• Genomics & Informatics
• /
• 제1권2호
• /
• pp.101-107
• /
• 2003

Loss of heterozygosity (LOH) has been used to detect deleted regions of a specific chromosome in cancer cells. LOH on chromosome 16q has been reported to occur frequently in progressed hepatocellular carcinoma (HCC). Liver tissues from 37 Korean HCC patients were analyzed for LOH by using 25 polymorphic microsatellite markers distributed along 16q. Out of the 37 HCC patients studied, 21 patients (56.8%) showed LOH in various regions of 16q with at least one polymorphic marker. Puring the analysis of these 21 LOH cases, 6 patients showed interstitial LOHs in which the boundary of the LOH region was defined. With two rounds of LOH analysis, five commonly occurring interstitial LOH regions were identified; 16q21-22.1, 16q22.2 - 22.3, 16q22.3, 16q23.2 and 16q23.3 - 24.1. Among the five LOH regions the 16q23.3 - 24.1 region has been reported to be related with chromosome instability. A complete physical map, which covers the 3.2 Mb region of 16q23.3 - 24.1 (D16S402 and D16S486), was constructed to identify novel candidate tumor suppressor genes. We provide the minimally tiling path map consisting of 28 BAC clones. There was one gap between NT_10422.11 and NT_019609.9 of the human genome sequence contig (NCBI sequence build 33, April 29, 2003). This gap can be filled by sequencing the R-1425M20 clone which bridges these sequence contigs.

• Journal of applied mathematics & informatics
• /
• 제41권1호
• /
• pp.167-179
• /
• 2023

In this paper, we investigate solutions of equations which are linear (p, q)-difference equation of higher order by using (p, q)-derivative and integral. We also derive the solution of equation in the case of second order.

• 대한수학회논문집
• /
• 제27권3호
• /
• pp.557-564
• /
• 2012

This study concerns the existence of positive solution for the following nonlinear system $$\{-div(|x|^{-ap}|{\nabla}u|^{p-2}{\nabla}u)=|x|^{-(a+1)p+c_1}({\alpha}_1f(v)+{\beta}_1h(u)),x{\in}{\Omega},\\-div(|x|^{-bq}|{\nabla}v|q^{-2}{\nabla}v)=|x|^{-(b+1)q+c_2}({\alpha}_2g(u)+{\beta}_2k(v)),x{\in}{\Omega},\\u=v=0,x{\in}{\partial}{\Omega}$$, where ${\Omega}$ is a bounded smooth domain of $\mathbb{R}^N$ with $0{\in}{\Omega}$, 1 < $p,q$ < N, $0{{\leq}}a<\frac{N-p}{p}$, $0{{\leq}}b<\frac{N-q}{q}$ and $c_1$, $c_2$, ${\alpha}_1$, ${\alpha}_2$, ${\beta}_1$, ${\beta}_2$ are positive parameters. Here $f,g,h,k$ : $[0,{\infty}){\rightarrow}[0,{\infty})$ are nondecresing continuous functions and $$\lim_{s{\rightarrow}{\infty}}\frac{f(Ag(s)^{\frac{1}{q-1}})}{s^{p-1}}=0$$ for every A > 0. We discuss the existence of positive solution when $f,g,h$ and $k$ satisfy certain additional conditions. We use the method of sub-super solutions to establish our results.

• Progress in Superconductivity
• /
• 제1권1호
• /
• pp.36-41
• /
• 1999

Methods for mode identification and accurate measurements of the unloaded Q ($Q_0$) of a dielectric-loaded $TE_{01{\delta}}$ mode cavity resonator with HTS endplates are proposed. A resonator with a sapphire rod and $YBa_2Cu_3O_{7-x}$(YBCO) endplates was prepared and its microwave properties were studied at temperatures above 30 K. The $TE_{01{\delta}}$ mode $Q_0$ of the resonator, designed to work as a tunable resonator with variations in the gap distance (s) between the sapphire rod and the top YBCO, was more than 1000000 at s = 0 mm and at 30 K with the resonant frequency of 19.56 GHz. The $TE_{01{\delta}}$ mode $Q_0$ decreases as s increases for s < 2 mm until mode couplings between the $TE_{01{\delta}}$ mode and other modes appeared at s = 2 mm. Significant dependence of the $TE_{01{\delta}}$ mode $Q_0$ on the input and output coupling constants was also observed. Applications of the open-ended $TE_{01{\delta}}$ mode cavity resonator for a tunable resonator with a very high Q as well as a characterization tool for the surface resistance measurements of HTS films are described.

• 한국정보통신학회논문지
• /
• 제26권1호
• /
• pp.58-63
• /
• 2022

코로나19의 일일 확진자 수는 천명 후반대에서 2천명대를 유지하고 있으며, 백신접종률이 증가함에도 불구하고 확진자수가 쉽게 줄어들지 않는 상황이다. 변이바이러스는 계속해서 등장하고, 현재는 뮤 변이 바이러스까지 국내에 유입되었다. 본 논문은 코로나 예방전략을 위해 SARIMA 모델을 통해 코로나19 국내 확진자 수를 예측한다. ADF Test와 KPSS Test를 통해 데이터에 추세와 계절성이 있음을 확인한다. SARIMA(p,d,q)(P,D,Q,S)의 p, d, q, P, D, Q의 값은 모형 차수결정 정리로 파라미터를 추출한다. ACF와 PACF를 통해 p, q 파라미터를 추론한다. 차분, 로그변환, 계절성제거 등을 통해 데이터를 정상성 형태로 변환하고, 도식화 하여 파라미터를 도출하고, 계절성이 있다면 S를 정하고, SARIMA P,D,Q를 정하고, 계절성을 제외한 차수에 대해 ACF와 PACF를 보고 ARIMA p,d,q를 정한다.

• 충청수학회지
• /
• 제31권2호
• /
• pp.231-237
• /
• 2018

Hardy's inequality is refined non-trivially as the form $${\int_{0}^{{\infty}}}\{{\frac{1}{x}}{\int_{0}^{x}}f(t)dt\}^pdx{\leq}Q_f{\times}({\frac{p}{p-1}})^p{\int_{0}^{x}}f^p(x)dx$$ for some $Q_f:0{\leq}Q_f{\leq}1$. $P{\acute{o}}lya$-Knopp's inequality is also refined by the similar form.

• Journal of Applied Biological Chemistry
• /
• 제65권4호
• /
• pp.277-286
• /
• 2022

Schizophragma hydrangeoides (S. hydrangeoides) is a vine endogenous to Jeju Island and Ulleungdo, where it grows attached to the foothills and rock surfaces. Previous research has mostly focused on the whitening effect of S. hydrangeoides leaf extract. In this study, we investigated S. hydrangeoides leaf extract further, and detected four phytochemicals in the extract: chlorogenic acid, quercetin-3-O-glucosyl-(1-2)-rhamnoside, quercetin-3-O-xylosyl-(1-2)-rhamnoside, and quercitrin. We pretreated human dermal fibroblast (HDFn) cells with previously established concentrations of the four compounds for 1 h before ultraviolet A (UVA) irradiation. Among the four compounds, quercetin-3-O-glucosyl-(1-2)-rhamnoside (Q-3-GR) best inhibited matrix metalloproteinase-1 (MMP-1) levels. Thus, we investigated the protective effects of Q-3-GR on photoaging and its underlying mechanisms. Q-3-GR significantly reduced MMP-1 production and inhibited MMP-1 protein expression in UVA-irradiated HDFn cells. Furthermore, Q-3-GR increased procollagen type I production and protein expression. Q-3-GR exerted its anti-photoaging effects by downregulating the mitogen-activated protein kinase/ activator protein-1 signaling pathway, and upregulating the transforming growth factor-β/Smad signaling pathway. Thus, S. hydrangeoides leaf-derived Q-3-GR is a potential potent cosmetic ingredient for UV-induced skin aging.

• 지질공학
• /
• 제16권1호
• /
• pp.31-43
• /
• 2006

연약한 실트지반(ML)과 모래 섞인 연약한 실트지반(ML', SM, SM')에 대한 지지력의 산정결과, 모든 종류의 지반에서 기존의 제안식보다 과소한 값을 나타내고 있어 이론값을 적용할 경우 신중한 검토가 요구된다. 극한하중(지지력)은 연약한 실트지반의 극한하중 $q_{ult}=1.34C_u$, 3종류의 모래 섞인 연약한 실트지반 중 ML'지반의 극한하중 $q_{ult}=1.40s$, SM지반의 극한하중 $q_{ult}=1.73s$, SM'지반의 극한하중 $q_{ult}=2.72s$로 산정되었다. 이와 같은 결과를 통해 실트질에 비해 투수성이 큰 모래의 함유량이 증가할수록 점차 지반이 안정화가 되어 감을 알 수 있다.

• Kyungpook Mathematical Journal
• /
• 제47권3호
• /
• pp.381-392
• /
• 2007

In 1906, da Rios, a student of Leivi-Civita, wrote a master's thesis modeling the motion of a vortex in a viscous fluid by the motion of a curve propagating in $R^3$, in the direction of its binormal with a speed equal to its curvature. Much later, in 1971 Hasimoto showed the equivalence of this system with the non-linear Schr$\ddot{o}$dinger equation (NLS) $$q_t=i(q_{ss}+\frac{1}{2}{\mid}q{\mid}^2q$$. In this paper, we use the same idea as Terng used in her lecture notes but different technique to extend the above relation to the case of $R^3$, and obtained an analogous equation that $$q_t=i[q_{ss}+(\frac{1}{2}{\mid}q{\mid}^2+1)q]$$.

• 대한전자공학회논문지TC
• /
• 제45권6호
• /
• pp.27-33
• /
• 2008

차수가 h인 다항식 ${\hbar}(x){\in}F_q[x]$에서, $x-s_1,\;x-s_2,\;{\cdots},\;x-s_n$에 의해 생성된 $\(F_q[x]/({\hbar(x))\)*$의 multiplicative subgroup의 크기를 결정하는 것은 대단히 중요한 과제이다. 여기서 $\{s_1,\;s_2,\;{\cdots},\;s_n\}{\sebseteq}F_q$이고 모든 i 에 대해서, ${\hbar}(x){\neq}0$이다. 지금까지 알려진 asymptotic lower bound는 $(rh)^{O(1)}\(2er+O(\frac{1}{r})\)^h$이며, 여기서 $r=\frac{n}{h}$이고 e(=2.718...)는 natural logarithm의 기저이다. 본 논문에서는, coding theory 문제와 연계해서 더 낳은 lower bound인 $(rh)^{O(1)}\(2er+{\frac{e}{2}}{\log}r-{\frac{e}{2}}{\log}{\frac{e}{2}}+O{(\frac{{\log}^2r}{r})}\)^h$를 증명하고자 한다. 여기서 log는natural logarithm을 나타내며, 또한 이방식의 제약점에 대해서도 논의한다.