• Genomics & Informatics
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• v.1 no.2
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• pp.101-107
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• 2003

Loss of heterozygosity (LOH) has been used to detect deleted regions of a specific chromosome in cancer cells. LOH on chromosome 16q has been reported to occur frequently in progressed hepatocellular carcinoma (HCC). Liver tissues from 37 Korean HCC patients were analyzed for LOH by using 25 polymorphic microsatellite markers distributed along 16q. Out of the 37 HCC patients studied, 21 patients (56.8%) showed LOH in various regions of 16q with at least one polymorphic marker. Puring the analysis of these 21 LOH cases, 6 patients showed interstitial LOHs in which the boundary of the LOH region was defined. With two rounds of LOH analysis, five commonly occurring interstitial LOH regions were identified; 16q21-22.1, 16q22.2 - 22.3, 16q22.3, 16q23.2 and 16q23.3 - 24.1. Among the five LOH regions the 16q23.3 - 24.1 region has been reported to be related with chromosome instability. A complete physical map, which covers the 3.2 Mb region of 16q23.3 - 24.1 (D16S402 and D16S486), was constructed to identify novel candidate tumor suppressor genes. We provide the minimally tiling path map consisting of 28 BAC clones. There was one gap between NT_10422.11 and NT_019609.9 of the human genome sequence contig (NCBI sequence build 33, April 29, 2003). This gap can be filled by sequencing the R-1425M20 clone which bridges these sequence contigs.

• Journal of applied mathematics & informatics
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• v.41 no.1
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• pp.167-179
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• 2023

In this paper, we investigate solutions of equations which are linear (p, q)-difference equation of higher order by using (p, q)-derivative and integral. We also derive the solution of equation in the case of second order.

• Communications of the Korean Mathematical Society
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• v.27 no.3
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• pp.557-564
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• 2012

This study concerns the existence of positive solution for the following nonlinear system $$\{-div(|x|^{-ap}|{\nabla}u|^{p-2}{\nabla}u)=|x|^{-(a+1)p+c_1}({\alpha}_1f(v)+{\beta}_1h(u)),x{\in}{\Omega},\\-div(|x|^{-bq}|{\nabla}v|q^{-2}{\nabla}v)=|x|^{-(b+1)q+c_2}({\alpha}_2g(u)+{\beta}_2k(v)),x{\in}{\Omega},\\u=v=0,x{\in}{\partial}{\Omega}$$, where ${\Omega}$ is a bounded smooth domain of $\mathbb{R}^N$ with $0{\in}{\Omega}$, 1 < $p,q$ < N, $0{{\leq}}a<\frac{N-p}{p}$, $0{{\leq}}b<\frac{N-q}{q}$ and $c_1$, $c_2$, ${\alpha}_1$, ${\alpha}_2$, ${\beta}_1$, ${\beta}_2$ are positive parameters. Here $f,g,h,k$ : $[0,{\infty}){\rightarrow}[0,{\infty})$ are nondecresing continuous functions and $$\lim_{s{\rightarrow}{\infty}}\frac{f(Ag(s)^{\frac{1}{q-1}})}{s^{p-1}}=0$$ for every A > 0. We discuss the existence of positive solution when $f,g,h$ and $k$ satisfy certain additional conditions. We use the method of sub-super solutions to establish our results.

• Progress in Superconductivity
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• v.1 no.1
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• pp.36-41
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• 1999

Methods for mode identification and accurate measurements of the unloaded Q ($Q_0$) of a dielectric-loaded $TE_{01{\delta}}$ mode cavity resonator with HTS endplates are proposed. A resonator with a sapphire rod and $YBa_2Cu_3O_{7-x}$(YBCO) endplates was prepared and its microwave properties were studied at temperatures above 30 K. The $TE_{01{\delta}}$ mode $Q_0$ of the resonator, designed to work as a tunable resonator with variations in the gap distance (s) between the sapphire rod and the top YBCO, was more than 1000000 at s = 0 mm and at 30 K with the resonant frequency of 19.56 GHz. The $TE_{01{\delta}}$ mode $Q_0$ decreases as s increases for s < 2 mm until mode couplings between the $TE_{01{\delta}}$ mode and other modes appeared at s = 2 mm. Significant dependence of the $TE_{01{\delta}}$ mode $Q_0$ on the input and output coupling constants was also observed. Applications of the open-ended $TE_{01{\delta}}$ mode cavity resonator for a tunable resonator with a very high Q as well as a characterization tool for the surface resistance measurements of HTS films are described.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.1
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• pp.58-63
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• 2022

The daily number of confirmed cases of Coronavirus disease 2019(COVID-19) ranges between 1,000 and 2,000. Despite higher vaccination rates, the number of confirmed cases continues to increase. The Mu variant of COVID-19 reported in some countries by WHO has been identified in Korea. In this study, we predicted the number of confirmed COVID-19 cases in Korea using the SARIMA for the Covid-19 prevention strategy. Trends and seasonality were observed in the data, and the ADF Test and KPSS Test was used accordingly. Order determination of the SARIMA(p,d,q)(P, D, Q, S) model helped in extracting the values of p, d, q, P, D, and Q parameters. After deducing the p and q parameters using ACF and PACF, the data were transformed and schematized into stationary forms through difference, log transformation, and seasonality removal. If seasonality appears, first determine S, then SARIMA P, D, Q, and finally determine ARIMA p, d, q using ACF and PACF for the order excluding seasonality.

• Journal of the Chungcheong Mathematical Society
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• v.31 no.2
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• pp.231-237
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• 2018

Hardy's inequality is refined non-trivially as the form $${\int_{0}^{{\infty}}}\{{\frac{1}{x}}{\int_{0}^{x}}f(t)dt\}^pdx{\leq}Q_f{\times}({\frac{p}{p-1}})^p{\int_{0}^{x}}f^p(x)dx$$ for some $Q_f:0{\leq}Q_f{\leq}1$. $P{\acute{o}}lya$-Knopp's inequality is also refined by the similar form.

• Journal of Applied Biological Chemistry
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• v.65 no.4
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• pp.277-286
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• 2022

Schizophragma hydrangeoides (S. hydrangeoides) is a vine endogenous to Jeju Island and Ulleungdo, where it grows attached to the foothills and rock surfaces. Previous research has mostly focused on the whitening effect of S. hydrangeoides leaf extract. In this study, we investigated S. hydrangeoides leaf extract further, and detected four phytochemicals in the extract: chlorogenic acid, quercetin-3-O-glucosyl-(1-2)-rhamnoside, quercetin-3-O-xylosyl-(1-2)-rhamnoside, and quercitrin. We pretreated human dermal fibroblast (HDFn) cells with previously established concentrations of the four compounds for 1 h before ultraviolet A (UVA) irradiation. Among the four compounds, quercetin-3-O-glucosyl-(1-2)-rhamnoside (Q-3-GR) best inhibited matrix metalloproteinase-1 (MMP-1) levels. Thus, we investigated the protective effects of Q-3-GR on photoaging and its underlying mechanisms. Q-3-GR significantly reduced MMP-1 production and inhibited MMP-1 protein expression in UVA-irradiated HDFn cells. Furthermore, Q-3-GR increased procollagen type I production and protein expression. Q-3-GR exerted its anti-photoaging effects by downregulating the mitogen-activated protein kinase/ activator protein-1 signaling pathway, and upregulating the transforming growth factor-β/Smad signaling pathway. Thus, S. hydrangeoides leaf-derived Q-3-GR is a potential potent cosmetic ingredient for UV-induced skin aging.

• The Journal of Engineering Geology
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• v.16 no.1 s.47
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• pp.31-43
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• 2006

As a result of calculating bearing capacity of soft silt soil(ML) and soft silt soils(ML', SM, SM') mixed with sand, all kinds of soils showed smaller values than existing expressions and when theoretical values are applied, considerable review is required. It was found that ultimate surcharge(bearing capacity) of soft silt soil was $q_{ult}=1.34C_u$ that of ML' soil in soft silt soils mixed with 3 kinds of sand $q_{ult}=1.40s$, that of SM soil $q_{ult}=1.73s$ and that of SM' soil $q_{ult}=2.72s$, Consequently, as content of sand having greater permeability than silt soil in creased, soil was stabilized gradually.

• Kyungpook Mathematical Journal
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• v.47 no.3
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• pp.381-392
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• 2007

In 1906, da Rios, a student of Leivi-Civita, wrote a master's thesis modeling the motion of a vortex in a viscous fluid by the motion of a curve propagating in $R^3$, in the direction of its binormal with a speed equal to its curvature. Much later, in 1971 Hasimoto showed the equivalence of this system with the non-linear Schr$\ddot{o}$dinger equation (NLS) $$q_t=i(q_{ss}+\frac{1}{2}{\mid}q{\mid}^2q$$. In this paper, we use the same idea as Terng used in her lecture notes but different technique to extend the above relation to the case of $R^3$, and obtained an analogous equation that $$q_t=i[q_{ss}+(\frac{1}{2}{\mid}q{\mid}^2+1)q]$$.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.6
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• pp.27-33
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• 2008

Given a polynomial ${\hbar}(x){\in}F_q[x]$ of degree h, it is an important problem to determine the size of multiplicative subgroup of $\(F_q[x]/({\hbar(x))\)*$ generated by $x-s_1,\;x-s_2,\;{\cdots},\;x-s_n$, where $\{s_1,\;s_2,\;{\cdots},\;s_n\}{\sebseteq}F_q$, and for all ${\hbar}(x){\neq}0$. So far the best known asymptotic lower bound is $(rh)^{O(1)}\(2er+O(\frac{1}{r})\)^h$, where $r=\frac{n}{h}$ and e(=2.718...) is the base of natural logarithm. In this paper, we exploit the coding theory connection of this problem and prove a better lower bound $(rh)^{O(1)}\(2er+{\frac{e}{2}}{\log}r-{\frac{e}{2}}{\log}{\frac{e}{2}}+O{(\frac{{\log}^2r}{r})}\)^h$, where log stands for natural logarithm We also discuss about the limitation of this approach.