• Title/Summary/Keyword: AIP

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Isolation and Expression of Aluminum Induced Protein(ClAIP) Gene from Codonopsis lanceolata (더덕에서 Aluminum Induced Protein (ClAIP) 유전자의 분리 및 발현분석)

  • 양덕춘;김종학;인준교;이범수;이강
    • Korean Journal of Plant Resources
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    • v.17 no.3
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    • pp.289-296
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    • 2004
  • A cDNA clone (GenBank accession no. CF924621) homologous to aluminum induced protein gene was isolated and characterized from Codonopsis lanceolata (ClAIP). The ClAIP is 906 nucleotides long and has an open reading frame of 711 bp with a deduced amino acid sequence of 236 residues. The ClAIP shows high homology to A. marina (84%), G. hirsutum(83%), V. radiata (83%), A. thaliana (80%), B. nap us (78%) and T. aestivum (68%). The deduced amino acid sequence of ClAIP also has homology to the N-terminal end of plant Asn synthetase. This region does not contain the active sites of the enzyme and the significance of this conservation is currently not clear. To investigate the expression of ClAIP against several heavy metal stresses, we treated the sliced tap root of C. lanceolata with various heavy metals. The expression of ClAIP was increased by 25 uM $Al_2$(SO$_3$)$_4$ in proportion to incubation time and also increased by 50 uM CdCl$_2$.

Comparison of health indicators and lifestyle according to atherogenic index of plasma in Korean adults in their 20s and 30s (한국 20-30대 성인의 Atherogenic Index of Plasma에 따른 건강지표 및 생활습관비교)

  • Bora Hwang;Yoon Jung Yang
    • Journal of Nutrition and Health
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    • v.56 no.2
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    • pp.168-183
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    • 2023
  • Purpose: Cardiovascular disease is one of the major causes of death not only in Korea but also worldwide. Atherogenic index of plasma (AIP) has been extensively investigated, but studies on nutritional intake and eating habits are scarce. The purpose of this study was to analyze the general characteristics, dietary habits, and nutritional status of Korean adults based on their AIP values using data from the 2013-2015 Korea National Health and Nutrition Examination Survey. Methods: A total number of 3,040 adults in their 20s and 30s were included as study subjects. They were divided into quintiles according to their AIP values. Comparisons were then made among the general information, eating habits, and nutritional intake statuses of the groups. Results: The averages of AIP were different by age, obese status, education, occupation, alcohol drinking frequency, smoking, and exercise in men. As for women, the averages of AIP were different by age, obese status, education, occupation, alcohol drinking frequency, and smoking status. Except for high-density lipoprotein (HDL)-cholesterol, higher AIP values in men were associated with significant increasing trends in health indicators, including systolic and diastolic blood pressure, fasting blood glucose, insulin, hemoglobin A1c, total cholesterol, triglyceride, and low-density lipoprotein (LDL)-cholesterol. As for women, as AIP increased, systolic and diastolic blood pressure, fasting blood glucose, insulin, total cholesterol, triglyceride, and LDL-cholesterol showed significant increasing trends except HDL-cholesterol. HDL-cholesterol showed a significant decreasing trend as AIP increased in men and women. In the high AIP group of women, the frequency of breakfast was lower, whereas the frequency of alcohol beverage consumption was higher. Conclusion: Among young adults, the risk of arteriosclerosis was higher in obese, smoking, and non-exercise individuals. More frequent alcohol drink consumption in women is associated with a higher risk of arteriosclerosis. Therefore, weight and lifestyle management are necessary for the prevention of atherosclerosis among young adults.

잠수함 동력원으로서의 연료 전지

  • Baek, Hyeon-Jong
    • Defense and Technology
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    • no.8 s.246
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    • pp.30-39
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    • 1999
  • 재래식 잠수함의 잠항 능력을 향상시키기 위해 제안된 AIP 장치들도 끊임없는 기술의 진보와 경쟁 그리고 실선 적용에 의한 검증을 거쳐 미래에는 어느 한 AIP 장치가 표준으로 자리잡게 될 것으로 추측된다. 시스템 자체의 소음수준이 낮을 것으로 기대되는 연료전지 AIP도 많은 홍보와 관심 속에서 실선용이 개발 중이다. 하지만 모든 AIP 장치들이 제각기 고유의 비효용성을 갖고 있는 것처럼 연료전지 역시 안전성 저하를 비롯한 여러 가지 부담을 추가한다는 점에 유의해야 할 것이다.

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The composition and structure of Archival Information Packages(AIP) for a long-term preservation of electronic records (전자기록의 장기보존을 위한 보존정보패키지(AIP) 구성과 구조)

  • YIM, Jin-Hee
    • The Korean Journal of Archival Studies
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    • no.13
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    • pp.41-90
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    • 2006
  • It's needed for the archivists to design a flexible and stable ERMS(Electronic Records Management System) which can ingest and store records through a consistent way and let users search and use records easily what they want. The basis of the design for ERMS are the conceptual composition and the logical and physical structure of the records when they are stored and managed in the ERMS. This paper explains the process of defining components and designing structure of electronic records using 3-layered approaches which consist of conceptual, logical and physical layer and shows advantages of this approaches. After benchmarking the information models of OAIS which is a reference model for the long-term preservation of digital information objects, this paper applies the model of AIP to a record as a 'Record AIP' and discusses the composition and structure of it. It's a critical task to identify mandatory or optional metadata groups which consists of the 'Record AIP's in the conceptual layer. This paper emphases that the metadata group related to services for the record information to users is required as a result of benchmarking OAIS information models. Various issues about the structure of 'Record AIP's are discussed according to the kind of preservation strategy such as migration or emulation and whether the encapsulation of records is required or not in the logical layer.

Four-Week Repeated Oral Toxicity Study of AIP1, a Water-soluble Carbohydrate Fraction from Artemisia iwayomogi in Mice

  • Ryu, Sung-Ha;Jo, Hae-Ran;Kim, Ji-Won;Youn, Hyun-Joo;Kim, Kyu-Bong
    • Toxicological Research
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    • v.27 no.4
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    • pp.261-267
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    • 2011
  • Artemisia iwayomogi, a member of the Compositae, is a perennial herb easily found in Korea and used as a traditional medicine to treat liver disease. AIP1, a water-soluble carbohydrate fraction from Artemisia iwayomogi, showed anti-tumor and immuno-modulating activities in animal studies. A subacute toxicological evaluation of AIP1 was performed for 4 weeks in ICR mice. After administration of AIP1 (0, 20, 100, 500 mg/kg/day), the clinical signs, mortalities, body weight changes, hematology, blood clinical biochemistry, urinalysis, organ histopathology, organ weights and gross finding were examined. The results showed that there were no significant differences in body weight changes, food intakes, water consumptions, or organ weights among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally treated with AIP1 and the control group, there was no statistical significance in hematological test or serum biochemical values. Histopathological examination showed no abnormal changes in AIP1 groups. These results suggest that no observed adverse effect level (NOAEL) of the oral administration of AIP1 for 4 weeks was considered to be more than 500 mg/kg/day in mice under the condition investigated in current study.

Effect of Residential Environmental Satisfaction on Aging in Place : Analysis of Moderated Effects of Housing Characteristics (주거환경 만족도가 지역사회 계속 거주 욕구에 미치는 영향 : 주거특성의 조절효과 분석)

  • Baek, Seong-Wook;Lee, Chan-Ho
    • Journal of Industrial Convergence
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    • v.20 no.8
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    • pp.25-31
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    • 2022
  • This study examines the impact of residential environmental satisfaction on AIP(Aging in Place), and analyzes how their relationship differs depending on housing characteristic variables (ownership type, housing type, and residential area). For this purpose, as of November to December 2020, a questionnaire analysis was conducted on 373 adult males and females residing in Busan and Gyeongnam. The results of this study are summarized in two ways as follows. First, the higher the satisfaction with the residential environment, the higher the AIP. Second, it was analyzed that the positive relationship between satisfaction with the residential environment and AIP was higher in ownership than in rental cases, and further decreased in detached houses compared to apartment houses. In addition, compared to other regions, metropolitan cities or small and medium-sized cities had a higher positive (+) relationship between satisfaction with the residential environment and AIP. This study will provide important implications for policymaking related to population and urban planning.

Effect of Hematological Factors on the Risk Index of Cardiovascular Disease (혈액학적 인자가 심혈관 질환 위험지수에 미치는 영향)

  • Hyun An;Hyun-Seo Yoon;Chung-Mu Park
    • Journal of radiological science and technology
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    • v.46 no.4
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    • pp.303-313
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    • 2023
  • This study aimed to investigate the relevance of cardiovascular disease risk factors AI and AIP, divided into three groups, among 300 individuals who underwent health checkups at the hospital. Various variables such as Age, Sex, BMI, WC, TC, TG, HDL-C, LDL-C, FBS, HbA1C, SBP, DBP, HR, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) were analyzed using statistical methods including frequency analysis, cross-tabulation, one-way ANOVA, Pearson's correlation analysis, and multiple linear regression analysis. The cross-analysis based on cardiovascular disease risk criteria revealed that men and individuals in their 50s had higher cardiovascular disease risk based on AI and AIP. Significant differences were observed in TG, TC, HDL-C, LDL-C, SBP, DBP, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) according to AI criteria. For the AIP criteria, TG, TC, HDL-C, FBS, HbA1C, HR, AI (TC/HDL-C), and AIP (log(TG/HDL-C)) were identified as cardiovascular disease risk factors. FBS and HbA1c showed the highest positive correlation In the correlation analysis, followed by TC and LDL-C. The lowest positive correlation was observed between LDL-C and DBP. In terms of negative correlation, HDL-C and AI had the highest negative correlation, while LDL-C and TG showed the lowest negative correlation. Multiple regression analysis indicated that the AI and AIP risk criteria had explanatory powers of 73.6% and 72.5%, respectively. HDL-C had the greatest negative effect on the AI risk criterion, while TG had the most significant influence on the AIP risk criterion. In conclusion, while other serological variables are important, managing HDL-C and TG levels may help reduce the risk of cardiovascular disease.

A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier $K^+$ Channels in Rabbit Ventricular Myocytes

  • Park, Won-Sun;Son, Youn-Kyoung;Ko, Eun-A;Choi, Seong-Woo;Kim, Na-Ri;Choi, Tae-Hoon;Youn, Hyun-Joo;Jo, Su-Hyun;Hong, Da-Hye;Han, Jin
    • The Korean Journal of Physiology and Pharmacology
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    • v.14 no.3
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    • pp.119-125
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    • 2010
  • We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier $K^+$ current ($I_K$) using the patch clamp technique. The carbohydrate fraction AIP1 dose-dependently increased the heart rate with an apparent $EC_{50}$ value of $56.1{\pm}5.5\;{\mu}g/ml$. Application of AIP1 reduced the action potential duration (APD) in concentration-dependent fashion by activating $I_K$ without significantly altering the resting membrane potential ($IC_{50}$ value of $APD_{50}$: $54.80{\pm}2.24$, $IC_{50}$ value of $APD_{90}$: $57.45{\pm}3.47\;{\mu}g/ml$). Based on the results, all experiments were performed with $50\;{\mu}g/ml$ of AIP1. Pre-treatment with the rapidly activating delayed rectifier $K^+$ current ($I_{Kr}$) inhibitor, E-4031 prolonged APD. However, additional application of AIP1 did not reduce APD. The inhibition of slowly activating delayed rectifier $K^+$ current ($I_{Ks}$) by chromanol 293B did not change the effect of AIP1. AIP1 did not significantly affect coronary arterial tone or ion channels, even at the highest concentration of AIP1. In summary, AIP1 reduces APD by activating $I_{Kr}$ but not $I_{Ks}$. These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome.

Improved Accountable Internet Protocol Using Signature (시그니처를 이용한 향상된 Accountable 인터넷 프로토콜)

  • Park, Gi-Tae;Lee, Jae-Hwoon;Jung, Hee-Young
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.39B no.4
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    • pp.200-206
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    • 2014
  • Accountable Internet Protocol (AIP) is one of the future Internet architectures to provide accountability concept by using the self-certifying address that is derived by the public key of the host. In AIP, when a host sends a packet, a domain that is located between the source and the destination hosts discards the packet in order to verify the source IP address. Therefore, performance degradation can occur due to packet discard especially when there is asymmetric route. In this paper, we propose the improved AIP mechanism to verify the source IP address without discarding the packet by including the timestamp, public key value and the signature for protecting from forfeiting the source address. Security safety of the proposed mechanism is evaluated and the proposed mechanism can provide the more robust security as well as reducing the latency due to discarding packets.