• Analytical Science and Technology
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• v.8 no.4
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• pp.707-714
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• 1995

Two types of regularization method (singular system and HMP approaches) for generating depth-concentration profiles from angle-resolved XPS data were evaluated. Both approaches showed qualitatively similar results although they employed different numerical algorithms. The application of the regularization method to simulated data demonstrates its excellent utility for the complex depth profile system. It includes the stable restoration of the depth-concentration profiles from the data with considerable random error and the self choice of smoothing parameter that is imperative for the successful application of the regularization method. The self choice of smoothing parameter is based on generalized cross-validation method which lets the data themselves choose the optimal value of the parameter.

• Mass Spectrometry Letters
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• v.8 no.3
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• pp.49-52
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• 2017

Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, $ibuprofen-d_3$, was added as an internal standard into sample extracts. Ibuprofen and $ibuprofen-d_3$, was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrological quality of the method.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2003.09a
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• pp.49-57
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• 2003

Lately, a guideline for seismic design of electric substation facilities has been newly prepared and issued. The guideline adopts a new simplified dynamic analysis technique called "pseudo-resonance method" from the design code of Japan. The method can effectively consider resonance effect of structural system during earthquake motion. However, reliability and practical applicability of the method have not been fully guaranteed under the different seismic and engineering situations in Korea. This paper presents a validation study of the pseudo-resonance method for practical seismic analysis. For this purpose, various parametric studies have been performed using recorded earthquake motions and idealized substation equipment models. The results showed that the pseudo-resonance method can be effectively used for the practical seismic design of substation facilities in Korea.

• Bulletin of the Korean Chemical Society
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• v.34 no.6
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• pp.1857-1863
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• 2013

Most of biomaterials come in direct contact with the body, making standardized methods of evaluation and validation of biocompatibility an important aspect to biomaterial development. However, biomaterial validation guidelines have not been fully established, until now. This study was to compare the in vitro behavior of osteoblasts cultured on nanomaterial $TiO_2$ surfaces to osteoblast behavior on culture plates. Comparisons were also made to cells grown in conditioned media (CM) that creates an environment similar to the in vivo environment. Comparisons were made between the different growth conditions for osteoblast adhesion, proliferation, differentiation, and functionality. We found that the in vivo-like system of growing cells in concentrated CM provided a good validation method for biomaterial development and in vivo implant therapy. The $TiO_2$ materials were biocompatible, showing similar behavior to that observed in vivo. This study provided valuable information that would aid in the creation of guidelines into standardization and evaluation of biocompatibility in $TiO_2$ biomaterials.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.12 no.3
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• pp.3-13
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• 2002

There are cases that revoke the certification because of disclosure of private key, deprivation of qualification and the expiration of a term of validity on PKI. So, a user has to confirm the public key whether valid or invalid in the certification. There are many methods such as CRL, Delta-CRL, OCSP for the cert-validation of certification. But these methods have many problems, which cause overload traffic on network and the CRL server because of realtime processing for cert-validation of certification. In this paper we proposed cert-validation of certification improvement method based on FM Subcarrier Broadcasting, which solved problems that are data integrity by different time between transmission and receiving for CRL, and overload traffic on network and the CRL server the realtime management.

• Microbiology and Biotechnology Letters
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• v.36 no.1
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• pp.12-20
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• 2008

Validation of viral safety is essential in ensuring the safety of mammalian cell culture-derived biopharmaceuticals, because numerous adventitious viruses have been contaminated during the manufacture of the products. Mammalian cells are highly susceptible to minute virus of mice(MVM), and there are several reports of MVM contamination during the manufacture of biopharmaceuticals. In order to establish the validation system for the MVM safety, a real-time PCR method was developed for quantitative detection of MVM in cell lines, raw materials, manufacturing processes, and final products as well as MVM clearance validation. Specific primers for amplification of MVM DNA was selected, and MVM DNA was quantified by use of SYBR Green I. The sensitivity of the assay was calculated to be $6{\times}10^{-2}TCID_{50}/mL$. The real-time PCR method was proven to be reproducible and very specific to MVM. The established real-time PCR assay was successfully applied to the validation of Chinese hamster ovary (CHO) cell artificially infected with MVM. MVM DNA could be Quantified in CHO cell as well as culture supernatant. When the real-time PCR assay was applied to the validation of virus removal during a virus filtration process, the result was similar to that of virus infectivity assay. Therefore, it was concluded that this rapid, specific, sensitive, and robust assay could replace infectivity assay for detection and clearance validation of MVM.

• Journal of the Korean Data and Information Science Society
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• v.21 no.1
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• pp.155-162
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• 2010

In this paper we propose a doubly penalized kernel method which estimates both the mean function and the variance function simultaneously by kernel machines for heteroscedastic autoregressive data. We also present the model selection method which employs the cross validation techniques for choosing the hyper-parameters which aect the performance of proposed method. Simulated examples are provided to indicate the usefulness of proposed method for the estimation of mean and variance functions.

• Journal of the Korean Data and Information Science Society
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• v.21 no.6
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• pp.1319-1325
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• 2010

Quantile regression provides a more complete statistical analysis of the stochastic relationships among random variables. Sometimes quantile functions estimated at different orders can cross each other. We propose a new non-crossing quantile regression method applying support vector median regression to restricted regression quantile, restricted support vector quantile regression. The proposed method provides a satisfying solution to estimating non-crossing quantile functions when multiple quantiles for high dimensional data are needed. We also present the model selection method that employs cross validation techniques for choosing the parameters which aect the performance of the proposed method. One real example and a simulated example are provided to show the usefulness of the proposed method.

• Communications for Statistical Applications and Methods
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• v.15 no.3
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• pp.441-450
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• 2008

In this paper we propose a new method for solving multiclass problem with least squares support vector machine(LS-SVM) regression. This method implements one-against-all scheme which is as accurate as any other approach. We also propose cross validation(CV) method to select effectively the optimal values of hyper-parameters which affect the performance of the proposed multiclass method. Experimental results are then presented which indicate the performance of the proposed multiclass method.

• Nuclear Engineering and Technology
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• v.26 no.3
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• pp.367-373
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• 1994

It is necessary to adopt a simple signal validation for avoiding the complexity of algorithm and verification in the design process of the instrumentation and control system in nuclear plants. This paper suggests a signal validation method developed on the basis of consistency checking for the multi-channel measurement system without any analytic process model. It includes a simplified algorithm for estimating the fixed bias error of each channel and a weighted averaging method. The weighting factor of each channel is updated according to its calculated bias error. The developed method has been tested to verify its performance through several input scenarios.