• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5599-5608
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• 2013

With the high morbidity and mortality caused by cancer, finding new and more effective anti-cancer drugs is very urgent. In current research, biotransformation plays a vital role in the research and development of cancer drugs and has obtained some achievements. In this review, we have summarized four applications as follows: to exploit novel anti-cancer drugs, to improve existing anti-cancer drugs, to broaden limited anti-cancer drug resources and to investigate correlative mechanisms. Three different groups of important anti-cancer compounds were assessed to clarify the current practical applications of biotransformation in the development of anti-cancer drugs.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.3
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• pp.127-135
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• 2020

The paper aims to examine whether business cycles affect the link between financial development and bank risk, measured by Zscore and non-performing loans to total loans in six Southeast Asian countries, namely Indonesia, Philippines, Malaysia, Singapore, Thailand and Vietnam. This study uses a sample of 95 listed commercial banks over a 15-year period between 2004 and 2018 in the six Southeast Asian countries. This study employs panel OLS regression and modifications to tackle issues such as endogeneity and heteroscedasticity. The results show that the impact of stock market development (the ratio of the market capitalization to GDP) on Zscore is significantly positive, whereas its effect on non-performing loans is significantly negative. The findings suggest that financial development, in terms of stock market capitalization, improves banks' Zscores and reduces their level of non-performing loans, suggesting that financial development on average reduces bank risk. The impact of business cycle is insignificant towards bank risk, thus rejecting both counter- and pro-cyclical hypotheses, except for the case of risk indicator of loan loss provisions. Examining the joint effect of the business cycle and financial development on bank risk, we find that the phase of business cycles generally does not moderate the link between financial development and bank risk.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.4
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• pp.1136-1146
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• 2015

The purpose of this study was to clarify the meaning of marine officer's self-efficacy, job satisfaction, definition of self-development and factors of determination. It shows that how their self-efficacy affects job satisfaction, self-development and that how their job satisfaction affects self-development. To achieve the purpose of the research, checked the definition and factors of marine officer's duty, self-efficacy, job satisfaction and self-development. Furthermore, cultivated a research model about the factors to influence between self-efficacy and job satisfaction, self-efficacy and self-development, job satisfaction and self-development. A result of hypothesis test by regression analysis is that 11 hypotheses were adopted among 17, and the rest of them were dismissed. The contents of hypotheses were set as follows; self-efficacy and internal job satisfaction, self-efficacy and external job satisfaction, self-efficacy and self-development, job satisfaction and self-development.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.495-502
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• 2021

The study is devoted to substantiation of directions of intensification of development of small innovative enterprise, which has a significant impact on the overall innovation activity of the country and promotes innovative development, transition to more advanced technological systems. The outlined role of small business in innovative development in the direction of intensifying innovation in the economy, improving organization and production, as well as in the form of direct participation in the innovation process, production of science-intensive products, stimulating demand for innovation. A group of factors hindering the development of small innovative entrepreneurship was identified, including: financial aspects of the activity, shortcomings of organizational and communicative nature, underdeveloped technology market, information plan problems, internal production problems of small business, market problems. The directions of intensification of the development of small innovative entrepreneurship are substantiated, namely: financial and credit support of small innovative entrepreneurship; introduction of tax incentives; material and technical support; nationwide intensification of innovation activity; information support; development of innovation infrastructure. The involvement of the outlined directions of intensification of small innovative entrepreneurship will help to obtain a synergistic effect of innovative development of both small innovative business structures and the economy as a whole.

• Journal of Agricultural Extension & Community Development
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• v.31 no.1
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• pp.27-39
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• 2024

Community participation, community satisfaction and sense of community stand out as key factors that promote community development. This study aims to examine the structural equation model among sense of community, community participation, and community satisfaction in the Rural New Revitalization Plus Projects in Kongju. Data were collected from 411 structured questionnaires twenty-three rural communities, Kyeongnam and Chungnam province. Results showed that individuals with shared emotional connection were more likely to participate community development projects. And individuals with membership and fulfillment of needs are more like to be satisfied with their community. Additionally community participation has the fully moderating effect between shared emotional connection and satisfaction. Findings suggest that policy makers and community development practitioners consider community participation and sense of community for enhancing community development.

• Bulletin of the Korean Chemical Society
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• v.34 no.7
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• pp.2011-2015
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• 2013

To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)-phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2003.10a
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• pp.141-141
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• 2003

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4309-4315
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• 2011

For synthesis of benzastatin E, F and G analogues, the indole-2-carbaldehydes with or without substituents at C-5 position were prepared as key intermediates. Several synthetic attempts to achieve benzastatin E-G analogues were suggested using the indole-2-carbaldehyde intermediates.

• 한국초전도학회:학술대회논문집
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• v.12
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• pp.71-71
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• 2002

• Clinical and Experimental Reproductive Medicine
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• v.27 no.4
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• pp.381-385
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• 2000

Objective: To verify the effect of two forms (growth factor and growthfactor-reduced) of solubilized Matrigel on the development in mouse preimplantation embryos. Methods: Late 2-cell stage eggs were cultured through the blastocyst stage in the presence of GF- or GFR-Matrigel (0.5%, v/v). Morphological development, cell number and % apoptotic nuclei of blastocyst were measured by Roecst staining and TUNEL of nuclei. Results: Morphological development, number of cells per embryo was significantly increased in the presence of GF- or GFR-Matrigel. Culture of the embryos in the GF-Matrigel gave the best result. Conclusion: Low concentration of solubilized Matrigel improved development of mouse embryos regardless of growth factor content of the Matrigel. Growth factors and extracellular matrix protein included in the Matrigel synergistically potentiated the development of mouse embryos.