Biomolecules & Therapeutics

  • 제10권1호
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  • Pages.32-36
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  • 2002
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지

사염화탄소 유발 간독성에 대한 금은화의 작용

Effect of Lonicera Japonica Flower on CCl4-induced Hepatotoxicity

  • 박선관 (동덕여자대학교 약학과) ;
  • 최병기 (동덕여자대학교 약학과) ;
  • 이은방 (서울대학교 천연물과학연구소)
  • 발행 : 2002.03.01
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초록

Methanol extract of Lonicera Japonica (Caprifoiaceae) flower significantly inhibited serum GPT, GOT, LDH and AIP activities at the doses of 500 and 1,000mg／kg in $CCl_4$-intoxicated rats. As confirmed with the fiactions of hexane, chlorofom, ethyl acetate, butanol and water, the butanol fraction showed significant inhibition of increased activity of serum GPT, LDH and AIP in $CCl_4$-intoxicated rats, indicating that the most active components might be contained in the butanol fraction.

키워드

참고문헌

  1. Bensky, D. and Gamble, A. (1986). Chinese Herbal Medicine, Materia Medica, pp. 85-86 Eastland Press, Incorporated
  2. Chang, C. W., Lin, M. T., Lee, S. S., Liu, K. C., Hsu, F. L. and Lin J. Y. (1995). DifFerential inhibition of reverse trans-criptase and cellular DNA polymerase-activities by lignans isolated from chinese herbs, AntiviraI Res., 27, 367-374 https://doi.org/10.1016/0166-3542(95)00020-M
  3. Chang, H. W., Baek, S. H., Chung, K. W., Son, K. H., Kim, H. P. and Kang S. S. (1994). Inactivation of phospholipase A2 by naturally occurring biflavoniod, ochnaflavone, Biochem. Biophys. Res. Commun., 205, 843-849
  4. Chung, K. C., Kwon, D. Y, Baek, S. H., Kim, S. H. and Chang, H. W. (1988). Effect of Lonicerae Flos' ethyl acetate Fraction on Mutagenicity, Yakhak Hoeji, 32, 328-333
  5. Han, W. Y. (1990). Study on anti-inflammatory effect of Lonicera japonica., Department of Phannacy Graduate School, Sookmyung Women's University, MS Thesis
  6. Hofmann, A. F. and Popper, H. (1987). Ursodeoxycholic acid for primaiy biliary cirrhosis, Lancet, 2, 398-399
  7. Kawai, H., Kuroyanagi, M., Umehara, K., Ueno, A. and Satake, M. (1998). Studies on the saponins of Lonicera japonica Thumb. Chem. Pharm. BuIL, 36, 4769-4775
  8. Kawano, S., Nakagawa, H., Toga, H. (1982). Investigations on physiological values of blood in industrial workers, Report 3. Serum colloid reaction and enzyme activity values, Sangyo. Igaku, 24, 275-283 https://doi.org/10.1539/joh1959.24.275
  9. King, J. (1972). Effect of hydrogen ion concentration on lactate dehydrogenase (LDH) assays, Clin, Chem., 18, 1443
  10. Mehrotra, R., Singh, C., Popli, S. P. (1998). Isolation of secoxyloganin from Lonicera japonica and conversion into secologanin,J. Nat. Prod., 51, 319-321
  11. Park, J. 0, (1997). Studies on the flavonoid components of Lonicera japonica and their biological activities. Depart- ment of Pharmacy Graduate School, Yeungnam University, Ph. D. Thesis
  12. Park J. 0. (1989). Study on the inhibition of lipid peroxidation by Lonicerae Flos' EtOAc fraction., Department of Pharmacy Graduate School, Ycungnam University, MS Thesis
  13. Plaa, G. L. and Hewitt, W. R. (1982). Principles and Methods of Toxicology, pp. 407-445, Raben Press
  14. Rao, V. C and Nehendale, H. M. (1991). Colchicine antimiosis abolishes $CCl_4$ autoprotection, Toxicol Pathol., 19, 597--606 https://doi.org/10.1177/019262339101900405
  15. Reitman, S. and Frankel, S (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases, Am. J. Clin, Pathol., 28, 56-63 https://doi.org/10.1093/ajcp/28.1.56
  16. Samuel, Y. L. and Yonsop, C. (1986). Laboratory Methods in Clinical Pathology, pp. 229-230, Yonsei University Press, Seoul
  17. Sherlock, D. S. (1992). Disease of Liver and Biliary System. 8th ed. Oxford, Blackwell Scientific publications
  18. Sim, K. S., Moon, C. K., Ryu, C. K., Cheon, I. S., Chung, J. H. and Park, D. S. (1979. Giinnol, sterols and glycosides from Lonicerae Flos, Yakhak NonmunjiP, 4, 79, Seoul Univ. Press, Seoul
  19. Son K. H., Jung K. Y., Chang H. W., Kim H. P. and Kang. S. S. (1994). Triterpenoid saponins from the aerial parts of Lonicera japonica. Phytochemistry, 35, 1005-1008 https://doi.org/10.1016/S0031-9422(00)90656-3
  20. Taguchi, H., Iketani, Y., Niitsu, K. and Mori, K (1985). Pharmaceuticals for tre.atment of influenza virus infection, pp. 60, 243, 016, Jpn. Kokai Tokkyo Koho J., Tokyo
  21. Tang, W., Eisenbrand, G. (1992). Chinese Drugs of Plant Origin, pp. 621-625 Springer-Verlag, Berlin
  22. Wang, G., Zbu, X., Wang, J., Jia, W., Yuan, Y., Nan, P. and Yuan, P. (1992). Analysis of Chemical constituent of essential oil in Lonicera japonica Thumb. cultivated on the northern plain of Henan Province, Chung Kuo Chung Yao Tsa Chih, 17, 268-270
  23. Wang, L., Yee, L. (1981). Studies on the components of the flowers of Lonicera japonica Thumb, and their antibacterial activities, Hsiang-kang Ch'in Huk Hsue Than Hsueh Pao, 8, 1115
  24. 上海科技出版社編(1985). 中藥大辭典, pp. 523-526, 小學館, 東京
  25. 陳再民(1982). 原設韓方醫藥大辭典(中國藥學大典), pp.I601, 講談社, 中國