성과 지역사회운동프로그램의 불참군에서 가장 신체비활동이 큰 것으로 파악되었다.

• Korean Journal of Adult Nursing
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• 제17권4호
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• pp.539-547
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• 2005

Purpose: To examine an estimate factor and grasp the relation of difference for Type A Behavior Pattern(TABP), Perceived Stress Questionnaire, Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the $19^{th}$ of October to 10th of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP).These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

• Journal of Life Science
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• 제20권5호
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• pp.760-767
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• 2010

The oxidative damage of lipids, protein, and DNA is known to be involved in not only chronic inflammations such as arthritis, hepatitis, nephritis, gastritis, colitis, and periodontitis but also metastasis. It has given impetus to searching for natural compounds without toxicity, which prevent the development of these diseases. The direct scavenging effects of aged black garlic extract (ABGE) were evaluated in vitro on DPPH radical, hydroxyl radical, hydrogen peroxide, and genomic DNA damage related to oxidative stress. Furthermore, its antioxidant effect on lipid peroxidation was investigated in human fibrosarcoma cells (HT1080), which were exposed to the hydroxyl radical generated by the Fenton reaction. It was observed that ABGE exhibited a greater inhibitory effect on hydrogen peroxide than other reactive oxygen species, and also blocked DNA oxidation and lipid peroxidation induced by the hydroxyl radical. The oxidative stress in live cells was also inhibited in the presence of ABGE. In addition, its inhibitory effects on the activity and expression of MMP-2 and -9 related to metastasis were determined using gelatin zymography and western blot. The data showed that it inhibited MMP-2 and -9 in PMA-stimulated HT1080 cells. Therefore, these results suggest that ABGE show potential as an excellent agent for prevention of metastasis related to oxidative stress.

• Korean Journal of Ecology and Environment
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• 제40권3호
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• pp.459-467
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• 2007

The effects of turbid water on fish community was investigated in a clear reference stream (the Bongsan Steam) and a turbid stream (the Daegi Stream) located in the upstream region of the South Han River, Korea. The stress index (SI) of suspended solids (SS) were calculated during a rain event concentration by the equation SI=LN (SS${\times}$duration). EMC of SS was $1{\sim}13$ mg $L^{-1}$ in the clear stream with a mean SI of 5.2, while SS was $97{\sim}1,150$ mg $L^{-1}$ in the turbid stream with a mean SI of 10.3. Even though the number of species was not much different, the dominant species of the two steams were distinctly different. The reference stream was dominated by upstream species such as Rhynchocypris kumgangensis, Brachymystax lenok tsinlingensis, and Cottus poecilopus which are typical upstream community. Whereas the turbid streams was dominated by Rhynchocypris kumgangensis, Zacco koreanus, and Orthrias nudus which are representatives of middle reache community. Fish density was four times higher in the clear steam than the turbid stream. In the similarity analysis of fish communities the community of the turbid stream showed large dissimilarity with other communities in other streams of similar size. In conclusion, although turbidity might be at the sublethal concentration, fish communities are under stress in some turbid streams of Korea that is strong enough to induce community change. It can be an example of a chronic ecological toxicity of turbidity at the community level.

• Proceedings of the KSCN Conference
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• 대한지역사회영양학회 2003년도 추계학술대회
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• pp.1079-1079
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• 2003

최근 노인인구의 증가와 함께 식생활의 변화에 의해 사망원인의 변화가 일어나고 있다 한국인의 주요 사망원인 중 뇌혈관 및 심장질환 등 순환기계 질환에 의한 사망이 증가하고 있는 추세이며, 심장순환계 질환의 위험요인인 고혈압의 이환률도 65세 이상 노인에게서 증가하고 있다. 고혈압은 만성질환으로 산화적 스트레스를 증가시키는 질환이므로 본 연구에서는 건강한 노인과 고혈압 노인의 체내 항산화 영양상태를 비교하기 위해 울산지역 50세 이상 노인을 대상으로 하였다. 대조군은 질환이 없거나 골다공증, 위장질환과 같은 기타 질환을 가진 사람 96명이었으며, 고혈압환자군은 고혈압을 가진 모든 질환자 118명이었고, 항산화 영양소 섭취나 혈장내 항산화 영양상태에 영향을 미치는 성별, 연령, 흡연 및 음주상태를 보정하여 비교하였다. 고혈압환자의 평균 유병기간은 6.1년이었으며, 항산화 비타민 섭취량은 비타민 A, retinol, $\beta$-carotene과 비타민 C 섭취량 모두 고혈압 유무에 따른 유의적인 차이가 나타나지 않았으나 고혈압환자의 섭취량이 높은 경향을 보였다. 한국인영양권장량과 비교한 결과 대조군의 비타민 A 섭취는 권장량의 86.2%, 고혈압환자군은 권장량의 103.0%를 섭취하여 고혈압군에서 유의적으로 높았고, 권장량의 75% 이하 섭취자의 비율은 대조군에서 46.9%, 고혈압군에서 41.5%로 조사되었다. 비타민 C 섭취는 대조군에서 권장량의 176.6%, 고혈압군에서는 189.0%로 나타나 질환의 유무에 관계없이 두 군 모두 권장량의 170%이상을 섭취하고 있었으나 권장량의 75% 이하를 섭취하는 사람의 비율이 대조군에서 13.5%, 고혈압군에서 17.0%로 고혈압군에서 높게 나타났다. 혈장 비타민 C의 농도는 대조군 15.3 mg/L, 고혈압환자 15.9mg/L, 혈장 $\beta$-carotene 농도는 대조군 0.21mg/L, 고혈압환자 0.22 mg/L로 나타나 고혈압 유무에 따른 차이가 없었고, 혈장 비타민 A,E 농도 및 총 항산화능력은 대조군에 비해 고혈압환자에게서 유의적으로 높게 나타났다. 또한 혈장 지질과산화물의 농도도 유의적이지는 않지만 고혈압환자에게서 높은 경향이 나타났다. 따라서 고혈압에 따른 항산화 영양상태를 비교한 결과 전반적인 항산화 비타민의 섭취량, 혈중 비타민 농도 및 총 항산화능력이 예상과 달리 대조군 보다 고혈압환자에게서 유의적으로 높게 나타났다. 이런 결과는 질환자들이 자신이 가진 질병의 진전을 막거나 치료의 목적으로 치료제를 복용하고, 식이요법을 실시하고 있기 때문으로 사료되며, 고혈압과 같이 산화적 스트레스가 증가하는 질환의 경우 체내 항산화 체계 반응이 이러한 변화에 효율적으로 대처하기 위한 방향으로 증가되었을 가능성이 있을 것으로 사료된다. 특히, 본 연구의 대상자들의 유병기간이 6.1년으로 비교적 길기 때문에 질환의 진행정도에 따른 항산화 상태를 측정하거나 비교적 질환으로 판정된 직후의 사람들의 대상으로 한 연구 등 더 많은 연구가 필요하다.

• Korean Journal of Psychosomatic Medicine
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• 제28권2호
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• pp.99-107
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• 2020

Fibromyalgia is a disorder characterized by the core symptom of chronic widespread pain, along with fatigue, sleep disturbances, mood changes, and cognitive difficulties. The etiology of fibromyalgia involves a combination of biological factors, such as genetic vulnerability, alterations in pain processing and stress response system ; psychological factors, such as anxiety, depression, anger, and perceived stress ; environmental factors, such as infections, febrile diseases, and trauma. Central sensitization, which is amplified in the process of sensory stimulation, has been emphasized as a key etiological factor, as supported by enhanced wind-up, delayed aftersensation, decreased nociceptive flexion reflex threshold and functional imaging studies. Several guidelines recommend that a multimodal approach be used to treat fibromyalgia, including both pharmacological and non-pharmacological treatments, tailored to each individual, and that clinicians should provide an intellectual framework through sufficient education and emphasis on the importance of self-management. The prevalence of mood disorders, anxiety disorders, and other psychiatric problems is 7-9 times higher in patients with fibromyalgia than in the general population ; moreover, the association between fibromyalgia and certain psychopathologies or sleep problems has also been suggested. Since psychiatric problems, with shared vulnerabilities and risk factors, interact with fibromyalgia bidirectionally and also affect the disease course, an integrated management approach is needed to determine the risk of comorbidities.

• Journal of Applied Biological Chemistry
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• 제64권1호
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• pp.69-74
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• 2021

Chronic alcohol is responsible for oxidative stress and neurodegenerative diseases such as dementia. In the present study, we investigated the antioxidant activity and protective effects of seed of Carthamus tinctorius L. on ethanol-induced C6 glial cells. Antioxidant effect of seed of C. tinctorius L. was measured by scavenging activity of 1,1-diphenyl-2-prcrylhydrazy (DPPH), hydroxyl radical (·OH), superoxide radical, and nitric oxide. The seed of C. tinctorius L. extract showed significant radical scavenging activities in a concentration-dependent manner. In particular, it revealed strong DPPH and ·OH scavenging activity, displaying more than 80% at 500 and 100 ㎍/mL, respectively. Treatment of 500 mM ethanol to C6 glial cell led to decline of cell viability and elevation of reactive oxygen species (ROS) generation. However, seed of C. tinctorius L.-treated groups significantly increased cell viability and decreased ROS levels, compared to ethanol-induced control group. These results suggest that seed of C. tinctorius L. would have protective effect against neuronal oxidative stress induced by alcohol.