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http://dx.doi.org/10.5012/bkcs.2013.34.7.2011

Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)  

Bang, Seong-Cheol (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University)
Lee, Ki-Cheul (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University)
Sharma, Vinay K. (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University)
Sharma, Niti (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University)
Yang, Hyun-Sun (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University)
Jung, Sang-Hun (College of Pharmacy and Institute of Drug Research and Development, Chungnam National University)
Publication Information
Bulletin of the Korean Chemical Society / v.34, no.7, 2013 , pp. 2011-2015 More about this Journal
Abstract
To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)-phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.
Keywords
Arylsulfonylimidazolidinone; Solubility; Cytotoxicity; Anti-cancer;
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