• Title/Summary/Keyword: $I_2$-convergence

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Antiinflammatory Activity of Solvent-partitioned Fractions from Atriplex gmelinii C. A. Mey. in LPS-stimulated RAW264.7 Macrophages (염생식물 가는갯는쟁이 용매 추출물의 항염증활성)

  • Jeong, Heejeong;Kim, Hojun;Ju, Eunsin;Lee, Seul-Gi;Kong, Chang-Suk;Seo, Youngwan
    • Journal of Life Science
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    • v.27 no.2
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    • pp.187-193
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    • 2017
  • As a part of ongoing research to elucidate and characterize antiinflammatory nutraceuticals, the crude extracts from Atriplex gmelinii C. A. Mey. and their solvent-partitioned fractions were tested for their antiinflammatory potential in lipopolysaccharide (LPS)-stimulated RAW 264.7 mouse macrophages. The crude extracts of A. gmelinii C. A. Mey. were fractioned according to polarity with n-hexane, 85% aqueous methanol (85% aq. MeOH), n-butanol, and $H_2O$. Their antiinflammatory activities were investigated in LPS-induced inflammation in mouse macrophages by measuring nitric oxide (NO) generation and mRNA expression of inflammation mediators, namely, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-$1{\beta}$ ($IL-1{\beta}$), and IL-6. As a result, we confirmed that the crude extracts of A. gmelinii C. A. Mey. inhibited LPS-stimulated NO production and mRNA expression of iNOS and COX-2 as important inflammatory factors. The inhibition of NO production through the downregulation of important inflammatory factors such as iNOS, COX-2, $IL-1{\beta}$, and IL-6 was found by treatment with all solvent-partitioned fractions. Among all tested fractions, 85% aq. MeOH showed the strongest antiinflammatory response. Based on the current results, A. gmelinii C. A. Mey. was suggested to possess natural antiinflammatory components, indicating that it could be used as a valuable source of antiinflammatory substances.

Convergence study of long-term care insurance system for elderly of awareness of middle-aged people and demand for dental services in the system (한국 중년층의 노인장기요양보험제도에 대한 인식과 구강보건진료에 대한 요구의 융합 연구)

  • Park, Jeong-Ran;Youn, Mi-Sun;Choi, Yu-Ri
    • Journal of the Korea Convergence Society
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    • v.9 no.7
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    • pp.95-103
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    • 2018
  • The purpose of this study was to awareness of dental care services in the elderly long-term care insurance system and retirement preparation of middle-aged people. The survey respondents had a 56.1% saving for old age life, And showed a tendency to they don't like depend on one's family(41.8%), elderly care was intended to use facility services and nursing care. 36.7% of respondents answered "I know a little" about the system. Also, the need for dental care services within the system was high (98.5%), If the service is provided, 92.3% of the respondents said that they would participate, otherwise unrecognized rate of dental care services in long-term care insurance was 85.2%. Therefore, it is necessary to expand the awareness of the part of dental care service in the system. The results of this study can be used as basic data for the improvement of the system of dental care services in long-term care insurance for elderly.

Recent Trends in Standards Related to the Internet of Things and Machine-to-Machine Communications

  • Husain, Syed;Prasad, Athul;Kunz, Andreas;Papageorgiou, Apostolos;Song, JaeSeung
    • Journal of information and communication convergence engineering
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    • v.12 no.4
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    • pp.228-236
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    • 2014
  • One of major purposes of these standard technologies is to ensure interoperability between entities from different vendors and enable interworking between various technologies. As interoperability and interworking are essential for machine-to-machine communications (M2M) and Internet of Things (IoT) for them to achieve their ultimate goal, i.e., things to be connected each other, multiple standards organizations are now working on development M2M/IoT related specifications. This paper reviews the current activities of some of the most relevant standardization bodies in the area of M2M and IoT: third-generation partnership project (3GPP) core and radio network aspects, broadband forum, and oneM2M. The major features and issues being focused upon in these standards bodies are summarized. Finally, some key common trends among the different bodies are identified: a common service layer platform, new technologies mitigating an explosive growth of network traffic, and considerations and efforts related to the development of device management technologies.

A Convergence Study on the Effect of Self-directed Practice based Peer-tutoring on Performance, Confidence and Self-efficacy of Core Nursing Skills in Nursing Students (동료 교수학습 기반 자율실습이 핵심기본간호술 숙련도, 수행자신감 및 자아효능감에 미치는 효과에 관한 융합연구)

  • Koo, Heesun
    • Journal of the Korea Convergence Society
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    • v.10 no.12
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    • pp.453-463
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    • 2019
  • The purpose of study was the non-equivalent control group pretest-posttest design to test the effect of self-directed nursing practice based peer-tutoring of same sophomore, on the level of confidence, performance and self-efficacy of core nursing skills in nursing students. The subjects were 68 nursing students in K City from May 1th to June 12th in 2019. The participants were shared into the peer tutoring practice group (experimental group, n=34) and the lecturer guided practice group (control group, n=34). The results of study, the experimental group scored significantly higher on the foley catheterization performance (t=11.60, p<.001), confidence (t=4.123, p<.001) and wearing protection equipment performance (t=5.91, p<.001), confidence (t=4.24, p<.001) and enema performance (t=2.82, p=.008), confidence (t=2.09, p=.044) and self-efficacy (t=4.52, p<.001) than control group. Therefore, the results justified that self-directed nursing practice based peer-tutoring could be effective in improving the performance, confidence and self-efficacy of core nursing skills in nursing students. Based on this, I suggest the study that examines the effects of peer-tutoring by applying it to various majors.

Design and implementation of Serial Communication for IoT Sensing Technology (IoT의 센싱 기술을 위한 직렬통신 설계 및 구현)

  • Park, Sangbong;Jeong, Daeseung
    • The Journal of the Convergence on Culture Technology
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    • v.3 no.3
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    • pp.27-30
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    • 2017
  • IoT could be applied to various areas because of the important role of sensor. The existing sensor communication method is to quickly transmit data by using clock and two data pins based on the I2C serial communication method. As the objects used are gradually light-weighted and the amount of data transmission is decreased, the simplification of hardware is more emphasized as an essential design element than the speed of transmission. This paper designed a circuit to send/receive data in series, and also realized arduino, by analyzing the existing communication method and then using a single pin for light-weight. The single pin serial communication could reduce power consumption, which is suitable for the sensor area using digital communication of IoT area.

A Study on Software Development and Legal Regulation (소프트웨어 개발과 법적규제)

  • Kim, Hyung-Man
    • Journal of Digital Convergence
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    • v.9 no.5
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    • pp.11-20
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    • 2011
  • Internet users and copyright holder have been at the center of a severe legal dispute because file-sharing soft (P2P) through Napster aggravates the violation of copyright as well as takes on the world. Though it is natural that we should hold users a criminal penalty for the illegal use of various computer programs, I think that if the supply of a computer program is generally within a circle of development act, program developer ought not to hold users criminally liable for the unintended illegal act of users. Two main issues are addressed in this work: (i) the basis and validity of legal responsibility and condemnation that appear in the precedent set as to P2P in America, Japan, and Korea. (ii) the necessity of both scientific technology development and efficient legal regulation of copyright holder. For this purpose, software development and legal regulation are reviewed analyzed from viewpoint of the criminal law.

The Effects of Protecting Liver and Improving Liver Function on Cabbage Extract (양배추 추출물의 간보호 및 간기능 개선 효과)

  • Kim, Hyun Kyoung
    • The Journal of the Convergence on Culture Technology
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    • v.5 no.2
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    • pp.389-395
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    • 2019
  • This study investigated the pharmaceutical extraction and the functional health food extraction, which have a beneficial effect on the human body and which can be used safely for a long period of time without adverse side effects and also have excellent effects of protecting liver and improving liver function. As the results, the cabbage extract does not show cytotoxicity, and thus can be used safely. In an experiment performed on an animal model with liver injury induced by a drug (APAP), it could be seen that the cabbage extract exhibited the effects of protecting liver and improving liver function by effectively reducing AST and ALT which are liver injury markers, indicating that the cabbage extract is effective as a pharmaceutical extraction for preventing or treating liver disease. In particular, the cabbage extract was effective in treating inflammation of the liver by reducing the expression of the inflammatory mediators iNOS and COX-2 and the proinflammatory cytokine $IL-1{\beta}$, which are involved in acute inflammatory reactions accompanying liver injury. In the results, an extract of cabbage heat-treated at a temperature of 100 to $150^{\circ}C$ had a better liver function-improving effect or anti-inflammatory effect than an extract of raw cabbage.

The Anti-inflammatory Effects of Heat-treated Broccoli Extract (열처리된 브로콜리 추출물의 항염증 효과)

  • Kim, Hyun Kyoung
    • The Journal of the Convergence on Culture Technology
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    • v.5 no.2
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    • pp.397-404
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    • 2019
  • This study was carried out to investigate the heat-treated broccoli extraction which have a beneficial effect on the human body and which can be used safely for a long period of time without adverse side effects and also have excellent effects of protecting liver and improving liver function. The heat-treated broccoli extract does not show cytotoxicity, and thus can be used safely. In an experiment performed on an animal model with liver injury induced by a drug (APAP), it could be seen that the heat-treated cabbage extract exhibited the effects of protecting liver and improving liver function by effectively reducing AST and ALT which are liver injury markers, indicating that the heat-treated brocoli extract is effective as a pharmaceutical extraction for preventing or treating liver disease. In particular, the heat-treated broccoli extract was effective in treating inflammation of the liver by reducing the expression of the inflammatory mediators iNOS and COX-2 and the proinflammatory cytokine $IL-1{\beta}$, which are involved in acute inflammatory reactions accompanying liver injury.

A Study on Inequality Rate of Integrated Cylinder Lubricator System with an Accumulated Distribution by the Electronic Control in a Large Two-stroke Diesel Engine (대형 2행정 디젤기관에 있어서 일체형 전자제어 축압분배 실린더 주유기 시스템의 주유 불균일률에 관한 연구)

  • Bae, Myung-Whan;Jung, Hwa;Kim, Su-Min;Bae, Chang Hwan
    • Transactions of the Korean Society of Automotive Engineers
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    • v.22 no.2
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    • pp.123-133
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    • 2014
  • Minimizing the cylinder wear and the consumption rate of cylinder oil in a large two-stroke diesel engine is of great economic importance. A motor-driven cylinder lubricator for Sulzer RT-flex large two-stroke diesel engines developed by authors is in need of improving the lubricating system to lubricate cylinder parts optimally by an electronically controlled quill device according to changes of engine load and revolution speed. In order to apply the developed accumulating distributor to an integrated cylinder lubricator by the electronically controlled system as the third research stage, the lubricating system is improved in the electronically controlled quill device with a solenoid valve. In this study, the effects of lubricator revolution speed, driving pressure(or plunger stroke) and cylinder back pressure on oil feed rate and lubrication inequality rate are investigated by using the integrated cylinder lubricator system with an accumulated distribution by the electronic control(I.C.S.), and the oil feed rate and lubrication inequality rate of I.C.S. are compared with those of the motor-driven cylinder lubricator by the electronically controlled quill system equipped with an accumulating distributor(E.D.S.). It is found that the oil feed rate of I.C.S. is smaller than that of E.D.S. due to the reduction of delivery velocity by the higher delivery pressure, and the variances of lubrication inequality rate for I.C.S. have become smaller than those of E.D.S. as the driving pressure in all experimental conditions increases, except for the driving pressure of 26 bar(plunger stroke 2 mm) at the cylinder lubricator speed of 120 rpm.

A Study on Anti-oxidant and Anti-wrinkle Effect of Supercritical Fluid Extraction of Black Carrot as a Functional Cosmetic Material (기능성화장품소재로서 자색당근 초임계추출물의 항산화 및 항주름 효능 연구)

  • Kim, Ji-Su;Lee, Ji-An
    • Journal of Convergence for Information Technology
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    • v.11 no.12
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    • pp.236-243
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    • 2021
  • The aim of this study was to evaluate the anti-oxidant and anti-wrinkle effect of the black carrot(BC) extracted by supercritical dioxide(SC-CO2). DPPH/ABTS radical scavenging and total polyphenol contents were measured to investigate the anti-oxidant activity of the BC supercritical extract. Collagen production and MMP-1 expression were assessed in normal human dermal fibroblasts(NHDF) for anti-wrinkle activity, The black carrot extract showed the highest total phenolic content(9.037±1.123 mg GAE/g extract) and the best antioxidant properties as shown by DPPH and ABTS assay. The supercritical fluid extracts of black carrot exhibited low toxicity to NHDF cells. In addition, the supercritical fluid extracts showed MMP-1 inhibition and type I pro-collagen synthesis inducing activities in a dose-dependent manner, respectively. Therefore, these results suggest that the black carrot is a potential source of high anti-oxidative, solvent-free and anti-aging material with promising applications in cosmetic, food, and beauty-food industries.