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http://dx.doi.org/10.5012/bkcs.2003.24.9.1308

Analysis of Folate by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry  

Cha, Sang-Won (School of Chemistry & Molecular Engineering, Seoul National University)
Kim, Hie-Joon (School of Chemistry & Molecular Engineering, Seoul National University)
Publication Information
Bulletin of the Korean Chemical Society / v.24, no.9, 2003 , pp. 1308-1312 More about this Journal
Abstract
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to observe folic acid and its derivatives such as tetrahydrofolate and 5-methyltetrahydrofolate in a vitamin tablet and in foods. Folic acid in a vitamin tablet was determined using angiotensin I as an internal reference. Tetrahydrofolic acid, 5-methyltetrahydrofolic acid, and an oxygenated folate were observed from a human blood sample using graphite plate. The results show that these mass spectrometric methods are useful for quickly obtaining a profile of folates.
Keywords
Folate; MALDI-TOF MS; Graphite plate; Vitamin; Blood;
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