To overcome the limits of prevention and treatment against Diabetes Mellitus(DM) in Western medicine, there have been tendency finding solutions in traditional medicine based on Sogal. But Sogal had been so various concepts, classification and names. As a result there has been confusion in applying Sogal treatment to DM. So in order to clarify, it is necessary to study Sogal concepts and classification historically. The results of studying changes of Sogal concepts and classification are following : Untill AD 8 century, Sogal had not been only syndrome but also disease with throat and urinating difficulties. From 10c to 13c, Sogal had been divided three types in addition to the theories of internal organs, Samcho and complications. From 13c to 14c, the three types of Sogal theory was improved by various medical theory. But still Sogal covered the concepts of syndrome and disease. After 16c, in Chosun Dynasty. concepts of syndrome was eliminated and concepts of disease was strengthend by accounts on pathology, prognosis. complications and malignities. This tendeny was showed well in ${\ulcorner}DongEuiBoGam{\lrcorner}$ and connected to post doctors in Chosun. It was distiction with Chinese Traditional Medicine's view regarding Sogal as syndrome and disease as well, up to the present.

Neo-Confucianism(性理學) which provided an ideological base to found Chosun Dynasty which substituted for Koryu Dynasty, presented In-Cheong(仁政) as ideal statecraft. In-Cheong(仁政) is realizing spirit of In(仁) which means a forever creating power(生生之心), for that reason it was a natural result that the ruling class of Chosun Dynasty had interest in medical science. Therefore they remarked 'In-Cheong(仁政) has achieved' when medical books were published, also remarked Hwal-In-Seo(活人署） as an institute of realizing Wang-Cheong(王政) while Hwal-In-Seo(活人署) was placed in very low civil service grade, although the ruling class classified medical science as a Chap-Hak(雜學) which means not essential but necessary knowledge, and ranked it much lower than Confucianism. While had improved medical service system of Korea Dynasty, Chosun Dynasty had special interest in local medicine: expanding provincal medical centers, educating a medical student(醫生) in a medical school who was core human power in local medicine, etc. Nevertheless the local medicine was still depressed. The reasons are ; not providing enough medical center, not much fund to run each center and mobilizing a medical student(醫生) for miscellaneous labor. Depressed local medicine had changed when 士族 came to have an interest in medical science. 士族 had read a lots of medical books from the early Chosun Dynasty. 16th century they even wrote some books on medicine by themselves based on their experience as a provincial governor.　On the other hand Yi-Mun-Geon(李文楗) who wrote Muk-Jae Diary belongs to the latter. He did not use the art of acupucture. He was a civil official in Seoul, so he could get a lots of books and enough medical stuffs. After a while. he was exiled in Seong-Ju(星州) and took part in local medicine there. The local medicine was depressed in Seong-Ju(星州) at that time. Yi-Mun-Geon(李文楗) was a kind of medical consultant as well as a local doctor. Such medical doings by Sa-Jok(士族) may be a moment that provide power to local Sa-Jok(士族). Sa-Jok(士族) themselves were enthusiastic in treating their sick slaves because the slaves were financial foundation of Sa-Jok(士族). After 17th century, however, the relative importance which Sa-Jok(士族) in the country had held in 16th century had decreased gradually while professional doctors bad increased.

Hibiscus syriacus is rarely used herb. For finding up new applications of this herb, the medicinal parts and expected efficacys that recorded in 24 classics of oriental medicine were inquired. As a result of the literature review, medicinal parts and expected efficacys of Hibiscus syriacus were as follows: The medicinal parts were mainly flower and bark. But the root, branch, leaf and fruit were mentioned too. Some unidentified medicinal parts seemed to be branch or bark. The mentioned symptoms that prescribed Hibiscus syriacus are intestinal 'wind', red-white dysentery, thirst with fever after dysentery, insomnia, 'wind' syndrom, leukorrhea, regurgitation, etc. And this herb was mentioned that applied externally for scabies, hemorrhoids, prolapse of the rectum, headache, extracted tooth, etc. Therefore, bleeding intestinal diseases, insomnia, vaginal or uterine hemorrhage(for internal use), scabies or mycosis, hemorrhoids. anal fistula, prolapse of the rectum, headache(for external use) were presented as expected efficacys of Hibiscus syriacus. In future, studies for verifying the efficacys are needed.

Background : The 'Korean Medicine' is the traditional medicine in Korea, which has preserved its homogeneous quality in the long historic period. But since 1945 when Korea was divided, the Korean Medicine has also been independently developed in South and North Korea. As a Result, it has lost its national homogeneity. Objective : In order to illuminate the past and an actuality of the transition and medical system of traditional medicine in North Korea. Method : Overview a preceding research paper and the various data of traditional medicine in North Korea. Result : 1. The name of North Korea traditional medicine from 'East medicine' was changed history with 'Korean medicine', It with the method which combines a traditional medicine and a Western medicine is endeavoring to modernization. 2. The administrative systems which take charge of the traditional medicine of North Korea are the organization which manages the Korean medicine and the Bureau of The Korean medicine production control. Also there is relation of the Bureau of the treatment prevention. 3. There are 8 medical colleges other than P'yongyang medical college. There is 6 years 6 months and 7 years 7 month follows in curriculum. Conclusions : It evaluated the past and an actuality of the transition and medical system of traditional medicine in North Korea.

In Oriental medicine, the status of tongue is the important indicator to diagnose one's health, because it represents physiological and clinicopathological changes of inner parts of the body. The method of tongue diagnosis is not only convenient but also non-invasive, therefore, tongue diagnosis is one of the most widely used in Oriental medicine. But tongue diagnosis is affected by examination circumstances a lot. It depends on a light source, degrees of an angle, doctor's condition and so on. So it is not easy to make an objective and standardized tongue diagnosis. As part of way to solve this problem, in this study, we tried to design a discriminant function for white and yellow coating with multi-dimensional color vectors. There were 62 subjects involved in this study, among them 48 subjects diagnosed as white-coated tongue and 14 subjects diagnosed as yellow-coated tongue by oriental doctors. And their tongue images were acquired by a well-made Digital Tongue Diagnosis System. From those acquired tongue images, each coating section were extracted by oriental doctors, and then mean values of multi -dimensional color vectors in each coating section were calculated. By statistical analysis, two significant vectors, R in RGB space and H in HSV space, were found that they were able to describe the difference between white coating section and yellow coating section very well. Using these two values, we designed the discriminant function for coating classification and examined how good it works. As a result, the overall accuracy of coating classification was 98.4%. We can expect that the discriminant function for other coatings can be obtained in a similar way. Furthermore, if an automated segmentation algorithm of tongue coating is combined with these discriminant functions, an automated tongue coating diagnosis can be accomplished.

Background and Purpose : The purpose of this study was to investigate that which symptoms are adequate indicator of the Dampness-Phlegm pattern in the stroke patients. Methods : In the time period Jul. 2005 to Sep. 2006, 136 patients with a first-ever stroke admitted in the department of Internal Medicine of Daejeon University Oriental Medical Hospital in Daejeon city, Wonkwang Oriental Medical Hospital in Iksan, JeonJu city were included. Patients were hospitalized within 3 months after the onset of stroke. Stroke patients had been interviewed by resident who studied standard operation procedures in Fundamental Study for Standardization and Objectification of Differentiation and Pattern Identification of Syndrome of Oriental Medicine for Stroke. Gi-deficiency patients was confirmed by medical specialist diagnosis, resident diagnosis, case report form analysis without a dissenting voice. Results : Dampness-Phlegm group included 37 case, Non Dampness-Phlegm group 45 case out of 136 patients. white tongue coating, slippery purse, yellowish complexion, enlarged tongue, swollen tongue were higher among Dampness-Phlegm group. Dampness-Phlegm and Non Dampness-Phlegm patients do not significantly differ in heavy sensation in the head, voice with sputum, teeth printed tongue, borborygmus, dizziness with nausea. Conclusions : This study was insufficiency because sample size is very small. More data from prospective cohort studies will help to Korean Standard Differentiation of the Symptoms and Signs for the Stroke.

The purpose of this study was to diagnosis that what patterns identification using the statistical method. Discriminant analysis using the medical specialist and resident pattern identification agree case in stroke patients within 1 month of onset. The agreement rate of dificiency of Gi(75%), heat-transformation(74%), dampphlegm syndrome(69%), deficiency of Eum(51%) and syndrome of blood stagnation(43%) are respectively 0.75, 0.74, 0.69, 0.51 and 0.43 in medical specialist and using linear discriminant function pattern identification are same. The study of inspection, pulse feeling and palpitation will be continued to evaluate concordance rate. Discrimination model will be make to get higher Accuracy and prediction, it means becomes the help in pattern identification diagnosis objectivity and scientific.

Background and Purpose : The purpose of this case-control study was to show the relationship between risk factors(past medical history, BMI, WHR, smoking, drinking), warning signs(dyscinesia, sightless, dysarthria, sensory disorder, numbness, blephalospasm, facial spasm, tension) and the incidence of stroke in korean adults. Methods : 455 stroke patients were enrolled as the case group and 180 non-stroke patients as control group from Oct. 2005 to Feb. 2006. Patients were hospitalized within 2 weeks after the onset of stroke. Obesity were defined as $BMI{\geq}25kg/m2$, $WHR{\geq}0.9$ in male and $WHR{\geq}0.8$ in female. Risk factors and warning signs were obtained from personal interview. The analysis of the data was done by chi-square test. Fisher's exact test and test-sample t-test. Results : The percentage of current smokers(or current drinkers) of case group is higher significantly than that of control group. The past medical history of risk factors were found to be transient ischemic attack(p=0.0698), facial palsy(p=0.4061), hypertension(p<0.0001), hyperlipidemia(p=0.1484), DM(p<0.0001), ischemic heart disease(p=0.0093), migraine(p=0.0014) and hypochondria(p=0.2370). $WHR{\geq}0.9$ in male had a 6.696 (3.711-12.082) odds ratio, $WHR{\geq}0.8$ in female had a 1.567 (0.659-3.726) odds ratio. $BMI{\geq}25kg/m2$ had a 2.017(1.263-3.222). The dyscinesia and sensory disorder of warning signs were found to be statistical difference between case and control group. Conclusions : According to the above results, it was found that smoking, drinking, BMI, WHR, hypertension, DM, ischemic heart disease, migraine affected to the incidence of stroke.

Background : Sasang Constitutional Medicine (SCM) is the field of traditional Korean medicine that emphasize four constitutional types for diagnosis and treatment. Appearance, personalities and pathological characteristics are main factors of Sasang constitutional classification. Previous studies carried out by the pulse analyzer showed that the pulse wave can discriminate these types. In addition, It was reported that the pulse wave are affected by age and sexuality. In this study, we investigated the pulse wave characteristics related Sasang constitution types in control group regarding their age and sexuality. Subjects and Method : Two hudred and eighteen volunteers participated in this study: healthy men in $20{\sim}49$ years old. Participants were interviewed and examined to evaluate their health condition and Sasang constitution type. Then they were tested with pulse analyzer when they ere stabilized. The pulse at the radial artery just beside styloid process was measured, because this area is landmark for pulse diagnosis in oriental medicine. 3-D Mac pulse analyzer (Daeyo Medi Co. Ansan. Korea) was used in this study. We analyzed main features of pulse waves with the Sasang condtitution types by the SPSS for Windows (ver 12.0). Results : There was significant difference between Taeum and other types in contact pressure as weil as in coefficient of floating and sinking pulse. Conclusion : By analyzing pulse waves of healthy adult men. we found significant differences exist between Taeum and other types. These pulse differences may characterize Taeum type, and it will be helpful for the evaluation of Taeum type.

The need for the study of the revealing Sasang constitution at scientific term is increasing as the application of this discipline to the patient produces more accurate result. To obtain scientific evidence of Sasang constitution, it is crucial to analyze accumulated clinical information and associate them to the biological indices that may classify Sasang constitution. Thus, the analysis of clinical information is the most important stepping stone to go toward to the stage of developing model and decision support system (DSS) for classifying Sasang constitution. This study is a preliminary analysis of 1,109 samples collected with 171 clinical indices. To find meaningful clinical indices for classifying Sasang constitutional medicine, we applied decision tree model for them. The skin of 66.5% within whole Taeeumin is thick and non feeble. In the case of 69.8% within whole Soyangin, the skin is non feeble and slippery. In the case of 64.4% within whole Soeumin. they have feeble skin. Therefore, the property of skin can be suggested to be more important than any other index for the classification of Sasang constitution.

The aim of the study was to analyze recent trends of experimental studies regarding to acupuncture and moxibustion (AM) through reviewing the 492 papers in the PubMed database in order to help researchers from overlapping study on the same theme and to spur them to investigate experimental studies on AM with understanding the current flow of that. For the analysis, we include papers in which abstract was written in English. First, we performed quantitative analysis of the experimental studies using whole of the first filtrated 492 papers. From this analysis, we could obtain the followings: 'Trends of study in the most frequently appeared journals and leading authors in experimental study of AM'. 'The number of papers and name of journals by leading authors in experimental study of AM'. 'Trends of Korean papers in the most frequently appeared journals and Korean leading authors in experimental study of AM", 'Classification of experimental studies related to acupuncture and moxibustion according to intervention methods or individual country' and 'Assortment of experimental studies related to acupuncture and moxibustion in terms of intervention methods on leading countries'. Second, we collected 72 papers considering impact factor of the journal and influential effect of the papers' result for qualitative analysis, and we divided the papers into pain related one or not, because the effect of AM on pain is major subject of AM study. The results showed that experimental studies regarding to AM still has several weakness such as limited usage of acupuncture points and inclined application of electroacupucture even though there are 361 acupuncture points in the human body and various kinds of stimulation methods using traditional needles and moxibustion. Therefore, we suggest that researchers should pay more attention to the study on basic AM research creatively and systematically through strengthening and enhancing the cooperation among colleges, research institutes and hospitals. Moreover, in order to promote the basic research of the AM, it is required that we need cross-disciplinary research as well as international collaboration research.

In this paper, We tried to analyze the patent trend on constitution diagnosis and treatment related technologies. For this, constitution diagnosis and treatment related technologies divided into 16 sub-technology by the advisory committee. And we analyzed patents applied in Korea, Japan, U.S.A., China, and Europe. The 16 sub-technology consist of pulse analyzer, skin diagnosis, tongue analyzer, face and body detector, face analyzer, voice analyzer, intelligence ontology, meridian diagnosis, infrared thermography, electric stimulation, laser, high and low frequency, physical, magnetic, and ultrasound therapy. As a result we found that patents of constitution diagnosis and treatment in Korea has been growing steadily in both quality and quantity since 1980s. The number of patent the pulse analyzer and low frequency therapy are larger than others. But applied relevant international patents, marketability of the patent and Cites per Patent (CPP) index are shown to be very low. In conclusion, to occupy key original technologies of the Oriental medical device, we need to apply more patent of the whole related technology and international patents.

Objective : This study was aimed to review the trend of clinical research articles of acupuncture and moxibustion from the year of 1995 to 2006. Methods : The retrieving and analyzing period were from January 1995 to July 2006. Articles were collected by retrieving Pubmed database. Search terms were as follows; 'Acupuncture', 'Acupuncture & Meridian', 'Moxibustion'. After reviewing articles by our pre-defined criteria, Correlation was assessed qualitatively between contents of the final selected articles and those of Korea Institute of Oriental Medicine. Results : The number of acupuncture research articles have increased with higher rate since the year of 2000. In the field of medical devices, the articles were sparsely existed. The percentage of clinical acupuncture research articles was 75%. However, in the category of Korean investigators' researches, it was 46%. Publications by Korean investigators were concentrated to several specific journals of which their impact factor were below 1 point. Conclusion : There needs more qualifying studies in acupuncture studies which are represented by impact factor in Journal Citation Reports. It is necessary to research and develop the medical devices quantatively rating the outcome of acupuncture trials. The secondary research, such as, systematic reviews, meta-analysis, would be a key approach to evaluate the effectiveness and safety of acupuncture treatments. Moxibustion research would be noticeable in regard to its historical effectiveness and its variable indications.

1. 뜸 특허의 한국 출원인은 타국가의 특허에 비해 자국내 집중적인 출원 양상을 보이고 있었고 국적별 출원 점유율에서는 한국 국적 출원인이 전체 80%의 출원 점유율을 보였다. 2. 분야별 특허 점유율에서는 뜸구(587건) 26%, 가열수단(495건) 23%, 가열제어(96건) 4%, 제조방법(78건) 및 기타(70건)가 각 3%로 나타났다. 3. 뜸 특허 다출원자로는 한국의 유태우, 김근식이 가장 많았고, 일본에서는 Kamaya Mogusa, Obika Reiko, 미국에서는 유태우, Shimada 및 Osamu 인 것으로 나타났다. 4. 뜸 연소재에서 가장 많은 출원을 한 종류는 ‘쑥’ 이었고, 가열제어 분야의 ‘쑥뜸기’가 가장 많이 출원되었다.

Background and Purpose : The purpose of this study was done to investigate what kinds of statistical techniques have been used to analyze data from oriental medicine research Methods : 135 original articles which used statistical techniques in their data analysis were selected from the articles published in The Journal of Korea Institute of Oriental Medicine(JKIOM) between 1995 to 2007. Results : Among 135 articles, 59 articles used descriptive statistics while 76 articles used inferential statistics for data analysis. For that 76 articles, two-sample t-test(33 articles), analysis of variance(29 articles), regression(9 articles), chi-square test(5 articles), nonparametic test(4 articles), Fisher's exact test(3 articles), and other test(9 articles) were chosen to analyze the data. SAS and SPSS statistical softwares(82.50%) were mostly used to analyze the data. Nonparametic tests were used to 4 articles(6.97%) of 67 articles and parametic tests were used to 63 articles(93.03%) of 67 articles. Among 29 articles used analysis of variance, duncan(8 articles), dunnet(4 articles), bonferroni(4 articles), turkey(3 articles), scheff(1 article) were used to do multiple comparison. 9 articles did not carry out the multiple comparison. Conclusions : It was found that the frequencies of statistical package used and statistical analysis used were not much by now. High level statistical analyses were not used most for oriental medicine research.

Objectives : This study were aimed to estimate the needs for clinical research educational program development focused on oriental medicine. Methods : Department Medical Research of Korea Institute of Oriental Medicine surveyed 204 certified subjects in total by using web-based questionnaires through e-mail from Jan. 17th to Jan. 31th, 2007. Reply from 62 on-line correspondents were collected and statistically analyzed. Results : The number of clinical trial involving oriental medicine continues to increase. According to the survey, many Issues were raised as problems such as difficulty of recruitment, lack of fund and lack of stepped program. Emphasized issues were clinical research methodologies, development of protocols and case report form (CRF), and Regulations including Institutional Review Boards (IRBs) in these three consecutive education training program. Conclusion : The results of this study may contribute to the development of an educational program for oriental medicine, a program that should be taken into consideration for developing practical items, such as, problem-based learnings which reflects participants' actual needs in their works. Also this report be used for future strategy plans and execution of training program for oriental medical clinical trial.

General health exanimation comes into operation to focus on physical inspection for industrial workers and doesn't contain oriental health care. Thus we need information of health status and disease prevention, so develop a questionnaire software for health examination in oriental medicine. Items of this soft ware consists of personal information and symptoms to could check oneself , pulse and tongue diagnosis by oriental medical doctor. Symptoms are made up of syndrome differentiation about Qi and blood, Yin and Yang, body fluid, five Zang organs, Sasang Constitutional Medicine. And we reconstruct 116 items by whole body, chest and abdomen, urine and feces, head, limbs, waist and back, five sensory organs, objective signs. A subject enter symptoms and a oriental medical doctor input diagnosis of pulse and tongue, then this software return the result of health index and explanation for oriental health care. This software would be used as tool not only health examination but also clinical research.

The present study examined inhibitory effects of 20 efficient experience prescriptions on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry. Among them, a hot water extract of KIOM 2003-080 was selected to be the most effective candidate. In an in vivo study using a mouse acute thrombosis model, the anti-thrombotic effects of the KIOM2003-080 crude extract were also observed. In addition, we accessed bio-marker of platelet activation using thromboxane B2 by ELISA assay. A significantly decrease in thromboxane B2 production was seen in the presence of KIOM2003-080. Consequently, the results from this experiment provide pharmacological evidence for the traditional use of KIOM2003-080 prescription, suggesting that its hot water extracts could be used to prevent platelet aggregation and thrombosis disease.

Objective : Using a spontaneously hypertensive rat (SHR) model of essential hypertension, this study investigated whether electroacupuncture (EA) could reduce early stage hypertension by examining whether EA increased nitric oxide (NO) levels in plasma, which compensates for elevated blood pressure (BP). Methods : EA was applied to the acupoint, Baekhoe (GV20), and to a non acupoint in the tail at 10 Hz and an intensity of 1 mA for 10 minutes on the first and fourth day of the week for three weeks under isoflurane anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY) rats, blood pressure was determined the day after EA treatment by the tail cuff method using an automatic BP monitoring system. We also measured NO concentration of blood serum in SHR and WKY. Results : Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were lower after 3 weeks of GV20 treatment than in non EA treated or non acupoint treated SHR rats. The NO level of plasma was significantly lower in hypertensive SHR than in normotensive WKY. EA prevented the augmentation of blood pressure, and also increased NO concentrations from $7.91{\pm}0.42$ ${\mu}M$ to $11.50{\pm}0.93$ ${\mu}M$ in SHR serum. Conclusions : We suggest that acupuncture may be an early intervention to delay the development of hypertension and enhance NO/NOS activity.

An imbalance in bone remodeling that is caused by increased bone resorption over bone formation leads to most adult skeletal diseases including osteoporosis. Since the development of anti-resorptive agents from natural substances has recently gained more interest in the treatment of osteoporosis, we evaluated the effects of 222 natural compounds on receptor activator of $NF-{\kappa}B$ ligand (RANKL)-induced of tartrate-resistance acid phosphatase (TRAP) activity in RAW264.7 murine macrophage cell, and found that berberine chloride is one of compounds inhibiting RANKL-induced TRAP activity. Berberine chloride significantly inhibited the RANKL-induced TRAP activity and the formation of multinucleated osteoclasts in a dose-dependent manner. In addition, berberine chloride prevented the RANKL-induced mRNA expression of TRAP, matrix metalloproteinase 9 and c-Src, which have been known to be highly expressed in the process of osteoclastogenesis. Interestingly, berberine chloride prevented the RANKL-induced activation of extracellular signal-regulated kinase (ERK) which is one of mitogen-activated protein (MAP) kinases. In conclusion, berberine chloride could inhibit the osteoclastogenesis via preventing the activation of ERK/MAP kinase signaling pathway.