Purpose. This study was to investigate the relationships among mobile internet addiction, sleep quality, anxiety, and interpersonal relationship in university students. Method. A descriptive study design was used. Between 10 and 31 March 2016, 213 subjects completed a questionnaire consisting of questions on mobile internet addiction, anxiety, sleep quality, and interpersonal relationship. The data were analyzed using descriptive statistics, One way-ANOVA, and Pearson's correlation coefficient SPSS/WIN 21.0 programs. Results. Among mobile internet addiction there were significant differences between gender (t=3.40, p<.001), grade (F= 2.31, p<.001), majority field (F=5.34, p=.005), and take exercise (t=3.50, p<.001). This study has shown that mobile internet addiction were associated with sleep quality (r=-.40, p<.001) and anxiety (r=.14, p=.037). In addition, a correlation has been found significant between anxiety, and sleep quality (r=.48, p<.001), and sleep quality has associated with interpersonal relationship (r=-.46, p<.001). Conclusion. In this study, we revealed the observed a meaningful significant correlation between mobile internet addiction, sleep quality and anxiety. Therefore, it is important to emphasize control of mobile internet addiction for university students. The results of this study can be used as a basis on which to develop a mobile internet addiction intervention program.