• Journal of Chest Surgery
• /
• v.35 no.5
• /
• pp.336-342
• /
• 2002

Background: Recently, cell transplantation has been extensively investigated to improve heart function in dysfunctional heart. This study was designed to compare the effects of smooth muscle cells (SMC) and heart cells (HC) transplantation in dilated cardiomyopathic hamsters. Material and Method: HC and SMC were isolated from heart and ductus deferens of BIO 53.58 hamsters, and cultured for transplantation. HC and SMC or culture medium were transplanted into the left ventricle of 17 weeks old adult hamsters in HC transplanted (HCTx), SMC transplantation (SMCTX), and control groups (Con) (N = 10 each). Cyclosporine (5 mg/Kg) was administered subcutaneously for HCTx. Sham operated hamsters (N=10) underwent the surgery but did not receive an injection. At 4 weeks after transplantation, heart function was evaluated in all groups using a Langendorff perfusion apparatus. Result: Histology showed severe focal myocardial necrosis in all groups. HCTx and SMCTx formed huge muscle tissue in dilated myocardium. SMCTx and HCTx had better heart function than Con and sham (p<0.01). And SMCTx had better peak systolic pressure (p<0.05) antral developed pressure (p<0.05) than HCTx. But sham and Con did not any statistical make difference. Conclusion: SMCTx and HCTx formed muscle tissue and improved ventricular function in hamsters with dilated cardiomyopathy And SMCTx showed better heart function in peak systolic pressure and developed pressure than HCTx.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.48 no.10
• /
• pp.72-81
• /
• 2011

In this paper, we proposed and designed a novel floating point converter which supports single and double precisions of IEEE754 standard. The proposed convertor supports conversions between floating point number single/double precision and signed fixed point number(32bits/64bits) as well as conversions between signed integer(32bits/64bits) and floating point number single/double precision and conversions between floating point number single and double precisions. We defined a new internal format to convert various input types into one type so that overflow checking could be conducted easily according to range of output types. The internal format is similar to the extended format of floating point double precision defined in IEEE754 2008 standard. This standard specifies that minimum exponent bit-width of the extended format of floating point double precision is 15bits, but 11bits are enough to implement the proposed converting unit. Also, we optimized rounding stage of the convertor unit so that we could make it possible to operate rounding and represent correct negative numbers using an incrementer instead an adder. We designed single cycle data path and 5 cycles data path. After describing the HDL model for two data paths of the convertor, we synthesized them with TSMC 180nm technology library using Synopsys design compiler. Cell area of synthesis result occupies 12,886 gates(2 input NAND gate), and maximum operating frequency is 411MHz.

• Journal of the Korean Institute of Intelligent Systems
• /
• v.24 no.3
• /
• pp.271-278
• /
• 2014

In spite of that stop line and crosswalk should be aware of the most basic objects in transportation system, its features extracted are very limited. In addition to image-based recognition technology, laser and RF, GPS/INS recognition technology, it is difficult to recognize. For this reason, the limited research in this area has been done. In this paper, the algorithm to recognize the stop line and crosswalk is designed and implemented using image-based recognition technology with the images input through a vision sensor. This algorithm consists of three functions.; One is to select the area, in advance, needed for feature extraction in order to speed up the data processing, 'Region of Interest', another is to process the images only that white color is detected more than a certain proportion in order to remove the unnecessary operation, 'Color Pattern Inspection', the other is 'Feature Extraction and Recognition', which is to extract the edge features and compare this to the previously-modeled one to identify the stop line and crosswalk. For this, especially by using case based feature comparison algorithm, it can identify either both stop line and crosswalk exist or just one exists. Also the proposed algorithm is to develop existing researches by comparing and analysing effect of in-vehicle camera installation and changes in recognition rate of distance estimation and various constraints such as backlight and shadow.

• Journal of Navigation and Port Research
• /
• v.31 no.5 s.121
• /
• pp.435-445
• /
• 2007

Ship structures are thin-walled structures and lots of cutouts, for example, of inner bottom structure, girder, upper deck hatch, floor and dia-frame etc. In the case where a plate has cutout it experiences reduced buckling and ultimate strength and at the same time the in-plane stress under compressive load produced by hull girder bending will be redistributed. In the present paper, we investigated several kinds of perforated stiffened model from actual ship structure and series of elasto-plastic large deflection analyses were performed to investigate into the influence of perforation on the buckling and ultimate strength of the perforated stiffened plate varying the cutout ratio, web height, thickness and type of cross-section by commercial FEA program(ANSYS). Closed-form formulas for predicting the ultimate strength of the perforated stiffened plate are empirically derived by curve fitting based on the Finite Element Analysis results. These formulas are used to evaluate the ultimate strength, which showed good correlation with FEM results. These results will be useful for evaluating the ultimate strength of the perforated stiffened plate in the preliminary design.

• Investigative Magnetic Resonance Imaging
• /
• v.6 no.2
• /
• pp.158-165
• /
• 2002

Purpose : To evaluate the effect of Gd-DTPA on signal intensity of diffusion-weighted magnetic resonance(MR) image and apparent diffuse coefficient (ADC) in dog brain with hype racute stroke. Materials and methods : Experimental canine model of hyperacute cerebral infarction was made by selective intraarterial embolization with particulate embolic material. Diffusion-weighted MR imaging was performed in five dogs at 1 hour after the embolization of internal carotid artery. After intravenous bolus injection of Gd- DTPA, additional 11 diffusion-weighted MR images were serially obtained from 2 minutes to 90 minutes after injection in each dog. The author evaluated findings of hyperacute cerebral infarction on diffusion-weighted MR imaging, and calculated mean signal intensity and mean ADC in infarcted region and contralateral normal region. Statistical analysis of mean signal intensity, mean ADC and contrast-noise ratio before and after Gd-DTPA injection was performed. Results : Hyperacute cerebral infarction developed in all five dogs on diffusion-weighted MR images obtained 1 hour after embolization. The area of hyperacute infarction had steady increase in signal intensity on diffusion-weighted MR image and decrease in ADC. In normal perfusion area, decrease in signal intensity was observed at 2 minutes the Gd-DTPA injection, whereas ADC did not changed. Conclusion : Intravenous injection of Gd-DTPA had no influence on ADC in both hyperacute infarction and normally perfused are a, but caused initial transient signal reduction in normally perfused area on diffusion-weighted MR image due to susceptibility effect of Gd-DTPA. It is important to calculate ADC in evaluating the effect of diffusion after injection of Gd-DTPA.

• Journal of Engineering Education Research
• /
• v.11 no.1
• /
• pp.64-75
• /
• 2008

A new product development and product realization process (PRP) is a circulating and feedback process by generating ideas through creative problem solving process. The early stages of PRP correspond to conceptual design and product development, in which a large portion of product life cycle cost can be saved. The optimal design method for this stage is a robust design suggested by Taguchi. Quality must be 'engineered in' since it can not be 'inspected out.' A robust design is an engineering methodology to improve the quality of a product by minimizing the efforts of variations without eliminating the causes. The objective of this study is to propose a scheme and a case study of robust design for exploring design parameters, and introduce a creative problem solving process. Major research subjects include a creative problem solving process, robust design procedure and their implementation. For the experiment of Taguchi method, a toy catapult is adopted. For the creativity development, a short project is assigned to devise a similar tool with the toy catapult. A reference model is suggested to compare and evaluate their ideas.

• Journal of radiological science and technology
• /
• v.39 no.4
• /
• pp.595-600
• /
• 2016

The diagnostic multileaf collimator(MLC) was designed for patient dose reduction in diagnostic radiography We used monte carlo simulation code (MCNPX, LANL, USA) to evaluate efficiency of shielding material for making diagnostic MLC as preliminary study. The diagnostic radiography unit was designed using SRS-78 program according to tube voltage (80,100,120 kVp) and acquired energy spectrums. The shielding material was SKD11 alloy tool steel that is composed of 1.6% carbon(C), 0.4% silicon(Si), 0.6% manganese (Mn), 5% chromium (Cr), 1% molybdenum(Mo) and vanadium(V). The density of it was $7.89g/cm^3$.Using tally card 6, we calculated the shielding efficiency of MLC according to tube voltage. The results was that 98.3% (80 kVp), 95.7 %(100 kVp), 93.6% (120 kVp). We certified efficiency of diagnostic MLC fabricated from SKD11 alloy steel by monte calro simulation. Based on the results, we designed the diagnostic MLC and will develop the diagnostic MLC for reduction of patient dose in diagnostic radiography.

• Korean Journal of Remote Sensing
• /
• v.35 no.6_4
• /
• pp.1327-1339
• /
• 2019

Surface reflectance obtained by absolute atmospheric correction from satellite images is useful for scientific land applications and analysis ready data (ARD). For Landsat and Sentinel-2 images, many types of radiometric processing methods have been developed, and these images are supported by most commercial and open-source software. However, in the case of KOMPSAT 3/3A images, there are currently no tools or open source resources for obtaining the reflectance at the top-of-atmosphere (TOA) and top-of-canopy (TOC). In this study, the atmospheric correction module of KOMPSAT 3/3A images is newly implemented to the optical calibration algorithm supported in the Orfeo ToolBox (OTB), a remote sensing open-source tool. This module contains the sensor model and spectral response data of KOMPSAT 3A. Aerosol measurement properties, such as AERONET data, can be used to generate TOC reflectance image. Using this module, an experiment was conducted, and the reflection products for TOA and TOC with and without AERONET data were obtained. This approach can be used for building the ARD database for surface reflection by absolute atmospheric correction derived from KOMPSAT 3/3A satellite images.

• Journal of the Korean Society of Radiology
• /
• v.14 no.4
• /
• pp.375-383
• /
• 2020

This study aimed to propose a methodology for quantitatively analyzing problems resulting from the performance and combination of the ionization chamber when using an automatic exposure control (AEC) and to optimize the performance of the digital radiography (DR). In the experimental method, the X-ray quality of the parameters used for the examination of the abdomen and pelvis was evaluated by percentage average error (PAE) and half value layer (HVL). Then, the stability of the radiation output and the image quality were analyzed by calculating the entrance surface dose (ESD) and entropy when the three ionization chambers were combined. As a result, all of the X-ray quality of the digital radiography used in the experiment showed a percentage average error and a half value layer in the normal range. The entrance surface dose increased in proportion to the combination of chambers, and entropy increased in proportion to the combination of ionization chambers except when three chambers were combined. In conclusion, analysis using entrance surface dose and entropy was found to be a useful method for evaluating the performance and combination problems of the ionization chamber, and the optimal performance of the digital radiography can be maintained when two or less ionization chambers are combined.

• Journal of the Korean Society of Radiology
• /
• v.5 no.1
• /
• pp.11-18
• /
• 2011

The periosteum contains multipotent cells that can differentiate into osteoblasts and chondrocytes. Cultured periosteum-derived cells (PDCs) have an osteogenic capacity. The purpose of this study was to evaluate the interaction of PDCs with bone graft biomaterial. After cell isolation from the calvarial periosteum of Sprague-Dawley rats, cultured PDCs were placed in critical-sized calvarial defects with beta-tricalcium phosphate (${\beta}$-TCP). All rats were sacrificed 8 weeks after bone graft surgery, and the bone regenerative ability of bone grafting sides was evaluated by plain radiography, micro-computed tomography (CT), and histological examination. PDCs grafted with ${\beta}$-TCP displayed enhanced calcification in the defect site, density of regenerated bone and new bone formation within the defect and its boundaries. Furthermore, these PDCs more efficiently regenerated new bone as compared to grafted ${\beta}$-TCP only. The results suggest that cultured PDCs have the potential to promote osteogenesis in bone defects.