• Korean Journal of Clinical Pharmacy
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• v.21 no.1
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• pp.30-35
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• 2011

The objective of this study was to find out drug use pattern of narcotic analgesics in university hospitals in Korea. A university hospital located in Kyungbuk province was chosen for this study. The drug use pattern was analyzed in terms of ingredient, administration route, patient type, and attending department. Amount of drug usage was counted by unit dose defined by the number of ampule or vial for injectable, tablet or capsule for oral, and each for patch preparations. Result showed that 11 narcotic analgesic ingredients were used during 2007-2009, and the drug usage was increased by about 20% annually during the period. Proportion of oral preparations used for pain management was about two third of all narcotic analgesics usage and kept increasing during the period. Proportion of the drug usage for outpatients was also steadily increased. Notably, the usage of oral preparations of oxycodone, morphine, and hydromorphone was rapidly increased for the management of cancer pain while the usage of codeine and codeine-containing composite preparations for cancer pain were minimal (<10%). About 90% of all narcotic analgesics were used by physicians in Internal Department, especially in Oncology Division of the Department. These findings suggest that pain management is becoming more aggressive and in agreement with WHO's guidelines regarding selection of administration route. However, in terms of 3-step ladder for cancer pain management, the drug use pattern was not congruent to WHO's guidelines. Therefore, in conclusion, it appears that physicians need to try to be congruent to the guidelines when using narcotic analgesics for cancer pain.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.1
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• pp.161-171
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• 2014

When the Hough transform is applied to identify an instance of a given model, the output is typically a histogram of votes cast by a set of image features into a parameter space. The next step is to threshold the histogram of counts to hypothesize a given match. The question is "What is a reasonable choice of the threshold?" In a standard implementation of the Hough transform, the threshold is selected heuristically, e.g., some fraction of the highest cell count. Setting the threshold too low can give rise to a false alarm of a given shape(Type I error). On the other hand, setting the threshold too high can result in mis-detection of a given shape(Type II error). In this paper, we derive two conditional probability functions of cell counts in the accumulator array of the generalized Hough transform(GHough), that can be used to select a scientific threshold at the peak detection stage of the Ghough.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.5
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• pp.563-571
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• 2012

In 3D integration package using TSV technology, bonding is the core technology for stacking and interconnecting the chips or wafers. During bonding process, however, warpage and high stress are introduced, and will lead to the misalignment problem between two chips being bonded and failure of the chips. In this paper, a finite element approach is used to predict the warpages and stresses during the bonding process. In particular, in-plane deformation which directly affects the bonding misalignment is closely analyzed. Three types of bonding technology, which are Sn-Ag solder bonding, Cu-Cu direct bonding and SiO2 direct bonding, are compared. Numerical analysis indicates that warpage and stress are accumulated and become larger for each bonding step. In-plane deformation is much larger than out-of-plane deformation during bonding process. Cu-Cu bonding shows the largest warpage, while SiO2 direct bonding shows the smallest warpage. For stress, Sn-Ag solder bonding shows the largest stress, while Cu-Cu bonding shows the smallest. The stress is mainly concentrated at the interface between the via hole and silicon chip or via hole and bonding area. Misalignment induced during Cu-Cu and Sn-Ag solder bonding is equal to or larger than the size of via diameter, therefore should be reduced by lowering bonding temperature and proper selection of package materials.

• Journal of Microbiology and Biotechnology
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• v.25 no.2
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• pp.196-205
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• 2015

A Sulfolobus-E. coli shuttle vector for an efficient expression of the target gene in S. acidocaldarius strain was constructed. The plasmid-based vector pSM21 and its derivative pSM21N were generated based on the pUC18 and Sulfolobus cryptic plasmid pRN1. They carried the S. solfataricus P2 pyrEF gene for the selection marker, a multiple cloning site (MCS) with C-terminal histidine tag, and a constitutive promoter of the S. acidocaldarius gdhA gene for strong expression of the target gene, as well as the pBR322 origin and ampicillin-resistant gene for E. coli propagation. The advantage of pSM21 over other Sulfolobus shuttle vectors is that it contains a MCS and a histidine tag for the simple and easy cloning of a target gene as well as one-step purification by histidine affinity chromatography. For successful expression of the foreign genes, two genes from archaeal origins (PH0193 and Ta0298) were cloned into pSM21N and the functional expression was examined by enzyme activity assay. The recombinant PH0193 was successfully expressed under the control of the gdhA promoter and purified from the cultures by His-tag affinity chromatography. The yield was approximately 1 mg of protein per liter of cultures. The enzyme activity measurements of PH0913 and Ta0298 revealed that both proteins were expressed as an active form in S. acidocaldarius. These results indicate that the pSM21N shuttle vector can be used for the functional expression of foreign archaeal genes that form insoluble aggregates in the E. coli system.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.43 no.5 s.311
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• pp.30-36
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• 2006

In this paper, a new type of written image segmentation based on relative comparison of region areas is proposed. The original image is composed of two distinctive regions; information and background. Compared with this binary original image, the observed one is the gray scale which is represented with complex regions with speckles and noise due to degradation or contamination. For applying threshold or statistical approach, there occurs the region-deformation problem in the process of binarization. At first step, the efficient iterated conditional mode (ICM) which takes the lozenge type block is used for regions formation into the binary image. Secondly the information region is estimated through selecting action and restored its primary state. Not only decision of the attachment to a region but also the calculation of the magnitude of its area are carried on at each current pixel iteratively. All region areas are sorted into a set and selected through the decision parameter which is obtained statistically. Our experiments show that these approaches are effective on ink-rubbed copy image (拓本 'Takbon') and efficient at shape restoration. Experiments on gray scale image show promising shape extraction results, comparing with the threshold-segmentation and conventional ICM method.

• Convergence Security Journal
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• v.14 no.4
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• pp.55-60
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• 2014

In this study, we propose a cryptographic module quality evaluation system referenced by ISO/IEC 9000 quality system with Quality, Quality Factor, Quality Subfactor, Metric. Practical application process encryption algorithm based on the encryption algorithm to encrypt the pros and cons valuation of diagnosis, point selection algorithm, analysis, and quality items(quality factor), eliciting constraints derived, such as the cryptographic module design quality evaluation system is set to step 5. The five steps are examples of field-based diagnostic tool for cryptographic operations, the most essential work to be done in order to derive one will work. 2-Factor encryption module for connection between indicator items(quality factor) to identify and ensure the quality of the item the constraints of the environment are two kinds of cryptographic operations. This study is an encryption module and a practical field application system, it presents the standardized model. We have to meet the rapid changes in information technology. The environment, development and the encryption algorithm applied to model a wide variety of on-site development encryption will be able to expect the efficiency.

• Journal of Mechanical Science and Technology
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• v.19 no.10
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• pp.1919-1931
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• 2005

Human joint motion can be kinematically described in three planes, typically the frontal, sagittal, and transverse, and related to experimentally measured data. The selection of reference systems is a prerequisite for accurate kinematic analysis and resulting development of the equations of motion. Moreover, the development of analysis techniques for the minimization of errors, due to skin movement or body deformation, during experiments involving human locomotion is a critically important step, without which accurate results in this type of experiment are an impossibility. The traditional kinematic analysis method is the Angular-based method (ABM), which utilizes the Euler angle or the Bryant angle. However, this analysis method tends to increase cumulative errors due to skin movement. Therefore, the objective of this study was to propose a new kinematic analysis method, Position-based method (PBM), which directly applies position displacement data to represent locomotion. The PBM presented here was designed to minimize cumulative errors via considerations of angle changes and translational motion between markers occurring due to skin movements. In order to verify the efficacy and accuracy of the developed PBM, the mean value of joint dislocation at the knee during one gait cycle and the pattern of three dimensional translation motion of the tibiofemoral joint at the knee, in both flexion and extension, were accessed via ABM and via new method, PBM, with a Local Reference system (LRS) and Segmental Reference system (SRS), and then the data were compared between the two techniques. Our results indicate that the proposed PBM resulted in improved accuracy in terms of motion analysis, as compared to ABM, with the LRS and SRS.

• Ocean and Polar Research
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• v.31 no.4
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• pp.369-377
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• 2009

Performance of the Korea Ocean Research and Development Institute (KORDI) operational storm surge prediction system for the Korean coast is presented here. Results for storm surge hindcasts and forecasts calculations were analyzed. The KORDI storm surge system consists of two important components. The first component is atmospheric models, based on US Army Corps of Engineers (CE) wind model and the Weather Research and Forecasting (WRF) model, and the second components is the KORDI-storm surge model (KORDI-S). The atmospheric inputs are calculated by the CE wind model for typhoon period and by the WRF model for non-typhoon period. The KORDI-S calculates the storm surges using the atmospheric inputs and has 3-step nesting grids with the smallest horizontal resolution of ${\sim}$300 m. The system runs twice daily for a 72-hour storm surge prediction. It successfully reproduced storm surge signals around the Korean Peninsula for a selection of four major typhoons, which recorded the maximum storm surge heights ranging from 104 to 212 cm. The operational capability of this system was tested for forecasts of Typhoon Nari in 2007 and a low-pressure event on August 27, 2009. This system responded correctly to the given typhoon information for Typhoon Nari. In particular, for the low-pressure event the system warned of storm surge occurrence approximately 68 hours ahead.

• The Plant Pathology Journal
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• v.34 no.2
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• pp.104-112
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• 2018

Accurate and rapid detection of bacterial plant pathogen is the first step toward disease management and prevention of pathogen spread. Bacterial plant pathogens Clavibacter michiganensis subsp. nebraskensis (Cmn), Pantoea stewartii subsp. stewartii (Pss), and Rathayibacter tritici (Rt) cause Goss's bacterial wilt and blight of maize, Stewart's wilt of maize and spike blight of wheat and barley, respectively. The bacterial diseases are not globally distributed and not present in Korea. This study adopted comparative genomics approach and aimed to develop specific primer pairs to detect these three bacterial pathogens. Genome comparison among target pathogens and their closely related bacterial species generated 15-20 candidate primer pairs per bacterial pathogen. The primer pairs were assessed by a conventional PCR for specificity against 33 species of Clavibacter, Pantoea, Rathayibacter, Pectobacterium, Curtobacterium. The investigation for specificity and sensitivity of the primer pairs allowed final selection of one or two primer pairs per bacterial pathogens. In our assay condition, a detection limit of Pss and Cmn was $2pg/{\mu}l$ of genomic DNA per PCR reaction, while the detection limit for Rt primers was higher. The selected primers could also detect bacterial cells up to $8.8{\times}10^3cfu$ to $7.84{\times}10^4cfu$ per gram of grain seeds artificially infected with corresponding bacterial pathogens. The primer pairs and PCR assay developed in this study provide an accurate and rapid detection method for three bacterial pathogens of grains, which can be used to investigate bacteria contamination in grain seeds and to ultimately prevent pathogen dissemination over countries.

• Korean Journal of Computational Design and Engineering
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• v.13 no.2
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• pp.139-152
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• 2008

In order to survive worldwide competition, today's industries are experiencing strong pressure to introduce higher quality products with lower cost and shorter lead-time. Therefore, the role of design in the process of product development is increasing in significance. In this research, two methods for improving the design capability are proposed: construction of design environment and design automation using 3D CAD system. The designers and design process are the core of product design using 3D CAD system. In order to maximize the design performance, construction of the design environment including selection of a suitable system, designer training for best use of the system, establishment of an efficient design process, and stabilization of the environment are required. A method is suggested to construct design environment by systematizing the contents of the projects and consulting experiences carried out for various categories of business such as electronic devices, motorcycles, electricity parts, sanitary wares, injection molds, and die casing molds. Design automation helps reduce tedious and time-consuming jobs, simplify complicated and error-prone modeling and drawing works to shorten the lead time and improve the product quality. To develop a design automation system, understanding the process and the related knowledge on design are very important before implementing the system using API provided by 3D CAD system. In this research, an eight-step procedure is proposed for the development of a design automation system. These eight steps are analysis of needs, determination of specification, verification of specification using 3D CAD system, inspection of related API functions, programming, field test, application in practice, and maintenance. A case study in which five design automation systems in the design of turbine generators using the proposed method is introduced in detail. These systems play important roles in the generation of various output items including 3D models, drafts, material information, and NC data. The case study shows how effectively the design time is reduced and the quality improved using those systems.