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The Effects of Muscle Cell Transplantation into the Hearts of the Hamsters with a Dilated Cardiomyopathy  

유경종 (연세대학교 의과대학 심장혈관병원 심장혈관외과)
임상현 (연세대학교 의과대학 심장혈관병원 심장혈관외과)
송석원 (연세대학교 의과대학 심장혈관병원 심장혈관외과)
홍유선 (연세대학교 의과대학 심장혈관병원 심장혈관외과)
박현영 (연세대학교 의과대학 심장혈관병원 심혈관연구소)
Publication Information
Journal of Chest Surgery / v.35, no.5, 2002 , pp. 336-342 More about this Journal
Abstract
Background: Recently, cell transplantation has been extensively investigated to improve heart function in dysfunctional heart. This study was designed to compare the effects of smooth muscle cells (SMC) and heart cells (HC) transplantation in dilated cardiomyopathic hamsters. Material and Method: HC and SMC were isolated from heart and ductus deferens of BIO 53.58 hamsters, and cultured for transplantation. HC and SMC or culture medium were transplanted into the left ventricle of 17 weeks old adult hamsters in HC transplanted (HCTx), SMC transplantation (SMCTX), and control groups (Con) (N = 10 each). Cyclosporine (5 mg/Kg) was administered subcutaneously for HCTx. Sham operated hamsters (N=10) underwent the surgery but did not receive an injection. At 4 weeks after transplantation, heart function was evaluated in all groups using a Langendorff perfusion apparatus. Result: Histology showed severe focal myocardial necrosis in all groups. HCTx and SMCTx formed huge muscle tissue in dilated myocardium. SMCTx and HCTx had better heart function than Con and sham (p<0.01). And SMCTx had better peak systolic pressure (p<0.05) antral developed pressure (p<0.05) than HCTx. But sham and Con did not any statistical make difference. Conclusion: SMCTx and HCTx formed muscle tissue and improved ventricular function in hamsters with dilated cardiomyopathy And SMCTx showed better heart function in peak systolic pressure and developed pressure than HCTx.
Keywords
Cell transplautation; Transplantation; Cardiomyopathy;
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1 Cellular cardiomyoplasty: Myocardial regeneration with satellite cell implantation /
[ Chiu RC-J;Zibaitis A;Kao RL ] / Ann Thorac Surg   DOI
2 Smooth muscle cell transplantation into myocardial scar tissue improves heart function /
[ Li R-K;Jia ZQ;Weisel RD;Merante F;Mickle DAG ] / J.Mol Cell Cardiol   DOI   ScienceOn
3 Partial left ventriculectomy and mitral valve repair for end-stage heart failure /
[ McCarthy JF;McCarthy PM;Starling RC(et al.) ] / Eur J Cardiothorac Surg   DOI   ScienceOn
4 Depressed transient outward current density in ventricular myocytes from cardiomyopathic Syrian hamsters of different ages /
[ Thuringer D;Coulombe A;Deroubaix E;Coraboeuf E;Mercadier J-J ] / J.Mol Cell Cardiol   DOI   ScienceOn
5 The registry of the International Society for Heart and Lung Transplantation: Sixteenth official report-1999 /
[ Hosenpud JD;Bennett LE;Keck BM;Fiol B;Boucek MM;Novick RJ ] / J.Heart Lung Transplant   DOI   ScienceOn
6 Effect of trimetazidine and verapamil on the cardiomyopathic hamster myosin phenotype /
[ DHahan N;Taouil K;Janmot C;Morel JE ] / Br J.Pharmacol   DOI   ScienceOn
7 Cardiomyocyte transplantation improves heart function /
[ Li R-K;Jia ZQ;Weisel RD(et al.) ] / Ann Thorac Surg   DOI
8 Regenerating functional myocardium; Improved performance after skeletal myoblast transplantation /
[ Taylor DA;Atkins BZ;Hungspreugs P(et al.) ] / Nature Medicine   DOI   ScienceOn
9 Dynamic cardiomyoplasty /
[ Acker MA ] / Ann Thorac Surg   DOI   ScienceOn
10 Alteration of extracellular matrix in dilated cardiomyopathic hamster heart /
[ Okada H;Kawaguchi H;Kudo T(et al.) ] / Mol Cell Biochem
11 Method of culturing cardiomyocytes from human pediatric ventricular myocardium /
[ Li RK;Weisel RD;Williams WG;Mickle DAG ] / J.Tiss Cult Meth   DOI
12 Abnormalities in plasma catecholamines and myocardial adrenoreceptors in cardiomyopathic BIO 53.58 Syrian hamsters and improvement by metoprolol treatment /
[ Yamada S;Ohkura T;Yamadera T(et al.) ] / JPET
13 Can cellular transplantation improve function in doxorubicin-induced heart failure? /
[ Scorsin M;Hagege AA;Dolizy I(et al.) ] / Circulation
14 Heart Cell Transplantation Improves Heart Function in Dilated Cardiomyopathic Hamsters /
[ Yoo K-J;Li R-K;Weisel RD(et al.) ] / Circulation
15 Morbidity,functional status,and immunosuppressive therapy after heart transplantation: An analysis of the Joint International Society for Heart and Lung Transplantation / United Network for Organ Sharing Thoracic Registry /
[ Brann WM;Bennett LE;Keck BM;Hosenpud JD ] / J Heart Lung Transplant
16 Natural history of fetal rat cardiomyocytes transplanted into adult rat myocardial scar tissue /
[ Li R-K;Mickle DAG;Weisel RD(et al.) ] / Circulation
17 Permanent ventricular assist device support versus cardiac transplantation /
[ Pennington DG;Oaks TE;Lohmann DP ] / Ann Thorac Surg   DOI   ScienceOn
18 Autologous Smooth Muscle Cell Transplantation Improved Heart Function in Dilated Cardiomyopathy /
[ Yoo K-J;Li R-K;Weisel RD;Mickle DAG;Li GM;Yau TM(ed.) ] / Ann Thorac Surg   DOI   ScienceOn
19 Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies /
[ Richardson P;McKenna W;Bristow M(et al.) ] / Circulation   DOI   ScienceOn
20 Cardiomyocyte transplantation in a porcine myocardial infarction model /
[ Watanabe E;Smith DM;Delcarpio JB(et al.) ] / Cell Transplantation