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Effect of Lonicera Japonica Flower on CCl4-induced Hepatotoxicity  

박선관 (동덕여자대학교 약학과)
최병기 (동덕여자대학교 약학과)
이은방 (서울대학교 천연물과학연구소)
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Biomolecules & Therapeutics / v.10, no.1, 2002 , pp. 32-36 More about this Journal
Methanol extract of Lonicera Japonica (Caprifoiaceae) flower significantly inhibited serum GPT, GOT, LDH and AIP activities at the doses of 500 and 1,000mg/kg in $CCl_4$-intoxicated rats. As confirmed with the fiactions of hexane, chlorofom, ethyl acetate, butanol and water, the butanol fraction showed significant inhibition of increased activity of serum GPT, LDH and AIP in $CCl_4$-intoxicated rats, indicating that the most active components might be contained in the butanol fraction.
Lonicera japopnica flower; butanol fraction; GPT; GOT; LDH; AIP;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 Bensky, D. and Gamble, A. (1986). Chinese Herbal Medicine, Materia Medica, pp. 85-86 Eastland Press, Incorporated
2 Chang, C. W., Lin, M. T., Lee, S. S., Liu, K. C., Hsu, F. L. and Lin J. Y. (1995). DifFerential inhibition of reverse trans-criptase and cellular DNA polymerase-activities by lignans isolated from chinese herbs, AntiviraI Res., 27, 367-374   DOI   ScienceOn
3 Chang, H. W., Baek, S. H., Chung, K. W., Son, K. H., Kim, H. P. and Kang S. S. (1994). Inactivation of phospholipase A2 by naturally occurring biflavoniod, ochnaflavone, Biochem. Biophys. Res. Commun., 205, 843-849
4 Chung, K. C., Kwon, D. Y, Baek, S. H., Kim, S. H. and Chang, H. W. (1988). Effect of Lonicerae Flos' ethyl acetate Fraction on Mutagenicity, Yakhak Hoeji, 32, 328-333
5 Han, W. Y. (1990). Study on anti-inflammatory effect of Lonicera japonica., Department of Phannacy Graduate School, Sookmyung Women's University, MS Thesis
6 Hofmann, A. F. and Popper, H. (1987). Ursodeoxycholic acid for primaiy biliary cirrhosis, Lancet, 2, 398-399
7 Kawai, H., Kuroyanagi, M., Umehara, K., Ueno, A. and Satake, M. (1998). Studies on the saponins of Lonicera japonica Thumb. Chem. Pharm. BuIL, 36, 4769-4775
8 Mehrotra, R., Singh, C., Popli, S. P. (1998). Isolation of secoxyloganin from Lonicera japonica and conversion into secologanin,J. Nat. Prod., 51, 319-321
9 Park, J. 0, (1997). Studies on the flavonoid components of Lonicera japonica and their biological activities. Depart- ment of Pharmacy Graduate School, Yeungnam University, Ph. D. Thesis
10 Park J. 0. (1989). Study on the inhibition of lipid peroxidation by Lonicerae Flos' EtOAc fraction., Department of Pharmacy Graduate School, Ycungnam University, MS Thesis
11 Plaa, G. L. and Hewitt, W. R. (1982). Principles and Methods of Toxicology, pp. 407-445, Raben Press
12 Rao, V. C and Nehendale, H. M. (1991). Colchicine antimiosis abolishes $CCl_4$ autoprotection, Toxicol Pathol., 19, 597--606   DOI   ScienceOn
13 Reitman, S. and Frankel, S (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases, Am. J. Clin, Pathol., 28, 56-63   DOI
14 Samuel, Y. L. and Yonsop, C. (1986). Laboratory Methods in Clinical Pathology, pp. 229-230, Yonsei University Press, Seoul
15 Sherlock, D. S. (1992). Disease of Liver and Biliary System. 8th ed. Oxford, Blackwell Scientific publications
16 上海科技出版社編(1985). 中藥大辭典, pp. 523-526, 小學館, 東京
17 Sim, K. S., Moon, C. K., Ryu, C. K., Cheon, I. S., Chung, J. H. and Park, D. S. (1979. Giinnol, sterols and glycosides from Lonicerae Flos, Yakhak NonmunjiP, 4, 79, Seoul Univ. Press, Seoul
18 Wang, G., Zbu, X., Wang, J., Jia, W., Yuan, Y., Nan, P. and Yuan, P. (1992). Analysis of Chemical constituent of essential oil in Lonicera japonica Thumb. cultivated on the northern plain of Henan Province, Chung Kuo Chung Yao Tsa Chih, 17, 268-270
19 Wang, L., Yee, L. (1981). Studies on the components of the flowers of Lonicera japonica Thumb, and their antibacterial activities, Hsiang-kang Ch'in Huk Hsue Than Hsueh Pao, 8, 1115
20 陳再民(1982). 原設韓方醫藥大辭典(中國藥學大典), pp.I601, 講談社, 中國
21 Tang, W., Eisenbrand, G. (1992). Chinese Drugs of Plant Origin, pp. 621-625 Springer-Verlag, Berlin
22 Kawano, S., Nakagawa, H., Toga, H. (1982). Investigations on physiological values of blood in industrial workers, Report 3. Serum colloid reaction and enzyme activity values, Sangyo. Igaku, 24, 275-283   DOI   ScienceOn
23 King, J. (1972). Effect of hydrogen ion concentration on lactate dehydrogenase (LDH) assays, Clin, Chem., 18, 1443
24 Son K. H., Jung K. Y., Chang H. W., Kim H. P. and Kang. S. S. (1994). Triterpenoid saponins from the aerial parts of Lonicera japonica. Phytochemistry, 35, 1005-1008   DOI   ScienceOn
25 Taguchi, H., Iketani, Y., Niitsu, K. and Mori, K (1985). Pharmaceuticals for tre.atment of influenza virus infection, pp. 60, 243, 016, Jpn. Kokai Tokkyo Koho J., Tokyo