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http://dx.doi.org/10.15188/kjopp.2017.10.31.5.270

Effect of Albizziae Cortex Water Extract on Cognition and Memory Impairments  

Kee, Ji Ye (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Hong, Seung Heon (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Park, Jin Han (Division of Bio-technology and Convergence, Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.31, no.5, 2017 , pp. 270-276 More about this Journal
Abstract
The aim of this study was to investigate the effects of the water extract of Albizziae Cortex (AC) on the learning and memory impairments. AC was administered to normal mouse and scopolamine-injected amnesia mouse model. Passive avoidance test, Y-maze test, and Morris water maze test were conducted to confirm the cognitive-enhancing activities of AC. Acetylcholinesterase (AChE) activity and acetylcholine (Ach) content were measured after oral administration of AC. On the passive avoidance test, AC (200 mg/kg) significantly increased latency time and recovered scopolamine-impaired learning and memory in mice. In addition, AC (200 mg/kg) reduced Exploration time in target quadrant and reversed the scopolamine-induced cognitive impairments in the Y-maze test. Moreover, AC (200 mg/kg) increased exploration time in target quadrant and improved scopolamine-reduced escape latencies in the Morris water maze test. These effects were presented by regulatory effects of AC on AChE activity and Ach content. Taken together, AC increases cognitive-enhancing activities and ameliorates scopolamine-induced learning and memory impairment. AC might be a potential agent for prevention and treatment of amnesia and dementia.
Keywords
Albizziae Cortex; Scopolamine; Acetylcholine; Cognation; Memory;
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