The purpose of this study was to investigate self care, depression, and Yangsaeng and to confirm the factors related to Yangsaeng of diabetes mellitus patients. The survey was conducted on 116 subjects who consented to Institutional Review Board for diabetes mellitus patients in the area and data were collected by self-report questionnaire. The questionnaires consisted of self care, depression, and Yangsaeng. Date analysis was done by SPSS 22.0 with T-test, ANOVA, $Scheff{\acute{e}}$ test, Pearson correlation coefficient, and multiple regression. Yangsaeng was significantly related to the educational level, partner, income, perceived health status, depression, and admission for diabetes mellitus. Yangsaeng and self care showed positive correlation, on the other hand Yangsaeng and depression showed negative correlation. Yangsaeng was found to be related to education level, self care, and depression through the multiple regression. In conclusion, the Yangsaeng score increased with improving of blood glucose level and depression. Based on these results, we considered various characteristics such as patient's age and illness characteristics, therefore it is necessary to develop a method to measure Yangsaeng.