• Journal of Convergence for Information Technology
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• v.7 no.6
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• pp.35-43
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• 2017

The purpose of this study was to analyze the converged influencing factors on the stages of exercise behavior changes in shift work nurses. The subjects were 120 shift work nurses working in hospitals who understood the purpose of the study and agreed to participate in the study. Data were analyzed using frequency, percentage, mean, standard deviation, t-test, $X^2$ test, and multiple logistic regression analysis. The exercise motivation factors of shift work nurses had a significant effect on stages of exercise behavior change (${\beta}=2.480$, p=.022), health status perceptions(${\beta}=1.151$, p=.013). Social support factors (${\beta}=1.819$, p=.002) and marital status (${\beta}=-1.820$, p=.004) also had significant effects on the stages of exercise behavior change of shift work nurses. In other words, subjects with change in exercise behavior had 11.9 times higher motivation and 3.1 times higher health status perception than those without change in exercise behavior, social support was 6.1 times higher, and unmarried subjects showed 16 times showed higher than that of married subjects. Therefore, it is important to develop a strategy to practice continuous and regular exercise in consideration of the exercise motivation, social support, and health status perception of the nurses in shift work.

• Journal of the Korea Convergence Society
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• v.9 no.7
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• pp.105-115
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• 2018

This study examined convergence factors influencing the job embeddedness of nurses in general hospitals. Data were collected using a structured questionnaire. Data were analyzed using t-test, ANOVA, Pearson's correlation coefficient, and multiple regression. The job embeddedness in participants showed a significant correlation between job stress (r=-.50, p<.001), meaning of work (r=.70, p<.001), and calling (r=.58, p<.001). The significant factors influencing the job embeddedness were meaning of work (${\beta}=.57$, p<.001) and job stress (${\beta}=-.19$, p=.008); these factors explained 51.2% of the variance. Based on these findings, nursing college need to develop a curriculum to foster meaning of work and calling in clinical practice courses and to remain nurses.

• Journal of the Korea Convergence Society
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• v.9 no.3
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• pp.289-295
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• 2018

This study is to investigate the HPV vaccination intention among male university students by cervical cancer knowledge and health belief. A sample of 159 male non-health related majoring students was asked to respond to a self-administrated questionnaire about the intention to inject HPV vaccine, knowledges of cervical cancer, and the level of health belief. T-test, ANOVA, pearson's correlation coefficient and multiple group analysis were utilized. Vaccination intention had a positive relation with knowledge of cervical cancer(${\beta}=.200$, p=.01). Health belief was also related with the vaccination intention. There was a significant relation between the vaccination intention and perceived seriousness (${\beta}=.362$, p=.01). This study suggested that the health and HPV convergent education at least as an extracurricular course should be offer to male university students for them to develop an intention to HPV vaccination.

• Korean Journal of Microbiology
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• v.55 no.1
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• pp.9-16
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• 2019

Acetoin is generated by numerous microorganisms using ${\alpha}$-acetolactate decarboxylase (ALDC) to prevent overacidification of cells and their environment and to store remaining energy. Because acetoin has been used as a safe flavor enhancer in food products, industries have been interested in biotechnological production of acetoin using ALDC. ALDC is a metal-dependent enzyme that produces acetoin from ${\alpha}$-acetolactate through decarboxylation reaction. Here, we report the crystal structure of ALDC from Bacillus subtilis subspecies spizizenii (bssALDC) at $1.7{\AA}$ resolution. bssALDC folds into a two-domain ${\alpha}/{\beta}$ structure where two ${\beta}$-sheets form a central core. bssALDC assembles into a dimer through central hydrophobic interactions and peripheral hydrophilic interactions. bssALDC coordinates a zinc ion using three histidine residues and three water molecules. Based on comparative analyses of ALDC structures and sequences, we propose that the active site of bssALDC includes the zinc ion and its neighboring bssALDC residues.

• Journal of the Korea Convergence Society
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• v.9 no.6
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• pp.241-250
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• 2018

The purpose of this study was to determine factors affecting the suicidal ideation in spouse caregivers of the elderly with dementia Living in the Community. The data were collected from 160 spouses of elderly people with dementia who use dementia support centers and long-term care service in seoul. Data were collected with structured questionnaires to investigate the general characteristics and suicidal ideation-related factors, and analyzed using t-test, ANOVA, Pearson's correlation coefficient, Multiple regression analysis with SPSS win version 24.0 program. The significant factors affecting suicidal ideation were entrapment(${\beta}=.452$), SDAP(${\beta}=.273$), coping strategies(${\beta}=-.199$), it were explained 55.7%(F=19.199, p<.001). Therefore, counseling and education should be provided to help reduce the entrapment and enhance coping strategy with the dementia condition of the elderly with dementia. Measures also need to be made to improve the accessibility of a spouse with dementia that are left neglected.

• Journal of the Korea Convergence Society
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• v.9 no.10
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• pp.457-465
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• 2018

The purpose of this study is to investigate the effect of nurse's hospital work environment and supervisor trust on turnover intention. The subjects were 122 nurses in five hospitals in B city and collected data by using giving questionnaire, and used the SPSS 22.0 program to analyze. As a result of the study, there was a positive correlation between the hospital environment and turnover intention (r=534, p<.001), there were negative correlation between hospital work environment and supervisor trust(r=-.232, p=.010), between supervisor trust and turnover intention (r=-.314, p=.001). The factors affecting the turnover intention of nurses were hospital work environment (${\beta}=.505$, p<.001), supervisor trust (${\beta}=-.229$, p=.003), and job position (${\beta}=-.213$, p=.011). Therefore, in order to reduce the turnover intention of nurses, it is necessary to improve the hospital work environment and to establish a strategic program to build and improve supervisor trust.

• Journal of the Korea Convergence Society
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• v.9 no.12
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• pp.355-363
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• 2018

Found pesticide-contaminated eggs in 2017, the situation became a hot issue in many countries in the world as well as Korea. In the context of the pesticide-contaminated egg, this study explored that preventive behavioral intention would be predicted by perceived susceptibility and severity from health belief model, trust in the government and evaluation of information from the government, and subjective knowledge. We found that preventive behavioral intention was explained by perceived severity (${\beta}=.262$, t=3.531, p<0.001), trust in the government (${\beta}=.25$, t=3.281, p<0.001), and evaluation of the information from the government (${\beta}=.226$, t=2.936, p<0.01) through stepwise multiple linear regression analysis. The findings imply the government would administer policy in terms of credibility, accuracy, and consistency for decreasing the public's sense of unease and panic when a similar incident occurs.

• Parasites, Hosts and Diseases
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• v.57 no.4
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• pp.379-387
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• 2019

Clonorchis sinensis is a carcinogenic human liver fluke that promotes hepatic inflammatory environments via direct contact or through their excretory-secretory products (ESPs), subsequently leading to cholangitis, periductal fibrosis, liver cirrhosis, and even cholangiocarcinoma (CCA). This study was conducted to examine the host inflammatory responses to C. sinensis ESPs and their putative protein components selected from C. sinensis expressed sequenced tag (EST) pool databases, including $TGF-{\beta}$ receptor interacting protein 1(CsTRIP1), legumain (CsLeg), and growth factor binding protein 2 (CsGrb2). Treatment of CCA cells (HuCCT1) with the ESPs or bacterial recombinant C. sinensis proteins differentially promoted the secretion of proinflammatory cytokines ($IL-1{\beta}$, IL-6, and $TNF-{\alpha}$) as well as anti-inflammatory cytokines (IL-10, $TGF-{\beta}1$, and $TGF-{\beta}2$) in a time-dependent manner. In particular, recombinant C. sinensis protein treatment resulted in increase (at maximum) of ~7-fold in $TGF-{\beta}1$, ~30-fold in $TGF-{\beta}2$, and ~3-fold in $TNF-{\alpha}$ compared with the increase produced by ESPs, indicating that CsTrip1, CsLeg, and CsGrb2 function as strong inducers for secretion of these cytokines in host cells. These results suggest that C. sinensis ESPs contribute to the immunopathological response in host cells, leading to clonorchiasis-associated hepatobiliary abnormalities of greater severity.

• Journal of Convergence for Information Technology
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• v.9 no.5
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• pp.48-54
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• 2019

This study was conducted to investigate the relationship between depression and stress self-esteem, self-efficacy and nursing students influence factors. This study is a descriptive research study of 116 nursing college students in 3rd graders at two c, h colleges in c area. The data were analyzed by SPSS/WIN 21.0 program, descriptive statistics, ANOVA, t-test, and Pearson correlation coefficient calculation and multiple regression analysis. Data collection took place from October 2017 to December 2017. The factors affecting depression were stress (${\beta}=0.246$, p=.000), self-efficacy(${\beta}=-.170$, p=.000) and self-esteem(${\beta}=-.131$, p=.000). In order to prevent depression in nursing college students, it is necessary to investigate the cause of depression and the degree of depression, and to reduce the depression and find ways to counteract emotional health problems.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.2
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• pp.118-122
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• 2016

Integrin ${\alpha}_v{\beta}_3$ plays an important role in the tumor metastases and angiogenesis. Arginine-glycine-aspartate (RGD) peptide motif binds to the integrin ${\alpha}_v{\beta}_3$. General $^{68}Ga$-labeled cyclic RGD peptides was rapidly eliminated from the circulatory system by renal excretion because of its hydrophilic property. The purpose of this study was to develop a novel $^{68}Ga$-labeled cyclic RGD peptides, which could acquire enhanced PET tumor images with improved pharmacokinetics by adopting biphenyl group between chelator and RGD peptides. $^{68}Ga$-DOTA-2P-c(RGDyK) was demonstrated a 12% higher lipophilicity level than $^{68}Ga$-DOTA-c(RGDyK) as a reference compound. In the animal PET, $^{68}Ga$-DOTA-2P-c(RGDyK) represented relatively lower blood-clearance, and an increased signal to noise ratio compared to $^{68}Ga$-DOTA-c(RGDyK). From these perspective, $^{68}Ga$-DOTA-2P-c(RGDyK) could be a good candidate for in integrin ${\alpha}_v{\beta}_3$-expressed tumor imaging.