[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5478/MSL.2017.8.3.49

Development of an Isotope Dilution Mass Spectrometry (IDMS)-Based Method for the Analysis of Ibuprofen

Lee, Joonhee (Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science)
Kim, Byungjoo (Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science)

Publication Information

Mass Spectrometry Letters / v.8, no.3, 2017 , pp. 49-52 More about this Journal

Abstract

Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, $ibuprofen-d_3$ , was added as an internal standard into sample extracts. Ibuprofen and $ibuprofen-d_3$ , was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrological quality of the method.

Keywords

Ibuprofen; ID-LC/MS; Method Validation; Pharmaceuticals;

Citations & Related Records

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