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http://dx.doi.org/10.15188/kjopp.2017.10.31.5.277

Anti-allergic Effects of Jagamcho-tang in Ovalbumin-induced Atopic Dermatitis Mouse Model  

Noh, Hyeon-Min (Department of Korean Medical Ophthalmology, Otolaryngology & Dermatology, Wonkwang University)
Park, Sung-gu (Department of Korean Medical Ophthalmology, Otolaryngology & Dermatology, Wonkwang University)
Kim, Wonjeong (Traditional Korean Medical Dermatology Institute, Wonkwang University)
Jo, Eun-Hee (Department of Acupunture and Moxibustion, Wonkwang University)
Ki, Hyeon-Hui (Department of Medicine, Chonbuk National University & Medical Science Institute)
Kim, Dae-Ki (Department of Medicine, Chonbuk National University & Medical Science Institute)
Park, Min-Cheol (Department of Korean Medical Ophthalmology, Otolaryngology & Dermatology, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.31, no.5, 2017 , pp. 277-283 More about this Journal
Abstract
Activated T helper 2 (Th2) immune function is hallmark of various allergic diseases. We investigated the anti-allergic effect of Jagamcho-tang extract(JE) on ovalbumin(OVA)-induced atopic dermatitis mice model and OVA-stimulated splenocytes isolated from the mice. Mice were intraperitoneally injected OVA/alum solution 2 times at interval of 14 days, followed by oral administration of JE for 7 days. After administration, mice were subcutaneously injected with OVA in ear. JE treatment reduced ear swelling and infiltration of inflammatory cells in ear. Serum levels of interleukin(IL)-4 and immunoglobulins, such as total-IgE and OVA-specific IgE, were decreased in JE treated group. Furthermore, JE treatment decreased OVA-induced Th2-associated cytokines like IL-4, IL-5 and IL-13 mRNA levels in splenocytes. In conclusion, JE reduced allergic immune response via IgE production and Th2 response in OVA-sensitized mice, suggesting that JE could be useful prescription for allergic diseases including atopic dermatitis.
Keywords
Jagamcho-tang(炙 甘 草 湯 ); Atopic dermatitis; Allergy; T helper 2; Immunoglobulin E;
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Times Cited By KSCI : 3  (Citation Analysis)
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1 Moreno AS, McPhee R, Arruda LK, Howell MD. Targeting the T Helper 2 Inflammatory Axis in Atopic Dermatitis. Int Arch Allergy Immunol. 2016;171(2):71-80.   DOI
2 Karshikoff B, Sundelin T, Lasselin J. Role of Inflammation in Human Fatigue: Relevance of Multidimensional Assessments and Potential Neuronal Mechanisms. Front Immunol. 2017;8:1-12.
3 Kwak KK, Cho JH, Son CG. Study on Chronic Fatigue Syndrome from Oriental Medicine Point of View. Korean J Orient Int Med. 2008;29(4):962-9.
4 Yi JH, Lee JH, Park SM, Kim YC, Lee JH, Woo HJ. Clinical Investigation and Follow-up Monitoring of Fatigue Patients Visiting the Oriental Medical Hospital. J Korean Oriental Med. 2000;21(4):55-63.
5 Kim EH, Lee BW, Kim EH. A Literal Study of the Main Symptoms of Atopic Dermatitis. J of Korean Med Classics. 2009;22(1):207-28.
6 Kim EH, Lee BW, Kim EH. A Literal Study of the Main Symptoms of Atopic Dermatitis. J Orient Med Class. 2009;22(1):207-28.
7 Yang NR, Kim MK, Choi DJ, Han CH. One Case of Bradyarrhythmia Treated with Jagamcho-tang(炙甘草湯) and Acupuncture. J of int korean med. 2010;183-9.
8 Lee TH, Lee JG, Yoon HS, Lee YG. One Case of PSVT(Paroxysmal Supraventricular Tachycardia) Patient Treated with Jagamcho-tang-gami(炙甘草湯加味). J Int Korean Med. 2002;73-8.
9 Kim CH, Kim HS, Hwang SR, Lee WC. A Case of Chest Pain Patient Diagnosed as Angina Pectoris and Treated with Jagamcho-tang(炙甘草湯). J of Oriental Chr Dis. 2000;6(1):127-32.
10 Matsunaga MC, Yamauchi PS. IL-4 and IL-13 Inhibition in Atopic Dermatitis. J Drugs Dermatol. 2016;15(8):925-9.
11 Lee RC, Jo NS, Jo D, Um SS, Kang SD, Lee CW, et al. Effects of Jagamchotang on the Cultured Rat Neonatal Myocardial Cells. J of Oriental Physiology. 1999;14(2):179-87.
12 Amin K. The Role of Mast Cells in Allergic Inflammation. Respir Med. 2012;106(1):9-14.   DOI
13 Seung YC. A Study on the Immune Modulation of Chenggihaedok-tang (CGT) on the Atopic Dermatitis. Docter's dissertation of Daejeon University. 2014.
14 Furue M, Chiba T, Tsuji G, Ulzii D, Kido-Nakahara M, Nakahara T, et al. Atopic Dermatitis: Immune Deviation, Barrier Dysfunction, IgE Autoreactivity and New Therapies. Allergol Int. 2017;66(3):398-403.   DOI
15 De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, et al. Neuroendocrine Effects on Immune System. 2009;1-30.
16 Kim MJ, Lee SY. A Literature Study of Atopic Dermatitis for Children. J Korean Oriental Med. 2000;14(2):169-84.
17 Han SD. Effects of Jagamchotang on hyperthyroidism of Sodium Levothyroxine Induced Rats. Master's dissertation of Daegu Korean Medical University. 1994.
18 Na YH. Effects of Jagamchotang on the C6 glial Cell Injured by LPS Combined PMA. Master's dissertation of Wonkwang University. 2000.
19 Jeong HC. The Effects of Aqua-acupuncture Jagamchotang on Nitric Oxide Production in RAW 264.7 and C6-glial Cell. Docter's dissertation of Wonkwang University. 2000.
20 Barnes PJ. Th2 Cytokines and Asthma: an Introduction. Respir Res. 2001;2(2):64-5.   DOI