• 제목/요약/키워드: $IP_3R$

검색결과 137건 처리시간 0.028초

핸드오프를 지원하는 H.323 게이트키퍼 구조 (An H.323 Gatekeeper Architecture Providing Handoff function)

  • 이영신;최기무;강환종
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2001년도 하계종합학술대회 논문집(1)
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    • pp.341-344
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    • 2001
  • H.323 proposes to use Mobile IP and H.323 ad hoc conference signaling to provide Handoff function to an H.323 mobile terminal. But the H.323 ad hoc conference signaling has a drawback. It requires an H.323 terminal to do a complex conference signaling which takes a longer signaling time. In this paper, we propose an GK architecture that provides Handoff function effectively using 3$^{rd}$ P'||'||'||'||'||'&'||'||'||'||'||'R(Third party initiated Pause and Rerouting) signaling which are done through H.245 logical channel. The GK which is implementing 3$^{rd}$ P'||'||'||'||'||'&'||'||'||'||'||'R signaling only requires an H.323 endpoint to do the H.323 basic signaling in reestablishing media channel and gives the faster Handoff signaling. To do this, our GK has derived H.245 control channel using tunneling f3r all H.323 calls including the fast connect calls which enable terminals communicate each other if they doesn't have H.245 control channel .municate each other if they doesn't have H.245 control channel .

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Histone Deacetylase-3/CAGE Axis Targets EGFR Signaling and Regulates the Response to Anti-Cancer Drugs

  • Kim, Hyuna;Kim, Youngmi;Goh, Hyeonjung;Jeoung, Dooil
    • Molecules and Cells
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    • 제39권3호
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    • pp.229-241
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    • 2016
  • We have previously reported the role of miR-326-HDAC3 loop in anti-cancer drug-resistance. CAGE, a cancer/testis antigen, regulates the response to anti-cancer drug-resistance by forming a negative feedback loop with miR-200b. Studies investigating the relationship between CAGE and HDAC3 revealed that HDAC3 negatively regulated the expression of CAGE. ChIP assays demonstrated the binding of HDAC3 to the promoter sequences of CAGE. However, CAGE did not affect the expression of HDAC3. We also found that EGFR signaling regulated the expressions of HDAC3 and CAGE. Anti-cancer drug-resistant cancer cell lines show an increased expression of $pEGFR^{Y845}$. HDAC3 was found to negatively regulate the expression of $pEGFR^{Y845}$. CAGE showed an interaction and co-localization with EGFR. It was seen that miR-326, a negative regulator of HDAC3, regulated the expression of CAGE, $pEGFR^{Y845}$, and the interaction between CAGE and EGFR. miR-326 inhibitor induced the binding of HDAC3 to the promoter sequences in anti-cancer drug-resistant $Malme3M^R$ cells, decreasing the tumorigenic potential of $Malme3M^R$ cells in a manner associated with its effect on the expression of HDAC3, CAGE and $pEGFR^{Y845}$. The down-regulation of HDAC3 enhanced the tumorigenic, angiogenic and invasion potential of the anti-cancer drug-sensitive Malme3M cells in CAGE-dependent manner. Studies revealed that $PKC{\delta}$ was responsible for the increased expression of $pEGFR^{Y845}$ and CAGE in $Malme3M^R$ cells. CAGE showed an interaction with $PKC{\delta}$ in $Malme3M^R$ cells. Our results show that HDAC3-CAGE axis can be employed as a target for overcoming resistance to EGFR inhibitors.

Nutrient Utilization, Body Composition and Lactation Performance of First Lactation Bali Cows (Bos sondaicus) on Grass-Legume Based Diets

  • Sukarini, I.A.M.;Sastradipradja, D.;Sutardi, T.;Mahardika, IG.;Budiarta, IG.A.
    • Asian-Australasian Journal of Animal Sciences
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    • 제13권12호
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    • pp.1681-1690
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    • 2000
  • A study on energy and protein utilization, and milk production of Bali cows on grass-legume diets was carried out using 12 first lactation cows (initial BW $263.79{\pm}21.66kg$) during a period of 16 weeks starting immediately post calving. The animals were randomly allotted into 4 dietary treatment groups R1, R2, R3 and R4, receiving from the last 2 months of pregnancy onwards, graded improved rations based on a mixture of locally available grass and legume feed ad libitum. R1 contained on a DM basis 70% elephant grass (PP, Penisetum purpureum) plus 30% Gliricidia sepia leaves (GS), R2 was 30% PP plus 55% GS supplemented with 15% Hibiscus tilliactus leaves (HT, defaunating effect), R3 and R4 were 22.5% PP+41.25% GS+11.25% HT+25% concentrate, where R3 was not and R4 supplemented with zinc di-acetate. TDN, CP and zinc contents of the diets were 58.2%, 12.05% and 18.3 mg/kg respectively for R1, 65.05%, 16.9% and 25.6 mg/kg respectively for R2, 66.03%, 16.71% and 29.02 mg/kg respectively for R3 and 66.03%, 16.71% and 60.47 mg/kg respectively for R4. Milk production and body weight were monitored throughout the experimental period. In vivo body composition by the urea space technique validated by the body density method and supported by carcass data was estimated at the start and termination of the experiment. Nutrient balance and rumen performance characteristics were measured during a balance trial of 7 days during the 3rd and 4th week of the lactation period. Results indicated that quality of ration caused improvement of ruminal total VFA concentration, increments being 52 to 65% for R2, R3 and R4 above R1, with increments of acetate being less (31 to 48%) and propionate being proportionally more in comparison to total VFA increments. Similarly, ammonia concentrations increased to 5.24 to 7.07 mM, equivalent to 7.34 to 9.90 mg $NH_3-N/100ml$ rumen fluid. Results also indicated that feed quality did not affect DE and ME intakes, and heat production (HP), but increased GE, UE, energy in milk and total retained energy (RE total) in body tissues and milk. Intake-, digestible- and catabolized-protein, and retained-protein in body tissues and milk (Rprot) were all elevated increasing the quality of ration. Similar results were obtained for milk yield and components with mean values reaching 2.085 kg/d (R4) versus 0.92 kg/d (R1) for milk yield, and 170.22 g/d (R4) vs 71.69 g/d (R1), 105.74 g/d (R4) vs 45.35 g/d (R1), 101.34 g/d (R4) vs 46.36 g/d (R1) for milk-fat, -protein, and -lactose, respectively. Relatively high yields of milk production was maintained longer for R4 as compared to the other treatment groups. There were no significant effects on body mass and components due to lactation. From the relationship $RE_{total}$ (MJ/d)=12.79-0.373 ME (MJ/d); (r=0.73), it was found that $ME_{m}=0.53MJ/kgW^{0.75}.d$. Requirement of energy to support the production of milk, ranging from 0.5 to 3.0 kg/d, follows the equation: Milk Prod. ($Q_{mp}$, kg/d)=[-2.48+4.31 ME($MJ/kg^{0.75}.d$)]; (r=0.6) or $Q_{mp}$=-3.4+[0.08($ME-RE_{body\;tissue}$)]MJ/d]; (r=0.94). The requirement for protein intake for maintenance ($IP_m$) equals $6.19 g/kg^{0.75}.d$ derived from the relationship RP=-47.4+0.12 IP; (r=0.74, n=9). Equation for protein requirement for lactation is $Q_{nl}$=[($Q_{mp}$)(% protein in milk)($I_{mp}$)]/100, where $Q_{nl}$ is g protein required for lactation, $Q_{mp}$ is daily milk yield, Bali cow's milk-protein content av. 5.04%, and $I_{mp}$ is metabolic increment for milk production ($ME_{lakt}/ME_{m}=1.46$).

유연한 곁가지 말단에 이온성 작용기를 가지는 양이온성 수분산 PU의 제조와 물성 (Preparation and Properties of Water-borne PU Having Ionic Center onto Flexible Side Chain)

  • 김동민;방문수;김형중
    • 접착 및 계면
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    • 제7권1호
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    • pp.3-9
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    • 2006
  • 세 개의 isocyanate작용기를 가지는 IP-$75^{(R)}$와 하나의 hydroxyl작용기를 가지는 여러 가지 amino alcohol을 ionomer로 이용하여 수분산에 필요한 ionic center가 측쇄에 위치하는 양이온성 수분산 polyurethane (PU)을 합성하였다. NCO/OH몰 비, ionomer의 종류 및 중화제의 종류에 따라 수분산 PU의 입도, 점도, 분산안정성, 접촉각, 표면에너지, $T_g$, 그리고 접착강도의 변화를 알아보았다. 제조된 수분산 PU는 주쇄에 ionic center를 가지는 양이온 수분산 PU보다 더 작은 입도를 가지며 분산안정성도 우수함을 확인하였다.

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수치사진측량을 이용한 도로정보체계 개발 (Development of Road Information System Using Digital Photogrammetry)

  • 서동주;이종출
    • 대한공간정보학회지
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    • 제11권4호
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    • pp.3-11
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    • 2003
  • 최근 수치사진측량은 사진측량의 기본원리를 이용하여, 각종 첨단 산업분야에 그 응용이 증대되고 있으며, 많은 관심과 연구가 진행되고 있는 실정이다. 본 연구에서는 수치사진측량에 의한 도로정보체계 개발을 하고자한다. 수치 사진측량에서 취득된 자료들을 객체 지향적인 언어인 Delphi를 이용하여 도로평면선형정보 (BC, EC, R, IP)와 도로종단선형정보 및 도로시설물정보를 구축하는 프로그램을 개발하였고, 개발된 프로그램은 영상자료를 많이 이용하여 기존보다 시각적인 효과를 극대화 할 수 있었다.

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System Level Architecture Evaluation and Optimization: an Industrial Case Study with AMBA3 AXI

  • Lee, Jong-Eun;Kwon, Woo-Cheol;Kim, Tae-Hun;Chung, Eui-Young;Choi, Kyu-Myung;Kong, Jeong-Taek;Eo, Soo-Kwan;Gwilt, David
    • JSTS:Journal of Semiconductor Technology and Science
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    • 제5권4호
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    • pp.229-236
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    • 2005
  • This paper presents a system level architecture evaluation technique that leverages transaction level modeling but also significantly extends it to the realm of system level performance evaluation. A major issue lies with the modeling effort. To reduce the modeling effort the proposed technique develops the concept of worst case scenarios. Since the memory controller is often found to be an important component that critically affects the system performance and thus needs optimization, the paper further addresses how to evaluate and optimize the memory controllers, focusing on the test environment and the methodology. The paper also presents an industrial case study using a real state-of-the-art design. In the case study, it is reported that the proposed technique has helped successfully find the performance bottleneck and provide appropriate feedback on time.

IP 기반 통합 네트워크에서 사용자 이동성 지원을 위한 세션 관리 방안 (Session Management Scheme for Supporting User Mobility in a IP-Based Convergence Network)

  • 유명주;박주만;이종성
    • 한국통신학회논문지
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    • 제41권6호
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    • pp.652-662
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    • 2016
  • 본 논문은 IP 기반의 통합 네트워크 환경에서 사용자가 단말을 변경해가며 서비스를 이용하고자 하는 경우에 끊김없는 서비스 이용이 가능한 사용자 이동성 관리 방안을 제안한다. 기존 이동성 기술들과 현재 진행 중인 대부분의 이동성 관련 연구들은 단말 이동성 지원에 집중되어 있어 다양한 유형의 이동성을 지원하기에 한계가 있다. 제안방안은 사용자 고유의 식별자인 UID(User Identifier)와 사용자가 이용하는 단말 고유의 식별자인 TID(Terminal Identifier) 간 매핑 관계와 사용자 고유의 영구적인 3계층 주소를 이용한 패킷 구성으로 사용자가 서비스 이용 중에 단말을 변경하더라도 세션이 유지될 수 있도록 한다. 제안방안에 의한 성능 향상을 검증하기 위해 수식을 이용하여 기존 사용자 이동성 방안과 제안방안의 핸드오버 시그널링 비용을 분석하고 비교하였다. 그 결과 제안방안이 기존방안 보다 더 나은 성능을 보임을 확인하였다.

유도분극을 활용한 해저터널 굴착면 전방 지반상태 예측: 실내실험 (Utilization of induced polarization for predicting ground condition ahead of tunnel face in subsea tunnelling: laboratory test)

  • 박진호;이강현;이성원;유영무;이인모
    • 한국터널지하공간학회 논문집
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    • 제17권3호
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    • pp.383-392
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    • 2015
  • 해저터널 건설 중 터널 굴착면 전방에 존재하는 고수압 조건의 함수대 (또는 포화상태의 파쇄대)의 상태를 정확히 예측하는 것은 터널 안전시공의 핵심적인 요소이다. 이 연구는 해저터널 굴착면에서 전방지반의 상태를 예측하기 위해 유도분극(Induced Polarization, IP) 탐사의 활용 가능성을 입증하였다. 모래지반에서의 충전성(chargeability)을 산정하기 위해 간극모델을 제안하고, 충전성과 이에 영향을 미치는 변수들 사이의 관계식을 유도하였다. 관계식을 사용하여 매개변수 분석을 실시하였으며 그 결과 입자 사이의 간극 중 좁은 간극($r_1$)의 크기와 간극수의 염도가 충전성에 가장 큰 영향을 미쳤다. 또한, 실내실험으로 유도분극 현상에 영향을 미치는 지반조건을 파악하기 위해 간극수의 염도와 파쇄대의 두께 변화 그리고 가우지(gouge) 존재 여부에 따른 충전성과 전기비저항의 변화 추이를 규명하고자 하였다. 그 결과 파쇄대의 절리 사이에 가우지가 충진된 경우, 해수조건에서도 충전성이 높게 나타났다. 이는 가우지가 좁은 간극($r_1$)의 크기를 감소시키기 때문이라고 판단된다.

Cordycepin-Enriched WIB801C from Cordyceps militaris Inhibits Collagen-Induced [Ca2+]i Mobilization via cAMP-Dependent Phosphorylation of Inositol 1, 4, 5-Trisphosphate Receptor in Human Platelets

  • Lee, Dong-Ha;Kim, Hyun-Hong;Cho, Hyun-Jeong;Yu, Young-Bin;Kang, Hyo-Chan;Kim, Jong-Lae;Lee, Jong-Jin;Park, Hwa-Jin
    • Biomolecules & Therapeutics
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    • 제22권3호
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    • pp.223-231
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    • 2014
  • In this study, we prepared cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha, and investigated the effect of CE-WIB801C on collagen-induced human platelet aggregation. CE-WIB801C dose-dependently inhibited collagen-induced platelet aggregation, and its $IC_{50}$ value was $175{\mu}g/ml$. CE-WIB801C increased cAMP level more than cGMP level, but inhibited collagen-elevated $[CA^{2+}]_i$ mobilization and thromboxane $A_2$ ($TXA_2$) production. cAMP-dependent protein kinase (A-kinase) inhibitor Rp-8-Br-cAMPS increased the CE-WIB801C-downregulated $[CA^{2+}]_i$ level in a dose dependent manner, and strongly inhibited CE-WIB801C-induced inositol 1, 4, 5-trisphosphate receptor ($IP_3R$) phosphorylation. These results suggest that the inhibition of $[CA^{2+}]_i$ mobilization by CE-WIB801C is resulted from the cAMP/A-kinase-dependent phosphorylation of $IP_3R$. CE-WIB801C suppressed $TXA_2$ production, but did not inhibit the activities of cyclooxygenase-1 (COX-1) and $TXA_2$ synthase (TXAS). These results suggest that the inhibition of $TXA_2$ production by WIB801C is not resulted from the direct inhibition of COX-1 and TXAS. In this study, we demonstrate that CE-WIB801C with cAMP-dependent $CA^{2+}$-antagonistic antiplatelet effects may have preventive or therapeutic potential for platelet aggregation-mediated diseases, such as thrombosis, myocardial infarction, atherosclerosis, and ischemic cerebrovascular disease.

Linearity-Distortion Analysis of GME-TRC MOSFET for High Performance and Wireless Applications

  • Malik, Priyanka;Gupta, R.S.;Chaujar, Rishu;Gupta, Mridula
    • JSTS:Journal of Semiconductor Technology and Science
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    • 제11권3호
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    • pp.169-181
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    • 2011
  • In this present paper, a comprehensive drain current model incorporating the effects of channel length modulation has been presented for multi-layered gate material engineered trapezoidal recessed channel (MLGME-TRC) MOSFET and the expression for linearity performance metrics, i.e. higher order transconductance coefficients: $g_{m1}$, $g_{m2}$, $g_{m3}$, and figure-of-merit (FOM) metrics; $V_{IP2}$, $V_{IP3}$, IIP3 and 1-dB compression point, has been obtained. It is shown that, the incorporation of multi-layered architecture on gate material engineered trapezoidal recessed channel (GME-TRC) MOSFET leads to improved linearity performance in comparison to its conventional counterparts trapezoidal recessed channel (TRC) and rectangular recessed channel (RRC) MOSFETs, proving its efficiency for low-noise applications and future ULSI production. The impact of various structural parameters such as variation of work function, substrate doping and source/drain junction depth ($X_j$) or negative junction depth (NJD) have been examined for GME-TRC MOSFET and compared its effectiveness with MLGME-TRC MOSFET. The results obtained from proposed model are verified with simulated and experimental results. A good agreement between the results is obtained, thus validating the model.