Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effect of Lonicera Japonica Flower on CCl4-induced Hepatotoxicity

사염화탄소 유발 간독성에 대한 금은화의 작용

  • 박선관 (동덕여자대학교 약학과) ;
  • 최병기 (동덕여자대학교 약학과) ;
  • 이은방 (서울대학교 천연물과학연구소)
  • Published : 2002.03.01
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Abstract

Methanol extract of Lonicera Japonica (Caprifoiaceae) flower significantly inhibited serum GPT, GOT, LDH and AIP activities at the doses of 500 and 1,000mg／kg in $CCl_4$-intoxicated rats. As confirmed with the fiactions of hexane, chlorofom, ethyl acetate, butanol and water, the butanol fraction showed significant inhibition of increased activity of serum GPT, LDH and AIP in $CCl_4$-intoxicated rats, indicating that the most active components might be contained in the butanol fraction.

Keywords

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