Mass Spectrometry Letters

  • 제8권3호
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  • Pages.49-52
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  • 2017
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  • 2233-4203(pISSN)
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  • 2093-8950(eISSN)
한국질량분석학회 (Korean Society for Mass Spectrometry)
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Development of an Isotope Dilution Mass Spectrometry (IDMS)-Based Method for the Analysis of Ibuprofen

  • Lee, Joonhee (Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science) ;
  • Kim, Byungjoo (Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science)
  • 투고 : 2017.07.25
  • 심사 : 2017.09.11
  • 발행 : 2017.09.30
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초록

Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, $ibuprofen-d_3$, was added as an internal standard into sample extracts. Ibuprofen and $ibuprofen-d_3$, was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrological quality of the method.

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