• 한국식품위생안전성학회지
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• 제37권2호
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• pp.114-120
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• 2022

본 연구에서는 체내에서 비타민 C의 지속성을 나타내기 위해 성분의 용출을 조절하는 기술이 적용된 용출조절형 비타민 C 제품과 일반적인 속방형 비타민 C 제품의 비교용출 실험을 진행하여, 일반적인 속방형 제품과 용출조절형 제품 간의 용출 양태를 비교분석 하였다. 비타민 C 정제들의 용출률을 확인하기 위해 '대한약전(제2020-88호)', '경구용의약품의 용출규격 설정 가이드라인'의 용출시험법, '건강기능식품의 기준 및 규격 고시(제2020-63호)'에 근거한 HPLC 함량시험을 수행하여 시간별 용출률을 분석하였다. 분석 결과 속방형 비타민 C 제품은 45분 이후 100% 용출이 이루어진 반면 용출조절형 비타민 C 제품은 480분(8시간) 이후에 100% 용출이 나타났으며, 용출조절형 비타민 C 제품의 60분에서의 용출률이 속방형 비타민 C 제품에 비해 더 느리게 나타나는 것을 확인하였다. 이러한 결과를 바탕으로 비타민 C를 주성분으로 한 용출조절형 정제의 개발 및 용출분석이 가능함을 확인하였다.

• Applied Biological Chemistry
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• 제49권2호
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• pp.103-107
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• 2006

비타민 정제 중의 지용성 비타민의 저장 습도 및 저장 온도에 따른 저장 안정성을 연구한 결과 개봉을 하지 않은 상태에서는 저장 온도에 상관없이 상당히 안정한 것으로 나타났다. 흥미로운 사실은 일부 지용성 비타민들이 개봉을 한 상태에서는 습도에 매우 민감하다는 사실이었는데, 지용성 비타민 중 분말형태로 제조하기 위하여 acetate form으로 존재하는 비타민 A acetate와 비타민 E acetate는 수분에 아주 민감하다는 사실을 확인할 수 있었다. 이들 지용성 비타민은 개봉을 한 상태에서는 습도에 매우 민감하여 그 손실 속도가 매우 빨라지는 경향을 나타내었다. 또한 비타민 정제의 경우 수분이 가소제로 작용하여 비타민 정제 중의 성분들의 mobility를 증진시킴으로써 비타민의 손실 속도가 빨라지는 것으로 판단된다. 따라서 이러한 결과로 볼 때 tablet형태의 복합 비타민제에 존재하는 지용성 비타민의 경우 저장 온도보다는 저장 습도에 유의를 하여야 할 것으로 판단된다.

• Bulletin of the Korean Chemical Society
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• 제32권5호
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• pp.1587-1592
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• 2011

The aim of the present study was to improve the solubility and bioavailability of a poorly water-soluble drug in human body, using a solid dispersion technique (hot melt extrusion). The solid dispersion was prepared by cooling the hot melt of the drug in the carrier (Vitamin E TPGS and PVP). The dissolution rate of formulation 1 from a novel formulation prepared by solid dispersion technique was equal to release of formulation 6 (40% of eprosartan mesylate is in contrast to teveten$^{(R)}$) within 60 min (Table 1). The oral bioavailability of new eprosartan mesylate tablet having vitamin E TPGS and PVP K29 was tested on rats and dogs. Of the absorption enhancer and polymer tested, vitamin E TPGS and PVP K29, resulted in the greatest increases of AUC in animals (about 2.5-fold increase in rat and dog). When eprosartan mesylate was mixed with the absorption enhancer and polymer in a ratio of 2.94:2:1, vitamin E TPGS and PVP K29 improved eprosartan mesylate bioavailability significantly compared with the conventional immediate release (IR) tablet Teveten$^{(R)}$ (formulation 7). These results show that solid dispersion using vitamin E TPGS and PVP K29 is a promising approach for developing eprosartan mesylate drug products.

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.100-118
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• 2002

This study was to investigate the effect of long-term high intensity endurance training on the activation of antioxidation enzyme activity, lipid peroxidation and lipoprotein metabolism. 15 subjects were divided into, endurance exercise + antioxidation Vitamin supplement(n=5), endurance exercise(n=5), and the control(n=5) groups. The endurance exercise groups(endurance exercise + antioxidation Vitamin supplement and endurance exercise) had 12 week of endurance exercise program. The antioxidation Vitamin supplement group was taken a Vitamin C tablet with 1000mg/day and Vitamin E tablet with 671.14mg/day right after lunch. The results obtained from this study were as follows; 1. Looking at the changes of SOD, Endurance exercise+antioxidation Vitamin supplement group and endurance exercise groups showed the significantly greater decrease in the activation of SOD after 12 weeks of all-out exercise. 2. Looking at the changes of CAT, Endurance exercise+antioxidation Vitamin supplement group revealed subjects tended to increase CAT after all-out exercise although statistically non-significant. Endurance exercise+antioxidation Vitamin supplement group showed the significantly greater increase in the activation of CAT after 12 weeks treatment for all-out exercise. 3. Looking at the changes of GPX, Endurance exercise+antioxidation Vitamin supplement group revealed subjects tended to increase GPX for the rest and after all-out exercise although statistically non-significant. Endurance exercise+antioxidation Vitamin supplement group showed the significantly greater increase in the activation of GPX after 12 weeks treatment for all-out exercise. 4. The MDA change showed the significant decrease after 6 weeks, after 12 weeks for the all-out exercise of Endurance exercise + antioxidation Vitamin supplement group. 5. There was non-significant change in lipoprotein metabolism for the rest and after all-out exercise.

• Bulletin of the Korean Chemical Society
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• 제24권9호
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• pp.1308-1312
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• 2003

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to observe folic acid and its derivatives such as tetrahydrofolate and 5-methyltetrahydrofolate in a vitamin tablet and in foods. Folic acid in a vitamin tablet was determined using angiotensin I as an internal reference. Tetrahydrofolic acid, 5-methyltetrahydrofolic acid, and an oxygenated folate were observed from a human blood sample using graphite plate. The results show that these mass spectrometric methods are useful for quickly obtaining a profile of folates.

• 한국포장학회지
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• 제8권2호
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• pp.60-72
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• 2002

포장된 복합비타민의 보관수명을 예측하기 위한 수학모델을 수치해석의 방법 중 finite difference method을 이용한 컴퓨터 프로그램을 개발하였다. 이 컴퓨터 프로그램에는 포장재료의 수분확산계수와 용해도를 비롯한 식품의 수분확산계수 등 다양한 인자들을 포함하고 있다. 포장재료를 통과하는 수분의 물질전달은 G.A.B water sorption isotherm을 기본으로 했다. 본 연구에서는 비정상상태에서의 물질전달로 기본 수학모델링을 구하였다. 본 수학모델과 프로그램의 결과는 실험치와 비교하지 않았고 대신 특정한 경우를 가상하여 이에 존재하는 analytical solutions를 실제로 구하여 본 수학모델과 컴퓨터 프로그램의 신뢰도 측정을 하였다.

• 한국식품과학회지
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• 제37권6호
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• pp.1028-1034
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• 2005

시판 비타민 정제 중의 수용성 비타민의 저장 습도 및 온도에 따른 저장안정성을 연구한 결과 개봉을 하지 않은 상태에서는 저장온도에 상관없이 상당히 안정한 것으로 나타났다. 그러나 시판 비타민 정제 중의 vitamin $B_2$ 와 $B_3$를 제외한 대부분의 수용성 비타민 개봉을 한 상태에서는 습도에 매우 민감하여 그 손실 속도가 매우 빨라지는 경향을 나타내었다. 따라서 이러한 결과로 볼 때 tablet형태의 복합 비타민제의 경우 저장 온도보다는 저장 습도에 유의를 하여야 할 것으로 판단되며, 이에 따른 포장 재질 및 방법 등에 대한 사전 검토가 충실히 이루어져야 할 것으로 생각된다. 또한 소비자들에게도 개봉 후 수분에 일정시간 노출이 된 경우에는 유효성분의 변화 또는 분해가 일어날 수 있으므로 개봉 후에도 서늘하고 건조한 곳에서 저장을 해야 된다는 사실을 주지시킬 필요가 있다. 그러나 본 연구에서 사용한 개봉 후 제품은 뚜껑과 실리카 겔이 완전히 제거한 상태에서 수행한 실험이므로 실제적으로 가정에서 뚜껑과 실리카 겔이 존재한 상태에서의 저장 결과와는 같지 않을 것으로 생각되며, 이에 대한 추가적인 연구가 필요할 것으로 판단된다.

• 약학회지
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• 제38권1호
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• pp.38-45
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• 1994

An analytical method using capillary electrophoresis (CE) was developed for quantitation of water soluble vitamin contents in various vitamin products. The method includes the optimization of separation of 11 water soluble vitamins changing the micellar concentration and pH of running buffer, applied voltage and sample preparation. Best resolution was obtained with 25 mM phosphate buffer (pH=8.0) containing 50 mM sodium dodecyl sulphate (SDS) as micellar phase. At optimum condition, water soluble vitamins were determined in orange juice and vitamin products such as vitamin C pulvis, vitamin injection, coated multivitamin tablet. The quantitative analysis of water soluble vitamins with CE was suitable for quality control of pharmaceutical products with sound reproducibility.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.4111-4111
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• 2001

When a drug is prepared in a tablet, the active component represents only a small portion of the dosage form. The other components of the formulation include materials to assist in the dissolution, antioxidants, coloring agents and bulk fillers. The tablets are tested using approved testing methods usually involving separation and subsequent quantification of the active component. Tablets may also be tested by near-Infrared Reflectance spectrometry (NIRS). In the present study, based on NIRS and multivariate calibration methods, a novel and precise method is developed for direct determination of ascorbic acid in vitamin C tablet. Two different tablet formulations were powdered in three different sizes, 63-125 ${\mu}{\textrm}{m}$, and examined. Spectral region of 4750-4950 $cm^{-1}$ / was used and optimized for quantitative operations. Partial least squares (PLS) and multiple linear regression (MLR) methods were performed for this spectral region. The results of optimized PLS and MLR methods showed that reproducibility increase with decreasing grain size and standard error of calibration (SEP) of less than 1% w/w of ascorbic acid and a correlation coefficient of 0.998 can be achieved. The PLS method showed better results than MLR. Seven overdose and underdose samples (prepared in the laboratory to match marketed products) were tested by proposed and iodometric standard methods. A correlation between NIRS predicted ascorbic acid values and iodomet.ic values was calculated ($R^2$=0.9950). Finally, the direct analysis of individual intact tablets in their unit-dose packages (Blistering in aluminum and PVC foils) obtained from market were also carried out and a correlation coefficient of 0.9989 and SEP of 0.931% w/w of ascorbic acid were achieved.

• 한국조리학회지
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• 제6권3호
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• pp.263-280
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• 2000

This survey was conducted to investigated the status of nutritional consumption and relationship of nutrition of patients in hospitals from 1998.9.1 to 1998.9.10. Calorie intake of male patients was lower than RDA but that of female patients were higher than RDA except female younger than 64 years old. Protein intake of male patients was 130% higher than RDA, and that of female patients was 150% more than RDA. Calcium intake was lower than RDA in male patients but higher than RDA in female patients except older than 75 years. Iron intake was higher than RDA in all patients except in male patients older than 75 years. while vitamin B$_1$and vitamin C intake was higher than RDA in all patients but vitamin A and niacin intake was lower than RDA. The rich patients intake enough iron through animal foods and stabilized patients intake vitamin B$_2$ more than RDA. All patients were recognized the importance of protein and vegetable for health and they were recognized also careful choosing of foods for health. Positive relationships were showed between intake of nutritional tablet and nutritional status, between less vegetable intake and less intake of calorie, fat, sugar and fiber and between appetite and vitamin B$_1$ and vitamin C. The result showed that the shorter period staying in hospital, the more intake of sugar, vitamin A and vitamin C.